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Title: ANTIMICROBIAL SUSCEPTIBILITY PATTERNS FOR SALMONELLA ISOLATES OF VETERINARYORIGIN FOR NARMS 1999

Author
item HEADRICK, MARCIA - FDA-CVM
item Cray, Paula
item Gray, Jeffrey
item DARGATZ, D - USDA-APHIS-VS-CEAH
item TOLLEFSON, L - FDA-CVM

Submitted to: American Society for Microbiology
Publication Type: Abstract Only
Publication Acceptance Date: 2/9/2001
Publication Date: 5/20/2001
Citation: Headrick, M., Cray, P.J., Gray, J.T., Dargatz, D.A., Tollefson, L. 2001. Antimicrobial susceptibility patterns for salmonella isolates of veterinaryorigin for narms 1999. American Society for Microbiology. Session No.245/C. Abstract. C-405. P. 245.

Interpretive Summary:

Technical Abstract: The National Antimicrobial Resistance Monitoring System - Enteric Bacteria (NARMS) was established to provide descriptive data on the extent and temporal trends of antimicrobial susceptibility in zoonotic enteric pathogens from human and animal populations. As part of the 1999 study 8,505 Salmonella isolates of veterinary origin were tested using a SensititreTM custom designed microtiter plate to determine minimal inhibitory concentrations (MICs) for 17 antimicrobials. Isolates were obtained from cattle, swine, chickens, turkeys, raw product from federally inspected slaughter and processing plants, exotics, horses, dogs, and cats. These isolates were from both diagnostic and non-diagnostic submissions. All isolates were susceptible to Ciprofloxacin. The following percent susceptibility was observed for other antimicrobials - Amikacin (>99.5), Amoxicillin/clavulanic acid (88.4%), Ampicillin (81.9%), Apramycin (98.9%), Ceftiofur (96%), Ceftriaxone (97.7%), Cephalothin (92.3%), Chloramphenicol (90.1%), Gentamicin (90.8%), Kanamycin (87.7%), Nalidixic Acid (98.8%), Streptomycin (69%), Sulfamethoxazole (71.1%), Tetracycline (64.8%), and Trimethoprim/sulfamethoxazole (96.6%). Breakpoints are not available for Florfenicol but the MIC50 and MIC90 were 4 and 8 ug/ml, respectively. Collectively, for all antimicrobials, isolates from raw product were more susceptible than diagnostic isolates. Overall, S. typhimurium was more resistant to more antimicrobials followed by S. heidelberg and S. derby. These data will be helpful in monitoring the development of resistance over time and identifying areas for further research.