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ARS Home » Northeast Area » Beltsville, Maryland (BHNRC) » Beltsville Human Nutrition Research Center » Diet, Genomics and Immunology Laboratory » People & Locations » Joseph Urban
Joseph F Urban, Jr.
Diet, Genomics and Immunology Laboratory
Collaborator

Phone: (301) 504-5528 ext. 267
Fax: (301) 504-9062

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Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Metabolic pathway and network analysis integration for discovering the biomarkers in pig feces after a controlled fruit-vegetable dietary intervention Reprint Icon - (Peer Reviewed Journal)
Liu, Z., Solano Aguilar, G., Lakshman, S., Urban, J.F., Zhang, M., Chen, P., Yu, L., Sun, J. 2024. Metabolic pathway and network analysis integration for discovering the biomarkers in pig feces after a controlled fruit-vegetable dietary intervention. Food Chemistry. 461:140836. https://doi.org/10.1016/j.foodchem.2024.140836.
After bone marrow transplantation, cell-intrinsic T Helper-2 (Th2) pathway promotes recipient T lymphocyte survival and regulates the graft-versus-host disease Reprint Icon - (Peer Reviewed Journal)
Truscott, J., Guan, X., Fury, H., Atagozli, T., Metwali, A., Liu, W., Li, Y., Urban Jr, J.F., Li, R.W., Brombacher, F., Elliott, D., Blazer, B., Ince, M. 2023. After bone marrow transplantation, cell-intrinsic T Helper-2 (Th2) pathway promotes recipient T lymphocyte survival and regulates the graft-versus-host disease. Journal of Immunology. https://doi.org/10.4049/immunohorizons.2300021.
Identification and distribution of sterols, bile acids, and acylcarnitines by LC-MS/MS in humans, mice, and pigs – a qualitative analysis Reprint Icon - (Peer Reviewed Journal)
Babu, A.F., Koistinen, V.M., Turunen, S., Solano-Aguilar, G., Urban, Jr. J.F., Zarei, I., Hanhineva, K. 2022. Identification and distribution of sterols, bile acids, and acylcarnitines by LC-MS/MS in humans, mice, and pigs -- a qualitative analysis. Metabolites. 12(1):49. https://doi.org/10.3390/metabo12010049.
Fruit and vegetable supplemented diet modulates the pig transcriptome and microbiome after a two-week feeding intervention Reprint Icon - (Peer Reviewed Journal)
Solano-Aguilar, G.I., Lakshman, S., Shao, J.Y., Chen, C.T., Beshah, E., Dawson, H.D., Vinyard, B.T., Schroeder, S.G., Jang, S., Molokin, A., Urban Jr., J.F. 2021. Fruit and vegetable supplemented diet modulates the pig transcriptome and microbiome after a two-week feeding intervention. Nutrients. 13:4350. https://doi.org/10.3390/nu13124350.
The effects of consuming white button mushroom-Agaricus Bisporus-on the brain and liver metabolome using a targeted metabolomic analysis Reprint Icon - (Peer Reviewed Journal)
Solano-Aguilar, G.I., Lakshman, S., Jang, S., Gupta, R., Molokin, A., Schroeder, S.G., Gillevet, P.M., Urban Jr., J.F. 2021. The effects of consuming white button mushroom Agaricus bisporus on the brain and liver metabolome using a targeted metabolomic analysis. Metabolites. 11(11):779. https://doi.org/10.3390/metabo11110779.
Up-regulation of gasdermin C in mouse small intestine is associated with lytic cell death in enterocytes in worm-induced type 2 immunity Reprint Icon - (Peer Reviewed Journal)
Xi, R., Montague, J., Lin, X., Lu, C., Lei, W., Tanaka, K., Zhang, Y., Xu, X., Zheng, X., Zhou, X., Urban Jr, J.F., Iwatsuki, K., Margolskee, R.F., Matsumoto, I., Tizzano, M., Li, J., Jiang, P. 2021. Up-regulation of gasdermin C in mouse small intestine is associated with lytic cell death in enterocytes in worm-induced type 2 immunity. Proceedings of the National Academy of Sciences (PNAS). 118(30). Article e2026307118. https://doi.org/10.1073/pnas.2026307118.
Enteric helminth coinfection enhances host susceptibility to West Nile virus in the brain via a tuft cell-IL-4Ra signaling axis in gut epithelium Reprint Icon - (Peer Reviewed Journal)
Desai, P., Janova, H., White, J.P., Reynoso, G.V., Hickman, H.D., Baldridge, M.T., Urban Jr, J.F., Stappenbeck, T.S., Thackray, L.B., Diamond, M.S. 2021. Enteric helminth coinfection enhances host susceptibility to West Nile virus in the brain via a tuft cell-IL-4Ra signaling axis in gut epithelium . Cell. https://doi.org/10.1016/j.cell.2021.01.051.
Whipworm-associated intestinal microbiome members consistent across both human and mouse hosts Reprint Icon - (Peer Reviewed Journal)
Rosa, B.A., Snowden, C., Martin, J., Fisher, K., Kupritz, J., Beshah, E., Supali, T., Gankpala, L., Fisher, P.U., Urban Jr, J.F., Mitreva, M. 2021. Whipworm-associated intestinal microbiome members consistent across both human and mouse hosts. Frontiers in Cellular and Infection Microbiology. https://doi.org/10.3389/fcimb.2021.637570.
Western and heart healthy dietary patterns differentially affect the expression of genes associated with lipid metabolism, interferon signaling and inflammation in the jejunum of Ossabaw pigs Reprint Icon - (Peer Reviewed Journal)
Ye, S., Matthan, N., Lamon-Fava, S., Solano Aguilar, G., Turner, J., Walker, M.E., Chai, Z., Lakshman, S., Urban Jr, J.F., Lichtenstein, A.H. 2021. Western and heart healthy dietary patterns differentially affect the expression of genes associated with lipid metabolism, interferon signaling and inflammation in the jejunum of Ossabaw pigs. Journal of Nutritional Biochemistry. 90:108577. https://doi.org/doi: 10.1016/j.jnutbio.2020.108577.
Colon transcriptome is modified by dietary pattern/Atorvastatin interaction in the Ossabaw pig Reprint Icon - (Peer Reviewed Journal)
Shumao, Y., Nirupa, M., Lamon-Fava, S., Solano Aguilar, G., Turner, J.R., Walker, M.E., Zhi, C., Lakshman, S., Chen, C.T., Dawson, H.D., Urban Jr, J.F., Lichtenstein, A.H. 2021. Colon transcriptome is modified by dietary pattern/Atorvastatin interaction in the Ossabaw pig. Journal of Nutritional Biochemistry. 90:108577. https://doi.org/10.1016/j.jnutbio.2020.108570.
New paraprobiotic-based treatment for control of the barber pole worm Haemonchus contortus in sheep Reprint Icon - (Peer Reviewed Journal)
Sanders, J., Xie, Y., Gazzola, D., Li, H., Abraham, A., Flanagan, K., Rus, F., Miller, M., Hu, Y., Zarlenga, D.S., Li, R.W., Urban Jr, J.F., Ostroff, G., Zajac, A., Aroian, R.V. 2020. New paraprobiotic-based treatment for control of the barber pole worm Haemonchus contortus in sheep. International Journal for Parasitology: Drug and Drug Resistance. 14(230-236). https://doi.org/10.1016/j.ijpddr.2020.11.004.
Interleukin-33 promotes seratonin release from enterochromaffin cells for intestional homeostasis Reprint Icon - (Peer Reviewed Journal)
Chen, Z., Luo, J., Li, J., Kim, G., Stewart, A., Urban Jr, J.F., Huang, Y., Chen, S., Wu, L., Chester, A., Trinchieri, G., Li, W., Wu, C. 2020. Interleukin-33 promotes seratonin release from enterochromaffin cells for intestional homeostasis. Immunity. 54(1):151-163.e6. https://doi.org/doi:10.1016/j.immuni.2020.10.014.
Molecular and metabolomic changes in the proximal colon of pigs infected with Trichuris suis Reprint Icon - (Peer Reviewed Journal)
Dawson, H.D., Chen, C.T., Li, R.W., Bell, N., Shea-Donohue, T., Kringel, H., Beshah, E., Hill, D.E., Urban Jr, J.F. 2020. Molecular and metabolomic changes in the proximal colon of pigs infected with Trichuris suis. Scientific Reports. 10, 12853. https://doi.org/10.1038/s41598-020-69462-5.
Mechanistic insights into the attenuation of intestinal inflammation and modulation of the gut microbiome by krill oil using in vitro and in vivo models Reprint Icon - (Peer Reviewed Journal)
Liu, F., Smith, A.D., Solano Aguilar, G., Wang, T.T., Pham, Q., Tang, Q., Urban Jr, J.F., Xue, C., Li, R.W. 2020. Mechanistic insights into the attenuation of intestinal inflammation and modulation of the gut microbiome by krill oil using in vitro and in vivo models. Microbiome. 8:83. https://doi.org/10.1186/s40168-020-00843-8.
An inactivated bacterium (paraprobiotic) expressing Bacillus thuringiensis Cry5B as a therapeutic for Ascaris and Parascaris spp. infections in large animals Reprint Icon - (Peer Reviewed Journal)
Urban Jr, J.F., Nielsen, M., Gazzola, D., Xie, Y., Beshah, E., Hu, Y., Rus, F., Flanagan, K., Draper, A., Vakalapudi, S., Li, R.W., Ostroff, G.R., Aroian, R.V. 2020. An inactivated bacterium (paraprobiotic) expressing Bacillus thuringiensis Cry5B as a therapeutic for Ascaris and Parascaris spp. infections in large animals. Elsevier. 164:994-1005. https://doi.org/10.1016/j.onehlt.2021.100241.
Potentiation of IL-4 signaling by retinoic acid in intestinal epithelial cells and macrophages - mechanisms and targets Reprint Icon - (Peer Reviewed Journal)
Chen, C.T., Smith, A.D., Cheung, L., Pham, Q., Urban Jr, J.F., Dawson, H.D. 2020. Potentiation of IL-4 signaling by retinoic acid in intestinal epithelial cells and macrophages - mechanisms and targets. Frontiers in Immunology. 10.3389. https://doi.org/10.3389/fimmu.2020.00605.
Method: isolation of epithelial cell RNA from frozen jejunum segments while minimizing smooth muscle cell rNA contamination Reprint Icon - (Abstract Only)
Ye, S., Matthan, N.R., Lamon-Fava, S., Solano Aguilar, G., Turner, J.R., Wang, X., Walker, M.E., Chai, Z., Lakshman, S., Urban Jr, J.F., Lichtenstein, A.H. 2020. Method: isolation of epithelial cell RNA from frozen jejunum segments while minimizing smooth muscle cell rNA contamination. Current Developments in Nutrition. 4(Suppl_2):1182. https://doi.org/10.1093/cdn/nzaa056_029.
Western versus heart healthy dietary pattern alters genes expression associated with lipid metabolism, interferon signaling and inflammation in jejunum of Ossabaw pigs Reprint Icon - (Abstract Only)
Ye, S., Matthan, N.R., Lamon-Fava, S., Solano Aguilar, G., Turner, J.R., Wang, X., Walker, M.E., Chai, Z., Lakshman, S., Urban Jr, J.F., Lichtenstein, A.H. 2020. Western versus heart healthy dietary pattern alters genes expression associated with lipid metabolism, interferon signaling and inflammation in jejunum of Ossabaw pigs. Current Developments in Nutrition. 4(Suppl_2):577. https://doi.org/10.1093/cdn/nzaa046_077.
Inactivation of Toxoplasma gondii bradyzoites after salt exposure during preparation of dry cured hams Reprint Icon - (Peer Reviewed Journal)
Fredericks, J.N., Hawkins Cooper, D.S., Hill, D.E., Luchansky, J.B., Porto Fett, A.C., Shoyer, B.A., Fournet, V.M., Urban Jr, J.F., Dubey, J.P. 2020. Inactivation of Toxoplasma gondii bradyzoites after salt exposure during preparation of dry cured hams. Journal of Food Protection. 83(6):1038-1042. https://doi.org/10.4315/0362-028X.JFP-19-461.
Gut microbial signatures with predictive power for moxidectin treatment outcomes in Reprint Icon - (Peer Reviewed Journal)
Liu, F., Xie, Y., Zajaz, A.M., Hu, Y., Aroian, R.V., Urban Jr, J.F., Li, R.W. 2020. Gut microbial signatures with predictive power for moxidectin treatment outcomes in. Journal of Parasitology. 242(2020):108607. https://doi.org/10.1016/j.vetmic.2020.108607.
BBhlhe40 promotes TH2 cell-mediated anti-helminth immunity and reveals cooperative Csf2rb family cytokines Reprint Icon - (Peer Reviewed Journal)
Jarjour, N.N., Bradstreet, T.R., Schwarzkopf, E.A., Cook, M.E., Lai, C., Huang, S., Taneja, R., Stappenbeck, T.S., Urban Jr, J.F., Edelson, B.T. 2020. BBhlhe40 promotes TH2 cell-mediated anti-helminth immunity and reveals cooperative Csf2rb family cytokines. Journal of Immunology. 204(4):923-932. https://doi.org/10.4049/jimmunol.1900978.
An integrated computational and evidence-based approach identifies small molecule inhibitors detrimental to intestinal cells and tissue of parasitic nematodes Reprint Icon - (Peer Reviewed Journal)
Jasmer, D.P., Rosa, B.A., Tyagi, R., Bulman, C.A., Beernsten, B., Urban Jr, J.F., Sakanari, J., Mitreva, M. 2020. An integrated computational and evidence-based approach identifies small molecule inhibitors detrimental to intestinal cells and tissue of parasitic nematodes. PLOS Neglected Tropical Diseases. 14(5):e0007942. https://doi.org/10.1371/journal.pntd.0007942.
5-(Hydroxyphenyl)-y-valerolactone-sulfate, a key microbial metabolite of flavan-3-ols, is able to reach the brain: evidence from different in silico, in vitro and in vivo experimental models Reprint Icon - (Peer Reviewed Journal)
Angelino, D., Carregora, D., Domenech-Coca, C., Savi, M., Figueira, I., Brindani, N., Jang, S., Lakshman, S., Molokin, A., Urban Jr, J.F., Davies, C.D., Britto, M.A., Kim, K.S., Brighenti, F., Curti, C., Blade, C., Del Bas, J.M., Stilli, D., Solano Aguilar, G., Nunes Del Santos, C., Del Rio, D., Mena, P. 2019. 5-(Hydroxyphenyl)-y-valerolactone-sulfate, a key microbial metabolite of flavan-3-ols, is able to reach the brain: evidence from different in silico, in vitro and in vivo experimental models. Nutrients. 11(11). pii: E2678. https://doi.org/10.3390/nu11112678.
Neuropeptide CGRP limits group 2 innate lymphoid cell responses and constrainst type 2 inflammation Reprint Icon - (Peer Reviewed Journal)
Nagashima, H., Mahlakoiv, T., Shih, H., Davis, F.P., Meylan, F., Huang, Y., Harrison, O., Yao, C., Mikami, Y., Urban Jr, J.F., Caron, K., Belkaid, Y., Kanno, Y., Artis, D.C., O'Shea, J.J. 2019. Neuropeptide CGRP limits group 2 innate lymphoid cell responses and constrains type 2 inflammation. Immunity. 51(4):682-695e6. https://doi.org/10.1016/j.immuni.2019.06.009.
Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity Reprint Icon - (Peer Reviewed Journal)
Jarjour, N.N., Schwarzkopf, E.A., Bradstreet, T.R., Shchukina, I., Lin, C., Huang, S., Lai, C., Cook, M.E., Taneja, R., Stappenbeck, T., Randolph, G.J., Artyomov, M.N., Urban Jr, J.F., Edelson, B.T. 2019. Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity. Nature Immunology. 20:687-700. https://doi.org/10.1038/s41590-019-0382-5.
A Western-type dietary pattern induces an atherogenic gene expression profile in the coronary arteries of the Ossabaw pig Reprint Icon - (Peer Reviewed Journal)
Walker, M., Matthan, N., Lamon-Fava, S., Solano-Aguilar, G., Jang, S., Lakshman, S., Molokin, A., Urban Jr, J.F., Faits, T., Johnson, W.E., Lichtenstein, A.H. 2019. A Western-type dietary pattern induces an atherogenic gene expression profile in the coronary arteries of the Ossabaw pig. Current Developments in Nutrition. 3(5). https://doi.org/10.1093/cdn/nzz023.
Dietary patterns influence epicardial adipose tissue fatty acid composition and inflammatory gene expression in the Ossabaw pig Reprint Icon - (Peer Reviewed Journal)
Walker, M., Matthan, N., Goldbaum, A., Meng, H., Lamon-Fava, S., Lakshman, S., Jang, S., Molokin, A., Solano Aguilar, G., Urban Jr, J.F., Lichtenstein, A.H. 2019. Dietary patterns influence epicardial adipose tissue fatty acid composition and inflammatory gene expression in the Ossabaw pig. Journal of Nutritional Biochemistry. 70:138-146. https://doi.org/10.1016/j.jnutbio.2019.04.013.
Toxoplasma gondii tissue cyst formation and quantitative density of tissue cysts in shoulders of pigs 7 and 14 days after feeding infected mice tissues Reprint Icon - (Peer Reviewed Journal)
Rani, S., Cerqueira-Cézar, C.K., Murata, F.H., Sadler, M., Kwok, O.C., Pradhan, K., Urban Jr, J.F., Hill, D.E., Dubey, J.P. 2019. Toxoplasma gondii tissue cyst formation and quantitative density of tissue cysts in shoulders of pigs 7 and 14 days after feeding infected mice tissues. Veterinary Parasitology. 269:13-15. https://doi.org/10.1016/j.vetpar.2019.04.004.
The regulatory actions of retinoic acid on M2 polarization of porcine macrophages Reprint Icon - (Peer Reviewed Journal)
Chen, C.T., Perry, T.L., Chitko-Mckown, C.G., Smith, A.D., Cheung, L., Beshah, E., Urban Jr, J.F., Dawson, H.D. 2019. The regulatory actions of retinoic acid on M2 polarization of porcine macrophages. Developmental and Comparative Immunology. 98(9):20-23. https://doi.org/10.1016/j.dci.2019.03.020.
Low salt exposure results in inactivation of Toxoplasma gondii bradyzoites during formulation of dry cured ready-to-eat pork sausage Reprint Icon - (Peer Reviewed Journal)
Fredericks, J.N., Hawkins Cooper, D.S., Hill, D.E., Luchansky, J.B., Porto Fett, A.C., Gamble, H.R., Fournet, V.M., Urban Jr, J.F., Gajadhar, A.A., Holley, R., Dubey, J.P. 2019. Low salt exposure results in inactivation of Toxoplasma gondii bradyzoites during formulation of dry cured ready-to-eat pork sausage. Food and Waterborne Parasitology. 15:e00047. https://doi.org/10.1016/j.fawpar.2019.e00047.
Heligmosomoides polygyrus bakeri infection decreases Smad7 expression in intestinal CD4+ T cells which allows TGF-beta to induce IL10-producing regulatory T cells that block colitis Reprint Icon - (Peer Reviewed Journal)
Hang, L., Kumar, S., Blum, A.M., Urban Jr, J.F., Fantini, M.X., Weinstock, J.V. 2019. Heligmosomoides polygyrus bakeri infection decreases Smad7 expression in intestinal CD4+ T cells which allows TGF-beta to induce IL10-producing regulatory T cells that block colitis. Journal of Immunology. (8)2473-2481. https://doi.org/10.4049/jimmunol.1801392.
A Western dietary pattern and atorvastatin induce epicardial adipose tissue interferon signaling in the Ossabaw pig Reprint Icon - (Peer Reviewed Journal)
Walker, M., Matthan, N., Solano Aguilar, G., Jang, S., Lakshman, S., Molokin, A., Faits, T., Urban Jr, J.F., Johnson, W.E., Lamon-Fava, S., Lichtenstein, A.H. 2019. A Western dietary pattern and atorvastatin induce epicardial adipose tissue interferon signaling in the Ossabaw pig. Journal of Nutritional Biochemistry. https://doi.org/10.1016/j.jnutbio.2019.02.003.
The caprine abomasal microbiome - (Abstract Only)
Chronic helminth infection does not impair immune response to malaria transmission blocking vaccine Pfs230D1M-EPA/Alhydrogel® in mice Reprint Icon - (Peer Reviewed Journal)
Coelho, C.H., Gazzinelli-Guimaraes, P.H., Howard, J., Barnafo, E., Alani, N.A., Muratova, O., Mccormack, A., Kelnhofer, E., Urban Jr, J.F., Narum, D., Anderson, C., Langhorne, J., Nutman, T.B., Duffy, P.E. 2019. Chronic helminth infection does not impair immune response to malaria transmission blocking vaccine Pfs230D1M-EPA/Alhydrogel® in mice. Scientific Reports. 37(8):1038-1045. https://doi.org/10.1016/j.vaccine.2019.01.027.
The effect of dietary Agaricus bisporus mushroom on intestinal microbiota composition and host immunological function Reprint Icon - (Peer Reviewed Journal)
Solano Aguilar, G., Jang, S., Lakshman, S., Gupta, R., Beshah, E., Sikaroodi, M., Vinyard, B.T., Molokin, A., Gillevet, P., Urban Jr, J.F. 2018. The effect of dietary Agaricus bisporus mushroom on intestinal microbiota composition and host immunological function. Nutrients. 10(11):1721. https://doi.org/10.3390/nu10111721.
Ascaris suum infection was associated with a worm-independent reduction in microbial diversity and altered metabolic potential in the porcine gut microbiome Reprint Icon - (Peer Reviewed Journal)
Wang, Y., Liu, F., Urban Jr, J.F., Paerewijck, O., Geldhof, P., Li, R.W. 2019. Ascaris suum infection was associated with a worm-independent reduction in microbial diversity and altered metabolic potential in the porcine gut microbiome. International Journal for Parasitology. 49(3-4):247-256. https://doi.org/10.1016/j.ijpara.2018.10.007.
Analysis of the Trichuris suis excretory/secretory proteins as a function of life cycle stage and their immunomodulatory properties Reprint Icon - (Peer Reviewed Journal)
Leroux, L., Nasr, M., Valanparamabil, R., Tam, M., Rosa, B.A., Siciliani, E., Hill, D.E., Zarlenga, D.S., Jaramillo, M., Weinstock, J.V., Geary, T.G., Stevenson, M.M., Urban Jr, J.F., Makedonka, M., Jardim, A. 2018. Analysis of the Trichuris suis excretory/secretory proteins as a function of life cycle stage and their immunomodulatory properties. Scientific Reports. 8:15921. https://doi.org/10.1038/s41598-018-34174-4.
Helminth-induced production of TGFß and suppression of graft-versus-host disease is dependent on Interleukin 4 production by host cells Reprint Icon - (Peer Reviewed Journal)
Li, Y., Liu, W., Guan, X., Chen, H., Zavazava, N., Blumberg, R.S., Weiner, G.J., Urban Jr, J.F., Elliott, D.E., Ince, N.M., Truscott, J., Karakay, B. 2018. Helminth-induced production of TGFß and suppression of graft-versus-host disease is dependent on Interleukin 4 production by host cells. Journal of Immunology. 201(10):2910-2922. https://doi.org/10.4049/jimmunol.1700638
Aryl hydrocarbon receptor signaling cell intrinsically inhibits intestinal group 2 innate lymphoid cell function Reprint Icon - (Peer Reviewed Journal)
Li, S., Bostick, J.W., Ye, J., Qiu, J., Zhang, B., Urban Jr, J.F., Avram, D., Zhou, L. 2018. Aryl hydrocarbon receptor signaling cell intrinsically inhibits intestinal group 2 innate lymphoid cell function. Immunity. 49(5):915-928,e5. https://doi.org/10.1016/j.immuni.2018.09.015.
Comparative genomics of the major parasitic worms Reprint Icon - (Peer Reviewed Journal)
Beasely, H., Bennett, H.M., Coghlan, A., Cotton, J., Doyle, S.R., Gordon, D., Harsha, B., Huckvale, T., Lomax, J., Holroyd, N., Reid, A.J., Ribeiro, D., Rinaldi, G., Shafie, M., Stanley, E., Tracey, A., Berriman, M., Hallsworth-Pepin, K., Martin, J., Ozersky, P., Rosa, B.A., Tyagi, R., Zhang, X., Mitreva, M., Laetsch, D.R., Koutsovoulos, G., Kumar, S., Kaur, G., Blaxter, M., Howe, K.L., Leach, A.R., Mutowo, P., Rawlings, N., Kuo, T., Lee, T.J., Ke, H., Tsai, I.J., Wheeler, N.J., Day, T.A., Zamanian, M., Beech, R.N., Parkinson, J., Seshadri, S.L., Kikuchi, T., Maizels, R.M., Partono, F., Babayan, S., Allen, J.E., O'Boyle, N., Wang, L., Osuna, A., Cruz-Bustos, T., Samblas, M.G., Cuellar, C., Cooper, P.J., Devaney, E., Harcus, Y., Hodgkinson, J., Bah, G., Tanya, V.N., Eberhard, M.L., Asano, K., Rodriguez, P.F., Sato, H., Gilleard, J.S., Matthews, J.B., Cook, J., Toldeo, R., Scholz, T., Schnyder, M., Allan, F., Emery, A., Olson, P.D., Rollinson, D., Castillo, E., Kalbe, M., Eom, K.S., Horak, P., Mitreva, M., Hawdon, J.M., Urban Jr, J.F., Hill, D.E., Zarlenga, D.S., Bisset, S.A., Pfarr, K., Makepeace, B., Taylor, D.W. 2018. Comparative genomics of the major parasitic worms. Nature Genetics. 5:163-174. https://doi.org/10.1038/s41588-018-0262-1.
Rapid inactivation of Toxoplasma gondii bradyzoites in dry cured sausage Reprint Icon - (Peer Reviewed Journal)
Hill, D.E., Luchansky, J.B., Porto Fett, A.C., Gamble, H., Urban Jr, J.F., Fournet, V.M., Hawkins Cooper, D.S., Gajadhar, A., Holley, R., Juneja, V.K., Dubey, J.P. 2018. Rapid inactivation of Toxoplasma gondii bradyzoites in dry cured sausage. Food and Waterborne Parasitology. https://doi.org/10.1016/j.fawpar.2018.e00029.
Recirculating immunocompetent cells in colitic mice intensify their lung response to bacterial endotoxin Reprint Icon - (Peer Reviewed Journal)
Metwali, A., Thorne, P.S., Ince, M.N., Metwali, N., Winckler, S., Guan, X., Beyatli, S., Truscott, J., Urban Jr, J.F., Elliott, D.E. 2018. Recirculating immunocompetent cells in colitic mice intensify their lung response to bacterial endotoxin. Digestive Disease and Science. 63(11)2930-2939. https://doi.org/10.1007/s10620-018-5196-z.
Mechanisms of exacerbating lung inflammation in inflammatory bowel disease Reprint Icon - (Peer Reviewed Journal)
Metwali, A., Thorne, P., Winckler, S., Metwali, N., Urban Jr, J.F., Elliott, D.E., Ince, M., Guan, X., Beyatli, S., Truscott, J. 2018. Mechanisms of exacerbating lung inflammation in inflammatory bowel disease. Digestive Disease and Science. https://doi.org/10.1007/s10620-018-5196-z.
Bifidobacterium animalis subspecies lactis modulates the local immune response and glucose uptake in the small intestine of juvenile pigs infected with the parasitic nematode Ascaris suum Reprint Icon - (Peer Reviewed Journal)
Solano Aguilar, G., Shea-Donohue, T., Madden, K., Quinones, A., Beshah, E., Lakshman, S., Xie, Y., Dawson, H.D., Urban Jr, J.F. 2018. Bifidobacterium animalis subspecies lactis modulates the local immune response and glucose uptake in the small intestine of juvenile pigs infected with the parasitic nematode Ascaris suum. Gut Microbes. 19:1-15. https://doi.org/10.1080/19490976.2018.1460014.
Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine Reprint Icon - (Peer Reviewed Journal)
Lei, W., Ren, W., Ohmoto, M., Urban Jr, J.F., Matsumoto, I., Margolskee, R.F., Jiang, P. 2018. Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine. Proceedings of the National Academy of Sciences. (21):5552-5557. https://doi.org/10.1073/pnas.1720758115.
Bacillus thuringiensis Cry5B protein as a new pan-hookworm cure Reprint Icon - (Peer Reviewed Journal)
Hu, Y., Nguyen, T., Lee, A.C., Urban Jr, J.F., Miller, M.M., Zhan, B., Koch, D.J., Noon, J., Abraham, A., Fujiwara, T. 2018. Bacillus thuringiensis Cry5B protein as a new pan-hookworm cure. International Journal for Parasitology: Drug and Drug Resistance. 8:287-294. https://doi.org/10.1016/j.ijpddr.2018.05.001
Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma Reprint Icon - (Peer Reviewed Journal)
Lorentsen, K., Cho, J., Luo, X., Zuniga, A., Urban Jr, J.F., Zhou, L., Gharaibeh, R., Jobin, C., Kladde, M., Avram, D. 2018. Bcl11b is essential for licensing Th2 differentiation during helminth infection and allergic asthma. Nature Communications. 9(1)1679. https://doi.org/10.1038/s41467-018-04111-0.
Dietary fat influences epicardial adipose tissue fatty acid composition in the Ossabaw miniature pig - (Abstract Only)
Walker, M., Matthan, N., Solano-Aguilar, G., Goldbaum, A., Lakshman, S., Meng, H., Jang, S., Urban Jr, J.F., Lamon-Fava, S., Lichtenstein, A.H. 2018. Dietary fat influences epicardial adipose tissue fatty acid composition in the Ossabaw miniature pig [abstract]. American Society of Nutrition 2018 Meeting. Abstract No. P10-131.
