Wayne Zeller
Research Chemist

608-890-0071

1925 Linden Dr. W
Madison, WI 53706

Dr. Zeller joined the Cell Wall Biology and Utilization Research : USDA ARS unit in September of 2009.  Dr. Zeller's research specializes in condensed tannins in forages or more specifically their chemistry and characterization.

• Publications

  • (Clicking on the reprint icon will take you to the publication reprint.)
  • Effects of Sericea Lespedeza supplementation on steers grazing wild-type endophyte-infected tall fescue [abstract]-(Abstract Only)
    Poudel, S., Pent, G.J., Fike, J.H., Davis, B.E., Zeller, W.E. 2024. Effects of Sericea Lespedeza supplementation on steers grazing wild-type endophyte-infected tall fescue [abstract]. In: Journal of Animal Science. American Society of Animal Science Southern Section Meeting, January 27-30, 2024, Louisville, Kentucky. p. 48-49.
    
  • 1H-13C HSQC-NMR analysis of cranberry (Vaccinium macrocarpon) juice defines the chemical composition of juice precipitate -(Peer Reviewed Journal)
    Dorris, M.R., Zeller, W.E., and Bolling, B.W. 2023. 1H–13C HSQC–NMR Analysis of cranberry (Vaccinium macrocarpon) juice defines the chemical composition of juice precipitate. Journal of Agricultural and Food Chemistry. 71(28):10710-10717. https://doi.org/10.1021/acs.jafc.3c01629.
    
  • Analysis of total condensed tannins by the HCl-butanol-acetone-iron assay-(Abstract Only)
    Grabber, J.H., Zeller, W.E. 2023. Analysis of total condensed tannins by the HCl-butanol-acetone-iron assay. Association Official Analytical Chemists Midwest Section Program Abstracts. Midwest AOAC Meeting, June 2023.
    
  • Condensed tannins attributes: Potential solution to fescue toxicosis? -(Literature Review)
    Poudel, S., Zeller, W.E., Fike, J., Pent, G. 3023. Condensed tannins attributes: Potential solution to fescue toxicosis?. Agriculture. 13(3):672-688. https://doi.org/10.3390/agriculture13030672.
    
  • Effects of selected condensed tannins on Cryptosporidium parvum growth and proliferation in HCT-8 cell cultures -(Peer Reviewed Journal)
    Woolsey, I.D., Zeller, W.E., Blomstrand, B.M., Oines, O., Enemark, H.L. 2022. Effects of selected condensed tannins on Cryptosporidium parvum growth and proliferation in HCT-8 cell cultures. Experimental Parasitology. 241. Article 108353. https://doi.org/10.1016/j.exppara.2022.108353.
    
  • Dietary proanthocyanidins promote localized antioxidant responses in porcine pulmonary and gastrointestinal tissues during Ascaris suum-induced type 2 inflammation -(Peer Reviewed Journal)
    Andersen-Civil, A.S., Myhill, L.J., Gokgoz, N.B., Engstrom, M., Mejer, H., Zhu, L., Zeller, W.E., Salminen, J., Krych, L., Lauridsen, C., Nielsen, D.S., Thamsborg, S.M., Williams, A.R. 2022. Dietary proanthocyanidins promote localized antioxidant responses in porcine pulmonary and gastrointestinal tissues during Ascaris suum-induced type 2 inflammation. Journal of Federation of American Societies for Experimental Biology. 36(4). Article e22256. https://doi.org/10.1096/fj.202101603RR.
    
  • Condensed tannins in white clover (Trifolium repens) foliar tissues expressing the transcription factor TaMYB14-1 bind to forage protein and reduce ammonia and methane emissions in vitro -(Peer Reviewed Journal)
    Roldan, M.B., Cousins, G., Muetzela, S., Zeller, W.E., Fraser, K., Salminen, J., Blanc, A., Kaur, R., Richardson, K., Maher, D., Jahufer, Z., Woodfield, D., Caradus, J.R., Voisey, C.R. 2022. Condensed tannins in white clover (Trifolium repens) foliar tissues expressing the transcription factor TaMYB14-1 bind to forage protein and reduce ammonia and methane emissions in vitro. Frontiers in Plant Science. 12. Article 777354. https://doi.org/10.3389/fpls.2021.777354.
    
