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ARS Home » Northeast Area » Boston, Massachusetts » People & Locations » Chao Qiang Lai
Chao Qiang Lai (PhD)
Boston, Massachusetts
Research Molecular Biologist

Phone: (617) 556-3206
Fax: (617) 556-3299

(Employee information on this page comes from the REE Directory. Please contact your front office staff to update the REE Directory.)

Projects
Precision Nutrition for Health and Optimal Aging
In-House Appropriated (D)
  Accession Number: 445473
Using Deep Learning To Simulate Individual Responses In Cardiovascular Disease Risk To Different Dietary Patterns
Reimbursable Cooperative Agreement (R)
  Accession Number: 443758

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Rate-limiting enzymes in cardiometabolic health and aging in humans Reprint Icon - (Peer Reviewed Journal)
Parnell, L.D., McCaffrey, K.S., Brooks, A., Smith, C.E., Lai, C., Christensen, J.J., Wiley, C.D., Ordovas, J.M. 2023. Rate-limiting enzymes in cardiometabolic health and aging in humans. Lifestyle Genomics. 16:124-138. https://doi.org/10.1159/000531350.
The impact of alcoholic drinks and dietary factors on epigenetic markers associated with triglyceride levels Reprint Icon - (Peer Reviewed Journal)
Lai, C., Parnell, L.D., Lee, Y., Zeng, H., Smith, C., Mckeowan, N.M., Ordovas, J.M. 2023. The impact of alcoholic drinks and dietary factors on epigenetic markers associated with triglyceride levels. Frontiers in Genetics. https://doi.org/10.3389/fgene.2023.1117778.
Dietary responses of dementia-related genes encoding metabolic enzymes Reprint Icon - (Peer Reviewed Journal)
Parnell, L.D., Magadmi, R., Zwanger, S., Shukitt Hale, B., Lai, C., Ordovas, J.M. 2023. Dietary responses of dementia-related genes encoding metabolic enzymes. Nutrients. 15(3):644. https://doi.org/10.3390/nu15030644.
Metabolomic profiling in dogs with dilated cardiomyopathy eating non-traditional or traditional diets and in healthy controls Reprint Icon - (Peer Reviewed Journal)
Smith, C.E., Parnell, L.D., Lai, C., Rush, J.E., Adin, D.B., Ordovas, J.M., Freeman, L.M. 2022. Metabolomic profiling in dogs with dilated cardiomyopathy eating non-traditional or traditional diets and in healthy controls. Scientific Reports. https://doi.org/10.1038/s41598-022-26322-8.
Using machine learning to predict obesity based on genome-wide, epigenome-wide gene-gene and gene-diet interactions Reprint Icon - (Peer Reviewed Journal)
Lee, Y., Christensen, J.J., Parnell, L.D., Smith, C.E., Shao, J.Y., McKeown, N.M., Ordovas, J.M., Lai, C. 2022. Using machine learning to predict obesity based on genome-wide, epigenome-wide gene-gene and gene-diet interactions. Frontiers in Genetics. 12:783845. https://doi.org/10.3389/fgene.2021.783845.
Associations of network-derived metabolite clusters with prevalent type 2 diabetes among adults of Puerto Rican descent Reprint Icon - (Peer Reviewed Journal)
Haslam, D.E., Liang, L., Wang, D.D., Kelly, R.S., Wittenbecher, C., Perez, C.M., Martinez, M., Lee, C., Clish, C., Wong, D., Parnell, L.D., Lai, C., Ordovas, J.M., Manson, J.E., Hu, F.B., Stampfer, M.J., Tucker, K.L., Joshipura, K., Bhupathiraju, S.N. 2021. Associations of network-derived metabolite clusters with prevalent type 2 diabetes among adults of Puerto Rican descent. BMJ Open Diabetes Research & Care. https://doi.org/10.1136/bmjdrc-2021-002298.
Investigation of diets associated with dilated cardiomyopathy in dogs using foodomics analysis Reprint Icon - (Peer Reviewed Journal)
Smith, C., Parnell, L.D., Lai, C., Rush, J.E., Freeman, L.M. 2021. Investigation of diets associated with dilated cardiomyopathy in dogs using foodomics analysis. Scientific Reports. 11:15881. https://doi.org/10.1038/s41598-021-94464-2.