Associations between epicardial adipose tissue fatty acid composition and gene expression in the Ossabaw miniature pig - (Abstract Only)
Walker, M., Matthan, N., Solano-Aguilar, G., Goldbaum, A., Jang, S., Urban Jr, J.F., Molokin, A., Lakshman, S., Lamon-Fava, S., Lichtenstein, A.H. 2018. Associations between epicardial adipose tissue fatty acid composition and gene expression in the Ossabaw miniature pig [abstract]. American Society of Nutrition 2018 Meeting. Abstract No. P10-132.
The effect of feeding cocoa powder and Lactobacillus rhamnosus LGG on the composition and function of the intestinal microbiome Reprint Icon - (Peer Reviewed Journal)
Solano Aguilar, G., Lakshman, S., Jang, S., Beshah, E., Xie, Y., Sikaroodi, M., Gupta, R., Vinyard, B.T., Molokin, A., Urban Jr, J.F., Gillevet, P., Davis, C. 2018. The effect of feeding cocoa powder and Lactobacillus rhamnosus LGG on the composition and function of the intestinal microbiome. Current Developments in Nutrition. (2)5. https://doi.org/10.1093/cdn/nzy011.
B1 cell IgE impedes mast cell-mediated enhancement of parasite expulsion through B2 IgE blockade Reprint Icon - (Peer Reviewed Journal)
Martin, R.K., Damle, S.R., Zellner, M.P., James, B.N., Valentine, Y.A., Elkowich, A.J., Lownik, J.C., Demeules, M.M., Khandjian, L.M., Urban Jr, J.F., Conrad, D.H. 2018. B1 cell IgE impedes mast cell-mediated enhancement of parasite expulsion through B2 IgE blockade. Cell Reports. 22(7):1824-1834. https://doi.org/10.1016/j.celrep.2018.01.048.
Impact of micronutrients on the immune response of animals Reprint Icon - (Review Article)
Smith, A.D., Panickar, K.S., Urban Jr, J.F., Dawson, H.D. 2018. Impact of micronutrients on the immune response of animals. Annual Review of Animal Biosciences. 6:227-254. https://doi.org/10.1146/annurev-animal-022516-022914.
The Ossabaw pig is a suitable translational model to evaluate dietary patterns and coronary artery disease risk Reprint Icon - (Peer Reviewed Journal)
Matthan, N.R., Solano Aguilar, G., Meng, H., Lamon-Fava, S., Goldbaum, A., Walker, M.E., Jang, S., Lakshman, S., Molokin, A., Xie, Y., Beshah, E., Stanley, J., Urban Jr, J.F., Lichtenstein, A.H. 2018. The Ossabaw pig is a suitable translational model to evaluate dietary patterns and coronary artery disease risk. Journal of Nutrition. 148(4):542-552. https://doi.org/10.1093/jn/nxy002.
S1P dependent inter organ trafficking of group 2 innate lymphoid cells supports host defense Reprint Icon - (Peer Reviewed Journal)
Huang, Y., Mao, K., Chen, X., Sun, M., Kawabe, T., Li, W., Usher, N., Zhu, J., Urban Jr, J.F., Paul, W.E., Germain, R.N. 2018. S1P dependent inter organ trafficking of group 2 innate lymphoid cells supports host defense. Science. 359:114–119. https://doi.org/10.1126/science.aam5809.
Lactobacillus rhamnosus LGG and flavanol-enriched cocoa powder altered the immune response to infection with the parasitic nematode Ascaris suum Reprint Icon - (Peer Reviewed Journal)
Jang, S., Lakshman, S., Beshah, E., Xie, Yue, Molokin, A., Vinyard, B.T., Urban Jr, J.F., Davis, C., Solano Aguilar, G. 2017. Lactobacillus rhamnosus LGG and flavanol-enriched cocoa powder altered the immune response to infection with the parasitic nematode Ascaris suum. Nutrients. pii: 1113. https://doi.org/10.3390/nu9101113.
The porcine translational research database: A manually curated, genomics and proteomics-based research resource - (Peer Reviewed Journal)
Dawson, H.D., Chen, C.T., Gaynor, B., Shao, J.Y., Urban Jr, J.F. 2017. The porcine translational research database: A manually curated, genomics and proteomics-based research resource. Biomed Central (BMC) Genomics. doi: 10.1186/s12864-017-4009-7.
Il-4 up-regulates cyclooxygenase-1 expression in macrophages Reprint Icon - (Peer Reviewed Journal)
Shay, A.E., Tukaramrao, D.B., Guan, B., Narayan, V., Urban Jr, J.F., Prabhu, S.K. 2017. Il-4 up-regulates cyclooxygenase-1 expression in macrophages. Journal of Biological Chemistry. 292(35):14544-14555. https://doi.org/10.1074/jbc.M117.785014.
Ancylostoma ailuropodae sp. n. (Nematoda: Ancylostomatidae), a new hookworm parasite isolated from wild giant pandas in Southwest China - (Peer Reviewed Journal)
Xie, Y., Hoberg, E.P., Urban Jr, J.F., Yanga, G. 2017. Ancylostoma ailuropodae sp. n. (Nematoda: Ancylostomatidae), a new hookworm parasite isolated from wild giant pandas in Southwest China. Parasites & Vectors. 10:227-296. doi: 10.1186/s13071-017-2209-2212.
STAT6 and Furin are successive triggers for the production of TGFß by T cells Reprint Icon - (Peer Reviewed Journal)
Li, Y., Liu, W., Guan, X., Truscott, J., Creemers, J.W., Chen, H., Pesu, M., El Abiad, R., Karakay, B., Urban Jr, J.F., Elliott, D.E., Kaplan, M.H., Blazer, B.R., Ince, M. 2018. STAT6 and Furin are successive triggers for the production of TGFß by T cells. Journal of Immunology. 201(9):2612-2623. https://doi.org/10.4049/jimmunol.1700808
Down-regulation of E protein activity augments an ILC2 differentiation program in the thymus - (Peer Reviewed Journal)
Wang, H., Zhao, Y., Qian, M.L., Adrianto, I., Montgomery, C.G., Urban Jr, J.F., Fung, K., Sun, X. 2017. Downregulation of E protein activity augments an ILC2 differentiation program in the thymus. Journal of Immunology. 198(8):3149-3156. doi: 10.4049/jimmunol.1602009.
The Ossabaw pig as a model for diet induced atherosclerosis and statin responsiveness - (Abstract Only)
Matthan, N.R., Solano Aguilar, G., Lamon-Fava, S., Goldbaum, A., Walker, M., Meng, H., Stanley, J., Jang, S., Lakshman, S., Molokin, A., Xie, Y., Beshah, E., Urban Jr, J.F., Lichtenstein, A.H. 2016. The Ossabaw pig as a model for diet induced atherosclerosis and statin responsiveness. Journal of Federation of American Societies for Experimental Biology. 31(1):140.4.
Microfluidic platform for electrophysiological recordings from host-stage hookworm Ascaris suum larvae: a new tool for anthelmenthic research - (Peer Reviewed Journal)
Weeks, J.C., Roberts, W.M., Robinson, K.J., Keaney, M.I., Vermeire, J.J., Urban Jr, J.F., Lockery, S.R., Hawdon, J.M. 2016. Microfluidic platform for electrophysiological recordings from host-stage hookworm Ascaris suum larvae: a new tool for anthelmenthic research. International Journal for Parasitology: Drug and Drug Resistance. 6:314-328. doi: 10.1016/j.ijpddr.2016.08.001.
Critical role of fatty acid metabolism in ILC2 mediated barrier protection during malnutrition and helminth infection - (Peer Reviewed Journal)
Wilhelm, C., Harrison, O., Schmitt, V., Pelletier, M., Spencer, S., Urban Jr, J.F., Ploch, M., Ramalingam, T., Siegel, R., Belkaid, Y. 2016. Critical role of fatty acid metabolism in ILC2 mediated barrier protection during malnutrition and helminth infection. Journal of Experimental Medicine. 213(8):1409-1418. doi: 10.1084/jem.20151448.
An in-depth comparison of the porcine, murine and human inflammasomes; lessons from the porcine genome and transcriptome - (Peer Reviewed Journal)
Dawson, H.D., Smith, A.D., Chen, C.T., Urban Jr, J.F. 2016. An in-depth comparison of the porcine, murine and human inflammasomes; lessons from the porcine genome and transcriptome. Veterinary Microbiology. pii:S0378-1135(16)30137-7. doi: 10.1016/j.vetmic.2016.05.013.
Neuroimmune modulation of gut function - (Review Article)
Shea-Donohue, Urban Jr, J.F. 2016. Neuroimmune Modulation of Gut Function. Neuroimmune Modulation of Gut Function - Gastrointestinal Pharmacology. 165(5):1120-1133. doi: 10.1016/j.cell.2016.04.029.
Developmental acquisition of regulomes underlies innate lymphoid cell functionality - (Peer Reviewed Journal)
Shih, H., Sciume, G., Mikami, Y., Guo, L., Sun, H., Brooks, S.R., Urban Jr, J.F., Davis, F.P., Kanno, Y., O'Shea, J.J. 2016. Developmental acquisition of regulomes underlies innate lymphoid cell functionality. Cell. 165:1120-1133. doi: 10.1016/j.cell.2016.04.029.
Acidic Chitinase Limits Allergic Inflammation and Promotes Intestinal Nematode Expulsion - (Peer Reviewed Journal)
Vannella, K.M., Ramalingam, T.R., De Queiroz, P.R., Sciurba, J., Barron, L., Borthwick, L., Smith, A.D., Mentink-Kane, M., White, S., Thompson, R.W., Cheever, A.W., Bock, K., Moore, I., Fitz, L.J., Urban Jr, J.F., Wynn, T.A. 2016. Acidic Chitinase Limits Allergic Inflammation and Promotes Intestinal Nematode Expulsion. Nature Immunology. 17(5):538-44 doi: 101038/ni.3417.
Type 3 muscarinic receptors contribute to intestinal mucosal homeostasis and clearance of nippostrongylus brasiliensis through induction of Th2 cytokines - (Peer Reviewed Journal)
Mclean, L.P., Smith, A.D., Cheung, L., Urban Jr, J.F., Sun, R., Grinchuk, V., Dasai, Zhao, A., Raufman, J.P., Shea-Donohue, T. 2016. Type 3 muscarinic receptors contribute to intestinal mucosal homeostasis and clearance of nippostrongylus brasiliensis through induction of Th2 cytokines. American Journal of Physiology - Gastrointestinal and Liver Physiology. 311(1):G130-141. doi: 10.1152/ajpgi.00461.2014.
IL-13 working through IL-13Ra1 mediates critical functional responses to nematode infection in the gastrointestinal tract - (Peer Reviewed Journal)
Sun, R., Notari, L., Vanuytsel, T., Madden, K., Bohl, J., Ramalingam, T.R., Wynn, T.A., Urban Jr, J.F., Zhao, A., Shea-Donohue, T. 2016. Interleukin-13 receptor a1-dependent responses in the intestine are critical to parasite clearance. Infection and Immunity. 84(4):1032-1044. doi: 10.1128IAI.00990-009915.
The effect of helminth infection on the microbial composition and structure of the caprine abomasal microbiome - (Peer Reviewed Journal)
Li, R.W., Li, W., Baldwin, R.L., Yu, P., Urban Jr, J.F. 2016. The effect of helminth infection on the microbial composition and structure of the caprine abomasal microbiome. Scientific Reports. 6:20606.
Migratory CD103+ dendritic cells suppress Helminth-driven Type 2 immunity through constitutive expression of IL-12 - (Peer Reviewed Journal)
Everts, B., Tussiwand, R., Dreesen, L., Fairfax, K.C., Huang, S.C., Smith, A.M., Oneil, C.M., Lam, W.Y., Edelson, B.T., Urban Jr, J.F., Murphy, K.M., Pearce, E.J. 2016. Migratory CD103+ dendritic cells suppress Helminth-driven Type 2 immunity through constitutive expression of IL-12. Journal of Experimental Medicine. 213(1):35-51. doi: 10.1084/jem.20150235..
Selenoprotein expression in macrophages is critical for optimal clearance of parasitic helminth Helminth Nippostrongylus brasiliensis - (Peer Reviewed Journal)
Nelson, S.M., Shay, A.E., James, J.L., Carlson, B., Urban Jr, J.F., Prabhu, K.S. 2016. Selenoprotein expression in macrophages is critical for optimal clearance of parasitic helminth Helminth Nippostrongylus brasiliensis. Journal of Biological Chemistry. 291(6):2787-2798. doi: 10.1074/jbc.M115.684738.
IL-25 or IL-17E protects against high-fat diet-induced hepatic steatosis in mice dependent upon IL-13 activation of STAT6 - (Peer Reviewed Journal)
Wang, A., Yang, Z., Grinchuk, V., Smith, A.D., Qin, B., Lu, N., Wang, D., Wang, H., Ramalingam, T.R., Wynn, T.A., Urban Jr, J.F., Shea-Donohue, T., Zhao, A. 2015. IL-25 or IL-17E protects against high-fat diet-induced hepatic steatosis in mice dependent upon IL-13 activation of STAT6. Journal of Immunology. 195(10): 4771-4780. doi:10.4049/jimmunol.1500337.
Immunity-dependent reduction of segmented filamentous bacteria in mice infected with the helminthic parasite Nippostrongylus brasiliensis - (Peer Reviewed Journal)
Fricke, F.W., Song, Y., Wang, A., Smith, A.D., Grinchuk, V., Mongodin, E., Pei, C., Ma, B., Lu, N., Urban Jr, J.F., Shea-Donohue, T. 2015. Immunity-dependent reduction of segmented filamentous bacteria in mice infected with the helminthic parasite Nippostrongylus brasiliensis. BMC Microbiome. doi: 10.1186/S40168-015-0103-8.
Innate immunological function of TH2 cells in vivo - (Peer Reviewed Journal)
Guo, L., Huang, Y., Chen, X., Hu-Li, J., Urban Jr, J.F., Paul, W.E. 2015. Innate immunological function of TH2 cells in vivo. Nature Immunology. 16:1051-1059.
Type 3 Muscarinic Receptors Contribute to Clearance of Citrobacter rodentium - (Peer Reviewed Journal)
Mclean, L.P., Smith, A.D., Cheung, L., Sun, R., Grinchuk, V., Vanuytsel, T., Desai, N., Urban Jr, J.F., Zhao, A., Raufman, J.P., Shea-Donohue, T. 2015. Type 3 Muscarinic Receptors Contribute to Clearance of Citrobacter rodentium. Inflammatory Bowel Diseases. DOI: 10.1097/MIB.0000000000000408.
Immune antibodies and helminth products promote CXCR2-dependent repair of parasite-induced injury Reprint Icon - (Peer Reviewed Journal)
Von Bieren, J.E., Volpe, B., Sutherland, D.B., Burgi, J., Verbeek, S., Marsland, B.J., Urban Jr, J.F., Harris, N.L. 2015. Immune antibodies and helminth products promote CXCR2-dependent repair of parasite-induced injury. PLoS Pathogens. 11(3):e1004778.