  • Composition and protein precipitation capacity of condensed tannins in purple prairie clover (Dalea purpurea Vent.) -(Peer Reviewed Journal)
    Huang, Q., Hu, T., Xu, Z., Jin, L., McAllister, T.A., Acharya, S., Zeller, W.E., Mueller-Harvey, I., Wang, Y. 2021. Composition and protein precipitation capacity of condensed tannins in purple prairie clover (Dalea purpurea Vent.). Frontiers in Plant Science. 12. Article 715282. https://doi.org/10.3389/fpls.2021.715282.
    
  • Proanthocyanidin structural details revealed by ultrahigh resolution FT-ICR MALDI-mass spectrometry, 1H-13C HSQC NMR, and thiolysis-HPLC-DAD -(Peer Reviewed Journal)
    Reeves, S.G., Somogyi, A., Zeller, W.E., Ramelot, T.A., Wrighton, K.C., Hagerman, A.E. 2020. Proanthocyanidin structural details revealed by ultrahigh resolution FT-ICR MALDI-mass spectrometry, 1H-13C HSQC NMR, and thiolysis-HPLC-DAD. Journal of Agricultural and Food Chemistry. 68(47):14038-14048. https://doi.org/10.1021/acs.jafc.0c04877.
    
  • Proanthocyanidin Block Arrays (PACBAR) for Comprehensive Capture and Delineation of Proanthocyanidin Structures -(Peer Reviewed Journal)
    Jing, S., Zeller, W.E., Ferreira, D., Zhou, B., Nam, J., Russo-Bedran, A., Chen, S., Pauli, G.F. 2020. Proanthocyanidin Block Arrays (PACBAR) for Comprehensive Capture and Delineation of Proanthocyanidin Structures. Journal of Agricultural and Food Chemistry. 68(47):13541-13549. https://doi.org/10.1021/acs.jafc.0c05392.
    
  • Challenges in analyzing bioactive proanthocyanidins -(Book / Chapter)
    Zeller, W.E., Mueller-Harvey, I. 2021. Challenges in analyzing bioactive proanthocyanidins. In: Dreher Reed, J., Pereira de Freitas, V.A., Quideau, S. Recent Advances in Polyphenol Research. 1st edition. Hoboken, NJ: John Wiley & Sons, Inc. p. 131-175. https://doi.org/10.1002/9781119545958.ch6.
    
  • Comparison of protein precipitation ability of structurally diverse procyanidin-rich condensed tannins in two buffer systems -(Peer Reviewed Journal)
    Zeller, W.E., Reinhardt, L.A., Robe, J.T., Sullivan, M.L., Panke-Buisse, K. 2020. Comparison of protein precipitation ability of structurally diverse procyanidin-rich condensed tannins in two buffer systems. Journal of Agricultural and Food Chemistry. 68(7):2016-2023. https://doi.org/10.1021/acs.jafc.9b06173.
    
  • Condensed tannins: structure, activity and characterization-(Abstract Only)
    
    
  • Influence of elevated protein and tannin-rich peanut skin supplementation on growth performance, blood metabolites, carcass traits, and immune-related gene expression of grazing meat goats -(Peer Reviewed Journal)
    Min, B., McTear, K., Wang, H.H., Joakin, M., Gurung, N., Abrahamsen, F., Solaiman, S., Eun, J., Lee, J.H., Dietz, L.A., Zeller, W.E. 2019. Influence of elevated protein and tannin-rich peanut skin supplementation on growth performance, blood metabolites, carcass traits, and immune-related gene expression of grazing meat goats. Journal of Animal Physiology and Animal Nutrition. 104(1):88-100. https://doi.org/10.1111/jpn.13250.
    
