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United States Department of Agriculture

Agricultural Research Service

Research Project: NEWCASTLE DISEASE EPIDEMIOLOGY, PATHOGENESIS, AND CONTROL

Location: Exotic and Emerging Avian Viral Diseases Research Unit

Title: Avian paramyxovirus serotype 1 strains of low virulence with unusual fusion protein cleavage sites isolated from poultry species

Authors
item MILLER, PATTI
item Killian, Mary -
item Pederson, Janice -
item AFONSO, CLAUDIO

Submitted to: American Association of Avian Pathologists
Publication Type: Abstract Only
Publication Acceptance Date: March 1, 2011
Publication Date: July 16, 2011
Citation: Miller, P.J., Killian, M.L., Pederson, J.C., Afonso, C.L. 2011. Avian paramyxovirus serotype 1 strains of low virulence with unusual fusion protein cleavage sites isolated from poultry species [abstract]. American Association of Avian Pathologists Annual Meeting, July 16-19, 2011, St. Louis, Missouri. p. 114.

Technical Abstract: Avian paramyxo-serotype-1 viruses (APMV1) with fusion cleavage sites containing two basic amino acids and a phenylalanine (F) at position 117 have been isolated from poultry species in two states from 2007-2009. The intracerebral pathogenicity indices for these viruses are of low virulence at 0.00 and 0.04. The isolates have fusion protein sequences that are 97% similar to wild bird NDV strains on nucleotide and amino acid levels. The mean death time for chicken embryos ranged from 109-1271hrs and for turkey embryos 67-127hrs. Reported here are phylogenetic analyses for the nucleocapsid, phosphoprotein, matrix, hemagglutinin-neuraminidase, and polymerase genes.

Last Modified: 9/29/2014
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