Resource limitation alters the consequences of co-infection for both hosts and parasites - (Peer Reviewed Journal)
Budischak, S.A., Sakamoto, K., Megow, L.C., Cummings, K.R., Urban Jr, J.F., Ezenwa, V. 2015. Resource limitation alters the consequences of co-infection for both hosts and parasites. International Journal for Parasitology. 45(7):455-463.
Immune and inflammatory responses in pigs infected with Trichuris suis and Oesophagostomum dentatum - (Peer Reviewed Journal)
Andreasen, A., Petersen, H., Kringel, H., Iburg, T., Skovgaard, K., Dawson, H.D., Urban Jr, J.F., Thamsborg, S. 2015. Immune and inflammatory responses in pigs infected with Trichuris suis and Oesophagostomum dentatum. Veterinary Parasitology. 207(3-4):249-258.
Genetic deletion of IL-25 (IL-17E) confers resistance to dextran sulfate sodium-induced colitis in mice - (Peer Reviewed Journal)
Wang, A., Smith, A.D., Li, Y., Urban Jr, J.F., Thirumalai, R.R., Wynn, T., Lu, N., Shea-Donohue, T., Yang, Z., Zhao, A. 2014. Genetic deletion of IL-25 (IL-17E) confers resistance to dextran sulfate sodium-induced colitis in mice. Cell & Bioscience. DOI: 10.1186/2045-3701-4-72.
Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion - (Peer Reviewed Journal)
Chen, F., Wu, W., Millman, A., Craft, J.F., Chen, E., Patel, N., Boucher, J.L., Urban Jr, J.F., Kim, C.C., Gause, W.C. 2014. Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion. Nature Immunology. 15(10):938-946. doi: 10.1038/ni.2984.
Blastocystis tropism in the pig intestine - (Peer Reviewed Journal)
Fayer, R., Elsasser, T.H., Gould, R., Solano Aguilar, G., Santin, M., Urban Jr, J.F. 2014. Blastocystis tropism in the pig intestine. Parasitology Research. 113:1465-1472.
Adaptation of innate lymphoid cells to nutrient deprivation promotes type 2 barrier immunity - (Peer Reviewed Journal)
Spencer, S.P., Wilhelm, C., Yang, Q., Hall, J.A., Bouladoux, N., Boyd, A., Nutman, T.B., Urban Jr, J.F., Wang, J., Bhandoola, A., Ramalingam, T.R., Wynn, T.A., Belkaid, Y. 2014. Adaptation of innate lymphoid cells to nutrient deprivation promotes type 2 barrier immunity. Science. 343(6169):432-7.
Collection, handling and analysis of specimens for studies of mucosal immunity in animals of veterinary importance - Appendix III - (Book / Chapter)
Urban Jr, J.F., Dawson, H.D., Solano Aguilar, G., Li, R.W., Shea-Donohue, T. 2015. Appendix III - Collection, handling and analysis of specimens for studies of mucosal immunity in animals of veterinary importance. In: Mucosal Immunity,4th edition. Mestecky, Strober, Russell, Cheroutre, Lambrecht, and Kelsall (eds). Elsevier. p. 2369–2391. DOI:10.1016/B978-0-12-415847-4.15003-7.
Myeloid derived suppressor cells enhance IgE-mediated mast cell responses - (Peer Reviewed Journal)
Morales, J.K., Saleem, S.J., Martin, R.K., Barnstein, B.O., Graham, L., Bear, H.D., Urban Jr, J.F., Conrad, D.H., Ryan, J.J. 2014. Myeloid derived suppressor cells enhance IgE-mediated mast cell responses. Journal of Leukocyte Biology. 95(4):643-650 DOI: 10.1189/jlb.0913510.
Role of macrophages in the altered epithelial function during a type 2 immune response induced by enteric nematode infection - (Peer Reviewed Journal)
Notari, L., Riera, D.C., Sun, R., Bohl, J.A., Mcclean, L.P., Madden, K., Vanrooijen, N., Vanuytsel, T., Urban Jr, J.F., Zhao, A., Shea-Donohue, T. 2014. Role of macrophages in the altered epithelial function during a type 2 immune response induced by enteric nematode infection. PLoS One. 23:9(1)e84763.
The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response - (Peer Reviewed Journal)
He, J., Meyer-Hermann, M., Xiangying, D., Zuan, L.Y., Jones, L.A., Ramakrishna, L., De Vries, V.C., Dolpady, J., Aina, H., Joseph, S., Narayanan, S., Subramaniam, S., Putia, M., Wong, G., Xiong, H., Poidinger, M., Urban Jr, J.F., Lafaille, J.J., Curotto De Lafaille, M.A. 2013. The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response. Journal of Experimental Medicine. 210(12):2755-71. doi: 10.1084/jem.20131539.
Comparative non-targeted metabolite profiling of metabolic changes in tissues and bio-fluids in high-fat diet fed Ossabaw pig - (Peer Reviewed Journal)
Hanhineva, K., Barri, T., Kolemainen, M., Pekkinen, J., Pihlajamaki, J., Vesterbacka, A., Solano Aguilar, G., Mykkänen, H., Dragsted, L., Urban Jr, J.F., Poutanen, K. 2013. Comparative non-targeted metabolite profiling of metabolic changes in tissues and bio-fluids in high-fat diet fed Ossabaw pig. Journal of Proteome Research. DOI: 10.1021/pr400257d.
An extensive comparison of the effect of anthelmintic classes on diverse nematodes - (Peer Reviewed Journal)
Hu, Y., Ellis, B.L., Yiu, Y.Y., Miller, M.M., Urban Jr., J.F., Shi, L.Z., Aroian, R.V. 2013. Comprehensive comparison of anthelmintic classes on diverse nematodes. PLoS One. DOI: 10.1371/journal.pone.0070702.
Feeding probiotic Lactobacillus paracasei to Ossabaw pigs on a high fat diet prevents cholesteryl-ester accumulation and LPS modulation of the Liver X receptor and inflammatory axis in alveolar macrophages - (Peer Reviewed Journal)
Trasino, S.E., Dawson, H.D., Urban Jr, J.F., Wang, T.T., Solano Aguilar, G. 2013. Feeding probiotic Lactobacillus paracasei to Ossabaw pigs on a high fat diet prevents cholesteryl-ester accumulation and LPS modulation of the Liver X receptor and inflammatory axis in alveolar macrophages. Journal of Nutritional Biochemistry. 24(11):1931-1939.
SerpinB2 is critical to Th2 immunity against enteric nematode infection - (Peer Reviewed Journal)
Zhao, A., Yang, Z., Sun, R., Grinchuk, V., Netzel-Arnett, S., Anglin, I.E., Driesbaugh, K.H., Notari, L., Bohl, J.A., Madden, K.B., Urban Jr, J.F., Antalis, T.M., Shea-Donahue 2013. SerpinB2 is critical to Th2 immunity against enteric nematode infection. Journal of Immunology. 190(11):5779-87.
Parasitic nematode-induced modulation of body weight and associated metabolic dysfunction in mouse models of obesity - (Peer Reviewed Journal)
Yang, Z., Grinchuk, V., Smith, A.D., Qin, B., Bohl, J.A., Sun, R., Notari, L., Zhang, Z., Sesaki, H., Urban Jr, J.F., Shea-Donahue, T., Zhao, A. 2013. Parasitic nematode-induced modulation of body weight and associated metabolic dysfunction in mouse models of obesity. Infection and Immunity. 81(6):1905-1914.
Selenium status alters the immune response and expulsion of adult Heligmosomodies bakeri in mice - (Peer Reviewed Journal)
Smith, A.D., Cheung, L., Shea-Donohue, T., Urban Jr, J.F. 2013. Selenium status alters the immune response and expulsion of adult Heligmosomodies bakeri in mice. Infection and Immunity. 81(7):2546-2553.
Bacillus thuringiensis-derived Cry5B has potent anthelmintic activity against Ascaris suum - (Peer Reviewed Journal)
Urban, Jr., J.F., Hu, Y., Miller, M.M., Scheib, U., Yiu, Y.Y., Aroian, R.V. 2013. Bacillus thuringiensis-derived Cry5B has potent anthelmintic activity against Ascaris suum. PLOS Neglected Tropical Diseases. 7(6):e2263.
Heligmosomoides polygyrus bakeri infection activates colonic FoxP3+ T cells enhancing their capacity to prevent colitis - (Peer Reviewed Journal)
Hang, L., Blum, A.M., Setiawan, T., Urban Jr, J.F., Stoyanoff, K., Weinstock, J.V. 2013. Heligmosomoides polygyrus bakeri infection activates colonic FoxP3+ T cells enhancing their capacity to prevent colitis. Journal of Immunology. 191(4):1927-34.
Macrophages as IL-25/IL-33-responsive cells play an important role in the induction of type 2 immunity - (Peer Reviewed Journal)
Yang, Z., Grinchuk, V., Urban Jr, J.F., Bohl, J., Sun, R., Notari, L., Yan, S., Ramalingam, T., Keegan, A.D., Wynn, T.A., Shea-Donohue, T., Zhao, A. 2013. Macrophages as IL-25/IL-33-responsive cells play an important role in the induction of type 2 immunity. PLoS One. 8(3):e59441,1-11.
IL-33-induced alterations in murine intestinal function and cytokine responses are MyD88, STAT6, and IL-13-dependent - (Peer Reviewed Journal)
Yang, Z., Sun, R., Grinchuk, V., Blanco, J.A., Notari, L., Bohl, J.A., Mclean, L.P., Ramalingam, J.R., Wynn, T.A., Urban Jr, J.F., Vogel, S.N., Shea-Donohue, T., Zhao, A. 2013. IL-33-induced alterations in murine intestinal function and cytokine responses are MyD88, STAT6, and IL-13-dependent. American Journal of Physiology - Gastrointestinal and Liver Physiology. 304(4):G381-389.
Characterization of Fecal Microbiota of Children With Diarrhea in 2 Locations in Colombia - (Peer Reviewed Journal)
Solano Aguilar, G., Fernandez Duarte, K., Ets, H.K., Molokin, A., Vinyard, B.T., Urban Jr, J.F., Guitierrez, M. 2013. Characterization of Fecal Microbiota of Children With Diarrhea in 2 Locations in Colombia. Journal of Pediatric Gastroenterology and Nutrition. 56:503-511.
Heligmosomoides induces tolerogenic dendritic cells that block colitis and prevent antigen-specific gut Tcell responses - (Peer Reviewed Journal)
Blum, A.M., Hang, L., Setiawan, T., Urban Jr, J.F., Stoyanoff, K., Leung, J., Weinstock, J.V. 2012. Heligmosomoides induces tolerogenic dendritic cells that block colitis and prevent antigen-specific gut Tcell responses. Journal of Immunology. Sept 1:189(5):2512-2520.
Whole genome shotgun metagenomic sequences from the proximal colon microbiota in response to helminth parasites - (Other)
Li, R.W., Wu, S., Li, W., Hill, D.C., Urban Jr, J.F. 2012. Whole genome shotgun metagenomic sequences from the proximal colon microbiota in response to helminth parasites . National Center for Biotechnology Information (NCBI). SRX065855.
Sequences from the hypervariable V3-V5 regions of the 16S rRNA gene amplified from the porcine proximal colon - (Other)
Li, R.W., Wu, S., Li, W., Hill, D.C., Urban Jr, J.F. 2012. Sequences from the hypervariable V3-V5 regions of the 16S rRNA gene amplified from the porcine proximal colon . National Center for Biotechnology Information (NCBI). SRX065852.
Exploring the host transcriptome for mechanisms underlying protective immunity and resistance to helminth infection in ruminants - (Review Article)
Li, R.W., Choudhary, R.K., Capuco, A.V., Urban, Jr., J.F. 2012. Exploring the host transcriptome for mechanisms underlying protective immunity and resistance to helminth infection in ruminants. Veterinary Parasitology. 190(1-2):1-11.
Alterations in the Porcine Colon Microbiota Induced by the Gastrointestinal Nematode Trichuris suis - (Peer Reviewed Journal)
Li, R.W., Wu, S., Li, W., Hill, D.E., Urban, Jr., J.F., Navarro, K., Couch, R.D. 2012. Alterations in the Porcine Colon Microbiota Induced by the Gastrointestinal Nematode Trichuris suis. Infection and Immunity. 80(6):2150-2157.
Worm burden-dependent disruption of the porcine colon microbiota by Trichuris suis infection - (Peer Reviewed Journal)
Wu, S., Li, R.W., Li, W., Urban Jr, J.F., Dawson, H.D., Beshah, E. 2012. Worm burden-dependent disruption of the porcine colon microbiota by Trichuris suis infection. PLoS One. 7(4):e35470.
Molecular mimicry between cockroach and helminth glutathione S-transferases promotes cross-reactivity and cross-sensitization - (Peer Reviewed Journal)
Santiago, H.C., Leevan, E., Bennuru, S., Ribeiro-Gomes, F., Mueller, E., Wilson, M., Wynn, T., Garboczi, D., Urban Jr, J.F., Nutman, T.B. 2012. Molecular mimicry between cockroach and helminth glutathione S-transferases promotes cross-reactivity and cross-sensitization. Journal of Allergy Clinical Immunology. 130:248-256.
A procyanidin type A trimer from cinnamon extract attenuates glial cell swelling and the reduction in glutamate uptake following ischemic injury in vitro - (Peer Reviewed Journal)
Panickar, K.S., Polansky, M.M., Graves, D.J., Urban Jr, J.F., Anderson, R.A. 2012. A procyanidin type A trimer from cinnamon extract attenuates glial cell swelling and the reduction in glutamate uptake following ischemic injury in vitro. Neuroscience. 202:87-98.
An essential role for TH2-type response in limiting acute tissue damage during experimental helminth infection. - (Peer Reviewed Journal)
Chen, F., Liu, Z., Rozo, C., Wu, W., Bowdridge, S., Wynn, T., Urban Jr, J.F., Gauge, W. 2012. An essential role for TH2-type response in limiting acute tissue damage during experimental helminth infection.. Nature Medicine. 18(2):260-6.
Antibody repertoire development in fetal and neonatal piglets. XXI. VH usage remains constant during development in fetal piglets and postnatally in piglets exposed to environmental antigen - (Peer Reviewed Journal)
Butler, J.E., Sun, X., Wertz, N., Lager, K.M., Chaloner, L., Urban Jr., J., Francis, D.L., Nara, P.L., Tobin, G.J. 2011. Antibody repertoire development in fetal and neonatal piglets XXI. Usage of most VH genes remains constant during fetal and postnatal development. Molecular Immunology. 49(3):483-494.
Immunizing pigs with Ascaris suum hemoglobin increases the inflammatory response in the liver but fails to induce a protective immunity - (Peer Reviewed Journal)
Vlaminck, J., Martinez-Valladares, M., Tilleman, K., Deforce, D., Dewilde, S., Moens, L., Urban Jr, J.F., Claerebout, E., Vercruysse, J., Geldhof, P. 2011. Immunizing pigs with Ascaris suum hemoglobin increases the inflammatory response in the liver but fails to induce a protective immunity. Parasite Immunology. 33:250-254.
