Location: Avian Disease and Oncology Laboratory
Title: Genome-wide copy number variant analysis in inbred chickens lines with different susceptibility to Marek's disease Authors
Submitted to: Plant and Animal Genome Conference
Publication Type: Abstract Only
Publication Acceptance Date: November 30, 2012
Publication Date: January 14, 2013
Citation: Luo, J., Yu, Y., Mitra, A., Zhang, H., Liu, G., Song, J. 2013. Genome-wide copy number variant analysis in inbred chickens lines with different susceptibility to Marek's disease [abstract]. Plant and Animal Genome XXI Conference, January 12-16, 2013, San Diego, California. A-P0649. Avaliable: https://pag.confex.com/pag/xxi/webprogram/Paper5185.html. Technical Abstract: Breeding of genetically resistant chickens to Marek’s disease (MD) is a vital strategy to poultry health. To find the markers underlying the genetic resistance to MD, copy number variation (CNV) was initially examined in inbred MD-resistant and -susceptible chicken lines. A total of 45 CNV regions (CNVR) were found in 4 lines of chickens, and 28 of them were potentially involved in immune response and cell proliferation. More importantly, two CNVRs related with MD-resistance were transmitted to descendent recombinant congenic lines that differ in susceptibility to MD. Our findings may help to make a better strategy for MD resistance in poultry.