Author
KELLY, JENNIFER - Jean Mayer Human Nutrition Research Center On Aging At Tufts University | |
HARSHMAN, STEPHANIE - Jean Mayer Human Nutrition Research Center On Aging At Tufts University | |
BRENSINGER, COLLEEN - University Of Pennsylvania | |
BARGER, KATHRYN - Jean Mayer Human Nutrition Research Center On Aging At Tufts University | |
KIMMEL, STEPHEN - University Of Pennsylvania | |
BOOTH, SARAH - Jean Mayer Human Nutrition Research Center On Aging At Tufts University |
Submitted to: Federation of American Societies for Experimental Biology Conference
Publication Type: Abstract Only Publication Acceptance Date: 4/1/2017 Publication Date: 4/1/2017 Citation: Kelly, J.M., Harshman, S.G., Brensinger, C., Barger, K., Kimmel, S., Booth, S.L. 2017. A race-specific interaction between vitamin K status and statin use during warfarin therapy initiation [abstract]. Federation of American Societies for Experimental Biology Conference. 31(1):445.6. Interpretive Summary:
Technical Abstract: Vitamin K (VK) is required for the post-translational modification of several clotting factors. Warfarin is a vitamin K antagonist and anticoagulant. The most common dietary and circulating form of VK is phylloquinone (PK). PK is lipid soluble, carried by triglyceride-rich lipoproteins, and shares a metabolic pathway with cholesterol. Thus, there is biological plausibility for an interaction between serum PK and lipid-lowering medications (statins) in warfarin therapy.
The objective of this study was to examine if serum PK and/or statin treatment was associated with anticoagulation control in African Americans and Caucasians initiating warfarin therapy. Warfarin sensitivity differs between African Americans and Caucasians, so analyses were race-specific.
Cox proportional hazards and linear regression models were used in a cross-sectional analysis of the 2009-2013 International Normalized Ratio Adherence and Genetics II cohort of African Americans (n=331; 40% female) and Caucasians (n=140; 36% female) initiating warfarin therapy. Primary exposures included serum PK (categorized as quartiles 1: PK<0.6, 2: 0.6=PK=1.0, 3: 1.0 |