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ARS Home » People & Locations » Leela Noronha
Leela E Noronha
Foreign Arthropod Borne Animal Disease Research
Research Veterinary Medical Officer

Phone: (785) 776-2705
Fax:

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Projects
Development of Diagnostic Tools for Japanese Encephalitis Virus
Memorandum of Understanding (M)
  Accession Number: 443051
Defining the Upper and Lower Respiratory Tract Transcriptome of Cattle Health and Disease
Non-Assistance Cooperative Agreement (S)
  Accession Number: 443407
Assessing the Risk of Emergence, Transmission and Establishment of the Japanese Encephalitis Virus in the United States
Non-Assistance Cooperative Agreement (S)
  Accession Number: 443942
Characterization of Environmental Effects on Mosquito Saliva Composition Using Mass Spectrometry
Non-Assistance Cooperative Agreement (S)
  Accession Number: 444069
Vector Surveillance at an Active Cache Valley Virus Focus
Non-Assistance Cooperative Agreement (S)
  Accession Number: 444656
Xenosurveillance Using Arthropod Vectors to Characterize Vector-borne Disease Epidemiology
Non-Assistance Cooperative Agreement (S)
  Accession Number: 444667
Southwestern USA Arbovirus Landscape
Non-Assistance Cooperative Agreement (S)
  Accession Number: 444680
Host and Vector Transcriptional Responses for Transboundary Arboviral Disease of Livestock
Non-Assistance Cooperative Agreement (S)
  Accession Number: 444719
Animal Studies in BSL-3 Containment at Pat Roberts Hall for Comparative Zoonotic Arbovirus Studies
Non-Assistance Cooperative Agreement (S)
  Accession Number: 435561
Mammalian Responses to Arboviruses and Sorghum Polyphenols
Non-Assistance Cooperative Agreement (S)
  Accession Number: 437098
Investigating Risk Factors of Rift Valley Fever Virus Direct Transmission in Kenya
Non-Assistance Cooperative Agreement (S)
  Accession Number: 440614
Insecticidal Nanoparticles
Non-Assistance Cooperative Agreement (S)
  Accession Number: 441658
Evaluation of Transboundary Disease Mitigation Strategies in Kenya
Non-Assistance Cooperative Agreement (S)
  Accession Number: 442376
A Scalable Vascularized Hydrogel System for Agricultural Vector-borne Disease Research
Non-Assistance Cooperative Agreement (S)
  Accession Number: 442801
Assessment of CCHV in Ugandan Cattle Corridor and Kenyan Arid North Tick Populations
Non-Assistance Cooperative Agreement (S)
  Accession Number: 442808
Detection and Characterization of Potential Emerging and Emergent Arboviruses in Mosquitoes in the Caribbean
Non-Assistance Cooperative Agreement (S)
  Accession Number: 442817
Exosomes as Mediators of Arbovirus Transmission by Insects
Non-Assistance Cooperative Agreement (S)
  Accession Number: 442826
Development of Lateral Flow Assays for Rift Valley Fever Virus Antigen and Antibody Detection
Non-Assistance Cooperative Agreement (S)
  Accession Number: 442843
Bio-hardened Environments: Integrating AI-based Biothreat Detection Networks into Situational Awareness and Rapid Response Systems
Non-Assistance Cooperative Agreement (S)
  Accession Number: 442870
The Impact of Viral Recombination on the Epidemiology of Viruses
Non-Assistance Cooperative Agreement (S)
  Accession Number: 442874
Epidemiological Fitness Assessment of Segmented RNA Viruses
Non-Assistance Cooperative Agreement (S)
  Accession Number: 442875
Identifying Flavivirus Determinants of Entry and Replication and Design of Potential Vaccine Candidates
Non-Assistance Cooperative Agreement (S)
  Accession Number: 442924
Animal and Arthropod Studies in BSL3 Containment at Pat Roberts Hall for Comparative Zoonotic Arbovirus Studies
Non-Assistance Cooperative Agreement (S)
  Accession Number: 443000
Exploration of Novel Virus-like Particle Vaccine Candidates for Japanese Encephalitis Virus
Non-Assistance Cooperative Agreement (S)
  Accession Number: 443031
Exploration of Novel repRNA Vaccine Candidates for Japanese Encephalitis Virus
Non-Assistance Cooperative Agreement (S)
  Accession Number: 443041

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Rift Valley Fever Reprint Icon - (Book / Chapter)
Kimble, J.B., Noronha, L.E., Trujillo, J., Mitzel, D.N., Richt, J., Wilson, W.C. 2024. Rift Valley Fever. In: Hayes, T., Gopal, V., editors. Veterinary Clinics of North America. Philadelphia, PA: Elsevier. 40(2):293-304. https://doi.org/10.1016/j.cvfa.2024.01.004.
