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United States Department of Agriculture

Agricultural Research Service

Research Project: GENOMIC AND FUNCTIONAL ANALYSIS OF THE MUCOSAL IMMUNE RESPONSE AND ITS ROLE IN PROTECTION AGAINST RESPIRATORY PATHOGENS IN POULTRY

Location: Exotic and Emerging Avian Viral Diseases Research Unit

Title: Serologic cross reactivity of avian influenza H1 vaccinated commercial U.S. turkeys to the emergent H1N1 influenza virus

Authors
item Kapczynski, Darrell
item Gonder, Eric -
item Tilley, Becky -
item Suarez, David
item Swayne, David

Submitted to: American Association of Avian Pathologists
Publication Type: Abstract Only
Publication Acceptance Date: February 18, 2010
Publication Date: N/A

Technical Abstract: Recently, the 2009 human H1N1 influenza virus was identified in turkey breeders in Chile, Canada and the U.S. resulting in infection and production losses. In these studies sera from turkeys vaccinated against avian influenza H1 were tested against the recent human pandemic H1N1 virus. Genetic analysis demonstrated 92 percent nucleotide similarity in hemagglutinin gene sequences between avian and human H1N1. High levels of HI antibody were observed against the homologous avian vaccine viruses, while minimal cross reaction was observed against the human H1N1. Taken together, the current turkey H1N1 vaccines may have limited cross protection against the human pandemic H1N1.

Last Modified: 8/21/2014
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