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ARS Home » Plains Area » Houston, Texas » Children's Nutrition Research Center » Research » Publications at this Location » Publication #244086
Title: Embryonic vasculogenesis and hematopoietic specification

Author
item GOLDIE, LAUREN - Children'S Nutrition Research Center (CNRC)
item NIX, MELISSA - Children'S Nutrition Research Center (CNRC)
item HIRSCHI, KAREN - Children'S Nutrition Research Center (CNRC)

Submitted to: Organogenesis
Publication Type: Review Article
Publication Acceptance Date: 2/15/2007
Publication Date: 10/1/2008
Citation: Goldie, L.C., Nix, M.K., Hirschi, K.K. 2008. Embryonic vasculogenesis and hematopoietic specification. Organogenesis. 4(4):257-263.

Interpretive Summary:

Technical Abstract: Vasculogenesis is the process by which blood vessels are formed de novo. In mammals, vasculogenesis occurs in parallel with hematopoiesis, the formation of blood cells. Thus, it is debated whether vascular endothelial cells and blood cells are derived from a common progenitor. Whether or not this is the case, there certainly is commonality among regulatory factors that control the differentiation and differentiated function of both cell lineages. VEGF is a major regulator of both cell types and plays a critical role, in coordination with other signaling pathways and transcriptional regulators, in controlling the differentiation and behavior of endothelial and blood cells during early embryonic development, as further discussed herein.