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United States Department of Agriculture

Agricultural Research Service

Research Project: COUNTERMEASURES TO PREVENT AND CONTROL TUBERCULOSIS IN CATTLE AND WILDLIFE RESERVOIRS Title: Safety and Immunogenicity of the Mycobacterium tuberculosis {Delta}lysA {Delta}panCD Vaccine in Domestic Cats Infected with Feline Immunodeficiency Virus

Authors
item Zimmerman, D - MEMPHIS ZOO AND AQUARIUM
item Waters, Wade
item Lyashchenko, K - CHEMBIO DIAGNOSTIC SYS.
item Nonnecke, Brian
item Armstrong, D - HENRY DOORLY ZOO, OMAHA
item Jacobs, JR., W - HOWARD HUGHES MED. INST.
item Larsen, M - HOWARD HUGHES MED. INST.
item Egan, E - N. CAROLINA ST. UNIV.
item Dean, G - N. CAROLINA ST. UNIV.

Submitted to: Clinical and Vaccine Immunology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: January 7, 2009
Publication Date: March 1, 2009
Citation: Zimmerman, D., Waters, W.R., Lyashchenko, K.P., Nonnecke, B.J., Armstrong, D.L., Jacobs, Jr., W.R., Larsen, M.H., Egan, E., Dean, G.A. 2009. Safety and Immunogenicity of the Mycobacterium tuberculosis {Delta}lysA {Delta}panCD Vaccine in Domestic Cats Infected with Feline Immunodeficiency Virus. Clinical and Vaccine Immunology. 16(3):427-429.

Interpretive Summary: A high percentage of lions in Africa are infected with bovine tuberculosis and many of these lions are co-infected with an immunodeficiency virus. Prior to testing in lions, domestic cats were used as a feline model to test the immunogenicity and safety of a candidate vaccine. Four cats infected with feline immunodeficiency virus and four non-infected cats were vaccinated with an attenuated live tuberculosis vaccine. Adverse reactions were not detected and all cats had an immune response to the vaccine, although a lower response was detected for immunodeficiency infected cats. These findings demonstrate the potential for use of an attenuated live tuberculosis vaccine in lions.

Technical Abstract: Feline immunodeficiency virus (FIV)+ and FIV- cats (n = 4/group) received 2 x 10**6 cfu Mycobacterium tuberculosis Delta-lysA Delta-panCD intramuscularly. Vaccination elicited antibody responses; albeit, at lower levels in FIV+ cats as compared to FIV- cats. Delayed-type hypersensitivity responses were minimal in both groups. No adverse reactions were found.

Last Modified: 7/24/2014
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