IMPROVING GENETIC PREDICTIONS FOR DAIRY ANIMALS USING PHENOTYPIC AND GENOMIC INFORMATION
Title: High Resolution QTL Maps Of 31 Traits in Contemporary U.S. Holstein Cows
Submitted to: World Congress of Genetics Applied in Livestock Production
Publication Type: Proceedings
Publication Acceptance Date: June 1, 2010
Publication Date: August 1, 2010
Citation: Cole, J.B., Wiggans, G.R., Ma, L., Sonstegard, T.S., Crooker, B.A., Van Tassell, C.P., Yang, J., Matukumalli, L.K., Da, Y. 2010. High Resolution QTL Maps Of 31 Traits in Contemporary U.S. Holstein Cows. World Congress of Genetics Applied in Livestock Production. Proc. 9th World Congr. Genet. Appl. Livest. Prod., Leipzig, Germany, Aug. 1–6., 4 pp.
Interpretive Summary: Large numbers of DNA markers are now available for thousands of dairy cows. Those markers can be combined with information about cow performance for traits such as the amount of milk produced during a lactation or the lifetime profitability of an animal and used to identify changes in the genome of the cow resulting from forty years of genetic selection. High-resolution maps of genes associated with 31 different traits of economic importance were constructed, and the 100 genes with the largest effects identified. Large clusters of genes were identified on several chromosomes.
High-resolution QTL maps of 1586 SNPs affecting 31 dairy traits (top 100 effects per trait)were constructed based on a genome-wide association analysis of 1,654 contemporary U.S. Holstein cows genotyped with 45,878 SNPs. The 31 traits include net merit and its 8 compnent traits, 4 calving traits, and 18 body conformation traits. Most significant and influential gene regions include: INSR of BTA7; DGAT1-NIBP of BTA14, PGLYRP1-IGFL1 of BTA18, MGMT of BTA26, CD82 of BTA15, DST and MOCS1-LRFN2 of BTA23, REN of BTA16, and a 10Mb region of BTA11 with type trait effects. INSR, DGAT1-NIBP, and PGLYRP1-IGFL1 each was located in a large gene cluster with multiple QTL effects.