Title: Salmonella expression of the avian influenza HA and M2e genes for protection of poultry from lethal challenge Author
Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: September 9, 2009
Publication Date: N/A
Technical Abstract: Avian influenza (AI) is viral disease of poultry and detection in commercial flocks can result in trade embargos causing serious economic impact to the poultry industry. Vaccination is currently used to increase protection of birds against AI and limit transmission to susceptible cohorts. Because of differences between individual AI viruses, no single vaccine protects against all AI viruses. The objectives of the present research were to extend the knowledge of vaccine induced protection by developing an AI vaccine expressed by bacteria on mucosal surfaces with the potential to cross react with all AI viruses, and with specificity against highly pathogenic isolates. The results demonstrate that the vaccines developed against the AI M2e protein could increase protection and decrease transmission against low virulent AI, and that expression of the AI hemagglutinin can increase protection against highly pathogenic isolates. These results are an important step in further development of vaccines for poultry against AI.