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United States Department of Agriculture

Agricultural Research Service

Title: Genetic Resistance to Porcine Post-Weaning Diarrhea Caused by Enterotoxigenic Escherichia Coli That Express 2134p Pili

Authors
item Bosworth, Brad
item CASEY, THOMAS
item Nystrom, Evelyn
item Rothschild, Max - IOWA STATE UNIVERSITY
item Christian, Lauren - IOWA STATE UNIVERSITY

Submitted to: United States Animal Health Association Proceedings
Publication Type: Abstract Only
Publication Acceptance Date: October 28, 1995
Publication Date: N/A

Technical Abstract: Enterotoxigenic Escherichia coli (ETEC) expressing 2134P pili adhered to brush borders of intestinal epithelial cells of some, but not all, weaned pigs. Weaned pigs were inoculated with a 2134P+ ETEC and retrospectively phenotyped as having either nonadhesive or adhesive brush borders using an in vitro adhesion assay with a 2134P+ ETEC. Pigs with nonadhesive brush borders did not develop diarrhea or have histologic evidence of bacterial colonization. Pigs with adhesive brush borders developed diarrhea and/or had histologic evidence of bacterial colonization. Pigs with nonadhesive brush borders gained significantly more weight than did pigs with adhesive brush borders. The 2134P+ ETEC did not adhere to villous epithelium in ligated ileal loops in weaned pigs with nonadhesive brush borders, while 2134P+ ETEC did adhere in pigs with adhesive brush borders. Brush borders nonadhesive for 2134P+ ETEC were also nonadhesive for verotoxigenic Escherichia coli (VTEC) expressing the F107 pilus, while brush borders adhesive for 2134P+ ETEC were adhesive for F107+ VTEC. Examination of litters containing pigs with either nonadhesive or adhesive brush borders revealed that this trait was genetically controlled by a locus on porcine chromosome 6.

Last Modified: 9/10/2014
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