Title: Pathogenesis and transmission of novel 2013 H7N9 LPAIV from China in chickens Authors
Submitted to: American Association of Avian Pathologists
Publication Type: Abstract Only
Publication Acceptance Date: January 15, 2014
Publication Date: N/A
Technical Abstract: A novel influenza A lineage of the H7N9 subtype emerged in China in February 2013 where it was first recognized because it was causing severe disease and death in humans. The source of the virus was assumed to be an animal reservoir and poultry was considered likely since the genes of the virus were most closely related to avian viruses. Among poultry species chickens were considered as a high likelihood to be possible hosts, however this lineage has an unusual host range for avian influenza virus because of the number of human cases during the peak of spread. In order to characterize the H7N9 influenza lineage in chickens the pathogenesis and transmission were evaluated and the infectious dose was determined in white leghorn and white rock chickens. Results of these studies suggests that the human H7N9 lineage is not well adapted to chickens and transmits poorly within poultry.