The pathogenicity of an enteric Citrobacter rodentium infection is enhanced by deficiencies in the antioxidants selenium and vitamin E - (Peer Reviewed Journal)
Smith, A.D., Botero, S., Shea-Donohue, T., Urban Jr, J.F. 2011. The pathogenicity of an enteric Citrobacter rodentium infection is enhanced by deficiencies in the antioxidants selenium and vitamin E. Infection and Immunity. 79:1471-1478.
Critical role of intestinal epithelial cell-derived IL-25 in enteric nematode infection-induced changes in intestinal function - (Peer Reviewed Journal)
Zhao, A., Urban Jr, J.F., Sun, R., Stiltz, J., Morimoto, M., Notari, L., Madden, K., Ramalingam, T., Wynn, T., Shea-Donohue, T. 2010. Critical role of intestinal epithelial cell-derived IL-25 in enteric nematode infection-induced changes in intestinal function. Journal of Immunology. 185:6921-6929.
Role of enteric nerves in immune-mediated changes in protease activated receptor 2 effects on gut function - (Peer Reviewed Journal)
Shea-Donohue, T., Notari, L., Stiltz, J., Sun, R., Madden, K.B., Urban Jr, J.F., Zhao, A. 2010. Role of enteric nerves in immune-mediated changes in protease activated receptor 2 effects on gut function. Neurogastroenterology & Motility. 10:1138-e291.
Helogmosomoides polygyrus infection can inhibit colitis through direct interaction with innate immunity - (Peer Reviewed Journal)
Hang, L., Setiawan, T., Blum, A., Urban Jr, J.F., Stoyanoff, K., Reinecker, H.C., Weinstock, J. 2010. Helogmosomoides polygyrus infection can inhibit colitis through direct interaction with innate immunity. Journal of Immunology. 185(6):3184-9.
The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma - (Peer Reviewed Journal)
Yagi, R., Junttila, I., Wei, G., Urban Jr, J.F., Zhao, K., Paul, W., Zhu, J. 2010. The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. Immunity. 32:507-517.
B cells have distinct roles in host protection against different nematode parasites - (Peer Reviewed Journal)
Liu, Q., Kreider, T., Bowdridge, S., Liu, Z., Song, Y., Gaydo, A.G., Urban, J.F. Jr., Gause, W.C. 2010. B cells have distinct roles in host protection against different nematode parasites. Journal of Immunology. 184(9):5213-5223.
IL25 elicits a multipotent progenitor cell population that promotes TH2 cytokine responses - (Peer Reviewed Journal)
Saenz, S.A., Siracusa, M.C., Perrigoue, J.G., Spencer, S.P., Urban Jr, J.F., Tocker, J.E., Budelsky, A.L., Kleinschek, M.A., Kambayashi, T., Artis, D. 2010. IL25 elicits a multipotent progenitor cell population that promotes TH2 cytokine responses. Nature. 464(7923):1362-1366.
Helminth infection impairs the immunogenicity of a Plasmodium falciparum DNA vaccine, but not irradiated sporozoites, in mice - (Peer Reviewed Journal)
Noland, G.S., Chowdhury, D.R., Urban Jr, J.F., Zavala, F., Kumar, N. 2010. Helminth infection impairs the immunogenicity of a Plasmodium falciparum DNA vaccine, but not irradiated sporozoites, in mice. Vaccine. 28(17):2917-2923.
Immune regulation of epithelial cell function: Implications for GI pathologies - (Peer Reviewed Journal)
Shea-Donohue, T., Notari, L., Urban Jr, J.F., Zhao, A. 2010. Immune regulation of epithelial cell function: Implications for GI pathologies. International Dairy Journal. 20(4):248-252.
Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function - (Peer Reviewed Journal)
Morales-Tirado, V., Sojka, D.K., Katzman, S.D., Lazarski, C.A., Finkelman, L.D., Urban Jr, J.F., Fowell, D.J. 2010. Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function. Blood. 115(17):3498-3507.
Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection - (Peer Reviewed Journal)
Herbert, D.R., Yang, J.Q., Hogan, S.P., Groschwitz, K., Khodoun, M., Munitz, A., Orekov, T., Perkins, C., Wang, Q., Brombacher, F., Urban Jr, J.F., Rothenberg, M.E., Finkelman, F.D. 2009. Intestinal epithelial cell secretion of RELM-beta protects against gastrointestinal worm infection. Journal of Experimental Medicine. 206(13):2947-2957.
Supplemental dietary inulin influences expression of iron and inflammation related genes in young pigs - (Peer Reviewed Journal)
Yasuda, K., Dawson, H.D., Wasmuth, E.V., Roneker, C.A., Chen, C., Urban, J.F., Welch, R.M., Miller, D.D., Lei, X.G. 2009. Supplemental dietary inulin influences expression of iron and inflammation related genes in young pigs. Journal of Nutrition. 139(11):2018-2023.
Ascaris suum infection negatively affects the response to a Mycoplasma hyopneumoniae vaccination and subsequent challenge infection in pigs - (Peer Reviewed Journal)
Steenhard, N., Jungersen, G., Kokotovic, B., Beshah, E., Dawson, H.D., Urban Jr, J.F., Roepstorff, A., Thamsborg, S. 2009. Ascaris suum infection negatively affects the response to a Mycoplasma hyopneumoniae vaccination and subsequent challenge infection in pigs. Vaccine. 27:5161-5169.
IL-13 receptor alpha-2 regulates the immune and functional response to Nippostrongylus brasiliensis infection - (Peer Reviewed Journal)
Morimoto, M., Zhao, A., Sun, R., Stiltz, J., Madden, K.B., Mentink-Kane, M., Ramalingam, T., Wynn, T.A., Urban Jr, J.F., Shea-Donohue, T. 2009. IL-13 receptor alpha-2 regulates the immune and functional response to Nippostrongylus brasiliensis infection. Journal of Immunology. 183(3):1934-1999.
SURVIVAL OF NORTH AMERICAN GENOTYPES OF TRICHINELLA IN FROZEN PORK - (Peer Reviewed Journal)
Hill, D.E., Forbes, L., Zarlenga, D.S., Urban Jr, J.F., Gajadhar, A.A., Gamble, H. 2009. Survival of North American Genotypes of Trichinella in Frozen Pork. Journal of Food Protection. 72(12):2565-2570.
Retnla (Relma/Fizz1) suppresses helminth-induced Th2-Type immunity - (Peer Reviewed Journal)
Pesce, J.T., Ramalingam, T.R., Wilson, M.S., Mentink-Kane, M.M., Thompson, R.W., Cheever, A.W., Urban Jr, J.F., Wynn, T.A. 2009. Retnla (Relma/Fizz1) suppresses helminth-induced Th2-Type immunity. PLoS Pathogens. 5(4)1-15.
Role of T cell TGF beta signaling in intestinal cytokine responses and helminthic immune modulation - (Peer Reviewed Journal)
Ince, M.N., Elliott, D.E., Setiawan, T., Metwali, A.A., Blum, A., Chen, H.L., Urban Jr, J.F., Flavell, R.A., Weinstock, J.V. 2009. Role of T cell TGF beta signaling in intestinal cytokine responses and helminthic immune modulation. European Journal of Immunology. 39:(7):1870-8.
Localized Th1-, Th2-,and inflamation-associated hepatic and pulmonary immune responses in Ascaris-infected swine are increased by retinoic acid. - (Peer Reviewed Journal)
Dawson, H.D., Solano Aguilar, G., Beal, M.E., Beshah, E., Vangimalla, V.R., Jones, E., Botero, S., Urban Jr, J.F. 2009. Localized Th1-, Th2-,and inflamation-associated hepatic and pulmonary immune responses in Ascaris-infected swine are increased by retinoic acid. Infection and Immunity. 77(6):2576-87.
Dynamics of lung macrophage activation in response to helminth infection - (Peer Reviewed Journal)
Siracusa, M.C., Reece, J.J., Urban Jr, J.F., Scott, A.L. 2008. Dynamics of lung macrophage activation in response to helminth infection. Journal of Leukocyte Biology. 84(6):1422-1423.
Co-Infection With Intestinal Helminths Markedly Reduces Proinflammatory Cytokines And Disease Severity In Natural And Induced High-Pathology Schistosomiasis - (Peer Reviewed Journal)
Bazzone, L., Smith, P., Rutitzky, L., Shainheit, M., Urban Jr, J.F., Setiawan, T., Blum, A., Weinstock, J., Stadecker, M. 2008. Co-Infection with intestinal helminths markedly reduces proinflammatory cytokines and disease severity in natural and induced high-pathology Schistosomiasis. Infection and Immunity. 76(11):5164-72.
Characterization of effector mechanisms at the host: parasite interface during the immune response to tissue-dwelling intestinal nematode parasites - (Review Article)
Patel, N., Kreider, T., Urban Jr, J.F., Gause, W. 2009. Characterization of effector mechanisms at the host: parasite interface during the immune response to tissue-dwelling intestinal nematode parasites. International Journal for Parasitology. 39(1):13-21.
Anti-inflammatory Mechanisms of Enteric Heligmosomoides polygyrus Infection on TNBS-Induced Colitis in a Murine Model - (Peer Reviewed Journal)
Sutton, T.L., Zhao, A., Madden, K.B., Elfrey, J.E., Tuft, B.A., Sullivan, C.A., Urban Jr, J.F., Shea-Donohue, T. 2008. Anti-inflammatory mechanisms of enteric Heligmosomoides polygyrus infection on TNBS-induced colitis in a murine model. Infection and Immunity 76(10):4772-82.
Cinnamon: Molecular evidence for the health benefits through its insulin-like and anti-inflammatory effects - (Book / Chapter)
Cao, H., Urban Jr, J.F., Anderson, R.A. 2010. Cinnamon: Molecular evidence for the health benefits through its insulin-like and anti-inflammatory effects. In: Gupta V.K., Taneja, S.C., Gupta, B.D., editors. Comprehensive Bioactive Natural Products, Vol.6 - Extraction, Isolation & Characterization. Studium Press LLC, USA. p203-227.
Colonization with Heligmosomoides polygyrus suppresses mucosal IL-17 production - (Peer Reviewed Journal)
Elliott, D.E., Metwali, A., Leung, J., Setiawan, T., Blum, A.M., Ince, M.N., Bazzone, L.E., Stadecker, M.J., Urban Jr, J.F., Weinstock, J.V. 2008. Colonization with Heligmosomoides polygyrus suppresses mucosal IL-17 production. Journal of Immunology. 181(4):2414-2419.
Hookworm-induced persistent changes to the immunological environment of the lung. - (Peer Reviewed Journal)
Reece, J.J., Siracusa, M.C., Southard, T.L., Brayton, C.F., Urban Jr, J.F., Scott, A.L. 2008. Hookworm-induced persistent changes to the immunological environment of the lung. Infection and Immunity. 76(8):3511-24.
Counter-regulatory anti-parasite cytokine responses during concurrent Plasmodium yoelii and intestinal helminth infections in mice - (Peer Reviewed Journal)
Noland, G.S., Urban Jr, J.F., Fried, B., Kumar, N. 2008. Counter-regulatory anti-parasite cytokine responses during concurrent Plasmodium yoelii and intestinal helminth infections in mice. Parasite Immunology. 119(2):272-278.
Th2 cytokine-induced alterations in intestinal smooth muscle function depend on alternatively activated macrophages - (Peer Reviewed Journal)
Zhao, A., Urban Jr, J.F., Anthony, R.M., Sun, R., Stiltz, J., van Rooijen, N., Wynn, T.A., Gause, W.C., Shea-Donohue, T. 2008. Th2 cytokine-induced alterations in intestinal smooth muscle function depend on alternatively activated macrophages. Gastroenterology. 135(1):217-225.
The Suitability of Swine as Models for Humans to Assess the Effect of Nutrition on Immunity - (Proceedings)
Dawson, H.D., Reece, J.J., Chen, C.T., Urban Jr, J.F. 2008. The suitability of swine as models for humans to assess the effect of nutrition on immunity. International Symposium: Swine And Biomedical Research. p.48.
Cinnamon polyphenol extract affects immune responses by regulating anti- and proinflammatory and glucose transporter gene expression in mouse macrophages - (Peer Reviewed Journal)
Cao, H., Urban Jr, J.F., Anderson, R.A. 2008. Cinnamon polyphenol extract affects immune responses by regulating anti- and proinflammatory and glucose transporter gene expression in mouse macrophages. Journal of Nutrition. 138(5):833-840.
Production and characterization of ZFP36L1 antiserum against recombinant protein from Escherichia coli - (Peer Reviewed Journal)
Cao, H., Lin, R., Ghosh, S., Anderson, R.A., Urban Jr, J.F. 2008. Production and characterization of ZFP36L1 antiserum against recombinant protein from Escherichia coli. Biotechnology Progress. 24(2)326-333.
Neutrophils clear bacteria associated with parasitic nematodes augmenting the development of an effective Th2-type response - (Peer Reviewed Journal)
Pesce, J., Liu, Z., Hamed, H., Alem, F., Whitmire, J., Liu, H., Liu, Q., Urban Jr, J.F., Gause, W. 2008. Neutrophils clear bacteria associated with parasitic nematodes augmenting the development of an effective Th2-type response. Journal of Immunology. 180(1):464-474.
Production and Characterization of ZFP36L1 Antiserum Against Recombinant Protein From Escherichia coli - (Abstract Only)
Cao, H., Lin, R., Ghosh, S., Anderson, R.A., Urban Jr, J.F. 2008. Production and Characterization of ZFP36L1 Antiserum Against Recombinant Protein From Escherichia coli. [abstract]. Journal of Federation of American Societies for Experimental Biology. 22:1003.7.
The Unique Functions of the Type-II IL-4 Receptor are revealed in IL-13R¿1-deficient mice - (Peer Reviewed Journal)
Ramalingam, T.R., Pesce, J.T., Sheikh, F., Cheever, A.W., Mentink-Kane, M.M, Wilson, M.S., Stevens, S., Valenzuela, D.M., Murphy, A.J., Yancopoulos,G.D., Urban Jr, J.F., Donnelly, R.P.,Wynn, T.A. 2008. Unique functions of the type-II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha 1 chain. Nature Immunology. (1):25-33.
The Beltsville Human Nutrition Research Center's Porcine Immunology and Nutrition Resource Database - (Abstract Only)
Dawson, H.D., Guidry, C.A., Vangimalla, V.R., Urban Jr, J.F. 2007. The Beltsville Human Nutrition Research Center's Porcine Immunology and Nutrition Resource Database. Experimental Biology.
Protective Immune Mechanisms in Helminth Infection - (Review Article)
Anthony, R., Rutitzky, L., Urban Jr, J.F., Stadecker, M., Gause, W. 2007. Protective Immune Mechanisms in Helminth Infection. Nature Reviews Microbiology. 7(12)975-987.
THE ROLE OF B CELLS IN THE DEVELOPMENT OF CD4 EFFECTOR T CELLS DURING A POLARIZED TH2 IMMUNE RESPONSE. - (Peer Reviewed Journal)
Liu, Q., Liu, Z., Whitmire, J., Hossein, A., Vannoy, J., Urban Jr, J.F., Gause, W.C. 2007. The role of B cells in the development of CD4 effector T cells during a polarized TH2 immune response. Journal of Immunology. 179(6):3821-30.