  • Direct versus sequential analysis of procyanidin- and prodelphinidin-based condensed tannins by the HCl–butanol–acetone–iron assay -(Peer Reviewed Journal)
    Grabber, J.H., Zeller, W.E. 2019. Direct versus sequential analysis of procyanidin- and prodelphinidin-based condensed tannins by the HCl–butanol–acetone–iron assay. Journal of Agricultural and Food Chemistry. 68,10, 2906-2916. https://doi.org/10.1021/acs.jafc.9b01307.
    
  • Elucidating composition and structure of purified condensed tannins: Corroboration of thiolysis and spectroscopic data-(Abstract Only)
    
    
  • Activity, purification, and analysis of condensed tannins: current state of affairs and future endeavors -(Peer Reviewed Journal)
    Zeller, W.E. 2019. Activity, purification, and analysis of condensed tannins: current state of affairs and future endeavors. Crop Science. https://doi.org/10.2135/cropsci2018.05.0323.
    
  • Short communication: Gelatinization and enzymatic hydrolysis characteristics relevant to digestion and analysis of glycogen granules isolated from ruminal protozoa -(Peer Reviewed Journal)
    Hall, M., Zeller, W.E., Hoffstetter, H. 2019. Short communication: Gelatinization and enzymatic hydrolysis characteristics relevant to digestion and analysis of glycogen granules isolated from ruminal protozoa. Journal of Dairy Science. https://doi.org/10.3168/jds.2018-15758.
    
  • Effects of feeding Lespedeza cuneata pellets with Medicago sativa hay to sheep: Nutritional impact, characterization and degradation of condensed tannin during digestion -(Peer Reviewed Journal)
    Kronberg, S.L., Zeller, W.E., Waghorn, G., Grabber, J.H., Terrill, T.H., Liebig, M.A. 2018. Effects of feeding Lespedeza cuneata pellets with Medicago sativa hay to sheep: Nutritional impact, characterization and degradation of condensed tannin during digestion. Animal Feed Science And Technology. 245:41-47. https://doi.org/10.1016/j.anifeedsci.2018.08.011.
    
  • Relationships between structures of condensed tannins from Texas legumes and methane production during in vitro rumen digestion -(Peer Reviewed Journal)
    Naumann, H., Sepela, R., Rezaire, A., Masih, S.E., Zeller, W.E., Reinhardt, L.A., Robe, J.T., Sullivan, M.L., Hagerman, A.E. 2018. Relationships between structures of condensed tannins from Texas legumes and methane production during in vitro rumen digestion. Molecules. 2018, 23, 2123. https://doi.org/10.3390/molecules23092123.
    
  • Coupling of wet chemistry methods and spectroscopic data for elucidating composition and structure of purified condensed tannins-(Abstract Only)
    Zeller, W.E., Mueller-Harvey, I., Hagerman, A.E. 2018. Coupling of wet chemistry methods and spectroscopic data for elucidating composition and structure of purified condensed tannins. American Chemical Society Abstracts. AGFD 219.
    
  • Composition and structural features of condensed tannins from Texas legumes exhibiting methane abatement activity during in vitro rumen digestion-(Abstract Only)
    Naumann, H.D., Sepela, R., Rezaire, A., Hagerman, A.E., Reinhardt, L.A., Robe, J., Zeller, W.E. 2018. Composition and structural features of condensed tannins from Texas legumes exhibiting methane abatement activity during in vitro rumen digestion. American Chemical Society Abstracts. AGFD 203.
    
  • The role of condensed tannins in animal production: advances, limitations and future directions-(Peer Reviewed Journal)
    Naumann, H.D., Tedeschi, L.O., Zeller, W.E., Huntley, N.F. 2017. The role of condensed tannins in animal production: advances, limitations and future directions. Brazilian Journal of Animal Science. 46:929-949.
    
