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United States Department of Agriculture

Agricultural Research Service

Title: Comparative Sequence Analysis of the 5' Noncoding Region of the Classical Swine Fever Virus Strains from Europe, Asia, and America

Authors
item Stadejek, Tomasz - NATL VET RES INST, POLAND
item Warg, Janet - USDA, APHIS, NVSL, DVL
item Ridpath, Julia

Submitted to: Archives of Virology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: October 31, 1995
Publication Date: N/A

Interpretive Summary: Hog cholera virus (HCV), belongs to the same viral family as bovine viral diarrhea virus (BVDV). The two viruses are similar in the way their genes are organized and in the proteins they produce. Recently BVDVs were divided into two subgroups based on comparison of genetic material. Many problems with detection and control of diseases caused by BVDV can be explained by the existence of two distinct viral subgroups. The purpose o this study was to see if similar subgroups exist among HCVs. To do this, the genetic information from 29 HCVs were compared. These viruses originated in four different continents. Unlike BVDV, only small differences were found among HCV; thus, separate groups of HCV probably do not exist. The high similarity seen between HCVs isolated from different continents suggest it is possible to design vaccines and diagnostic reagents that are effective against HCVs whatever their origin. In addition, while small, the differences seen among HCVs may be useful in epidemiological studies of disease outbreaks caused by HCV. For example, during this study it was found that viruses from one geographic area were more similar to each other than to viruses from other areas. The information from this study is useful for vaccine production, diagnostic test development, and epidemiologic investigation of disease outbreaks.

Technical Abstract: Polymerase chain reaction was utilized to determine the sequence of a 280- base pair fragment from cDNAs of the 5' noncoding region of 29 isolates of classical swine fever virus. Phylogenetic analysis of the sequences revealed low level genomic variation that correlated with the geographic origins of the isolates.

Last Modified: 11/28/2014
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