Carbohydrate and fat intake associated with risk of metabolic diseases through epigenetics of CPT1A Reprint Icon - (Peer Reviewed Journal)
Lai, C., Parnell, L.D., Smith, C.E., Guo, T., Sayols-Baixeras, S., Aslibekyan, S., Tiwari, H.K., Irvin, M.R., Bender, C., Fei, D., Hidalgo, B., Hopkins, P., Absher, D.M., Province, M., Elosua, R., Arnett, D.K., Ordovas, J.M. 2020. Carbohydrate and fat intake associated with risk of metabolic diseases through epigenetics of CPT1A. American Journal of Clinical Nutrition. 112(5):1200–1211. https://doi.org/10.1093/ajcn/nqaa233.
Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood Reprint Icon - (Peer Reviewed Journal)
Zheng, Y., Huang, T., Want, T., Mei, Z., Sun, Z., Zhang, T., Ellervik, C., Chai, J., Sim, X., Van Dam, R.M., Tai, E., Koh, W., Dorajoo, R., Saw, S., Sabanayagam, C., Wong, T., Gupta, P., Rossing, P., Ahluwalia, T.S., Vinding, R.K., Bisgaard, H., Bonnelykke, K., Wang, Y., Graff, M., Voortman, T., Van Rooij, F., Hofman, A., Van Heemst, D., Noordam, R., Estampador, A.C., Varga, T.V., Enzenback, C., Scholz, M., Theiry, J., Burkhardt, R., Orho-Melander, M., Schulz, C.A., Ericson, U., Sonestedt, E., Kubo, M., Akiyama, M., Zhou, A., Kilpelainen, T.O., Hansen, T., Kleber, M.E., Dalgado, G., McCarthy, M., Lemaitre, R., Feliz, J.F., Jaddoe, V.W., Wu, Y., Mohlke, K.L., Lehtimaki, T., Wang, C.A., Pennell, C.E., Schunkert, H., Kessler, T., Zeng, L., Willenborg, C., Peters, A., Lieb, W., Grote, V., Rzehak, P., Koletzko, B., Erdmann, J., Munz, M., Wu, T., He, M., Yu, C., Lecoeur, C., Froguel, P., Corella, D., Moreno, L., Lai, C., Pitkanen, N., Boreham, C.A., Ridker, P.M., Rosendaal, F., de Mutsert, R., Power, C., Paternoster, L., Sorensen, T.I., Tjonneland, A., Overvad, K., Djousse, L., Rivadeneira, F., Lee, N.R., Raitakari, O., Kahonen, M., Viikari, J., Langhendries, J., Escribano, J., Verduci, E., Dedoussis, G., Coltell, O., Ordovas, J.M., Qi, L. 2020. Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood. European Journal of Epidemiology. 35:685-697. https://doi.org/10.1007/s10654-020-00638-z.
Metabolomic links between sugar-sweetened beverage intake and obesity Reprint Icon - (Peer Reviewed Journal)
Zhou, B., Ichikawa, R., Parnell, L.D., Noel, S.E., Zhang, X., Bhupathiraju, S., Smith, C., Tucker, K.L., Ordovas, J.M., Lai, C. 2020. Metabolomic links between sugar-sweetened beverage intake and obesity. Journal of Obesity. https://doi.org/10.1155/2020/7154738.
Salivary AMY1 copy number variation modifies age-related type 2 diabetes risk Reprint Icon - (Peer Reviewed Journal)
Liu, Y., Smith, C.E., Parnell, L.D., Lee, Y., An, P., Straka, R.J., Tiwari, H.K., Wood, A.C., Kabagame, E.K., Hopkins, P., Province, M., Arnett, D.K., Tucker, K., Ordovas, J.M., Lai, C. 2020. Salivary AMY1 copy number variation modifies age-related type 2 diabetes risk. Clinical Chemistry. 66(5):718-726. https://doi.org/10.1093/clinchem/hvaa072.
