Technical Abstract: The diseases of the silkworm (Bombyx mori) and managed bees, including the honey bee (Apis mellifera), bumbles bees (Bombus spp.), the alfalfa leafcutting bee (Megachile rotundata), and mason bees (Osmia spp.) are reviewed, with diagnostic descriptions and a summary of control methods for production systems. Silkworms and honey bees have been managed by humans for a few thousand years. This close association has provided insights into the nature of infectious diseases, influencing microbiologists such as Louis Pasteur and Agostino Bassi. Silkworms and bees are susceptible to a wide range of pathogens, including viruses, bacteria, fungi, and protists. However, pathogenic nematodes are conspicuously absent. These insects are also susceptible to parasitoids, mite parasites, pesticides, and environmental toxics. Control measures for silkworm diseases center around sanitation, as medication options are extremely limited. During the last century, honey beekeeping has developed a reliance on medications, an approach that has produced drug resistant diseases. Furthermore, beekeepers are vulnerable to the introduction of new diseases that do not yet have control methods. An integrated approach, with an emphasis on prevention and sanitation measures would help reduce these problems.