Alternatively activated macrophages in helminth infections - (Review Article)
Kreider, T., Anthony, R.M., Urban Jr, J.F., Gause, W.C. 2008. Alternatively activated macrophages in helminth infections. Current Opinions in Immunology. 19(4)448-453.
Infection with parasitic nematodes confounds vaccination efficacy - (Review Article)
Urban Jr, J.F., Steenhard, N.R., Solano-Aguilar, G.I., Dawson, H.D., Iweala, O.I., Nagler, C.R., Noland, G.S., Kumar, N., Anthony, R.M., Shea-Donohue, T., Weinstock, J., Gause, W.C. 2007. Infection with parasitic nematodes confounds vaccination efficacy. Veterinary Parasitology. 148(1):14-20.
The Porcine Immunology and Nutrition Resource Database - (Abstract Only)
Dawson, H.D., Guidry, C.A., Vangimalla, V.R., Urban Jr, J.F. 2007. The porcine immunology and nutrition resource database. Veterinary Immunology International Symposium. p15.
A Comparative Analysis of the Porcine, Murine, and Human Immune Systems - (Abstract Only)
Dawson, H.D., Reece, J.J., Urban Jr, J.F. 2007. A comparative analysis of the porcine, murine, and human immune systems. Veterinary Immunology International Symposium. p.120.
T cell IL-3 production is critical for parasite infection-induced basophil production, Aa well as basaphil survival in vitro, yet in vivo basophil survival is IL-3 independent. - (Peer Reviewed Journal)
Shen, T., Wang, L., Kim, S., Lantz, C., Urban Jr, J.F., Le Gros, G., Min, B. 2007. T cell IL-3 production is critical for parasite infection-induced basophil production, as well as basaphil survival in vitro, yet in vivo basophil survival is IL-3 independent. Journal of Immunology. July 15. epub ahead of print.
Feeding Probiotic Bacteria To Swine Enhances Immunity To Ascaris Suum - (Proceedings)
Solano Aguilar, G., Shea-Donohue, T., Madden, K., Dawson, H.D., Jones, Y., Restrepo, M.P., Beshah, E., Urban Jr, J.F. 2007. Feeding probiotic bacteria to swine enhances immunity to Ascaris Suum. Veterinary Immunology International Symposium. p.110.
Generating a Natural Porcine Model of Gastrointestinal Food Allergy to Peanut - (Abstract Only)
Reece, J.J., Kohn, K., Ets, H., Urban Jr, J.F., Dawson, H.D. 2007. Generating a Natural Porcine Model of Gastrointestinal Food Allergy to Peanut. BARC Poster Day.
Prevention of obesity by plant polyphenols via tristetraprolin-mediated cytokine mrna instability - (Abstract Only)
Cao, H., Urban Jr, J.F., Anderson, R.A. 2007. Prevention of obesity by plant polyphenols via tristetraprolin-mediated cytokine mrna instability. BARC Poster Day.
Insulin increases tristetraprolin and decreases VEGF gene expression in mouse 3T3-L1 adipocytes - (Peer Reviewed Journal)
Cao, H., Urban Jr, J.F., Anderson, R.A. 2008. Insulin increases tristetraprolin and decreases VEGF gene expression in mouse 3T3-L1 adipocytes. Obesity. 16:1208-1218.
Selenium (Se) deficiency alters intestinal diaphorase activity in mice infected with the intestinal parasitic worm Heligmosomoides polygyrus - (Abstract Only)
Urban Jr, J.F., Smith, A.D., Botero, S., Dawson, H.D., Anthony, R., Gause, W., Shea-Donohue, T. 2007. Selenium (Se) deficiency alters intestinal diaphorase activity in mice infected with the intestinal parasitic worm Heligmosomoides polygyrus. Experimental Biology.
Green tea increases the anti-inflammatory tristetraprolin and decreases the pro-inflammatory tumor necrosis factor mRNA levels in rats - (Peer Reviewed Journal)
Cao, H., Kelly, M.A., Kari, F., Dawson, H.D., Urban Jr, J.F., Coves, S., Roussel, A.M., Anderson, R.A. 2007. Green tea increases the anti-inflammatory tristetraprolin and decreases the pro-inflammatory tumor necrosis factor mRNA levels in rats. Journal of Inflammation. 4(1):1-12.
Heligmosomoides polygyrus promotes T regulatory cytokine production in the normal distal murine intestine. - (Peer Reviewed Journal)
Setiawan, T., Metwali, A., Blum, A., Urban Jr, J.F., Elliott, D., Weinstock, J. 2007. Heligmosomoides polygyrus promotes T regulatory cytokine production in the normal distal murine intestine. Infection and Immunity.
Unique maturation program of the IgE response in vivo - (Peer Reviewed Journal)
Erazo, A., Kutchukhidze, N., Leung, M., Guarnieri-Christ, A.P.,Urban Jr,J.F., Curotto De Lafailli, M.A., Laifaille, J.J. 2007. Unique maturation program of the IgE response in vivo. Immunity. 26(2):191-203.
L3L4ES antigen and secretagogues induce histamine release from porcine peripheral blood basophils after Ascaris suum infection - (Peer Reviewed Journal)
Uston, P.I., Urban Jr, J.F., Ashraf, M., Ampy, F.R. 2007. L3l4es antigen and secretagogues induce histamine release from porcine peripheral blood basophils after ascaris suum infection. Parasitology Research. 100(3):603-611.
Mechanisms of Neonatal Mucosal Antibody Protection - (Peer Reviewed Journal)
Harris, N.L., Spoerri, I., Schopfer, J.F., Nembrini, C., Merky, P., Massacand, J., Urban Jr, J.F., Lamarre, A., Burki, K., Odermatt, B., Zinkernagel, R.M., Macpherson, A.J. 2006. Mechanisms of neonatal mucosal antibody protection. Journal of Immunology. 177(9):6256-6262.
Amphiregulin-a Th2 cytokine enhancing resistance to nematodes - (Peer Reviewed Journal)
Zaiss, D.M., Yang, L., Shah, P.R., Kobie, J.J., Urban, J.F., Mosmann, T.R. 2006. Amphiregulin-a TH2 cytokine enhancing resistance to nematodes. Science. 314(5806):1746.
ASCARIS SUUM-DERIVED PRODUCTS SUPPRESS MUCOSAL ALLERGIC INFLAMMATION IN AN INTERLEUKIN-10-INDEPENDENT MANNER VIA INTERFERENCE WITH DENDRITIC CELL FUNCTION. - (Peer Reviewed Journal)
McConchie, B.W., Norris, H.H., Bundoc, V.G., Trivedi, S., Boesen, A., Urban Jr, J.F., Keane-Myers, A.M. 2006. Ascaris suum-derived products suppress mucosal allergic inflammation in an interleukin-10-independent manner via interference with dendritic cell function. Infection and Immunity. 74(12):6632-6641.
Il-4producing memory T-cells induce alternatively activated macrophages to mediate protection against nematode parasites. - (Peer Reviewed Journal)
Anthony, R.M., Urban Jr, J.F., Alem, F., Hamed, H.A., Boucher, J., Van Rooijen, N., Gauge, W.C. 2006. IL-4-producing memory T cells induce alternatively activated macrophages to mediate protection against nematode parasites. Nature (Medicine). 12(8):955-960.
A MAMMARY GLAND BIOLOGIST'S PERSEPECTIVE ON FUNCTIONAL GENOMICS - (Proceedings)
Capuco, A.V., Meyer, M.J., Li, R.W., Connor, E.E., Van Tassell, C.P., Boisclair, Y.R., Van Amburgh, M.E., Sonstegard, T.S., Urban Jr, J.F. 2006. A mammary gland biologist's persepective on functional genomics. World Congress on Genetics Applied to Livestock Production. Belo Horizonte, Brazil, August 13-18, pp 01-6.
BIOFIOBACTERIUM LACTIS ENHANCES TOLL-LIKE RECEPTOR (TLR) PATHWAY GENE EXPRESSION LOCALLY IN THE COLON AND ENHANCES GLUCOSE UPTAKE IN THE SMALL INTESTINE OF PIGS INFECTED WITH PARASITIC NEMATODE ASCARIS SUM. - (Proceedings)
Solano Aguilar, G., Dawson, H.D., Shea-Donohue, T., Madden, K., Jones, Y.L., Beshah, E., Restrepo, M., Schoene, N.W., Hare Jr, W.R., Urban Jr, J.F. 2006. Biofiobacterium lactis enhances toll-like receptor (tlr) pathway gene expression locally in the colon and enhances glucose uptake in the small intestine of pigs infected with parasitic nematode ascaris sum. American Society for Microbiology Proceedings. 106:45A.
IL-18 STIMULATES IL-13 MEDIATED IFN-GAMMA SENSITIVE HOST RESISTANCE IN VIVO - (Peer Reviewed Journal)
Liu, Q., Liu, Z., Whitmire, J., Alem, F., Hamed, H., Pesce, J., Urban Jr, J.F., Gause, W. 2006. IL-18 stimulates IL-13 mediated INF-gamma sensitive host resistance in vivo. European Journal of Immunology. 36(5):1187-1198.
BIFIDOBACTERIUM LACTIS AFFECTS IMMUNE DEVELOPMENT OF NEONATAL PIGS: A MODEL FOR NUTRIENT CONDITIONING IN INFANTS. - (Abstract Only)
Solano Aguilar, G., Dawson, H.D., Jones, Y.L., Schoene, N.W., Beshah, E., Restrepo, M., Hare, W., Urban Jr, J.F. 2006. Bifidobacterium lactis affects immune development of neonatal pigs: a model for nutrient conditioning in infants. Meeting Abstract.
CONTRIBUTION OF 5-HT2A RECEPTOR IN NEMATODE INFECTION-INDUCED MURINE INTESTINAL SMOOTH MUSCLE HYPER CONTRACTILITY - (Peer Reviewed Journal)
Zhao, A., Urban, Jr, J.F., Morimoto, M., Elfrey, J., Madden, K., Finkelman, F., Shea-Donohue, T. 2006. Contribution of 5-HT2A receptor in nematode infection-induced murine intestinal smooth muscle hyper contractility. Gastroenterology. 131(2):568-578
FUNCTIONAL IMPORTANCE OF REGIONAL DIFFERENCES IN LOCALIZED GENE EXPRESSION OF RECEPTORS FOR IL-13 IN MURINE GUT - (Peer Reviewed Journal)
Morimoto, M., Morimoto, M., Zhao, A., Madden, K., Dawson, H., Finkleman, F., Mentink-Kane, M., Urban Jr., J.F., Wynn, T., and Shea-Donohue, T. 2006. Functional importance of regional differences in localized gene expression of receptors for IL-13 in murine gut. Journal of Immunology. 176(1):491-495.
HELIGMOSOMOIDES POLYGYRUS INDUCES TLR4 ON MURINE MUCOSAL T CELLS THAT PRODUCE TGF-BETA AFTER LIPOPOLYSACCHARIDE STIMULATION - (Peer Reviewed Journal)
Ince, N., Elliott, D., Setiawan, T., Blum, A., Metwali, A., Wang, Y., Urban, J., Weinstock, J. 2006. Heligmosomoides polygyrus induces TLR4 on murine mucosal T cells that produce TGFbeta after lipopolysaccharide stimulation. Journal of Immunology. 176(2):726-729
ALTERNATIVELY ACTIVATED MACROPHAGES ACCUMULATE AT THE HOST PARASITE INTERFACE AND CONTRIBUTE TO PROTECTION AGAINST A NEMATODE PARASITE. - (Abstract Only)
Anthony, R., Urban Jr, J.F., Alem, F., Hamed, H., Van Rooijen, N., Gause, W. 2005. Alternatively activated macrophages accumulate at the host parasite interface and contribute to protection against a nematode parasite.. Meeting Abstract.
UP-REGULATION OF INFLAMMATORY, REGULATORY AND TH1-IMMUNE MARKERS IN SWINE RESPONDING TO ACUTE TOXOPLASMA GONDII INFECTION. - (Abstract Only)
Nishi, S.M., Dawson, H.D., Kuhar, D.J., Dubey, J.P., Urban Jr, J.F., Lunney, J.K. 2005. Up-regulation of inflammatory, regulatory and th1-immune markers in swine responding to acute toxoplasma gondii infection. Proceedings of American Association of Veterinary Parasitologists. p. 33-34.
Helminth infections in animals and man: Population dynamics, host susceptibility and immuno-modeulatory effects - (Proceedings)
Kringel, H., Dawson, H.D., Urban Jr, J.F., Roepstorff, A. 2005. Helminth infections in animals and man: Population dynamics, host susceptibility and immuno-modeulatory effects. Proceedings of the Abildgaard Symposium. University of Life Sciences. Danish Centre for Experimental Parasitology. pp. 65-72.
IMMUNE REGULATION OF PROTEASE-ACTIVATED RECEPTOR-1 EXPRESSION IN MURINE SMALL INTESTINE DURING NIPPOSTRONGYLUS BRASILIENSIS INFECTION - (Peer Reviewed Journal)
Zao, A., Morimoto, M., Dawson, H., Elfrey, J.E., Madden, K.B., Gause, W.C., Min, B., Finkelman, F.D., Urban, J.F. Jr., Shea-Donohue, T. 2005. Immune regulation of protease-activated receptor-1 expression in murine small intestine during nippostrongylus brasiliensis infection. Journal of Immunology. 175(4):2563-2569.
THE IL-21 RECEPTOR AUGUMENTS TH2 EFFECTOR FUNCTION AND ALTERNATIVE MACROPHAGE ACTIVATION. - (Peer Reviewed Journal)
Pesce, J., Kaviratne, M., Ramalingam, T., Thompson, R.W., Urban Jr, J.F., Cheever, A., Young, D., Collins, M., Grusby, M., Wynn, T. 2006. The IL-21 receptor auguments Th2 effector function and alternative macrophage activation. Journal of Clinical Investigation. 116(7):2044-2055.
EFFECT OF SELENIUM AND/OR VITAMIN E DEFICIENCIES ON HELIGMOSOMOIDES POLYGYRUS INFECTIONS IN MICE - (Peer Reviewed Journal)
Smith, A.D., Madden, K. B., Au Yeung, K., Zhao, A., Elfrey, J., Finkelman, F., Levander, O.A., Shea Donohue, P.T., and Urban Jr, J.F. 2005. Effect of selenium and/or vitamin E deficiencies on Heligmosomoides polygyrus infections in mice. Journal of Nutrition. 135:830-836.
LOCALIZED MULTI-GENE EXPRESSION PATTERNS SUPPORT AN EVOLVING TH1/TH2-LIKE PARADIGM IN RESPONSE TO INFECTION WITH TOXOPLASMA GONDII AND ASCARIS SUUM - (Peer Reviewed Journal)
Dawson, H., Beshah, E., Nishii, S., Solano-Aguilar, G., Morimoto, M., Zhao, A. Madden, K., Ledbetter, T., Dubey, J.P., Shea-Donohue, T., Lunney, J.K., and Urban, J. F. Jr. 2005. Localized multi-gene expression patterns support an evolving Th1/Th2-like paradigm in response to infections with Toxoplasma gondii and Ascaris suum. Infection and Immunity. 73(2):1116-1128.