Plasma metabolomic signatures of the American Heart Association diet score: findings from the Boston Puerto Rican Health Study Reprint Icon - (Abstract Only)
Haslam, D., Li, J., Liang, L., Clish, C., Lichtenstein, A.H., Lai, C., Ordovas, J.M., Manson, J.E., Wittenbecher, C., Hu, F.B., Qi, Q., Tucker, K.L., Bhupathiraju, S.N. 2020. Plasma metabolomic signatures of the American Heart Association diet score: findings from the Boston Puerto Rican Health Study. Circulation. 141:Abstract 52. https://doi.org/10.1161/circ.141.suppl_1.52.
Mediterranean diet adherence modulates anthropometric measures by TCF7L2 genotypes among Puerto Rican adults Reprint Icon - (Peer Reviewed Journal)
Sotos-Prieto, M., Smith, C.E., Lai, C., Tucker, K.L., Ordovas, J.M., Mattei, J. 2019. Mediterranean diet adherence modulates anthropometric measures by TCF7L2 genotypes among Puerto Rican adults. Journal of Nutrition. 150(1):167-175. https://doi.org/10.1093/jn/nxz210.
Association of birth weight with type 2 diabetes and glycemic traits: A Mendelian randomization study Reprint Icon - (Peer Reviewed Journal)
BIRTH-GENE (BIG) Study Working Group. 2019. Association of birth weight with type 2 diabetes and glycemic traits: A Mendelian randomization study. JAMA Network Open. 2(9):e1910915. https://doi.org/10.1001/jamanetworkopen.2019.10915.
A genome-wide association study identifies blood disorder-related variants influencing hemoglobin A1c with implications for glycemic status in U.S. Hispanics/Latinos Reprint Icon - (Peer Reviewed Journal)
Moon, J., Louie, T., Jain, D., Sofer, T., Schurmann, C., Below, J.E., Lai, C., Aviles-Santa, M., Talavera, G.A., Smith, C.E., Petty, L.E., Bottinger, E.P., Chen, Y.I., Taylor, K.D., Daviglus, M.L., Cai, J., Wang, T., Tucker, K.L., Ordovas, J.M., Hanis, C.L., Loos, R.J., Schneiderman, N., Rotter, J.I., Kaplan, R.C., Qi, Q. 2019. A genome-wide association study identifies blood disorder-related variants influencing hemoglobin A1c with implications for glycemic status in U.S. Hispanics/Latinos. Diabetes Care. 42(8). https://doi.org/10.2337/dc19-0168.
Development of a genetic score to predict an increase in HDL cholesterol concentration after a dietary intervention in adults with metabolic syndrome Reprint Icon - (Peer Reviewed Journal)
Guevara-Cruz, M., Medina-Vera, I., Flores-Lopez, A., Aguilar-Lopez, M., Smith, C.E., Parnell, L.D., Lee, Y., Lai, C., Tovar, A.R., Ordovas, J.M., Torres, N. 2019. Development of a genetic score to predict an increase in HDL cholesterol concentration after a dietary intervention in adults with metabolic syndrome. Journal of Nutrition. https://doi.org/10.1093/jn/nxz060.
Curcumin supplementation increases survival and lifespan in Drosophila under heat stress conditions Reprint Icon - (Peer Reviewed Journal)
Chen, Y., Liu, X., Jiang, C., Liu, L., Ordovas, J.M., Lai, C., Shen, L. 2018. Curcumin supplementation increases survival and lifespan in Drosophila under heat stress conditions. Biofactors. 44(6):577-587. https://doi.org/10.1002/biof.1454.
Dietary epicatechin improves survival and skeletal muscle function in aged mice Reprint Icon - (Peer Reviewed Journal)
Si, H., Wang, X., Zhang, L., Parnell, L.D., Admed, B., Leroith, T., Ansah, T., Zhang, L., Ordovas, J.M., Liu, D., Lai, C. 2018. Dietary epicatechin improves survival and skeletal muscle function in aged mice. Journal of Federation of American Societies for Experimental Biology. https://doi.org/10.1096/fj.201800554RR.
Long-term consumption of a Mediterranean diet improves postprandial lipemia in patients with type 2 diabetes: the Cordioprev randomized trial Reprint Icon - (Peer Reviewed Journal)
Gomez-Marin, B., Gomez-Delgado, F., Lopez-Moreno, J., Alcala-Diaz, J.F., Jimenez-Lucena, R., Torres-Pena, J.D., Garcia-Rios, A., Ortiz-Morales, A.M., Yubero-Serrano, E.M., Malagon, M., Lai, C., Delgado-Lista, J., Ordovas, J.M., Lopez-Miranda, J., Perez-Martinez, P. 2018. Long-term consumption of a Mediterranean diet improves postprandial lipemia in patients with type 2 diabetes: the Cordioprev randomized trial. American Journal of Clinical Nutrition. 108:963-970. https://doi.org/10.1093/ajcn/nqy144.
Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. - (Peer Reviewed Journal)
Lai, C., Smith, C.E., Parnell, L.D., Lee, Y., Corella, D., Hopkins, P., Hidalgo, B.A., Aslibekyan, S., Province, M.A., Absher, D.M., Arnett, D.K., Tucker, K.L., Ordovas, J.M. 2018. Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. American Journal of Clinical Nutrition. 108:188-200.
Weight gain prevention buffers the impact of CETP rs3764261 on high density lipoprotein cholesterol in young adulthood: the Study of Novel Approaches to Weight Gain Prevention (SNAP) Reprint Icon - (Peer Reviewed Journal)
McCaffery, J.M., Ordovas, J.M., Huggins, G.S., Lai, C., Espeland, M.A., Tate, D.F., Wing, R.R. 2018. Weight gain prevention buffers the impact of CETP rs3764261 on high density lipoprotein cholesterol in young adulthood: the Study of Novel Approaches to Weight Gain Prevention (SNAP). Nutrition Metabolism and Cardiovascular Disease. 28(8):816-821. https://doi.org/10.1016/j.numecd.2018.02.018.
Transethnic evaluation identifies low-frequency loci associated with 25-hydroxyvitamin D concentrations Reprint Icon - (Peer Reviewed Journal)
Hong, J., Hatchell, K.E., Bradfield, J.P., Bjonnes, A., Chesi, A., Lai, C., Langefeld, C.D., Lu, L., Lu, Y., Lutsey, P.L., Musani, S.K., Nalls, M.A., Robinson-Cohen, C., Roizen, J.D., Saxena, R., Tucker, K.L., Ziegler, J.T., Arking, D.E., Bis, J.C., Boerwinkle, E., Bottinger, E.P., Bowden, D.W., Gilsanz, V., Houston, D.K., Kalkwarf, H.J., Kelly, A., Lappe, J.M., Liu, Y., Michos, E.D., Oberfield, S.E., Palmer, N.D., Rotter, J.I., Sapkota, B., Shepherd, J.A., Wilson, J.G., Basu, S., De Boer, I.H., Divers, J., Freedman, B.I., Grant, S.F., Hakanarson, H., Harris, T.B., Kestenbaum, B.R., Kritchevsky, S.B., Loos, R.J., Norris, J.M., Norwood, A.F., Ordovas, J.M., Pankow, J.S., Psaty, B.M., Sanghera, D.K., Wagenknecht, L.E., Zemel, B.S., Meigs, J., Dupius, J., Florez, J.C., Wang, T.J., Liu, C., Engelman, C.D., Billings, L.K. 2018. Transethnic evaluation identifies low-frequency loci associated with 25-hydroxyvitamin D concentrations. Journal of Clinical Endocrinology and Metabolism. 103(4):1380-1392. https://doi.org/10.1210/jc.2017-01802.
Dairy consumption and body mass index among adults: Mendelian randomization analysis of 184802 individuals from 25 studies Reprint Icon - (Peer Reviewed Journal)
Huang, T., Ding, M., Bergholdt, H.K., Wang, T., Heianza, Y., Sun, D., Frazier-Wood, A.C., Aslibekyan, S., North, K.E., Voortman, T., Graff, M., Smith, C., Lai, C., Varbo, A., Lemaitre, R.N., De Jonge, M.A., Fumeron, F., Corella, D., Wang, C.A., Tjønneland, A., Overvad, K., Sørensen, T.I., Feitosa, M.F., Wojczynski, M.K., Kähönen, M., Renström, F., Psaty, B.M., Siscovick, D.S., Barroso, I., Johansson, I., Hernandez, D., Ferrucci, L., Bandinelli, S., Linneberg, A., Zillikens, M., Sandholt, C., Pederson, O., Hansen, T., Schulz, C.A., Sonestedt, E., Orho-Melander, M., Chen, T., Rotter, J.I., Allison, M.A., Rich, S.S., Sorli, J.V., Coltell, O., Pennell, C.E., Eastwood, P., Hofman, A., Uitterlinden, A.G., Van Rooij, F.J., Chu, A.Y., Rose, L.M., Ridker, P.M., Viikari, J., Raitakari, O., Lehtimäki, T., Mikkilä, V., Willet, W.C., Wang, Y., Tucker, K.L., Ordovas, J.M., Kilpeläinen, T.O., Province, M.A., Franks, P.W., Arnett, D.K., Tanaka, T., Toft, U., Ericson, U., Franco, O.H., Mazaffarian, D., Hu, F.B., Chasman, D.I., Nordestgaard, B.G., Ellervik, C., Qi, L. 2018. Dairy consumption and body mass index among adults: Mendelian randomization analysis of 184802 individuals from 25 studies. Clinical Chemistry. 64(1):183-191. https://doi.org/10.1373/clinchem.2017.280701.
