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Title: Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia

Author
item HEYMSFIELD, STEVEN - Louisiana State University
item AVENA, NICOLE - University Of Florida
item BAIER, LESLIE - National Institute Of Diabetes And Digestive And Kidney Diseases
item BRANTLEY, PHILLIP - Louisiana State University
item BRAY, GEORGE - Louisiana State University
item BURNETT, LISA - Columbia University
item BUTLER, MERLIN - Kansas State University
item DRISCOLL, DANIEL - University Of Florida
item EGLI, DIETER - Columbia University
item ELMQUIST, JOEL - University Of Texas Southwestern Medical Center
item FORSTER, JANICE - Pittsburgh Partnership
item GOLDSTONE, ANTHONY - Imperial College
item GOURASH, LINDA - Pittsburgh Partnership
item GREENWAY, FRANK - Louisiana State University
item HAN, JOAN - National Institutes Of Health (NIH)
item KANE, JAMES - Prader-Willi Syndrome Association, Usa
item LEIBEL, RUDOLPH - Columbia University
item LOOS, RUTH - Johns Hopkins University School Of Medicine
item SCHEIMANN, ANN - Johns Hopkins University School Of Medicine
item ROTH, CHRISTIAN - Center For Integrative Brain Research
item SEELEY, RANDY - University Of Cincinnati
item SHEFFIELD, VAL - University Of Iowa
item TAUBER, MAITHE - Paul Sabatier Universite
item VAISSE, CHRISTIAN - University Of San Francisco
item WANG, LIHENG - Columbia University
item WATERLAND, ROBERT - Children'S Nutrition Research Center (CNRC)
item WEVRICK, RACHEL - University Of Alberta
item YANOVSKI, JACK - National Institutes Of Health (NIH)
item ZINN, ANDREW - University Of Texas Southwestern Medical Center

Submitted to: Obesity
Publication Type: Review Article
Publication Acceptance Date: 10/11/2013
Publication Date: 2/1/2014
Citation: Heymsfield, S.B., Avena, N.M., Baier, L., Brantley, P., Bray, G.A., Burnett, L.C., Butler, M.G., Driscoll, D.J., Egli, D., Elmquist, J., Forster, J.L., Goldstone, A.P., Gourash, L.M., Greenway, F.L., Han, J.C., Kane, J.G., Leibel, R.L., Loos, R.J., Scheimann, A.O., Roth, C.L., Seeley, R.J., Sheffield, V., Tauber, M., Vaisse, C., Wang, L., Waterland, R.A., Wevrick, R., Yanovski, J.A., Zinn, A.R. 2014. Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia. Obesity. 22:S1-S17.

Interpretive Summary:

Technical Abstract: Hyperphagia is a central feature of inherited disorders (e.g., Prader-Willi Syndrome) in which obesity is a primary phenotypic component. Hyperphagia may also contribute to obesity as observed in the general population, thus raising the potential importance of common underlying mechanisms and treatments. Substantial gaps in understanding the molecular basis of inherited hyperphagia syndromes are present as are a lack of mechanistic of mechanistic targets that can serve as a basis for pharmacologic and behavioral treatments. An International conference with 28 experts, including scientists and caregivers, providing presentations, panel discussions, and debates was held. The reviewed collective research and clinical experience provides a critical body of new and novel information on hyperphagia at levels ranging from molecular to population. Gaps in understanding and tools needed for additional research were identified. This report documents the full scope of important topics reviewed at a comprehensive international meeting devoted to the topic of hyperphagia and identifies key areas for future funding and research.