Japanese encephalitis virus and infection of feral phenotype swine Reprint Icon - (Peer Reviewed Journal)
Park, S., Huang, Y.S., Lyons, A.C., Ayers, V.B., Hettenbach, S.M., Mcvey, D.S., Noronha, L.E., Burton, K.R., Higgs, S., Vanlandingham, D.L. 2023. Japanese encephalitis virus and infection of feral phenotype swine. Vector-Borne and Zoonotic Diseases. 25(12):605-669. https://doi.org/10.1089/vbz.2023.0030.
Perspectives on the changing landscape of epizootic hemorrhagic disease virus control Reprint Icon - (Literature Review)
Noronha, L.E., Cohnstaedt, L.W., Richt, J.A., Wilson, W.C. 2021. Perspectives on the changing landscape of epizootic hemorrhagic disease virus control. Viruses. 2021, 13(11), 2268. https://doi.org/10.3390/v13112268.
In vitro infection dynamics of Japanese encephalitis virus in established porcine cell lines Reprint Icon - (Peer Reviewed Journal)
Adetunji, S.A., Smolensky, D., Mitzel, D.N., Chitko-Mckown, C.G., Cernicchiaro, N., Noronha, L.E., Owens, J.L. 2021. In vitro infection dynamics of Japanese encephalitis virus in established porcine cell lines. Pathogens. 10(11). Article 1468. https://doi.org/10.3390/pathogens10111468.
Mosquito saliva modulates Japanese encephalitis virus infection in domestic pigs Reprint Icon - (Peer Reviewed Journal)
Park, S., Huang, Y.S., Lyons, A.C., Ayers, V.B., Hettenbach, S.M., McVey, D., Noronha, L.E., Burton, K.R., Hsu, W., Higgs, S., Vanlandingham, D.L. 2021. Mosquito saliva modulates Japanese encephalitis virus infection in domestic pigs. Frontiers in Virology. 1. Article 724016. https://doi.org/10.3389/fviro.2021.724016.
Tumor suppressive activity of high phenolic sorghum brans in colon cancer model Reprint Icon - (Peer Reviewed Journal)
Lee, S., Lee, H., Lee, J., Amarakoon, D., Lou, Z., Noronha, L.E., Herald, T.J., Perumal, R., Smolensky, D. 2021. Tumor suppressive activity of high phenolic sorghum brans in colon cancer model. Journal of Nutritional Biochemistry. 22. Article 8286. https://doi.org/10.3390/ijms22158286.
Examining the potential transmission of SARS-CoV-2 by insect vectors - (Abstract Only)
Infection dynamics of Japanese encephalitis virus in porcine cell lines - (Abstract Only)
Mechanical transmission of SARS-CoV-2 by house flies Reprint Icon - (Peer Reviewed Journal)
Balaraman, V., Drolet, B.S., Mitzel, D.N., Wilson, W.C., Owens, J.L., Gaultiero, N.N., Meekins, D.A., Bold, D., Trujillo, J.D., Noronha, L.E., Richt, J.A., Nayduch, D. 2021. Mechanical transmission of SARS-CoV-2 by house flies. Parasites & Vectors. 14:214. https://doi.org/10.1186/s13071-021-04703-8.
Porcine macrophage-like cell line C Delta 2+ is susceptible to Japanese encephalitis virus infection - (Abstract Only)
Susceptibility of midge and mosquito vectors to SARS-COV-2 by natural route of infection Reprint Icon - (Peer Reviewed Journal)
Balaraman, V., Drolet, B.S., Gaudreault, N.N., Wilson, W.C., Owens, J.L., Bold, D., Swanson, D.A., Jasperson, D.C., Noronha, L.E., Richt, J.A., Mitzel, D.N. 2021. Susceptibility of midge and mosquito vectors to SARS-COV-2 by natural route of infection. Journal of Medical Entomology. 58(4):1948-1951. https://doi.org/10.1093/jme/tjab013.
A comparative study on phenolic contents, antioxidant activity and anti-inflammatory capacity in lipopolysaccharide-induced RAW 264.7 macrophages of sorghum aqueous and ethanolic extracts Reprint Icon - (Peer Reviewed Journal)
Hong, S., Pangloli, P., Perumal, R., Cox, S.R., Noronha, L.E., Dia, V.P., Smolensky, D. 2020. A comparative study on phenolic contents, antioxidant activity and anti-inflammatory capacity in lipopolysaccharide-induced RAW 264.7 macrophages of sorghum aqueous and ethanolic extracts. Antioxidants. https://doi.org/10.3390/antiox9121297.
Porcine macrophage-like cell line Cdelta2+ is susceptible to Japanese encephalitis virus infection - (Abstract Only)
Research Updates from the Arthropod-Borne Animal Diseases Research Unit - (Proceedings)
Anti-cancer activity of a novel high phenolic sorghum bran in human colon cancer cells Reprint Icon - (Peer Reviewed Journal)
Lee, S., Lee, J., Herald, T.J., Cox, S.R., Noronha, L.E., Perumal, R., Smolensky, D. 2020. Anti-cancer activity of a novel high phenolic sorghum bran in human colon cancer cells. Oxidative Medicine and Cellular Longevity. https://doi.org/10.1155/2020/2890536.