Environmental and epigenetic regulation of postprandial lipemia - (Peer Reviewed Journal)
Lai, C., Ordovas, J.M., Parnell, L.D. 2018. Environmental and epigenetic regulation of postprandial lipemia. Current Opinion in Lipidology. 29(1):30-35.
Sex differences in blood HDL-c, the total cholesterol/HDL-c ratio, and palmitoleic acid are not associated with variants in common candidate genes Reprint Icon - (Peer Reviewed Journal)
Klingel, S.L., Roke, K., Hidalgo, B., Aslibekyan, S., Straka, R.J., An, P., Province, M.A., Hopkins, P.N., Arnett, D.K., Ordovas, J.M., Lai, C., Mutch, D.M. 2017. Sex differences in blood HDL-c, the total cholesterol/HDL-c ratio, and palmitoleic acid are not associated with variants in common candidate genes. Lipids. 52(12):969-980. https://doi.org/10.1007/s11745-017-4307-5.
Genome-wide interactions with dairy intake for body mass index in adults of European descent Reprint Icon - (Peer Reviewed Journal)
Smith, C.E., Follis, J.L., Dashti, H., Tanaka, T., Graff, M., Fretts, A.M., Kilpelainen, T., Wojczynski, M., Richardson, K., Nalls, M., Schulz, C.N., Liu, Y., Frazier-Wood, A., Van Eekelen, E., Wang, C., De Vries, P.S., Mikkila, V., Rohde, R., Psaty, B.M., Hansen, T., Feitosa, M.F., Lai, C., Houston, D.K., Ferrucci, L., Ericson, U., Wang, Z., De Mutsert, R., Oddy, W.H., De Jonge, E.A., Seppala, I., Justice, A.E., Lemaitre, R.N., Sorensen, T.I., Province, M.A., Parnell, L.D., Garcia, M.E., Bandinelli, S., Orho-Melander, M., Rich, S.S., Rosendaal, F.R., Pennell, C.E., Kiefte-Dejong, J.C., Kahonen, M., Young, K.L., Pederesen, O., Aslibekyan, S., Rotter, J.I., Mook-Kanamori, D.O., Zillikens, M.C., Raitakari, O.T., North, K.E., Overvad, K., Arnett, D.K., Hofman, A., Lehtimaki, T., Tjonneland, A., Uitterlinden, A.G., Rivadeneira, F., Franco, O.H., German, J., Siscovick, D.S., Cupples, L.A., Ordovas, J.M. 2017. Genome-wide interactions with dairy intake for body mass index in adults of European descent. Molecular Nutrition and Food Research. https://doi.org/10.1002/mnfr.201700347.
