Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: March 25, 2010
Publication Date: March 25, 2010
Citation: Appell, M.D., Jackson, M.A. 2010. Study of cyclodextrin-based polymers to extract patulin from apple juice [abstract]. American Chemical Society Meeting. #THA4. Technical Abstract: Synthetic sorbents offer a means to develop more robust materials to detect analytes in complex matrices, including methods to detect naturally occurring contaminants in agricultural commodities. Patulin is a mold metabolite associated with rotting apples and poses health risks to humans and animals. Beta-cyclodextrin-based polyurethane polymers were synthesized and evaluated for the ability to bind the toxin patulin under aqueous conditions. Freundlich isotherm analysis indicates a degree of heterogeneity in the affinity of the binding site population. Crosslinked polymers with tolylene 2,4-diisocyanate were suitable for the solid phase extraction and LC-analysis of patulin from apple juice. Studies of binding modes of patulin with the ß-cyclodextrin component using the PM3 semi-empirical method identified several preferred complexes possessing intermolecular hydrogen bond interactions. These nanoporous polymers exhibit favorable properties to assist the detection of patulin in aqueous solutions.