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ARS Home » Plains Area » Houston, Texas » Children's Nutrition Research Center » Research » Publications at this Location » Publication #256585
Title: Argininosuccinate lyase is an essential regulator of nictric oxide homeostatis

Author
item EREZ, A - Baylor College Of Medicine
item CHEN, Y - Baylor College Of Medicine
item SHCHELOCHKOV, O - Baylor College Of Medicine
item NAGAMANI, S - Baylor College Of Medicine
item MIAN, A - Baylor College Of Medicine
item BERTIN, T - Baylor College Of Medicine
item JIANG, M - Baylor College Of Medicine
item BLACK, J - Baylor College Of Medicine
item GARG, H - University Of Texas Health Science Center
item ZENG, H - Vanderbilt University
item SUMMAR, M - Vanderbilt University
item O'BRIEN, W - Baylor College Of Medicine
item MITCH, W - Baylor College Of Medicine
item ASCHNER, J - Vanderbilt University
item MARINI, J - Children'S Nutrition Research Center (CNRC)
item BRYAN, N - University Of Texas Health Science Center
item LEE, B - Children'S Nutrition Research Center (CNRC)

Submitted to: Molecular Genetics and Metabolism
Publication Type: Abstract Only
Publication Acceptance Date: 3/1/2009
Publication Date: 11/3/2009
Citation: Erez, A., Chen, Y., Shchelochkov, O.A., Nagamani, S.S., Mian, A., Bertin, T.K., Jiang, M., Black, J.0., Garg, H., Zeng, H., Summar, M., O'Brien, W.E., Mitch, W.E., Aschner, J.L., Marini, J.C., Bryan, N.S., Lee, B. 2009. Argininosuccinate lyase is an essential regulator of nictric oxide homeostatis [abstract]. Molecular Genetics and Metabolism. 98:142.

Interpretive Summary:

Technical Abstract: The regulation of nitric oxide synthesis is a complex mechanism, depending on the availability of substrates and the activity of the enzymes involved. Here we describe in a mouse model the channeling of urea cycle intermediates for the recycling of citrulline and the transport of extracellular arginine to sustain an arginine intracellular pool utilized for nitric oxide synthesis.