Dairy consumption, systolic blood pressure, and risk of hypertension: Mendelian randomization study - (Peer Reviewed Journal)
Ding, M., Huang, T., Bergholdt, H.K., Frazier Wood, A.C., Aslibekyan, S., North, K.E., Voortman, T., Graff, M., Smith, C.E., Lai, C., Varbo, A., Lemaitre, R.N., De Jonge, E.A., Fumeron, F., Corella, D., Wang, C.A., Tjonneland, A., Overvad, K., Sorensen, T.I., Feitosa, M.F., Wojczynski, M.K., Kahonen, M., Ahmad, S., Trndytom, F., Psaty, B.M., Siscovick, D.S., Barroso, I., Johansson, I., Hernandez, D.G., Ferrucci, L., Bandinelli, S., Linneberg, A., Sandholt, C.H., Pedersen, O., Hansen, T., Schulz, C., Sonestedt, E., Orho-Melander, M., Chen, T., Rotter, J.I., Allison, M.A., Rich, S.S., Sorli, J.V., Coltell, O., Pennell, C.E., Eastwood, P., Hofman, A., Uitterlinden, A.G., Zillikens, M., Van Rooij, F.J., Chu, A.Y., Rose, L.M., Ridker, P.M., Viikari, J., Raitakara, O., Lehtimaki, T., Mikkila, V., Willett, W.C., Wang, Y., Tucker, K.L., Ordovas, J.M., Kilpelainen, T.O., Province, M.A., Franks, P.W., Arnett, D.K., Tanaka, T., Toft, U., Ericson, U., Franco, O.H., Mozaffarian, D., Hu, F.B., Chasman, D.I., Nordestgaard, B.G., Ellervik, C., Qi, L. 2017. Dairy consumption, systolic blood pressure, and risk of hypertension: Mendelian randomization study. British Medical Journal. doi: 10.1136/bmj.j1000.
Epigenome-wide association study of triglyceride postprandial responses to high-fat dietary challenge in the Genetics of Lipid Lowering Drugs and Diet Network study - (Peer Reviewed Journal)
Lai, C., Wojczynski, M.K., Parnell, L.D., Hidalgo, B., Irvin, M.R., Aslibekyan, S., Province, M.A., Devin, A., Arnett, D.K., Ordovas, J. 2016. Epigenome-wide association study of triglyceride postprandial responses to high-fat dietary challenge in the Genetics of Lipid Lowering Drugs and Diet Network study. Journal of Lipid Research. 57:2200-2207.
Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization - (Peer Reviewed Journal)
Smith, C.E., Coltell, O., Sorli, J.V., Estruch, R., Martinez-Gonzalez, M., Salas-Salvado, J., Fito, M., Aros, F., Dashti, H.S., Lai, C., Miro, L., Serra-Majem, L., Gomez-Gracia, E., Fiol, M., Ros, E., Aslibekyan, S., Hidalgo, B., Neuhouser, M., Di, C., Tucker, K., Arnett, D.K., Ordovas, J.M., Corella, D. 2016. Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization. Scientific Reports. doi: 10.1038/srep33188.
Genetic admixture and body composition in Puerto Rican adults from the Boston Puerto Rican osteoporosis study - (Peer Reviewed Journal)
Noel, S.E., Arevalo, S., Smith, C.E., Lai, C., Dawson-Hughes, B., Ordovas, J.M., Tucker, K.T. 2016. Genetic admixture and body composition in Puerto Rican adults from the Boston Puerto Rican Osteoporosis Study. Journal of Bone and Mineral Research. doi: 10.1007/s00774-016-0775-6.
Supplementation with major royal jelly proteins increases lifespan, feeding and fecundity in Drosophila - (Peer Reviewed Journal)
Xin, X., Chen, Y., Chen, D., Xiao, F., Parnell, L.D., Zhao, J., Liu, L., Ordovas, J.M., Lai, C., Shen, L. 2016. Supplementation with major royal jelly proteins increases lifespan, feeding and fecundity in Drosophila. Journal of Agricultural and Food Chemistry. 64(29):5803–5812. doi: 10.1021/acs.jafc.6b00514.
Interaction of an S100A9 gene variant with saturated fat and carbohydrates to modulate insulin resistance in 3 populations of different ancestries - (Peer Reviewed Journal)
Blanco-Rojo, R., Delgado-Lista, J., Lee, Y., Lai, C., Perez-Martinez, P., Rangel-Zuniga, O., Smith, C.E., Hidalgo, B., Alcala-Diaz, J.F., Gomez-Delgado, F., Parnell, L.D., Arnett, D.K., Tucker, K.L., Lopez-Miranda, J., Ordovas, J.M. 2016. Interaction of an S100A9 gene variant with saturated fat and carbohydrates to modulate insulin resistance in 3 populations of different ancestries. American Journal of Clinical Nutrition. 104:508–517.
