LONGEVITY AND LINEAGES: TOWARD THE INTEGRATIVE BIOLOGY OF DEGENERATIVE DISEASES IN HEART, MUSCLE, AND BONE

Authors: CHIEN, KENNETH - UCSD SCHOOL MED; Karsenty, Gerald

Submitted to: Cell
Publication Type: Review Article
Publication Acceptance Date: 2/1/2005
Publication Date: 2/25/2005
Citation: Chien, K.R., Karsenty, G. 2005. Longevity and lineages: toward the integrative biology of degenerative diseases in heart, muscle, and bone. Cell. 120(4):533-544.

Interpretive Summary: No interpretive summary needed for review article.

Technical Abstract: Human aging is characterized by debilitating diseases, including heart failure, cardiac pacemaker defects, muscle wasting, and osteoporosis, in heart, skeletal muscle, and bone. Recent studies are identifying pathways for these aging-related diseases by examining how the process of aging influences tissue-specific progenitors and differentiated cell lineages in these organ systems. These advances form a foundation for new therapeutic strategies to delay the onset of aging-related disorders.