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Title: Virus-specific antibodies interfere with avian influenza infection in peripheral blood mononuclear leukocytes from young or aged chickens

Author
item Faulkner, Olivia
item Kapczynski, Darrell
item Pantin Jackwood, Mary
item Cagle, Caran
item Suarez, David

Submitted to: American Association of Avian Pathologists
Publication Type: Abstract Only
Publication Acceptance Date: 7/1/2011
Publication Date: 7/17/2011
Citation: Faulkner, O.B., Kapczynski, D.R., Pantin Jackwood, M.J., Cagle, C.A., Suarez, D.L. 2011. Virus-specific antibodies interfere with avian influenza infection in peripheral blood mononuclear leukocytes from young or aged chickens [abstract]. American Association of Avian Pathologists Meeting, July 16-19, 2011, St. Louis, Missouri. CD-ROM.

Interpretive Summary:

Technical Abstract: Avian influenza virus (AIV) infection was examined in peripheral blood mononuclear leukocyte cultures (PBMC) that were collected from 1-day-old chicks or from 52-week-old chickens. Virus-specific antibodies were incubated with AIV to model maternal antibody interference in vitro. Interferon-alpha (IFN-alpha), interleukin-1beta (IL-1beta), toll-like receptor (TLR) 7, and major histocompatibility complex class 1 (MHC1) genes were measured 24 hours after A/Turkey/Wisconsin/1968 (H5N9) low pathogenic AIV infection. Avian influenza increased all genes in PBMC from 52-week-old chickens; however TLR7 and MHC1 genes were lower in AIV infected PBMC from 1-day-old chicks. Virus-specific antibodies interfered with IFN-alpha more than IL-1beta in AIV infected PBMC.