| Huang Lab |
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HUANG LAB
Liping Huang, Ph.D. Research Leader Adjunct Professor, UC Davis Department of Nutrition Office: (530) 754-5756 Email address: liping.huang@usda.gov Research Interests The Huang lab is focused on the function of zinc transporters in maintaining body zinc homeostasis. Specifically 1) Determine novel functions of zinc related to energy metabolism, insulin resistance in skeletal muscle, and adipose tissue and immune function and 2) Measure and validate novel functional biomarkers of Zn status in response to supplementation of deficient human subjects. Huang Lab Themes Our research studies focus on cellular zinc regulation and its links to modulation of body weight gain, adiposity, glucose and insulin homeostasis, and immunity. The goal is to understand the mechanism of zinc action in the body. • QTL mapping of body weight and adiposity in mice • Zinc and immunity • Zinc and glucose/insulin metabolism
ARS Employees Catherine Kirschke, Molecular Biologist Surapun Tepaamorndech, PhD candidate, Integrated Genoics and Genetics Graduate Group
will take you to the publication reprint.)
Chin, E.L., Huang, L., Bouzid, Y.Y., Kirschke, C.P., Durbin-Johnson, B., Baldiviez, L.M., Bonnel, E.L., Keim, N.L., Korf, I., Stephensen, C.B., Lemay, D.G. 2019. Association of lactase persistence genotypes (rs4988235) and ethnicity with dairy intake in a healthy U.S. population. Nutrients. https://doi.org/10.3390/nu11081860.
Lemay, D.G., Huang, S., Huang, L., Alkan, Z., Kirschke, C.P., Burnett, D.J., Wang, Y., Hwang, D.H. 2019. Temporal changes in postprandial blood transcriptomes reveal subject-specific pattern of expression of innate immunity genes after a high-fat meal. Journal of Nutritional Biochemistry. 72:108209. https://doi.org/10.1016/j.jnutbio.2019.06.007.
Huang, L., Tepaamorndech, S., Kirschke, C.P., Cai, Y., Zhao, J., Cao, X., Rao, A. 2019. Subcongenic analysis of a quantitative trait locus affecting body weight and glucose metabolism in zinc transporter 7 (znt7)-knockout mice. BioMed Central (BMC) Genetics. 20:19. https://doi.org/10.1186/s12863-019-0715-2.
Cai, Y., Kirschke, C.P., Huang, L. 2018. SLC30A family expression in the pancreatic islets of humans and mice: cellular localization in the ß-cells. Journal of Molecular Histology. 49(2):133-145. https://doi.org/10.1007/s10735-017-9753-0.
Baldiviez, L.M., Keim, N.L., Laugero, K.D., Hwang, D.H., Huang, L., Woodhouse, L.R., Burnett, D.J., Zerofsky, M., Bonnel, E., Allen, L.H., Newman, J.W., Stephensen, C.B. 2017. Design and implementation of a cross-sectional nutritional phenotyping study in healthy US adults. Biomed Central (BMC) Nutrition. 3(79):1-13. https://doi.org/10.1186/s40795-017-0197-4.
Huang, L., Tepaamorndech, S., Kirschke, C.P., Newman, J.W., Keyes, W.R., Pedersen, T.L. 2018. Aberrant fatty acid metabolism in the skeletal muscle contributes to insulin resistance in zinc transporter 7 (Znt7) knockout mice. Journal of Biological Chemistry. 293(20):7549-7563. doi:10.1074/jbc.M117.817692.
Tepaamorndech, S., Oort, P.J., Kirschke, C.P., Yimeng, C., Huang, L. 2017. ZNT7 binds to CD40 and influences CD154-triggered p38 MAPK activity in B lymphocytes-a possible regulatory mechanism for zinc in immune function. FEBS Open Bio. 7(5):675–690. doi: 10.1002/2211-5463.12211.
Huang, L., Kirschke, C.P. 2016. Down-regulation of zinc transporter 8 (SLC30A8) in pancreatic beta-cells promotes cell survival. Austin Journal of Endocrinology and Diabetes. 3:1037.
