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United States Department of Agriculture

Agricultural Research Service

Research Project: GENETIC AND BIOLOGICAL DETERMINANTS OF AVIAN TUMOR VIRUS PATHOGENICITY, TRANSMISSION, AND EVOLUTION

Location: Avian Disease and Oncology Laboratory

Title: Avian oncogenesis induced by lymphoproliferative disease virus: a neglected or emerging retroviral pathogen?

Authors
item Allison, Andrew -
item Keel, Kevin -
item Philips, Jamie -
item Cartoceti, Andrew -
item Munk, Brandon -
item Nemeth, Nicole -
item Welsh, Trista -
item Thomas, Jesse -
item Crum, James -
item Lichtenwalner, Anne -
item Fadly, Aly
item Zavala, Guillermo -
item Holmes, Edward -
item Brown, Justin -

Submitted to: Virology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: November 25, 2013
Publication Date: February 1, 2014
Citation: Allison, A.B., Keel, K.M., Philips, J.E., Cartoceti, A.N., Munk, B.A., Nemeth, N.M., Welsh, T.I., Thomas, J.M., Crum, J.M., Lichtenwalner, A.B., Fadly, A.M., Zavala, G., Holmes, E.C., Brown, J.D. 2014. Avian oncogenesis induced by lymphoproliferative disease virus: a neglected or emerging retroviral pathogen? Virology. 450-451:2-12. Available: http://dx.doi.org/10.1016/j.virol.2013.11.037.

Interpretive Summary: Lymphoproliferative disease virus (LPDV) is a virus that can induce cancer-like disease in some species of birds, particularly turkeys. Historically, outbreaks of LPDV have been reported from Europe and Israel, while the virus has never been detected in North America. In this manuscript, we report on the widespread distribution, genetic diversity, pathogenesis, and evolution of LPDV in wild turkeys in the United States. Molecular characterization of the LPDVs isolated in the United States indicated that the majority of viruses fell into a single group termed North American linage. However, a small subset of LPDVs isolated from South Carolina grouped with the Israeli prototype virus. These results suggest that LPDV was transferred between continents to initiate outbreaks of disease, although the route (New World to Old World or vice versa), mechanism, and time frame of the transcontinental spread currently remain unclear.

Technical Abstract: Lymphoproliferative disease virus (LPDV) is an exogenous oncogenic retrovirus that induces lymphoid tumors in some galliform species of birds. Historically, outbreaks of LPDV have been reported from Europe and Israel. Although the virus has previously never been detected in North America, herein we describe the widespread distribution, genetic diversity, pathogenesis, and evolution of LPDV in the United States. Characterization of the provirus genome of the index LPDV case from North America demonstrated an 88% nucleotide identity to the Israeli prototype strain. Although phylogenetic analysis indicated that the majority of viruses fell into a single North American lineage, a small subset of viruses from South Carolina were most closely related to the Israeli prototype. These results suggest that LPDV was transferred between continents to initiate outbreaks of disease. However, the direction (New World to Old World or vice versa), mechanism, and time frame of the transcontinental spread currently remain unknown.

Last Modified: 11/22/2014
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