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United States Department of Agriculture

Agricultural Research Service

Research Project: MOLECULAR AND IMMUNOLOGICAL APPROACHES TO CONTROLLING GI NEMATODE INFECTIONS OF RUMINANTS

Location: Animal Parasitic Diseases

Title: An overview of live attenuated recombinant pseudorabies viruses for use as novel vaccines

Authors
item Ren, X -
item Dong, B -
item Zarlenga, Dante

Submitted to: Journal of Immunology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: March 23, 2014
Publication Date: June 5, 2014
Citation: Dong, B., Zarlenga, D.S., Ren, X., 2014. An overview of live attenuated recombinant pseudorabies viruses for use as novel vaccines. Journal of Immunology, 2014. 1-10. Article ID 824630, doi:10.1155/2014/824630.

Interpretive Summary: Pseudorabies virus (PRV) is a double-stranded, DNA-based swine virus with a genome approximating 150 kb in size. In cell culture, PRV has many non-essential genes which can be replaced with genes encoding foreign antigens without harming virus propagation. Recombinant PRVs expressing both native and foreign antigens are able to stimulate immune responses. In this paper, we review the current status of live attenuated recombinant PRVs and live PRV-based vector vaccines with potential for controling viral infections in animals.

Technical Abstract: Pseudorabies virus (PRV) is a double-stranded, DNA-based swine virus with a genome approximating 150 kb in size. In cell culture, PRV has many non-essential genes which can be replaced with genes encoding heterologous antigens but without deleterious effects on virus propagation. Recombinant PRVs expressing both native and foreign antigens are able to stimulate immune responses. In this paper, we review the current status of live attenuated recombinant PRVs and live PRV-based vector vaccines with potential for controling viral infections in animals.

Last Modified: 10/1/2014
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