Huang, L., Kirschke, C.P. 2016. Down-regulation of zinc transporter 8 (SLC30A8) in pancreatic beta-cells promotes cell survival.. Austin Journal of Endocrinology and Diabetes. 3(1):1-8.
Tepaamorndech, S., Kirschke, C.P., Pedersen, T.L., Keyes, W.R., Newman, J.W., Huang, L. 2015. Zinc transporter 7 deficiency affects lipid synthesis in adipocytes by inhibiting insulin-dependent Akt activity and glucose uptake. FEBS Journal. 283(2):378-394. doi: 10.1111/febs.13582. -(Peer Reviewed Journal)
Huang, L., Drake, V.J., Ho, E. 2015. Zinc. Advances in Nutrition. 6:224-226.
Huang, L. 2014. Zinc and its transporters, pancreatic beta cells, and insulin metabolism. In: Litwack, G. editor. Vitamins and Hormones. Atlanta, GA: Elsevier. p.365-390.
Huang, L., Tepaamorndech, S. 2013. The SLC30 family of zinc transporters – a review of current understanding of their biological and pathophysiological roles. European Journal of Applied Physiology. 34(2-3):548-560.
Parelman, M.A., Storms, D.H., Kirschke, C.P., Huang, L., Zunino, S.J. 2012. Dietary strawberry powder reduces blood glucose concentrations in obese and lean C57BL/6 mice and selectively lowers plasma C-reactive protein in lean mice. British Journal of Nutrition. 1-11. DOI: 10.1017/S0007114512000037.
Galvez, A., Huang, L., Magbanua, M.M., Dawson, K., Nandi, S., Rodriguez, R.L. 2011. Diet-influenced chromatin modification and expression of chemopreventive genes by the soy peptide, lunasin. In: Bidlack, W.R., Rodriguez, R.L., editors. Nutritional Genomics: The Impact of Dietary Regulation of Gene Function on Human Disease. Taylor and Francis Group. 25-40. -(Peer Reviewed Journal)
Tepaamorndech, S., Huang, L., Kirschke, C.P. 2011. A null-mutation in the Znt7 gene accelerates prostate tumor formation in a transgenic adenocarcinoma mouse prostate model. Cancer Letters. 308 (2011) 33-42.
Huang, L., Mi, Y., Kirschke, C.P. 2010. Over-expression of ZnT7 increases insulin synthesis and secretion in pancreatic beta-cells by promoting insulin gene transcription. Experimental Cell Research. 2010 Volume 316, Issue 16 2630-2643
Kirschke, C.P., Huang, L. 2008. Expression of ZNT (SLC30) family members in the epithelium of the mouse prostate during sexual maturation. Journal of Histochemistry and Cytochemistry (2008) 39:359-370.
Gao, H., Xu, H., Wang, X., Dahlstrom, A., Huang, L., Wang, Z. 2008. Expression of zinc transporter ZnT7 in mouse superior cervical ganglion. Autonomic Neuroscience: Basic & Clinical, 140 (2008) 59-65.
Chi, Z., Ren, H., Wang, X., Rong, M., Huang, L., Wang, Z. 2008. The cellular and subcellular localization of zinc transporter 7 in the mouse spinal cord. Histology and Histopathology Cellular and Molecular Biology, Vol.23:781-787
Zhang, L., Wang, X., Stoltenberg, M., Danscher, G., Huang, L., Wang, Z. 2008. Abundant Expression of Zinc Transporters in the Amyloid Plaques of Alzheimer’s Disease Brain. Elsevier. Brain Research Bulletin 77 (2008) 55-60.
Zhang, L., Wang, X., Zheng, Z., Ren, H., Stoltenberg, M., Danscher, G., Huang, L., Rong, M., Wang, Z. 2008. Altered expression and distribution of zinc transporters in app/ps1 transgenic mouse brain. Elsevier, Journal Neurobiology of Aging, Doi:10,1016:1-14, 2008.
Huang, L., Yu, Y., Kirschke, C.P., Gertz, E.R., Kent K.C., L. 2008. Znt7 (Slc30a7)-Deficient Mice Display Rreduced Body ZincC Status and Body Fat Accumulation. Journal of Biological Chemistry. 282,51:37053-37063, 2007.
