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United States Department of Agriculture

Agricultural Research Service

Research Project: Rice as a Source and Delivery System for Nutrients and Lipophilic Bioactive Compounds

Location: Food Processing and Sensory Quality Research

Title: Glyceollins as novel targeted therapeutic for the treatment of metastatic triple-negative breast cancer

Authors
item Rhodes, Lyndsay -
item Tilghman, Skreeta -
item Boue, Stephen
item Wang, Shuchun -
item Khalili, Hafez -
item Muir, Shannon -
item Bratton, Melyssa -
item Zhang, Qiang -
item Wang, Guangdi -
item Burow, Matthew -
item Collins-Burow, Bridgette -

Submitted to: Oncology Reports
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: September 21, 2011
Publication Date: December 11, 2011
Citation: Rhodes, L.V., Tilghman, S.L., Boue, S.M., Wang, S., Khalili, H., Muir, S., Bratton, M.R., Zhang, Q., Wang, G., Burow, M.E., Collins-Burow, B.M. 2011. Glyceollins as novel targeted therapeutic for the treatment of metastatic triple-negative breast cancer. Oncology Reports. 3:163-171.

Interpretive Summary: A mixture of soy compounds called glyceollins, are synthesized in response to environmental stresses such as microbial infections. Glyceollins inhibited the growth of triple-negative breast cancer cells that are typically resistant to therapy. Animal studies revealed the glyceollins suppressed the growth of 2 types of triple-negative breast cancer cells. Our results demonstrated that the glyceollins, previously described as having the ability to block the harmful effects of estrogen, also exert anti-tumor activity in triple negative breast carcinoma cell systems. This activity correlates with the glyceollin alteration of genomic and proteomic expression profiles.

Technical Abstract: The purpose of this study was to investigate the effects of glyceollins on the suppression of tumorigenesis in triple negative breast carcinoma cell lines. We further explored the effects of glyceollins on microRNA and protein expression in MDA MB 231 cells. Triple negative (ER , PgR, and Her2/neu ) breast carcinoma cells were used to test the effects of glyceollins on tumorigenesis in vivo. Following this procedure, unbiased microarray analysis of microRNA expression was performed. Additionally, we examined the changes in the proteome induced by glyceollins in the MDA MB 231 cells. Tumorigenesis studies revealed a modest suppression of MDA MB 231, and MDA MB 468 cell tumor growth in vivo. In response to glyceollins, we observed a distinct change in microRNA expression profiles and proteomes of the triple negative breast carcinoma cell line, MDA MB 231. Our results demonstrated that the glyceollins, previously described as anti estrogenic agents, also exert anti-tumor activity in triple negative breast carcinoma cell systems. This activity correlates with the glyceollin alteration of microRNA and proteomic expression profiles.

Last Modified: 7/28/2014
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