Location: Aquatic Animal Health Research
Title: Vaccination against enteric septicaemia of catfish Authors
|Wei Pridgeon, Yuping|
Submitted to: Book Chapter
Publication Type: Book / Chapter
Publication Acceptance Date: June 7, 2013
Publication Date: N/A
Technical Abstract: Edwardsiella ictaluri, the causative agent of enteric septicemia (ESC) of catfish, is one of the most economically important diseases of cultured channel catfish. In 2002, Wagner and coworkers reported that enteric septicemia of catfish (ESC) and columnaris (Flavobacterium columnaris) were the two most predominant catfish diseases in the US. The development and use of live attenuated bacterial vaccines are becoming more attractive due to their many advantages, despite concerns raised regarding their safety. Klesius and Shoemaker produced a live attenuated E. ictaluri mutant using rifampicin with a non channel catfish E. ictaluri EILO strain from an E. ictaluri diseased walking catfish. This live attenuated vaccine was shown to be able to immunize large numbers of fish by bath immersion with minimum stress. The loss of virulence was associated with an alternation in the LPS component. This live attenuated vaccine was found to be efficacious in catfish and licensed by USDA to Intervet/Scherng-Plough Animal Health as AQUAVAC-ESC@.