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United States Department of Agriculture

Agricultural Research Service

Research Project: CONTROL OF FUSARIUM VERTICILLIOIDES, FUMONISINS AND FUSARIUM DISEASES OF MAIZE Title: Advances in Understanding the Biosynthesis of Fumonisins

Authors
item Gerber, Ryan - UNIV OF NEB
item Lou, Lili - UNIV OF NEB
item Huffman, Justin - UNIV OF NEB
item Zhu, Xiangcheng - ZHEJIANG UNIV, CHINA
item Lin, Ting - XIAMEN UNIV, CHINA
item Li, Lucy - UNIV OF NEB
item Arreguin, Isis - UNIV OF NEB
item Butchko, Robert
item Proctor, Robert
item Du, Liangcheng - UNIV OF NEB

Submitted to: American Chemical Society Symposium Series
Publication Type: Book / Chapter
Publication Acceptance Date: October 26, 2008
Publication Date: December 20, 2009
Citation: Gerber, R., Lou, L., Huffman, J., Zhu, X., Lin, T., Li, L.Q., Arreguin, I., Butchko, R.A., Proctor, R., Du, L. 2009. Advances in Understanding the Biosynthesis of Fumonisins. In: Appell, M., Kendra, D. F., and Trucksess, M. W., editors. Mycotoxin Prevention and Control in Agriculture. Washington DC: American Chemical Society Symposium Series 1031. p. 167-182.

Technical Abstract: Fumonisins are a group of economically important mycotoxins that are derived polyketides. Since the cloning of the fumonisin polyketide synthase (PKS) gene from Fusarium verticillioides in 1999, significant advances have been made in understanding the molecular mechanisms for fumonisin biosynthesis. The 17-gene cluster (FUM) required for fumonisin biosynthesis, regulation, and possibly resistance has been extensively studied using the gene disruption approach. Genetic manipulations of the fumonisin PKS gene have shed light on the mechanism for fungal highly-reducing PKS to control the structure of products. A number of FUM genes have been heterologously expressed, and the role of these genes in fumonisin biosynthesis have been demonstrated by determining the chemical reactions catalyzed by the purified enzymes. Together, these efforts have established a general biosynthetic pathway for fumonisins and revealed several fascinating enzymatic reactions. In spite of the progress, many questions remain. Future efforts should focus on addressing the molecular mechanistic details in fumonisin polyketide chain assembly, releasing, and modifications by the unusual functional groups.

Last Modified: 10/23/2014
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