  • Facile purification of milligram to gram quantities of condensed tannins according to mean degree of polymerization and flavan-3-ol subunit composition-(Peer Reviewed Journal)
    Brown, R.H., Mueller-Harvey, I., Zeller, W.E., Reinhardt, L.A., Stringano, E., Gea, A., Drake, C., Ropiak, H.M., Fryganas, C., Ramsay, A., Hardcastle, E.E. 2017. Facile purification of milligram to gram quantities of condensed tannins according to mean degree of polymerization and flavan-3-ol subunit composition. Journal of Agricultural and Food Chemistry. 65:8072-8082.
    
  • The U.S. Dairy Forage Research Center (USDFRC) condensed tannin NMR database-(Peer Reviewed Journal)
    Zeller, W.E., Schatz, P.F. 2017. The U.S. Dairy Forage Research Center (USDFRC) condensed tannin NMR database. Journal of Agricultural and Food Chemistry. 65:5104-5106.
    
  • Activity, purification, and analysis of condensed tannins-(Abstract Only)
    Zeller, W.E., Mueller-Harvey, I., Grabber, J.H. 2015. Activity, purification, and analysis of condensed tannins [abstract]. American Society of Agronomy. Paper No. 259-2.
    
  • Redesigning forages with condensed tannins-(Popular Publication)
    Zeller, W.E., Grabber, J.H. 2015. Redesigning forages with condensed tannins. Progressive Forage Grower. 16(3):7-8.
    
  • 1H-13C HSQC NMR spectroscopy for estimating procyanidin/prodelphinidin and cis/trans flavan-3-ol ratios of condensed tannin samples: correlation with thiolysis -(Peer Reviewed Journal)
    Zeller, W.E., Ramsay, A., Ropiak, H.M., Fryganas, C., Mueller-Harvey, I., Brown, R.H., Drake, C., Grabber, J.H. 2015. 1H-13C HSQC NMR spectroscopy for estimating procyanidin/prodelphinidin and cis/trans flavan-3-ol ratios of condensed tannin samples: correlation with thiolysis. Journal of Agricultural and Food Chemistry. 63:1967-1973.
    
  • Synthesis of monomethyl 5,5'-dehydrodiferulic acid-(Peer Reviewed Journal)
    Zeller, W.E., Schatz, P.F. 2015. Synthesis of monomethyl 5,5'-dehydrodiferulic acid. Tetrahedron Letters. 56:1076-1079.
    
  • Impact by condensed tannins with different mean degrees of polymerization on protein precipitation-(Abstract Only)
    Zeller, W.E., Sullivan, M.L., Mueller-Harvey, I., Grabber, J.H., Ramsay, A., Drake, C., Brown, R.H. 2015. Impact by condensed tannins with different mean degrees of polymerization on protein precipitation [abstract]. 249th American Chemical Society Meeting, March 22-26, 2015, Denver, Colorado. Abstract No. AGFD 51.
    
  • Estimation of procyanidin/prodelphinidin and cis/trans flavanol ratios of condensed tannin fractions by 1H-13C HSQC NMR spectroscopy: Correlation with thiolysis-(Abstract Only)
    Zeller, W.E., Ramsay, A., Ropiak, H.M., Fryganas, C., Mueller-Harvey, I., Brown, R.H., Drake, C., Grabber, J.H. 2015. Estimation of procyanidin/prodelphinidin and cis/trans flavanol ratios of condensed tannin fractions by 1H-13C HSQC NMR spectroscopy: Correlation with thiolysis [abstract]. 249th American Chemical Society Meeting, March 22-26, 2015, Denver, Colorado. Abstract No. AGFD 50.
    
  • Researching ways to improve nitrogen-use efficiency on dairies through the use of condensed tannin-containing forages-(Popular Publication)
    Zeller, W.E., Grabber, J.H. December 2014. Researching ways to improve nitrogen-use efficiency on dairies through the use of condensed tannin-containing forages. Forage Focus. p. 10-11.
    
