2012 GFRA Scientific Workshop
Surveillance, Epidemiology, Vaccination and Control of Foot-and-Mouth Disease

Hosted by the ARC-OVI in Hazyview, South Africa
17 to 19 April 2012

AGENDA

17 April: Virus Ecology & Epidemiology

Introduction to the workshop and outline of objectives

Welcome to the meeting

Francois F Maree (ARC-OVI; South Africa)

Official opening of the meeting

Cyril Gay (USDA; USA); Mohammed Jeenah (ARC-OVI; South Africa); Keith Sumption (EuFMD; FAO)

Global Foot and Mouth Disease Research Alliance (GFRA): current actions and future perspective.
Presenters Luis L Rodriguez, Plum Island Animal Disease Center, USA; Cyril G Gay,Agricultural Research Service, USA; Francois F Maree, Onderstepoort Veterinary Institute, Agricultural Research Council, South Africa

Session 1: FMDV-wildlife interaction in an African context
Coordinators: Nick Juleff (IAH) and Lin-Mari de Klerk Lorist (DAFF)

• 1.1 Some epidemiological aspects of foot and mouth disease in wildlife in Sub-Saharan Africa. Speaker Roy Bengis, DAFF, South Africa

Structure of FMDV with special reference to SAT serotypes
Speaker: David Stuart (Oxford University, UK)

• 1.2 The multi-sectoral impacts of foot and mouth disease and its control in southern Africa. Speaker: Gavin Thompson (TAD Scientific)

(No file) Recent study of foot-and-mouth disease virus infection in naïve African buffalo.
Speaker: Nick Juleff (Institute for Animal Health; UK)

• 1.4 Stray buffaloes. Group & Spatio-temporal Characteristics. Greater Kruger National Park & Surrounds, 1998-2008. Speaker: Louis van Schalkwyk (DAFF, South Africa)

• 1.5 Surveillance of foot-and-mouth disease virus in wildlife in different ecosystems of Tanzania: achievements and challenges. Speaker: Robert Fyumagwa (Wildlife Research Institute; Tanzania)
  

• 1.6 Epidemiological patterns of foot-and-mouth disease in livestock-wildlife interface areas of northern Tanzania. Speaker: Tiziana Lembo (University of Glasgow; Scotland)

Session 2: FMD situation in Uganda
Coordinators: Christostom Ayebazibwe & Frank Mwiine

• 2.1 Foot and Mouth Disease in Uganda. Situation analysis in Uganda. Spatial distribution and trends. Speaker: Chris Rutebarika (Ministry of Agriculture Animal industry and fisheries; Uganda)

• 2.2 The role of wildlife in the maintenance of FMD in Uganda. Speaker: Christostom Ayebazibwe (Ministry of Agriculture Animal industry and fisheries; Uganda

• 2.3 FMD vaccines, vaccination and Efficacy in livestock in Uganda.Speaker: Frank N. Mwiine (Makerere University Kampala; Uganda)

Session 3: Epidemiology of FMD in Africa
Coordinators: Christopher Kasanga & Tiziana Lembo

• 3.1 Variation in the non-structural proteins of FMDV in Africa. Speaker: Peninah Nsamba (Makerere University Kampala; Uganda)

• 3.2 Molecular Epidemiology of Foot-and-Mouth Disease Virus in Tanzania. Speaker: Christopher Kasanga (Sokoine University of Agriculture; Tanzania)
  
  3.3 An Update of Foot-and-Mouth disease in Cameroon and Control Measures. Speaker: Simon Dickmu Jumbo (LANAVET; Cameroon)
  

• 3.4 Foot and Mouth Disease in Nigeria: The Current Status and Control Efforts. Speaker: Olatunde Olabode (Nigeria)

• 3.6 Foot-and-mouth disease (FMD) in Tanzania: conjectured status and upcoming FMD research initiatives in Southern and Eastern Africa.Speaker: Christopher Kasanga (Sokoine University of Agriculture; Tanzania)

• 3.7 Spatio-temporal Analysis of Risk Factors for Foot-and-Mouth Disease in Tanzania. Speaker: Frederich Kivaria (Dept of Veterinary Services; Tanzania)

• Not on agenda:
  3.5 Isolation and characterization of Foot and mouth disease virus in Nigeria for possible vaccine development. Speaker:H.G. Ularamu National Veterinary Research Institute, Vom

Session 4: Epidemiology of FMD in Africa
Coordinators: Rahana Dwarka and Gaolathe Thobokwe

• 4.1 Recent Foot-and-Mouth Disease outbreaks in Mpumalanga. Speaker: Ben du Plessis (Mpumalanga Vet Services; South Africa)
  
  4.2 SAT Type FMD Outbreaks in South Africa. Speaker: Rahana Dwarka (ARC-OVI; South Africa)
  
  4.3 Challenges associated with sampling of buffalo in the SADC region. Speaker: Brenda Botha (ARC-OVI; South Africa)

• 4.4 Foot and Mouth disease dynamics at the wildlife/livestock interface in the Great Limpopo Transfrontier Conservation Area. Lessons learned (2008-2011). Speaker: Ferran Jori (Mammalian Research Institute; UP; South Africa)

• 4.5 Molecular Epidemiology of FMDV in Southern Africa. Speaker: Andrez Perez (UC Davis; USA)

• Discussion
  Gaps in knowledge of FMDV-wildlife interaction and transmission

18 April: Epidemiology

Session 5: Novel vaccine approaches
Coordinators: Katherine Scott and Pamela Opperman