IMPACT OF VITAMIN E OR SELENIUM DEFICIENCY ON NEMATODE-INDUCED ALERATIONS IN MURINE INTESTINAL FUNCTION - (Peer Reviewed Journal)
Auyeung, K., Smith, A.D., Zhao, A., Madden, K., Elfrey, J., Sullivan, C., Levander, O.A., Urban Jr, J.F., Shea Donohue, P.T. 2005. Impact of vitamin E or selenium deficiency on nematode-induced alerations in murine intestinal function. Experimental Parasitology. 109:201-208.
INCREASED TH2-ASSOCIATED IMMUNITY IN ASCURIS-INFECTED SWINE TREATED WITH RETINOIC ACID - (Abstract Only)
Dawson, H.D., Jones, E.A., Beshah, E., Solano Aguilar, G., Urban Jr, J.F. 2005. Increased Th2-associated immunity in ascuris-infected swine treated with retinoic acid. [abstract]. Federation of American Societies for Experimental Biology Journal. 19:A1466.
TRICHURIS SUIS GUT THERAPY IN CROHN'S DISEASE - (Peer Reviewed Journal)
Summers, R., Elliott, D., Urban Jr, J.F., Thompson, R., Weinstock, J. 2005. Trichuris suis gut therapy in crohn's disease. Gut. 54:87-90.
IL-4 AND IL-13 MEDIATED HOST PROTECTION AGAINST INTESTINAL NEMATODE PARASITES. - (Review Article)
Finkelman, F., Shea-Donohue, T., Morris, S., Gildea, L., Strait, R., Madden, K., Urban Jr, J.F. 2004. IL-4 and IL-13 mediated host protection against intestinal nematode parasites. Immunological Reviews 201:139-155.
HELIGMOSOMOIDES POLYGYRUS INHIBITS ESTABLISHED COLITIS IN IL-10 DEFICIENT MICE - (Peer Reviewed Journal)
Elliott, D.E., Setiawan T., Metwali, A., Blum, A., Urban, Jr., J.F., Weinstock, J.V. 2004. Heligmosomoides polygyrus inhibites established colitis in IL-10 deficient mice. European Journal of Immunology. 34:2690-2696.
CONDITIONAL DELETION OF GATA-3 REVEALS ITS CRITICAL ROLE IN TH1/TH2 RESPONSES - (Peer Reviewed Journal)
Zhu, J., Min, B., Hu-Li, J., Watson, C., Grinberg, A., Wang, Q., Killeen, N., Urban Jr, J.F., Guo, L., Paul, W. 2004. Conditional deletion of gata-3 reveals its critical role in th1/th2 responses. Nature Immunology. 5(11):1157-1165.
REQUIREMENTS FOR THE DEVELOPMENT OF IL-4PRODUCING T CELLS DURING INTESTINAL NEMATODE INFECTIONS: WHAT IT TAKES TO MAKE A TH2 CELL IN VIVO. - (Review Article)
Liu, Z., Liu, Q., Pesce, J., Anthony, R., Lamb, E., Whitmire, J., Hamed, H., Morimoto, M., Urban Jr, J.F., Gause, W.C. 2004. Requirements for the development of IL-4producing T cells during intestinal nematode infections: what it takes to make a Th2 cell in vivo. Immunological Reviews 201:57-74.
TH2-INDUCING PARASITE INFECTION LEADS TO THE PRODUCTION OF IL-4 AND TISSUE ACCUMULATION OF BASOPHILS - (Peer Reviewed Journal)
Min, B., Prout, M., Hu-Li, J., Zhu, J., Jankovic, D., Morgan, E., Urban Jr, J.F., Dvorak, A., Finkelman, F., Legros, G. 2004. Th2-inducing parasite infection leads to the production of IL-4 and tissue accumulation of basophils. Journal of Experimental Medicine. 200:507-517 (2004)
MOLECULAR CLONING OF THE SWINE IL-4 RECEPTOR AND IL-13 RECEPTOR ALPHA 1 CHAINS: EFFECTS OF EXPERIMENTAL TOXOPLASMA GONDII, ASCARIS SUUM AND TRICHURIS SUIS INFECTIONS ON TISSUE MRNA LEVELS - (Peer Reviewed Journal)
Zarlenga, D.S., Dawson, H.D., Kringel, H., Solano Aguilar, G., Urban Jr, J.F. 2004. Molecular cloning of the swine IL-4 receptor and IL-13 receptor alpha 1 chains: effects of experimental toxoplasma gondii, ascaris suum and trichuris suis infections on tissue mrna levels. Veterinary Immunology and Immunopathology 101(3-4):223-234.
THE EFFECT OF PROBIOTIC BACTERIA ON THE IMMUNE SYSTEM OF WEANED PIGS MONITORED BY REAL TIME PCR - (Peer Reviewed Journal)
Solano Aguilar, G., Ledbetter, T., Dawson, H.D., Andrews, K., Harvey, R.B., Schoene, N., Urban Jr, J.F. 2004. The effect of probiotic bacteria on the immune system of weaned pigs monitored by Real time PCR. Proceedings 18th International Pig Veterinary Society Meeting, Hamburg, Germany, October 2004. p. 380.
MOLECULAR CLONING OF THE SWINE IL-4 RECEPTOR AND IL-13 RECEPTOR ALPHA 1 CHAINS: EFFECTS OF EXPERIMENTAL TOXOPLASMA GONDII, ASCARIS SUUM AND TRICHURIS SUIS INFECTIONS ON TISSUE MRNA LEVELS - (Peer Reviewed Journal)
Zarlenga, D.S., Dawson, H.D., Kringle, H., Solano Aguilar, G., Urban Jr, J.F. 2004. Molecular cloning of the swine il-4 receptor and il-13 receptor alpha 1 chains: effects of experimental toxoplasma gondii, ascaris suum and trichuris suis infections on tissue mrna levels. Veterinary Immunology and Immunopathology. 101(3-4):223-34 (2004)
TRICHURIS SUIS THERAPY FOR ACTIVE ULCERATIVE COLITIS: A RANDOMIZED CONTROLLED TRIAL - (Peer Reviewed Journal)
Summers, R.W., Elliott, D.E., Urban, J.F. Jr., Thompson, R.A., Weinstock, J.V. 2005. Trichuris suis therapy for active ulcerative colitis: A randomized controlled trial. Gastroenterology. 128:825-832.
ENTERIC NEMATODES INDUCE STEREOTYPIC STAT6-DEPENDENT ALTERATIONS IN INTESTINAL EPITHELIAL CELL FUNCTION - (Peer Reviewed Journal)
Madden, K., Auyeung, K., Zhao, A., Gause, W., Finkelman, F., Katona, I., Urban Jr, J.F., Shea Donohue, P.T. 2004. Enteric nematodes induce stereotypic stat6-dependent alterations in intestinal epithelial cell function. Journal of Immunology. 172:5616-5621 (2004)
SIMULTANEOUS DEFICIENCY IN CD28 AND STAT6 RESULTS IN CHRONIC ECTOPARASITES-INDUCED INFLAMMATORY SKIN DISEASE. - (Peer Reviewed Journal)
Liu, Q., Callendar, C., Liu, Q., Whitmire, J., Grusby, M., Finkleman, F., Darling, T., Cheever, A., Swearengen, J., Urban Jr, J.F. 2004. Simultaneous deficiency in cd28 and stat6 results in chronic ectoparasites-induced inflammatory skin disease. Infection and Immunity. 72:3706-3715 (2004)
EXPOSURE TO SCHISTOSOME EGGS PROTECTS MICE FROM TNBS COLITIS - (Peer Reviewed Journal)
Elliott, D.E., Crawford, C., Li, J., Blum, A., Metwali, A., Qadir, K., Urban Jr, J.F., Weinstock, J.V. 2003. Exposure to schistosome eggs protects mice from tnbs colitis. American Journal of Physiology - Gastrointestinal and Liver Physiology. 284:6385-6391 (2003)
SELENIUM (SE) AND VITAMIN E (VE) DEFICIENCIES IMPAIR INTESTINAL FUNCTION AND RESULT IN PERSISTENT INFECTION WITH HELIGMOSOMOIDES POLYGYRUS - (Abstract Only)
Smith, A.D., Madden, K., Zhao, A., Auyeung, K., Levander, O.A., Finkelman, F., Urban Jr, J.F., Shea Donohue, P.T. 2004. Selenium (se) and vitamin E (ve) deficiencies impair intestinal function and result in persistent infection with heligmosomoides polygyrus [abstract]. Federation of American Society of Experimental Biology Journal. 18(4):A9.
PERIPHERAL CD4 CELLS RAPIDLY ACCUMULATE AT THE HOST: PARASITE INTERFACE AN INFLAMMATORY TH2 MEMORY RESPONSE - (Peer Reviewed Journal)
Morimoto, M., Morimoto, M., Whitmire, J., Star, R., Urban Jr, J.F., Gause, W. 2004. Peripheral cd4 cells rapidly accumulate at the host: Parasite interface and express a polarized th2 memory response in situ. Journal of Immunology. 172:2424-2430 (2004).
GASTOINTESTINAL PARASITES AND HOST INTERACTIONS - (Literature Review)
Shea Donohue, P.T., Urban Jr, J.F. 2004. Gastointestinal parasites and host interactions. Current Opinions in Gastroenterology. 20:3-9 (2004).
IMPACT OF ASCARIS SUUM - (Trade Journal)
Urban Jr, J.F. 2003. Impact of ascaris suum. Pig Progress. 3-27. Available: http://www.agriworld.nl. 23-27
THE EFFECT OF HUMAN DERIVED PROBIOTIC BACTERIA ON THE IMMUNE AND INTESTINAL FUNCTION OF PIGS - (Abstract Only)
Solano Aguilar, G., Dawson, H.D., Ledbetter, T., Shea Donohue, P.T., Schoene, N.W., Call, J.E., Beshah, E., Hare Jr, W.R., Urban Jr, J.F. 2003. The effect of human derived probiotic bacteria on the immune and intestinal function of pigs [abstract]. Allen D. Leman Swine Conference. 30:26.
IN SITU LOCALIZATION OF GENE EXPRESSION USING LASER CAPTURE MICRO DISSECTION - (Peer Reviewed Journal)
Morimoto, M., Morimoto, M., Whitemire, J., Star, R., Urban Jr, J.F., Gause, W. 2003. In situ localization of gene expression using laser capture micro dissection. In: PCR Primer: A Laboratory Manual. 11:135-148.
HUMAN DERIVED PROBIOTIC BACTERIA SPECIES CAN REGULATE INTESTINAL RESPONSES TO PARASITIC NEMATODES IN PIGS - (Peer Reviewed Journal)
Solano Aguilar, G., Dawson, H.D., Ledbetter, T., Shea Donohue, P.T., Schoene, N.W., Call, J., Beshah, E., Hare Jr, W.R., and Urban Jr, J.F. 2004. Human derived probiotic bacteria species can regulate intestinal responses to parasitic nematodes in pigs. Veterinary Parasitology. 125:47-161.
THE EFFECTS OF DIETARY PROBIOTICS ON IMMUNITY TO ASCARIS SUUM IN PIGS - (Abstract Only)
Solano Aguilar, G., Dawson, H.D., Ledbetter, T., Shea Donohue, P.T., Schoene, N.W., Call, J., Beshah, E., Hare Jr, W.R., Urban Jr, J.F. 2003. The effects of dietary probiotics on immunity to ascaris suum in pigs [abstract]. Proceedings of American Association of Veterinary Parasitologists. Paper No. 56-54.
ENHANCEMENT OF DISEASE AND PATHOLOGY BY SYNERGY OF TRICHURIS SUIS AND CAMPYLOBACTER JEJUNI IN THE COLON OF IMMUNOLOGICALLY NAIVE SWINE - (Peer Reviewed Journal)
Mansfield, L., Gauthier, D., Abner, S., Jones, K., Wilder, S., Urban Jr, J.F. 2003. Enhancement of disease and pathology by synergy of trichuris suis and campylobacter jejuni in the colon of immunologically naive swine. American Journal of Tropical Medicine and Hygiene 68(1):70-80 (2003)
CLONING AND CHARACTERIZATION OF A TGF-BETA HOMOLOGUE WITHIN POPULATIONS OF ASCARIS SUUM 4TH STAGE LARVAE (L4): REGULATED TRANSCRIPTION AND MULTIPLE SPLICING DIFFERENTIATIVE L4 IN THE JEJUNUM AND ILEUM DURING SPONTANEOUS CURE. - (Abstract Only)
Zarlenga, D.S., Morimoto, M., Urban Jr, J.F., Mccarter, J.P. 2003. Cloning and characterization of a tgf-beta homologue within populations of ascaris suum 4th stage larvae (l4): regulated transcription and multiple splicing differentiative l4 in the jejunum and ileum during spontaneous cure [abstract]. World Association for the Advancement of Veterinary Parasitology.
DEPENDENCE OF I1-4, IL-13, AND NEMATODE-INDUCED ALTERATIONS IN MURINE SMALL INTESTINAL SMOOTH MUSCLE CONTRACTILITY ON STAT6 AND ENTERIC NERVES - (Peer Reviewed Journal)
Zhao, A., Mcdermott, J., Urban Jr, J.F., Gause, W., Madden, K., Auyeung, K., Morris, S., Finkelman, F., Shea-Donohue, T. 2004. Dependence of i1-4, il-13, and nematode-induced alterations in murine small intestinal smooth muscle contractility on stat6 and enteric nerves. Journal of Immunology. 171:948-954 (2003).
TRICHURIS SUIS APPEARS SAFE AND EFFECTIVE IN THE TREATMENT OF INFLAMMATORY BOWEL DISEASE - (Peer Reviewed Journal)
Summers, R.W., Elliott, D.E., Qadir, K., Urban Jr, J.F., Thompson, R., Weinstock, J.V. 2003. Trichuris suis appears safe and effective in the treatment of inflammatory bowel disease. American Journal of Gastroenterology. 11:420-426 (1999)
ANIMAL MODEL OF NIPPOSTRONGYLUS BRASILIENSIS AND HELIGMOSOMOIDES POLYGYRUS - (Book / Chapter)
Camberis, M., Le Gros, G., Urban Jr, J.F. 2003. Animal model of nippostrongylus brasiliensis and heligmosomoides polygyrus. In: Coico, R., editor. Current Protocols in Immunology. John Wiley and Sons, Incorporated. 19.12:1-27 (2003).
THE EFFECT OF DIETARY PROBIOTIC IN THE IMMUNE RESPONSE OF PIGS - (Abstract Only)
Solano Aguilar, G., Ledbetter, T., Dawson, H.D., Schoene, N.W., Urban Jr, J.F. 2003. The effect of dietary probiotic in the immune response of pigs [abstract]. 9th International Symposium on Digestive Physiology in Pigs. 2:69.
THE IMMUNE RESPONSE TO PARASITIC HELMINTHS: INSIGHT FROM MURINE MODELS. - (Review Article)
Gause, W., Urban Jr, J.F., Stadecker, M. 2003. The immune response to parasitic helminths: insight from murine models. Trends in Immunology. 24:269-277.
