Technical Abstract: The U.S. poultry consumption has experienced phenomenal growth over the last 50 years. Accordingly, production problems associated with increasing demands for poultry products require technological interventions to improve both poultry quality and the nutritional needs of consumers. Coccidiosis caused by Eimeria spp., remains to be the major parasitic disease for the poultry industry. Although current coccidiosis control strategies depend heavily upon prophylactic medication, efforts are underway to develop drug-free chickens. In this regard, novel approaches based upon nature's own immunity and genetics are the current targets of our research. Overall, these approaches will guide development of an integrated parasite control strategy to enhance animal health and well-being. Genetic improvements to increase disease resistance through genetic selection and by insertion of new genetic material directly into chicken should be feasible in the very near future.