The omega-3 index is inversely associated with depressive symptoms among individuals with elevated oxidative stress biomarkers - (Peer Reviewed Journal)
Bigornia, S.J., Harris, W.S., Falcon, L.M., Ordovas, J.M., Lai, C., Tucker, K.L. 2016. The omega-3 index is inversely associated with depressive symptoms among individuals with elevated oxidative stress biomarkers. Journal of Nutrition. 146(4):758-766. doi: 10.3945/jn.115.222562.
Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies & methylation analysis of 3 studies in the Cohorts for Heart & Aging Research - (Peer Reviewed Journal)
Ma, Y., Follis, J., Smith, C.E., Tanaka, T., Manichaikl, A., Chu, A.Y., Samieri, C., Zhou, X., Guan, W., Wang, L., Biggs, M., Chen, Y., Hernandez, D., Borecki, I.B., Chasman, D.I., Rich, S.S., Ferrucci, L., Irvin, M.R., Aslibekyan, S., Zhi, D., Tiwari, H.K., Claas, S.A., Sha, J., Kabagambe, E.K., Lai, C., Parnell, L.D., Lee, Y., Amouyel, P., Lambert, J., Psaty, B.M., King Irena, Mozaffarian, D., Mcknight, B., Bandinelli, S., Tsai, M.Y., Ridker, P.M., Ding, J., Mstat, K.L., Liu, Y., Sotoodehnia, N., Barberger-Gateau, P., Steffen, L.M., Siscovick, D.S., Absher, D.M., Arnett, D.K., Ordovas, J.M., Lemaitre, R.N. 2016. Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies & methylation analysis of 3 studies in the Cohorts for Heart & Aging Research. American Journal of Clinical Nutrition. doi: 10.3945/ajcn.115.112987.
Functional genomics analysis of big data identifies novel PPARy target SNPs showing association with cardio metabolic outcomes - (Peer Reviewed Journal)
Richardson, K., Schnitzler, G.R., Lai, C., Ordovas, J.M. 2015. Functional genomics analysis of big data identifies novel PPARy target SNPs showing association with cardio metabolic outcomes. Circulation: Cardiovascular Genetics. 8(6):842-851.
Functional genomics analysis of big data identifies novel peroxisome proliferator–activated receptor gamma target single nucleotide polymorphisms showing association with cardiometabolic outcomes - (Peer Reviewed Journal)
Richardson, K., Schnitzler, G.R., Lai, C., Ordovas, J.M. 2015. Functional genomics analysis of big data identifies novel peroxisome proliferator–activated receptor gamma target single nucleotide polymorphisms showing association with cardiometabolic outcomes. Circulation: Cardiovascular Genetics. 8:842-851. doi: 10.1161/CIRCGENETICS.115.001174.
Genetic variant modifies the effect of N3 PUFAs on DNA methylation of IL6 in the Genetics of Lipid Lowering Drugs and Diet Network study - (Peer Reviewed Journal)
Ma, Y., Smith, C.E., Lai, C., Invin, R.M., Parnell, L.D., Lee, Y., Pham, L., Aslibekyan, S., Claas, S.A., Tsai, M.Y., Borecki, I.B., Kabagambe, E.K., Ordovas, J.M., Absher, D., Donna, A.K. 2016. Genetic variant modifies the effect of N3 PUFAs on DNA methylation of IL6 in the Genetics of Lipid Lowering Drugs and Diet Network study. Epigenetics. doi: 10.1002/mnfr.201500436.
The effects of omega-3 polyunsaturated fatty acids and genetic variants on methylation levels of the interleukin-6 gene promoter - (Peer Reviewed Journal)
Ma, Y., Smith, C.E., Lai, C., Irvin, M.R., Parnell, L.D., Lee, Y., Pham, L.D., Aslibekyan, S., Claas, S.A., Tsai, M.Y., Borecki, I.B., Kagambe, E.K., Ordovas, J.M., Absher, D., Arnett, D.K. 2016. The effects of omega-3 polyunsaturated fatty acids and genetic variants on methylation levels of the interleukin-6 gene promoter. Epigenetics. 60(2):410-419. doi: 10.1002/mnfr.201500436.
