Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modulators from natural products as anti-cancer agents

Authors: YANG, MIN HYE - University Of Mississippi; KIM, JINWOONG - University Of Mississippi; KHAN, IKHLAS - University Of Mississippi; WALKER, LARRY - University Of Mississippi; KHAN, SHABANA - University Of Mississippi

Submitted to: Life Sciences
Publication Type: Review Article
Publication Acceptance Date: 1/21/2014
Publication Date: 2/12/2014
Citation: Yang, M., Kim, J., Khan, I.A., Walker, L., Khan, S.I. 2014. Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modulators from natural products as anti-cancer agents. Life Sciences. 100:75-84.

Interpretive Summary:

Technical Abstract: Natural products are rich source of gene modulators for prevention and treatment of cancer. In recent days, nonsteroidal anti-inflammatory drug (NSAID) activated gene-1 (NAG-1) has been focused as a new target of diverse cancers like colorectal, pancreatic, prostate, and breast. A variety of natural resources have been reported to play a pivotal role in regulation of NAG-1 through multiple transcriptional mechanisms. The aim of the present paper is to review the NAG-1 modulators derived from natural products including plants, marine organism and microorganism.