NUTRITION, CARDIOVASCULAR HEALTH, AND GENOMICS
Location: Human Nutrition Research Center on Aging
Title: Association of apolipoprotein A5 concentration with serum insulin and triglyceride levels and coronary artery disease in Korean men
| Hyun, Yae Jung - |
| Jang, Yangsoo - |
| Chae, Jey Sook - |
| Kim, Ji Young - |
| Paik, Jean Kyung - |
| Kim, So Yeon - |
| Yang, Ju Young - |
| Ordovas, Jose - |
| Ko, Young Guk - |
| Lee, Jong Ho - |
Submitted to: Atherosclerosis
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: December 16, 2008
Publication Date: August 1, 2009
Citation: Hyun, Y., Jang, Y., Chae, J., Kim, J., Paik, J., Kim, S., Yang, J., Ordovas, J., Ko, Y., Lee, J. 2009. Association of apolipoprotein A5 concentration with serum insulin and triglyceride levels and coronary artery disease in Korean men. Atherosclerosis. 205(2):568-573.
Interpretive Summary: Cardiovascular diseases are the major cause of death and disability in industrialized countries and a major barrier to healthy aging. Cardiovascular diseases are the result of the interaction between a number of genetic and environmental risk factors, being blood lipid concentrations (i.e., cholesterol and triglycerides) among the best studied and known. Apolipoprotein A5 (APOA5) is known to play a major role in triglyceride metabolism. However, the mechanisms of action and the associations between apoA5 concentrations, TG and cardiovascular diseases remain controversial. We investigated these relations in the setting of a case (n=367)-control (n=777) study involving Korean males. Our data show that plasma apoA5 concentration was lower in coronary artery disease (CAD) patients than controls. Moreover, plasma apoA5 concentration was negatively correlated with serum TG and insulin in control with normal triglycerides, whereas apoA5 was positively correlated with serum TG in hypertriglyceridemic controls,and CAD patients. In conclusion, our data support an inverse association between plasma apoA5 concentrations and coronary artery disease risk, probably due to the observed negative correlations of apoA5 with TGs and insulin. Therefore, APOA5 gene variants could be used for early identification of those at high risk for CAD and promote successful prevention therapies to facilitate healthy aging.
OBJECTIVE: Whereas the relation between apolipoprotein A5 (APOA5) gene polymorphisms and triglycerides (TG) levels is well established, the associations between apoA5 concentrations, TG and coronary artery disease (CAD) remain controversial. Therefore, we investigated these relations in the setting of a case-control study involving Korean males. METHODS: ApoA5, TG, insulin, free fatty acid (FFA) and lipoprotein profiles were determined using a cross-sectional design in 777 healthy controls and 367 CAD patients. RESULTS: Plasma apoA5 concentration was lower in CAD patients than controls (192.7+/-5.2 vs. 237.2+/-3.7ng/ml, P<0.001). Values in the second and top tertiles of apoA5 were associated with a decreased odds ratio (OR) for CAD when compared with values in the bottom tertile; OR for apoA5 top tertile was 0.33 (95% CI, 0.23-0.47) in the age- and BMI-adjusted model and 0.35 (95% CI, 0.23-0.56) following additional adjustments for smoking, drinking status, blood pressure, TG and HDL-cholesterol. After adjustment for age and BMI, plasma apoA5 concentration was negatively correlated with serum TG (r=-0.188, P<0.001) and insulin (r=-0.185, P<0.001) in normotriglyceridemic controls (TG<150mg/dL, n=509) whereas apoA5 was positively correlated with serum TG in hypertriglyceridemic controls (TG>/=150mg/dL, n=268)(r=0.246, P<0.001) and total CAD patients (r=0.177, P<0.01). Regardless of TG levels and CAD status, apoA5 concentration was positively correlated with HDL-cholesterol and FFA levels. CONCLUSIONS: Our data supports an inverse association between plasma apoA5 concentrations and CAD risk, probably due to the observed negative correlations of apoA5 with TGs and insulin, although these correlations were affected by TG levels.