Japanese encephalitis virus infects novel Culex cell line - (Other)
High-polyphenol extracts from Sorghum bicolor attenuate replication of Legionella pneumophila within RAW 264.7 macrophages Reprint Icon - (Peer Reviewed Journal)
Gilchrist, A., Smolensky, D., Cox, S.R., Perumal, R., Noronha, L.E., Shames, S. 2020. High-polyphenol extracts from Sorghum bicolor attenuate replication of Legionella pneumophila within RAW 264.7 macrophages. FEMS Microbiology Letters. https://doi.org/10.1093/femsle/fnaa053.
Evaluation of A baculovirus-expressed VP2 subunit vaccine for the protection of white-tailed deer (Odocoileus virginianus) from epizootic hemorrhagic disease - (Abstract Only)
Perspectives regarding the risk of introduction of the Japanese encephalitis virus (JEV) in the United States Reprint Icon - (Peer Reviewed Journal)
Oliveira, A., Cohnstaedt, L.W., Noronha, L.E., Mitzel, D.N., McVey, D.S., Cernicchiaro, N. 2020. Perspectives regarding the risk of introduction of the Japanese encephalitis virus (JEV) in the United States. Frontiers in Veterinary Science. https://doi.org/10.3389/fvets.2020.00048.
Differential responses of two porcine macrophage- like cell lines to infection with Rift Valley fever virus MP-12 - (Proceedings)
Smolensky, D., Wilson, W.C., Cox, V.G., Schirtzinger, E.E., Chitko-Mckown, C.G., Fawver, Z.T., Noronha, L.E. 2019. Differential responses of two porcine macrophage- like cell lines to infection with Rift Valley fever virus MP-12. Proceedings of International Veterinary Immunology Symposium. August 13-16, 2019, Seattle, Washington. P072:126-127. Available online at https://ivis2019.org/wp-content/uploads/2019/09/IVIS-2019-Abstract-book.pdf
Optimization of ethanol-based extraction conditions of sorghum bran bioactive compounds with downstream anticancer properties Reprint Icon - (Peer Reviewed Journal)
Cox, S.R., Noronha, L.E., Herald, T.J., Bean, S.R., Lee, S., Perumal, R., Smolensky, D. 2019. Optimization of ethanol-based extraction conditions of sorghum bran bioactive compounds with downstream anticancer properties. Heliyon. https://doi.org/10.1016/j.heliyon.2019.e01589.
Preliminary evaluation of the susceptibility of white-tailed deer (Odocoileus virginianus) to Rift Valley Fever Virus Reprint Icon - (Peer Reviewed Journal)
Wilson, W.C., Kim, I., Trujillo, J., Sunwoo, S., Noronha, L.E., Urbaniak, K., Mcvey, D.S., Drolet, B.S., Morozov, I., Faburay, B., Schirtzinger, E.E., Koopman, T., Indran, S., Balaraman, V., Richt, J. 2018. Preliminary evaluation of the susceptibility of white-tailed deer (Odocoileus virginianus) to Rift Valley Fever Virus. Emerging Infectious Diseases. 24(9):1717-1719. http://doi.org/10.3201/eid2409.180265.
Shedding of Japanese encephalitis virus in oral fluid of infected swine Reprint Icon - (Peer Reviewed Journal)
Lyons, A., Huang, Y., Park, S., Ayers, V., Hettenbach, S., Higgs, S., Mcvey, D.S., Noronha, L.E., Hsu, W., Vanlandingham, D. 2018. Shedding of Japanese encephalitis virus in oral fluid of infected swine. Vector-Borne and Zoonotic Diseases. 10.1089/vbz.2018.2283.
High-polyphenol sorghum bran extract inhibits cancer cell growth through DNA damage, cell cycle arrest, and apoptosis Reprint Icon - (Peer Reviewed Journal)
Smolensky, D., Rhodes, D.H., Mcvey, D.S., Fawver, Z.T., Perumal, R., Herald, T.J., Noronha, L.E. 2018. High-polyphenol sorghum bran extract inhibits cancer cell growth through DNA damage, cell cycle arrest, and apoptosis. Journal of Medicinal Food. DOI:10.1089/jmf.2018.0008.
Porcine Macrophage-Like Cells Permit Viral Replication, Produce Inflammatory Mediators, and Undergo Apoptosis Following Infection with Rift Valley Fever Virus MP-12 - (Abstract Only)
Noronha, L.E., Smolensky, D., Cox, V.G., Schirtzinger, E.E., Chitko-Mckown, C.G., Fawver, Z.T., Wilson, W.C. 2018. Porcine Macrophage-Like Cells Permit Viral Replication, Produce Inflammatory Mediators, and Undergo Apoptosis Following Infection with Rift Valley Fever Virus MP-12. Journal of Immunology. 200:59.31.