Author
EREZ, A - Baylor College Of Medicine | |
CHEN, Y - Baylor College Of Medicine | |
SHCHELOCHKOV, O - Baylor College Of Medicine | |
NAGAMANI, S - Baylor College Of Medicine | |
MIAN, A - Baylor College Of Medicine | |
BERTIN, T - Baylor College Of Medicine | |
JIANG, M - Baylor College Of Medicine | |
BLACK, J - Baylor College Of Medicine | |
GARG, H - University Of Texas Health Science Center | |
ZENG, H - Vanderbilt University | |
SUMMAR, M - Vanderbilt University | |
O'BRIEN, W - Baylor College Of Medicine | |
MITCH, W - Baylor College Of Medicine | |
ASCHNER, J - Vanderbilt University | |
MARINI, J - Children'S Nutrition Research Center (CNRC) | |
BRYAN, N - University Of Texas Health Science Center | |
LEE, B - Children'S Nutrition Research Center (CNRC) |
Submitted to: Molecular Genetics and Metabolism
Publication Type: Abstract Only Publication Acceptance Date: 3/1/2009 Publication Date: 11/3/2009 Citation: Erez, A., Chen, Y., Shchelochkov, O.A., Nagamani, S.S., Mian, A., Bertin, T.K., Jiang, M., Black, J.0., Garg, H., Zeng, H., Summar, M., O'Brien, W.E., Mitch, W.E., Aschner, J.L., Marini, J.C., Bryan, N.S., Lee, B. 2009. Argininosuccinate lyase is an essential regulator of nictric oxide homeostatis [abstract]. Molecular Genetics and Metabolism. 98:142. Interpretive Summary: Technical Abstract: The regulation of nitric oxide synthesis is a complex mechanism, depending on the availability of substrates and the activity of the enzymes involved. Here we describe in a mouse model the channeling of urea cycle intermediates for the recycling of citrulline and the transport of extracellular arginine to sustain an arginine intracellular pool utilized for nitric oxide synthesis. |