Author
LAMON-FAVA, STEFANIA - Jean Mayer Human Nutrition Research Center On Aging At Tufts University | |
DIFFENDERFER, MARGARET - Jean Mayer Human Nutrition Research Center On Aging At Tufts University | |
MARCOVINA, SANTICA - University Of Washington |
Submitted to: Current Opinion in Lipidology
Publication Type: Review Article Publication Acceptance Date: 3/3/2014 Publication Date: 6/1/2014 Citation: Lamon-Fava, S., Diffenderfer, M., Marcovina, S. 2014. Lipoprotein(a) metabolism. Current Opinion in Lipidology. 25(3):189-193. Interpretive Summary: Technical Abstract: Lipoprotein(a) [Lp(a)] is an atherogenic lipoprotein. The metabolism of this lipoprotein is still not well understood. It has long been known that the plasma concentration of Lp(a) is highly heritable, with its genetic determinants located in the apo(a) locus and regulating the rate of hepatic apo(a) production. Recent human intervention trials have convincingly established that, in addition to apo(a) production, hepatic apoB100 production plays an important role in Lp(a) levels. While the major site and mode of Lp(a) clearance remain unidentified, a recent cell and animal study points to the involvement of the hepatic scavenger receptor class B type I in the uptake of both the lipid and protein constituents of Lp(a) from plasma. Progress in the understanding of Lp(a) metabolism has the potential to lead to the development of novel and specific treatments for the reduction of Lp(a) levels and the associated risk of cardiovascular disease. |