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United States Department of Agriculture

Agricultural Research Service

Title: Bone Histomorphometry, Igf-I Levels, and Fatty Acid Composition of Bone Tissues Are Altered by Dietary Lipids

Authors
item Watkins B A, - PURDUE UNIVERSITY
item Bain S D, - ZYMOGENETICS
item Shen C L, - PURDUE UNIVERSITY
item Lim S, - PURDUE UNIVERSITY
item Xu H, - PURDUE UNIVERSITY
item McMurtry, John

Submitted to: Nutrition International Congress Proceedings
Publication Type: Abstract Only
Publication Acceptance Date: August 10, 1994
Publication Date: N/A

Technical Abstract: Semi-purified diets were fed to chicks containing one of the following lipid sources at 70g/kg: soybean oil (SBO), butter (BC), margarine (MAC) or menhaden oil (MEC). Corn oil was added to all lipid treatments except SBO to supplement the linoleic acid content of the diets. Body weights and tibiotarsal bone lengths were not influenced by dietary lipid treatments. Phospholipids in tibiotarsal bones of chicks fed MEC for 21 days contained higher concentrations of 20:5n3 and 22:6n3 but lower amounts of 20:4n6 compared to those fed SBO. Total n-3 PUFAs were highest in chondrocytes and matrix vesicles isolated from growth cartilage in the tibiotarsus of chicks fed MEC. The plasma levels of IGF-I in chicks at 14 days old were higher (23.3 ng/ml) in those fed MEC than in the SBO (16.8) and BC (14.9) groups. Cartilage and bone concentrations of IGF-I tended to follow those for plasma in chicks at 21 days. Plasma IGF-I increased with time to 56 days of age in all groups. This experiments confirms previous results where diet altered the fatty acid composition of bone and affected bone modeling.

Last Modified: 4/16/2014
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