IL-4 EXACERBATES ANAPHYLAXIS - (Peer Reviewed Journal)
Strait, R., Morris, S., Smiley, K., Urban Jr, J.F., Finkelman, F. 2003. Il-4 exacerbates anaphylaxis. Journal of Immunology. 170:3835-3842 (2003)
ASCARIS SUUM: CDNA MICROARRAY ANALYSIS OF 4TH STAGE LARVAE (L4) DURING SELF-CURE FROM THE INTESTINE - (Peer Reviewed Journal)
Morimoto, M., Zarlenga, D.S., Beard, H.S., Alkharouf, N., Matthews, B.F., Urban Jr, J.F. 2003. Ascaris suum: cdna microarray analysis of 4th stage larvae (l4) during self-cure from the intestine. Experimental Parasitology. 104:113-121 (2003)
THE ROLE OF OX40L INTERACTION IN THE DEVELOPMENT OF THE PRIMARY AND MEMORY TH2 RESPONSE TO THE GASTROINTESTINAL NEMATODE PARASITE HELIGMOSOMOIDES POLYGYRUS - (Peer Reviewed Journal)
Ekkens, M., Liu, Z., Liu, Q., Foster, A., Ehitmire, J., Pesce, J., Vannoy, J., Sharpe, A., Urban Jr, J.F., Gause, W. 2003. The role of ox40l interaction in the development of the primary and memory th2 response to the gastrointestinal nematode parasite heligmosomoides polygyrus. Journal of Immunology. 170:384-393 (2003)
ROLE OF STAT6 AND MAST CELLS IN IL4-AND IL-13-INDUCED ALTERATIONS IN MURINE INTESTINAL EPITHELIAL CELL FUNCTION - (Peer Reviewed Journal)
Madden, K., Whitman, L., Sullivan, C., Gause, W., Donaldson, D., Urban Jr, J.F., Katona, I., Finkelman, F., Shea Donohue, P.T. 2002. Role of stat6 and mast cells in il4-and il-13-induced alterations in murine intestinal epithelial cell function. Journal of Immunology. 169:4417-4432 (2002)
LIMITED EFFECT OF RECOMBINANT PORCINE INTERLEUKIN 12 ON PORCINE LYMPHOCYTES DUE TO A LOW LEVEL OF IL-12 BETA 2 RECEPTOR - (Peer Reviewed Journal)
Solano Aguilar, G., Zarlenga, D.S., Beshah, E., Gasbarre, L.C., Junker, D., Cochran, M., Dawson, H.D., Urban Jr, J.F., Lunney, J.K. 2002. Limited effect of recombinant porcine interleukin 12 on porcine lymphocytes due to a low level of il-12 beta 2 receptor. Veterinary Immunology and Immunopathology. 89:133-148 (2002)
HOST PROTECTION AND CYTOKINE PRODUCTION ARE B7-INDEPENDENT IN THE TH2 IMMUNE RESPONSE TO THE GASTROINTESTINAL NEMATODE PARASITE, NIPPOSTRONGYLUS BRASILIENSIS - (Peer Reviewed Journal)
Liu, Q., Liu, Z., Ekkens, M., Fang, H., Whitmire, J., Chen, A., Sharpe, A., Urban Jr, J.F., Gause, W. 2002. Host protection and cytokine production are b7-independent in the th2 immune response to the gastrointestinal nematode parasite, nippostrongylus brasiliensis. Journal of Immunology. 169:6959-6968 (2002)
FUNCTIONAL GENOMIC ASSESSMENT OF PORCINE DISEASE RESISTANCE: REAL TIME ASSAYS OF PORCINE IMMUNE GENE EXPRESSION - (Proceedings)
Dawson, H.D., Nishi, S., Beshah, E., Solano Aguilar, G., Zarlenga, D.S., Urban Jr, J.F., Lunney, J.K. 2002. Functional genomic assessment of porcine disease resistance: real time assays of porcine immune gene expression. World Congress of Genetics Applied in Livestock Production #13-41.
MEMORY TH2 EFFECTOR CELLS CAN DEVELOP IN THE ABSENCE OF B7-1/B7-2, CD28 INTERACTIONS, AND EFFECTOR T HELPER CELLS AFTER PRIMING WITH AN INTESTINAL NEMATODE PARASITE - (Peer Reviewed Journal)
Ekkens, M., Liu, Z., Liu, Q., Foster, A., Whitmire, J., Pesce, J., Urban Jr, J.F., Gause, W. Memory th2 effector cells can develop in the absence of b7-1/b7-2, cd28 interactions, and effector t helper cells after priming with an intestinal nematode parasite. Journal of Immunology. 168:6344-6351 (2002)
A TGF-BETA HOMOLOGUE WITHIN POPULATIONS OF ASCARIS SUUM 4TH STAGE LARVAE (L4): EVIDENCE FOR MULTIPLE SPLITING AND REGULATED TRANSCRIPTION BETWEEN L4 IN THE JEJUNUM AND ILEUM FOLLOWING SPONTANEOUSLY CURE. - (Abstract Only)
Zarlenga, D.S., Morimoto, M., Urban Jr, J.F., Mccarter, J.P. 2002. A tgf-beta homologue within populations of ascaris suum 4th stage larvae (l4): evidence for multiple spliting and regulated transcription between l4 in the jejunum and ileum following spontaneously cure [abstract]. American Association of Veterinary Parasitologists Proceedings.
EXPOSURE TO SCHISTOSOME EGGS PROTECTS MICE FROM TNBS COLITIS - (Peer Reviewed Journal)
Elliott, D.E., Li, J., Blum, A., Meetwali, A., Qadir, K., Urban Jr, J.F., Weinstock, J.V. 2003. Exposure to schistosome eggs protects mice from tnbs colitis. American Journal of Physiology - Gastrointestinal and Liver Physiology 284(3):6385-6391.
IL-10 IS CRITICAL FOR RESISTANCE AND SURVIVAL DURING GASTROINTESTINAL HELMINTH INFECTION - (Peer Reviewed Journal)
Schopf, L.R., Hoffmann, K.E., Cheever, A.W., Urban Jr, J.F., Wynn, T.A. 2002. Il-10 is critical for resistance and survival during gastrointestinal helminth infection. Journal of Immunology. 168:2383-2392 (2002)
RELEASE OF HYALURONIDASE DURING IN VITRO DEVELOPMENT OF ASCARIS SUUM FROM THE THIRD-TO FOURTH-LARVAL STAGE - (Peer Reviewed Journal)
Rhoads, M.L., Fetterer, R.H., Urban Jr, J.F. 2001. Release of hyaluronidase during in vitro development of ascaris suum from the third-to fourth-larval stage. Parasitology Research 87(9):693-697.
LOCALIZED IMMUNITY TO THE LARGE ROUNDWORM ASCARIS SUUM IN SWINE - (Proceedings)
Solano Aguilar, G., Beshah, E., Motoko, M., Schoene, N.W., Urban Jr, J.F. 2001. Localized immunity to the large roundworm ascaris suum in swine. Proceedings of Allen D Leman Swine Conference.
RESPONSE OF INTESTINAL EPITHELIAL CELLS TO TRICHURIS SUIS EXCRETORY- SECRETORY PRODUCTS AND THE INFLUENCE ON CAMPYLOBACTER JEJUNI INVASION UNDER IN VITRO CONDITIONS. - (Peer Reviewed Journal)
Abner, S.R., Hill, D.E., Turner, J.R., Black, E.D., Bartlett, P., Urban Jr, J.F., Mansfield, L.S. Response of intestinal epithelial cells to trichuris suis excretory- secretory products and the influence on campylobacter jejuni invasion under in vitro conditions.. Journal of Parasitology.
RESPONSES OF INTESTINAL EPITHELIAL CELLS TO TRICHURIS SUIS EXCRETORY- SECRETORY PRODUCTS AND THE INFLUENCE ON CAMPYLOBACTER JEJUNI INVASION UNDER IN VITRO CONDITIONS - (Peer Reviewed Journal)
THE OTHER SIDE OF THE COIN: THE PROTECTIVE ROLE OF THE TYPE 2(TH2) CYTOKINES - (Peer Reviewed Journal)
Finkelman, F., Urban Jr, J.F. The other side of the coin: the protective role of the type 2(th2) cytokines. Journal of Allergy Clinical Immunology. 107:772-780 (2001)
CUTICULAR COLLAGEN SYNTHESIS BY ASCARIS SUUM DURING DEVELOPMENT FROM THE THIRD- TO FOURTH-LARVAL STAGE; IDENTIFICATION OF A POTENTIAL CHEMOTHERAPEUTIC AGENT WITH A NOVEL MECHANISM OF ACTION - (Peer Reviewed Journal)
Rhoads, M.L., Fetterer, R.H., Urban Jr, J.F. 2001. Cuticular collagen synthesis by ascaris suum during development from the third- to fourth-larval stage; identification of a potential chemotherapeutic agent with a novel mechanism of action. Journal of Parasitology. 87:1144-1149 (2001)
WESTERN REGIONAL RESEARCH PROJECT W-102, INTEGRATED METHODS OF PARASITE - (Experiment Station)
STAT6 SIGNALING PROMOTES PROTECTIVE IMMUNITY AGAINST TRICHINELLA SPIRALIS THR0UGH A MAST CELL- AND T CELL-DEPENDENT MECHANISM - (Peer Reviewed Journal)
Urban Jr, J.F., Schopf, L.R., Morris, S., Orekhova, T., Madden, K.B., Betts, C.J., Gamble, H.R., Byrd, C., Donaldson, D., Else, K. 2000. Stat6 signaling promotes protective immunity against trichinella spiralis thr0ugh a mast cell- and t cell-dependent mechanism. Journal of Immunology. 164:2046-2052 (2000)
TRICHURIS SUIS: A SECRETORY CHYMOTRYPSIN/ELASTASE INHIBITOR WITH POTENTIAL AS A IMMUNOMODULATOR - (Peer Reviewed Journal)
Rhoads, M.L., Fetterer, R.H., Hill, D.E., Urban Jr, J.F. 2000. Trichuris suis: a secretory chymotrypsin/elastase inhibitor with potential as a immunomodulator. Molecular and Biochemical Parasitology. 95:36-44 (2000)
STAT6 REGULATION OF IN VIVO IL-4 RESPONSE - (Peer Reviewed Journal)
Finkelman, F.D., Morris, S.C., Orekhova, T., Mori, M., Donaldson, D., Reiner, S., Reilly, N.L., Schopf, L.R., Urban Jr, J.F. 2000. Stat6 regulation of in vivo il-4 response. Journal of Immunology.164:2303-2310 (2000)
GASSTROINTESTINAL NEMATODES AND THE IMMUNE SYSTEM - (Book / Chapter)
IL13 WORM EXPULSION IN B7 INDEPENDENT AND IFN-GAMMA SENSITIVE - (Peer Reviewed Journal)
Urban Jr, J.F., Fang, H., Liu, Q., Nguyen, D., Byrd, C., Ekkens, M.J., Chen, S.J., Donaldson, D.D., Peach, R. 2000. B7 costimulation is required for il-4 but not il-13 responses: interactionsamong b7, il-4, il-13, and ifn-gamma determines the host's ability to expel the nematode parasite, trichuris muris. Journal of Immunology. 164:4252-4256 (2000)
IL-13: ROLE IN HELMINTH-INDUCED INFLAMMATION AND PROTECTIVE IMMUNITY AGAINST NEMATODE INFECTIONS - (Peer Reviewed Journal)
Finkelman, F.D., Wynn, T.A., Donaldson, D.D., Urban Jr, J.F. 1999. Il-13: role in helminth-induced inflammation and protective immunity against nematode infections. Current Opinions in Immunology. 11:420-426 (1999)
LYMPHOGLANDULAR COMPLEXES OF THE COLON ARE INVADED BY CAMPYLOBACTER JEJUNI IN A SWINE ANIMAL MODEL - (Peer Reviewed Journal)
MECHANISMS OF INTESTINAL IMMUNITY TO NEMATODE PARASITES AND THTE C CONSEQUENCES TO INVASION BY OPPORTUNISTIC BACTERIA - (Review Article)
DEVELOPMENT OF AN ANTIGEN-SPECIFIC ELISPOT TO DETECT INTESTINAL ANTIBODY RESPONSES TO THE SWINE WHIPWORM, TRICHURIS SUIS - (Peer Reviewed Journal)
DIFFERENTIAL B7-2 DEPENDENT REGULATION OF THE CHRONIC TH2 IMMUNE RESPONSE DURING INFECTIOUS DISEASE - (Peer Reviewed Journal)
MIGRATION AND DEVELOPMENT OF ASCARIS SUUM LARVAE IN ERTHROCEBUS PATAS: MODEL FOR VISCERAL LARVA MIGRANS IN HUMANS - (Peer Reviewed Journal)
PROTECTIVE IMMUNITY TO E. VERMIFORMIS IS DEPENDENT UPON IL-12 AND IFN-Y, BUT NOT IL-10. - (Abstract Only)
EFFECT OF PROTEASE CLASS-SPECIFIC INHIBITORS IN VITRO DEVELOPMENT OF L3 TO L4 STAGE OF A. SUUM - (Peer Reviewed Journal)
COMMENTARY: DO EFFECTOR AND MEMORY T HELPER CELLS ALSO NEED B7 LIGAND COSTIMULATORY SIGNALS? - (Peer Reviewed Journal)
THE ROLE OF IL-4 IN HELIGMOSOMOIDES POLYGYRUS-INDUCED ALTERATIONS IN MURINE INTESTINAL EPITHELIAL CELL FUNCTION - (Peer Reviewed Journal)
NEITHER CD28 OR B7-2 IS REQUIRED FOR GERMINAL CENTER FORMATION DURING A B7-DEPENDENT TYPE 2 IN VIVO MUCOSAL IMMUNE RESPONSE - (Peer Reviewed Journal)
BOTH IL-4 AND IL-13 MEDIATE THE EXPULSION OF GASTROINTESTINAL NEMATODE PARASITE THROUGH AN IL-4RA CHAIN AND STAT6-DEPENDENT - (Peer Reviewed Journal)
AN IL-4-INDEPENDENT PATHWAY FOR CD4+ T CELL IL-4 PRODUCTION IS REVEALED IN IL-4 RECEPTOR DEFICIENT MICE - (Peer Reviewed Journal)
CYTOKINE IMMUNOMODULATION OF INFECTIOUS DISEASES IN HANDBOOK OF IMMUNE MODULATING AGENTS - (Book / Chapter)
SECRETION OF AN AMINOPEPTIDASE DURING TRANSITION OF THIRD- TO FOURTH-STAGE LARVAE OF ASCARIS SUUM - (Peer Reviewed Journal)
CONSTRUCTION OF INTERNAL CDNA COMPETITORS FOR MEASURING IL-10 AND IL-12 CYTOKINE GENE EXPRESSION IN SWINE - (Peer Reviewed Journal)
CONSTRUCTION OF MULTIPLE INTERNAL CDNA COMPETITORS FOR MEASURING SWINE CYTOKINE GENE EXPRESSION BY QUANTITATIVE PCR - (Proceedings)
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