  • Protein precipitation behavior of condensed tannins from Lotus pedunculatus and Trifolium repens with different mean degrees of polymerization -(Peer Reviewed Journal)
    Zeller, W.E., Sullivan, M.L., Mueller-Harvey, I., Grabber, J.H., Ramsay, A., Drake, C., Brown, R.H. 2015. Protein precipitation behavior of condensed tannins from Lotus pedunculatus and Trifolium repens with different mean degrees of polymerization. Journal of Agricultural and Food Chemistry. 63:1160-1168.
    
  • Supplementation of alfalfa (Medicago sativa) with condensed tannin-containing pellets of sericea lespedeza (Lespedeza cuneata): Effects on ruminant urinary urea excretion and digestibility-(Abstract Only)
    Kronberg, S.L., Zeller, W.E., Grabber, J.H., Terrill, T.H., Waghorn, G.C., Liebig, M.A. 2014. Supplementation of alfalfa (Medicago sativa) with condensed tannin-containing pellets of sericea lespedeza (Lespedeza cuneata): Effects on ruminant urinary urea excretion and digestibility. ASA-CSSA-SSSA Annual Meeting Abstracts. ASA Poster Section on Environmental Quality. Poster #431.
    
  • Purity assessment of condensed tannin fractions by nuclear magnetic resonance (NMR) spectroscopy-(Abstract Only)
    
    
  • Synthesis of 1-O-methylchlorogenic acid: reassignment of structure for MCGA3 isolated from bamboo (Phyllostachys edulis) leaves-(Peer Reviewed Journal)
    Zeller, W.E. 2014. Synthesis of 1-O-methylchlorogenic acid: reassignment of structure for MCGA3 isolated from bamboo (Phyllostachys edulis) leaves. Journal of Agricultural and Food Chemistry. 62:1860-1865.
    
  • Acetone enhances the direct analysis of Procyanidin- and Prodelphinidin-based condensed tannins in lotus species by the butanol-HCl-iron assay-(Peer Reviewed Journal)
    Grabber, J.H., Zeller, W.E., Mueller Harvey, I. 2013. Acetone enhances the direct analysis of Procyanidin- and Prodelphinidin-based condensed tannins in lotus species by the butanol-HCl-iron assay. Journal of Agricultural and Food Chemistry. 61:2669-2678.
    
  • Acetone enhances the direct analysis of total condensed tannins in plant tissues by the butanol-HCl-iron assay-(Abstract Only)
    
    
  • Impacts of flavanoid monomers and simple hydrolyzable tannins on ammonia emissions from dairy manure-(Abstract Only)
    
    
  • Efficacy of various naturally occurring caffeic acid derivatives in preventing post-harvest protein losses in forages-(Peer Reviewed Journal)
    Sullivan, M.L., Zeller, W.E. 2012. Efficacy of various naturally occurring caffeic acid derivatives in preventing post-harvest protein losses in forages. Journal of the Science of Food and Agriculture. 93:219-226.
    
  • Challenges in quantifying condensed tannins and their impact on the ruminal degradability of protein in birdsfoot trefoil-(Abstract Only)
    
    
  • Synthesis of (+) and (-)-phaselic acid-(Abstract Only)
    Zeller, W.E. 2012. Synthesis of (+) and (-)-phaselic acid [abstract]. American Chemical Society. Paper No. AGFD 168.
    
  • Progress in the synthesis of 1-O-methylchlorogenic acid-(Abstract Only)
    Zeller, W.E. 2012. Progress in the synthesis of 1-O-methylchlorogenic acid [abstract]. American Chemical Society. Paper No. AGFD 184.
    
  • Synthesis of (+)- and (-)-phaselic acid-(Peer Reviewed Journal)
    Zeller, W.E. 2013. Synthesis of (+)- and (-)-phaselic acid. Synthetic Communications. 43(10):1345-1350.
    

• Projects

  Identifying and Developing Strategies to Enhance Sustainability and Efficiency in Dairy Forage Production Systems In-House Appropriated (D)   Accession Number:445642

  Institutional Biological Safety Committee (IBC) Agreement - University of Wisconsin Madison Non-Funded Cooperative Agreement (N)   Accession Number:441643

• ARS News Articles

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