Author
CHEN, CHUNG-YEN - TUFTS/HNRCA | |
Blumberg, Jeffrey |
Submitted to: Obesity Epidemiology, Inherent Mechanisms and Novel Ingredients in Weight Management
Publication Type: Book / Chapter Publication Acceptance Date: 9/1/2006 Publication Date: 3/7/2007 Citation: Chen, C., Blumberg, J. 2007. Oxidative stress status in humans with metabolic syndrome. Obesity Epidemiology, Inherent Mechanisms and Novel Ingredients in Weight Management. Boca Raton, FL: CRC Press. Volume 1. p.123-137. Interpretive Summary: Technical Abstract: Each component of the constellation of Metabolic Syndrome signs - dyslipidemia, hyperglycemia, hypertension, and obesity - has been associated, though not unequivocally, with an elevation of oxidative stress. Moreover, reductions in these conditions appear generally associated with attenuation of biomarkers of oxidative stress, though these inverse correlations are not always strong. While hypotheses can be readily proffered regarding a vicious cycle of free radicals and pathology in the progression of these conditions and the potential for a beneficial impact of antioxidants in slowing the progress of Metabolic Syndrome toward Cardiovascular Disease, few direct data are available to support this approach as an adjunct to established lifestyle modifications and drug therapies for prevention or treatment. Nonetheless, the biological plausibility of these relationships clearly warrants further research in this area. |