• 5.1 The early pathogenesis of FMD and the implications for control measures. Speaker: Luis Rodriguiz (Plum Island Animal Disease Centre; USDA-ARS)

• 5.2 Structurally modified master seed viruses to enhance conventional foot-and-mouth disease virus vaccine production.Speaker: Bryan Charleston (Institute for Animal Health; UK)
  

• 5.3 Progress Toward the development of a safe antigenic marker Foot-and-Mouth Disease Vaccine Platform. Speaker: Elizabeth Rieder (Plum Island Animal Disease Centre; USDA-ARS)

• Intra-serotype chimeric vaccine that elicits protective immune response in cattle. Speaker: Peninah Nsamba

Session 6: Global FMD control
Coordinator: Katherine Scott and Pamela Opperman

• FAO Research Priorities in Support to the Global FMD Control Strategy.Speaker: Samia Metwally (FAO)

• 6.2 1- Progressive Control Pathway for FMD control (PCP-FMD) and 2- FMD Global Control Strategy Objectives, major principles, tools; Regional Road Maps. Speaker: Joseph Domenech (OIE)

Session 7: FMD situation in Egypt
Coordinator: Francois Maree

• 7.1 Current situation of Foot and mouth disease in Egypt. Speaker: Dr Mohamed Saad (CLEVB; Egypt)

• 7.2 Risk analysis of Foot and Mouth disease outbreak in Egypt. Speaker: Dr Mohamed El Bably (Alexandria University; Egypt)

Session 8: Epidemiology of FMD virus in Asia, Middle East and Eastern Europe
Coordinator: Francois Maree

• 8.1 The epidemiology of FMD in Vietnam and how that reflects the FMD situation in SEA. Speaker: Dr Long (Vietnam)

• 8.2 Epidemiology of FMD in South East Asia.Speaker: Wilai Linchongsubongkoch (Formerly from RRLSEA; Thailand

18:00 Special workshop dinner

19 April: Vaccine coverage & efficacy

Session 8: FMD vaccine efficacy
Coordinators: Tom Willems and Alejandra Capozzo

• 8.1 Relation between antibody response and protection in FMD vaccine depends on vaccination-challenge interval, route of injection and vaccine quality. Speaker: Aldo Dekker (Central Veterinary Institute; The Netherlands)

• 8.2 FMD vaccine efficacy: attributes of higher potency vaccines and more recent findings. Speaker: Paul Barnett (Institute for Animal Health; UK)
  
  8.3 Indirect parameters related to vaccine efficacy along the FMD-vaccine production process. Speaker: Alejandra Capozzo (CONICET-INTA; Argentina)

• 8.4 Use of Single Dilution Liquid Phase ELISA (slpELISA) for the evaluation of herd immunity and vaccination efficacy against FMD virus in Argentina. Speaker: Cristina Seki (ICT Milstein-CONICET; Argentina)

• 8.4 Vaccine efficacy and Post Vaccination Monitoring in SADC. Speaker: Livio Heath (ARC-OVI; South Africa)

• 8.5 Alternative way to test the efficacy of swine FMD vaccines: measurement of pigs median infected dose (PID50) and regulation of live virus challenge dose. Speaker: Dong Li (OIE/National Foot-and-Mouth Disease Reference Laboratory of China; China)

• 8.6 Quality Assurance of FMD Vaccines in India. Speaker: Muthukrishnan Madhanmohan (Indian Immunologicals; India

• 8.7 Short list of Influences on Efficacy of Foot-and-Mouth Disease Vaccines. Speaker: Tom Willems (CODA-CERVA-VAR; Belgium)

Session 9: Current approaches to FMD vaccine matching
Coordinators: Belinda Blignaut and Geoff Fosgate

• 9.1 FMDV Antigenicity and Vaccine Matching Studies. Speaker: Yanmin Li (Institute for Animal Health; UK)

• 9.2 Vaccine matching strain characterisation of FMDV in SEA region. Speaker: Wilai Linchongsubongkoch (Formerly from RRLSEA; Thailand)

• 9.3 FMD control by vaccination in SADC. Speaker: Gaolathe Thobokwe (Botswana Vaccine Institute; Botswana)

• 9.4 Vaccine matching and selection of vaccine strains for the control of foot-and-mouth disease in Kenya.Speaker: Abraham Sangula (FMD lab; Kenya)

• 9.5 Foot-and-mouth disease vaccines and vaccination status in Tanzania. Speaker: Mpelumbe-Ngeleja (CVL; Tanzania)
  
  9.6 Antibody titres in FMD type A strains: comparison of methodologies to predict cross-protection. Speaker: Tesfaalem T. Sebhatu (National Veterinary Laboratory; Eritrea)
  
  9.7 A naive approach to r1-value calculation: Variability, Friend or Foe? Speaker: Geoff Fosgate (University of Pretoria; SA)

Session 10: New approaches to FMD vaccine matching
Coordinators: Richard Reeve and Anna Ludi

• Mapping Antigenic Variation of FMDV Serotype A - Antigenic Cartography Speaker: Anna Ludi (Plum Island Animal Disease Centre; USDA-ARS)

• Identification of candidate amino acid substitutions, exposed on the surface of FMDV, leading to antigenic change. Speaker: Graham Belsham (National Veterinary Institute, Denmark)

• Combining structural modelling and serological analysis - validating sequence-based prediction. Speaker: Daryl Borley (Institute for Animal Health; UK)

• Validating and combining serological approaches to antigenic prediction: where to next? Speaker: Richard Reeve (Glasgow University; Scotland)

• Discussion and closure
  Vaccine needs in Africa