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United States Department of Agriculture

Agricultural Research Service

Title: Crystal and Molecular Structure of An Isomeric Gossypol-Acetic Acid Clathrate

item Dowd, Michael
item Thomas, Leonard - IOWA STATE UNIVERSITY
item Calhoun, Millard - TEXAS AG EXPERIMENT STAT

Submitted to: Journal of the American Oil Chemists' Society
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: September 2, 1999
Publication Date: N/A

Interpretive Summary: Research conducted by scientists at the USDA, ARS, SRRC in New Orleans, LA indicates that a crystalline form of gossypol can be used to separate the two isomers into separate crystals. In many cases, it is difficult to separate the biologically active form from the inactive forms. This is believed to be the case for gossypol, a compound from cottonseed that is responsible for the toxicity of cottonseed products but also has male anti-fertility, anti-viral, and anti-cancer properties. The compound exists in two isomeric forms, and preliminary studies suggest that the important physiological properties are associated with only one of the forms. Preparing samples of the individual gossypol isomers has been a difficult problem. Previous methods were time consuming, multi-step procedures that produced product in low yield. Samples can now be prepared by selecting individual crystals, determining the isomeric form of each crystal, and combining the crystals of each form. These samples are needed for medicinal research, and the results will be of particular interest to researchers working toward understanding gossypol's anti-cancer and male anti-fertility properties.

Technical Abstract:

Last Modified: 9/1/2014
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