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ARS Home » Midwest Area » Peoria, Illinois » National Center for Agricultural Utilization Research » Mycotoxin Prevention and Applied Microbiology Research » Research » Publications at this Location » Publication #233727
Title: Isolation of Chromanone and Isobenzofuran Derivatives from a Fungicolous Isolate of Epiccocum purpurascens

Author
item LEE, NAM - CHEJU NAT UNIV, KOREA
item GLOER, JAMES - UNIV OF IOWA
item Wicklow, Donald

Submitted to: Korean Chemical Society
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 4/15/2007
Publication Date: 11/15/2007
Citation: Lee, N.H., Gloer, J.B., Wicklow, D.T. 2008. Isolation of Chromanone and Isobenzofuran Derivatives from a Fungicolous Isolate of Epiccocum purpurascens. Bulletin of the Korean Chemical Society. 28(5):877-879.

Interpretive Summary: Fungi that parasitize and kill other fungi offer a potential source of novel antifungal agents useful to agriculture and medicine. The fungus Epicoccum purpurascens NRRL 37031, encountered as a colonist of a wood decay fungus in Florida, was examined for its ability to produce antifungal agents and other bioactive metabolites. New chromanone and isobenzofuran metabolites are reported, along with a known isobenzofuran metabolite originally reported as a potent antioxidant.

Technical Abstract: Chemical studies of an organic extract of Epicoccum purpurascens NRRL 37031, isolated from a wood decay fungus in Florida, led to the isolation of two new metabolites, 7-methoxy-4-oxo-chroman-5-carboxylic acid methyl ester (1) and 1,3-dihydro-5-methoxy-7-methylisobenzofuran (2). Two known isobenzofuran metabolites were also obtained. The structures of these compounds were elucidated on the basis of NMR and MS data.