Submitted to: Meeting Abstract
Publication Type: Proceedings
Publication Acceptance Date: September 17, 1996
Publication Date: N/A
Technical Abstract: Vesicular exanthema of swine virus (VESV), the prototype calicivirus, is the etiologic agent of the disease of swine called vesicular exanthema of swine (VES). VES is characterized by vesicle formation on the extremities, mouth and snout, and causes abortions and stillbirths if infection occurs during pregnancy. VESV is considered an exotic agent in the United States. The capsid protein gene of VESV serotype A48 was cloned and sequenced. The capsid protein open reading frame was encoded in the 3'-terminal 2427 bases of the genomic RNA. This region of the genome also contained a small, overlapping reading frame which encoded a basic protein of unknown function similar to that previously described for both animal and human caliciviruses. The VESV A48 capsid protein was 69% similar to the San Miguel sea lion virus serotype 1 (SMSV 1) and 89% similar to the SMSV serotype 4 capsid proteins. The six apparently functional regions (A-F) previously identified in SMSV 1, SMSV 4, feline calicivirus and rabbit hemorrhagic disease virus capsid proteins were present in VESV A48.