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United States Department of Agriculture

Agricultural Research Service

Research Project: NOVEL TECHNOLOGIES AND TECHNIQUES FOR THE DETECTION OF RESIDUES, TOXINS, AND OTHER CHEMICALS IN FOODS

Location: Residue Chemistry and Predictive Microbiology

Title: New Method for Analysis of Multiple Anthelmintic Residues in Animal Tissue

Authors
item Kinsella, Brian - TEAGASC, IRELAND
item Lehotay, Steven
item Lightfield, Alan
item Mastovska, Katerina
item Furey, Ambrose -
item Danaher, Martin - TEAGASC, IRELAND

Submitted to: Euroresidue Conference Proceedings
Publication Type: Proceedings
Publication Acceptance Date: March 1, 2008
Publication Date: May 19, 2008
Citation: Kinsella, B., Lehotay, S.J., Lightfield, A.R., Mastovska, K., Furey, A., Danaher, M. 2008. New Method for Analysis of Multiple Anthelmintic Residues in Animal Tissue. Euroresidue Conference Proceedings. p.1147-1152.

Technical Abstract: For the first time, 39 of the major anthelmintics can be detected in one rapid and sensitive LC-MS/MS method, including the flukicides, which have been generally overlooked in surveillance programs. Utilizing the QuEChERS approach, residues were extracted from liver and milk using acetonitrile, sodium chloride, and magnesium sulphate. Extracts were purified by dispersive SPE using magnesium sulphate and octadecylsilane before injection onto the LC-MS/MS. The method was single laboratory validated according to 2002/657/EC criteria. The limit of quantitation of the method was 5 ug/kg for all residues except dichlorvos (10 ug/kg).

Last Modified: 4/19/2014
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