Genetics and gene-environment interactions on longevity and lifespan - (Book / Chapter)
Lai, C., Ma, Y., Parnell, L.D. 2016. Genetics and gene-environment interactions on longevity and lifespan. In: Qi, L., Editor. Gene-Environment Interactions and Human Diseases. Hauppauge, NY: Nova Science Publishers, Inc. p. 245-264.
Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians - (Peer Reviewed Journal)
Fretts, A.M., Follis, J.L., Nettleton, J.A., Lemaitre, R.N., Ngwa, J.S., Wojczynski, M.K., Kalafati, I.P., Varga, T.V., Frazier-Wood, A.C., Houston, D.K., Lahti, J., Ericson, U., Van Den Hooven, E.H., Mikkila, V., Kiefte-De Jong, J.C., Mozaffarian, D., Rice, K., Renstrom, F., North, K.E., Mckeown, N.M., Feitosa, M.F., Kanoni, S., Smith, C.E., Garcia, M.E., Tiainen, A., Sonestedt, E., Manichaikul, A., Van Rooij, F.A., Dimitrious, M., Raitakara, O., Pankow, J.S., Djousse, L., Province, M.A., Hu, F.B., Lai, C., Keller, M.F., Perala, M., Rotter, J.I., Hofman, A., Graff, M., Kahonen, M., Mukamal, K., Johansson, I., Ordovas, J.M., Liu, Y., Mannisto, S., Utterlinden, A.G., Deloukas, P., Seppala, I., Psaty, B.M., Cupples, L.A., Borecki, I.B., Franks, P.W., Arnett, D.K., Nalls, M.A., Eriksson, J.G., Orho-Melander, M., Franco, O.H., Lehtimaki, T., Dedoussis, G.V., Meigs, J.B., Siscovick, D.S. 2015. Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians. American Journal of Clinical Nutrition. 102:1266-1278. doi:10.3975/ajcn.114.101238.
Genome-wide association study of triglyceride response to a high-fat meal among participants of the NHLBI genetics of lipid lowering drugs and diet network (GOLDN) - (Peer Reviewed Journal)
Wojczynski, M.K., Parnell, L.D., Pollin, T.I., Lai, C., Feitosa, M.F., O'Connel, J.R., Frazier-Wood, A.C., Gibson, Q., Aslibkeyan, S., Ryan, K.A., Province, M.A., Tiwari, H.K., Ordovas, J.M., Shuldiner, A.R., Arnett, D.K., Borecki, I.B. 2015. Genome-wide association study of triglyceride response to a high-fat meal among participants of the NHLBI genetics of lipid lowering drugs and diet network (GOLDN). Metabolism. 64:1359-1371.
Clock genes explain large proportion of phenotypic variance in systolic blood pressure and this control is not modified by environmental temperature - (Peer Reviewed Journal)
Dashti, H., Aslibekyan, S., Smith, C.E., Lamon-Fava, S., Lai, C., Arnett, D.K., Scheer, F., Jacques, P.F., Tucker, K.L., Ordovas, J.M. 2016. Clock genes explain large proportion of phenotypic variance in systolic blood pressure and this control is not modified by environmental temperature. American Journal of Hypertension. 29(1):132-140.
Genetic variants modify the effect of age on APOE methylation in the Genetics of Lipid Lowering Drugs and Diet Network study - (Peer Reviewed Journal)
Ma, Y., Smith, C.E., Lai, C., Irvin, M.R., Parnell, L.D., Pham, L., Aslibekyan, S., Claas, S.A., Tsai, M.Y., Borecki, I.B., Kabagambe, E.K., Berciano, S., Ordovas, J.M., Absher, D.M. 2014. Genetic variants modify the effect of age on APOE methylation in the Genetics of Lipid Lowering Drugs and Diet Network study. Aging Cell. 14:49-59.
Genome-wide interaction of genotype by erythrocyte n-3 PUFAs contributes to phenotypic variance of diabetes-related traits Reprint Icon - (Peer Reviewed Journal)
Ordovas, J., Lai, C., Parnell, L.D., Lee, Y., Shen, J., Smith, C.E., Richardson, K., Li, D., Arnett, D.K., Borecki, I.B., Zheng, J. 2014. Genome-wide interaction of genotype by erythrocyte n-3 PUFAs contributes to phenotypic variance of diabetes-related traits. