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United States Department of Agriculture

Agricultural Research Service

Research Project: IDENTIFICATION OF DISEASE MECHANISMS AND CONTROL STRATEGIES FOR BACTERIAL RESPIRATORY PATHOGENS IN CATTLE Title: Draft genome sequences of two virulent serotypes of avian Pasteurella multocida

Authors
item Abrahante, Juan -
item Johnson, Timothy -
item Hunter, Samuel -
item Maheswaran, Samuel -
item Hauglund, Melissa
item Bayles, Darrell
item Tatum, Fred
item Briggs, Robert

Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: November 19, 2012
Publication Date: January 31, 2013
Citation: Abrahante, J.E., Johnson, T.J., Hunter, S.S., Maheswaran, S.K., Hauglund, M.J., Bayles, D.O., Tatum, F.M., Briggs, R.E. 2013. Draft genome sequences of two virulent serotypes of avian Pasteurella multocida. Genome Announcements. 1(1):e00058. DOI:10.1128/genomeA.00058-12.

Interpretive Summary: Pasteurella multocida is a causative agent for prevalent and serious septicemic and respiratory diseases in a broad range of hosts. This bacterium generally lacks obvious virulence factors which contribute to its ability to cause disease and therefore it is difficult to design effective vaccine countermeasures to control disease. Using high-throughput sequencing technology, the genome sequence of two virulent representative avian isolates of P. multocida was ascertained. Preliminary analysis shows clear differences between these two strains and a previously sequenced non-virulent strain. Study of these unique differences, and those between avian and ruminant isolates, will yield a better understanding of disease pathogenesis and insight into new potential disease control methods.

Technical Abstract: Here we report the draft genome sequences of two virulent avian strains of Pasteurella multocida. Comparative analyses of these genomes were done with the published genome sequence of avirulent Pasteurella multocida strain Pm70.

Last Modified: 10/1/2014