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United States Department of Agriculture

Agricultural Research Service

Research Project: CHARACTERIZATION OF PROTECTIVE HOST RESPONSES TO AVIAN INFLUENZA VIRUS INFECTIONS IN AVIAN SPECIES

Location: Exotic and Emerging Avian Viral Diseases Research Unit

Title: Vaccine protection of chickens against the 2012 mexican H7N3 highly pathogenic avian influenza virus

Authors
item Kapczynski, Darrell
item Pantin-Jackwood, Mary
item Ricardez, Yadira -
item Guzman, Sofia -
item Spackman, Erica
item Suarez, David
item Swayne, David

Submitted to: Western Poultry Disease Conference
Publication Type: Abstract Only
Publication Acceptance Date: January 5, 2014
Publication Date: April 2, 2014
Citation: Kapczynski, D.R., Pantin Jackwood, M.J., Ricardez, Y., Guzman, S., Spackman, E., Suarez, D.L., Swayne, D.E. 2014. Vaccine protection of chickens against the 2012 mexican H7N3 highly pathogenic avian influenza virus [abstract]. Western Poultry Disease Conference, April 2-5, 2014, Pureto Vallarta, Mexico. CDROM. p.179.

Technical Abstract: In June of 2012, an outbreak of highly pathogenic avian influenza (HPAI) H7N3 was reported poultry in Jalisco, Mexico. Since that time the virus has spread to many surrounding States and new outbreaks continue to be reported. Vaccine trials were performed to determine protective efficacy of an inactivated H7 vaccine. In the first set of experiments, a Mexican-lineage low pathogenic AI (LPAI) H7N3 isolate from a duck, with 98 % sequence similarity to the HPAI virus, was applied to 2 week old chickens. When challenged, vaccinated birds demonstrated 100 % protection. In a second experiment, 26 week-old egg-laying hens were vaccinated either singly or doubly and challenged against the HPAI virus. All vaccinated birds reduced shedding of virus compared to sham vaccinated birds. The impact of HPAI challenge on egg production will be discussed. These results demonstrate the LPAI vaccine isolate can provide protection against the HPAI H7N3 virus.

Last Modified: 9/21/2014
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