Zhang, L., Chi, Z., Ren, H., Rong, M., Dahlstrom, A., Huang, L., Wang, Z. 2007. Imunoreactivity of zinc transporter 7 (ZNT7) in mouse dorsal root ganglia. Elsevier. Brain Research Bulletin 74 (2007) 278-283.
Huang, L., Kirschke, C.P. A di-leucine sorting signal in zip1 (slc39a1) mediates endocytosis of the protein. FEDERATION OF EUROPEAN BIOCHEMICAL SOCIETY, 274: 3986-3997, 2007.
Wang, X., Wang, Z., Gao, H., Danscher, G., Huang, L. Localization of ZnT7 and zinc ions in mouse retina-Immunohistochemistry and selenium autometallography. Brain Research Bulletin, 2006.71:91-96
Yu, Y.Y., Kirschke, C.P., Huang, L. 2006. IMMUNOHISTOCHEMICAL ANALYSIS OF ZNT1, 4, 5, 6, AND 7 IN THE MOUSE GASTROINTESTINAL TRACT. Journal of Histochemistry and Cytochemistry. Vol. 55(3):223-234, 2006.
Chi, Z., Wang, X., Wang, Z., Gao, H., Dahlstrom, A., Huang, L. 2006. Zinc transporter 7 is located in the cis-Golgi apparatus of mouse choroid epithelial cells. NeuroReport. 2006. Vol.17:1807-1811.
Huang, L., Kirschke, C.P., Zhang, Y. Decreased intracellular zinc in human tumorigenic prostate epithelial cells: a possible role in prostate cancer progression. Cancer Cell International 2006, 6:10, 2006.
Magvanua, M.J., Dawson, K., Huang, L., Malyj, W., Gregg, J., Galvez, A.F., Rodriguez, R.L. 2006. NUTRIENT-GENE INTERACTIONS INVOLVING SOY PEPTIDE AND CHEMOPREVENTIVE GENES IN PROSTATE EPITHELIAL CELLS. John Wiley & Sons, Inc. Chapter 11:255-276.
Huang, L., Kirschke, C.P., Zhang, Y., Yu, Y. 2005. ZIP7 GENE (SLC39A7) ENCODES A ZINC TRANSPORTER INVOLVED IN ZINC HOMEOSTASIS OF THE GOLGI APPARATUS. Journal of Biological Chemistry 280(15):15456-15463, 2005.
Wang, Z., Stoltenberg, M., Huang, L., Danscher, G., Dahlstrom, A., Shi, Y., Li, J. 2004. ABUNDANT EXPRESSION OF ZINC TRANSPORTERS IN BERGMAN GLIA OF MOUSE CEREBELLUM. Elsevier. Bulletin 64:441-44, 2004.
Andree, K.B., Kim, J., Kirschke, C.P., Gregg, J.P., Paik, H., Joung, H., Woodhouse, L.R., King, J., Huang, L. 2004. Investigation of lymphocyte gene expression for use as biomarkers for zinc status in humans. Journal of Nutrition. Journal of Nutrition. 134:1716-1723, 2004.
Wang, Z., Stoltenberg, M., Jo, S.M., Huang, L., Larsen, A., Dahlstrom, A., Danscher, G. 2004. Dynamic zinc pools in mouse choroid plexus. NeuroReport, 15:1801-1804, Lippincott, Williams & Wilkins.
Kirschke, C.P., Huang, L. 2004. Znt7, a novel mammalian zinc transporter, accumulates zinc in the golgi apparatus. Journal of Biological Chemistry. 278:4096-103, 2004.
Palmiter, R.D., Huang, L. 2004. Efflux and compartmentalization of zinc by members of the slc30 family of solute carriers. Journal of Physiology (2004) 447:744-51.
Molecular Determinants of Energy Metabolism Regulation and Gut Function in Response to Zinc Deficiency In-House Appropriated (D) Accession Number:430814
Methods and Technique Molecular biology methods (DNA/RNA isolation, PCR, Western blots, quantitative PCR
