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ARS Home » Research » Publications at this Location » Publication #98027
Title: BORDETELLA AVIUM DERMONECROTIC TOXIN CAUSES LYMPHOID LESIONS IN MICE (ORAL PRESENTATION FOR THE AVMA/AAAP MTG., JULY 1999)

Author
item Kunkle, Robert
item Sacco, Randy
item Rimler, Richard - Rick

Submitted to: American Veterinary Medical Association Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 7/10/1999
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Turkey coryza, caused by infection with Bordetella avium, is associated with vaccinal failure well into the convalescent phase of the disease, perhaps due to immunosuppression. In this study, mice were injected with a heat-labile dermonecrotic toxin (DNT) purified from B. avium. The toxin was lethal within 24 hours at doses greater than 5 ng. Lesions ascribed to olethality were not seen; however, multifocal necrosis in primary and secondary lymphoid organs was a consistent microscopic lesion. Results of this study indicate that the immunosuppression seen in turkeys with coryza may be mediated by the B. avium DNT.