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United States Department of Agriculture

Agricultural Research Service

Title: Structure of the anhydrous form of gossypol-Dianhydrogossypol

Authors
item Mamadrakhimov, Azimjon - INST. BIOORG. CHEM.
item Talipov, Samat - INST. BIOORG. CHEM.
item Tiljakov, Zavkibek - INST. BIOORG. CHEM.
item Dowd, Michael
item Ibragimov, Bakhtiyar - INST. BIOORG. CHEM.

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: April 1, 2008
Publication Date: August 23, 2008
Citation: Mamadrakhimov, A., Talipov, S.A., Tiljakov, Z.G., Dowd, M.K., Ibragimov, B.T. 2008. Structure of the anhydrous form of gossypol-Dianhydrogossypol (abstract). XXI Congress of the International Union of Crystallography. p. C395.

Technical Abstract: Gossypol, C30 H30 O8,is yellow pigment containing in glands of various species of cotton plants. By chemical modification of gossypol a great number of gossypol derivates-its ethers, Schiff's bases, etc.-have been obtained. Dianhydrogossypol which is formed by dehydratation of gossypol is of a special interest for our studies. The crystals of dianhydrogossypol were obtained from saturated solution in dichloromethane. Data collection has been carried out on a Gemini R X-ray diffractometer equipped with an Oxford Cryosystems open-flow cryostat at 100 K. The crystallographic parameters are: alpha-33.8265(4), c=9.1497(2)A, V-4677A3, Sp.gr.-I41/a. The results of the X-Ray studies show that molecular structure confirms anticipated one. The crystal structure has wide channels in the direction of c-axis and resembles the channel structure found earlier in one of gossypol polymorphs (zeolite-like structure). The packing factor of these crystals is very low and equal to 0.59. The volume of empty space of the an elementary cell is equal to 1641 A3 or 15,7% of the total volume. The dianhydrogossypol demonstrates good inclusion ability for molecules of many small volatile compounds which requires further detailed investigations in relation to potential new organic zeolite.

Last Modified: 12/22/2014
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