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United States Department of Agriculture

Agricultural Research Service

Research Project: IMMUNOLOGY AND INTERVENTION STRATEGIES FOR JOHNE'S DISEASE Title: Draft genome sequence of a Mycobacterium avium complex isolate from a broadbill bird

Authors
item Bannantine, John
item Bayles, Darrell
item Robbe-Austerman, Suelee -
item Burrell, Angela -
item Stabel, Judith

Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: January 6, 2014
Publication Date: January 30, 2014
Repository URL: http://handle.nal.usda.gov/10113/58551
Citation: Bannantine, J.P., Bayles, D.O., Robbe-Austerman, S., Burrell, A.M., Stabel, J.R. 2014. Draft genome sequence of a Mycobacterium avium complex isolate from a broadbill bird. Genome Announcements. 2(1):1.

Interpretive Summary: Mycobacterium avium complex (MAC) strains represent a diverse group of environmental bacteria. They have been studied principally for two reasons; some strains cause disseminated disease in patients with AIDS, and other strains cause Johne’s disease. It is the latter reason that the USDA conducts research on this group of bacteria. In this study, we sequenced the genomes of ten non-paratuberculosis strains. These genomes will help understand the basis for the close genetic relatedness of the MAC. Furthermore, comparative genomics with these strains with those of M. avium subspecies paratuberculosis, the pathogen that causes Johne’s disease, will benefit scientists studying this disease by helping to identify diagnostic targets for specific Johne’s disease tests.

Technical Abstract: We report the draft genome sequences of ten Mycobacterium avium complex isolates obtained from diverse hosts. This collection includes isolates obtained from deer, pig, elephant, ruddy duck and Red-tailed hawk species. The type strain of Mycobacterium avium subspecies silvaticum (ATCC 49884) is also present among this collection.

Last Modified: 7/24/2014
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