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Title: DEVELOPMENT OF A MODEL OF MYCOBACTERIUM BOVIS INFECTION IN SWINE

Author
item Bolin, Carole
item Whipple, Diana
item GUSTAFSON, K - UNIV OF MINNESOTA
item RISDAHL, J - UNIV OF MINNESOTA
item Stabel, Judith
item MOLITOR, T - UNIV OF MINNESOTA

Submitted to: International Symposium on Bovine Tuberculosis in Animals and Humans
Publication Type: Proceedings
Publication Acceptance Date: 5/10/1995
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: To evaluate the use of swine as a model of human and bovine tuberculosis, eighteen 4-week-old pigs were exposed to Mycobacterium bovis. Groups of 3 pigs were exposed to either 10*4 or 10*8 cells of a recent bovine isolate of M. bovis by IV, intratracheal, or tonsilar routes of inoculation. Pigs were observed for development of clinical signs and were euthanized at 1 or r2 months after challenge or earlier, if severe clinical signs developed. Gross lesions were recorded at necropsy and tissues were collected for histopathology and culture. The nature and extent of lesions produced were compared between different routes of inoculation and doses of M. bovis. These results will be useful for characterization of a swine model of tuberculosis in humans and cattle.