Therapeutics Evaluation and Registration Research |
Evaluation of Compounds and Strategies for Controlling Aquatic Animal Disease | |
SCIENTISTS:
David L. Straus, Aquatic Toxicologist, Lead Scientist Bradley Farmer, Support Scientist
Technicians:
Cindy Ledbetter, Biological Science Technician
OBJECTIVES: Objective 1: Develop data needed to demonstrate safety (animal, human, and environmental) and efficacy of compounds that are relevant to the needs of aquaculture. Technical sections will be completed to gain FDA-approval of copper sulfate and potassium permanganate to control mortality associated with Ichthyophthiriasis on channel catfish in earthen ponds. Technical sections for efficacy and target animal safety will be completed for florfenicol. The efficacy of florfenicol and Diquat ? for controlling mortality associated with Flavobacterium columnare will be investigated. Objective 2: Determine the efficacy of compounds, biological control strategies, clearance rate and pathogenesis (understanding of the disease process) of parasites and fungi applicable to catfish, baitfish, and Morone sp. culture. Snail-eating fish and chemicals will be used to manage trematode infestations. Chemical treatment strategies will be defined to manage the Asian tapeworm on grass carp and golden shiners, the anchor parasite and fish louse on goldfish, and fungus on channel catfish eggs.
NEED FOR RESEARCH
Description of Problem to be Solved Aquaculture has been a rapidly growing source of food production over the last few decades; total production value in the Available FDA-approved therapeutants are very limited, and the industry is frequently faced with disease epizootics and no effective measures to curb losses. There is currently one parasiticide and three antibiotics (one is no longer manufactured) approved for use in The development of effective strategies to control fish health problems is also hampered by the limited understanding of the biology, vectors, and epidemiology of fish pathogens plaguing the aquaculture industry. The need for disease control methods (chemical, biological, or environmental) not targeted at the pathogen, but at the intermediate host of these pathogens, is also immediate and critical. Potential Benefits Expected from Attaining Objectives Attaining these objectives will provide benefits to farmers, fish health providers, scientists, and the public which will result in increased economic growth by helping to overcome the impact of disease. Environmentally friendly, effective, and food-safe medicines to treat aquatic animal diseases and non-chemical methods to control diseases and disease vectors will become available not only to large commercial producers, but also to small, rural fish farmers. Research will provide the Anticipated Products of the Research Additional fish health management strategies for fish diseases (bacteria and parasites) including FDA-approved compounds and the development of chemical and biological control methods to eliminate or reduce populations of non-fish hosts. Customers of the Research and Their Involvement Fish farmers of cultured hybrid striped bass, catfish, tilapia, and baitfish species will benefit. Scientists will benefit from the basic knowledge of efficacy and safety of fisheries chemicals used for therapy and vector reduction and the use of biological controls. Fisheries extension agents and veterinarians will have more disease control methodologies available for recommendation to their user groups. Consumers demanding safe and wholesome fish products will benefit. |