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United States Department of Agriculture

Agricultural Research Service

Research Project: Molecular Biology of Human Pathogens Associated with Food

Location: Produce Safety and Microbiology Research

Title: Regulation of energy metabolism by the extracytoplasmic function (ECF) s factors of Arcobacter butzleri

Authors
item Martinez-Malaxetxeba, Irati -
item Mutts, Rudy -
item Parker, Craig
item Miller, William
item Huynh, Steven
item Gaastra, William -
item Van Putten, Jos -
item Fernandez-Astorga, Aurora -
item Wosten, Marc -

Submitted to: PLoS One
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: August 14, 2012
Publication Date: September 18, 2012
Citation: Martinez-Malaxetxeba, I., Mutts, R., Parker, C., Miller, W.G., Huynh, S., Gaastra, W., Van Putten, J.P., Fernandez-Astorga, A., Wosten, M.M. 2012. Regulation of energy metabolism by the extracytoplasmic function (ECF) s factors of Arcobacter butzleri. PLoS One. doi%2F10.1371%2Fjournal.pone.0044796.

Interpretive Summary: The extracytoplasmic function (ECF) s factors are important for bacterial adaptation to stressful environments. The emerging pathogen Arcobacter butzleri possesses seven putative pairs of s/anti-s factors belonging to the ECF family. We identified the genes regulated by five out of the seven A. butzleri ECF s factors. Three of the ECF s factors play an apparent role in transport, energy generation and the maintenance of redox balance. Several genes like the nap, sox and tct genes are regulated by more than one ECF s factor indicating that the A. butzleri ECF s factors form a network of overlapping regulons. In contrast to other eubacteria, these A. butzleri ECF regulons appear to primarily regulate responses to changing environments in order to meet metabolic needs instead of an obvious role in stress adaptation.

Technical Abstract: The extracytoplasmic function (ECF) s factors are fundamental for bacterial adaptation to distinct environments and for survival under different stress conditions. The emerging pathogen Arcobacter butzleri possesses seven putative pairs of s/anti-s factors belonging to the ECF family. Here, we report the identification of the genes regulated by five out of the seven A. butzleri ECF s factors. Three of the ECF s factors play an apparent role in transport, energy generation and the maintenance of redox balance. Several genes like the nap, sox and tct genes are regulated by more than one ECF s factor indicating that the A. butzleri ECF s factors form a network of overlapping regulons. In contrast to other eubacteria, these A. butzleri ECF regulons appear to primarily regulate responses to changing environments in order to meet metabolic needs instead of an obvious role in stress adaptation.

Last Modified: 10/25/2014
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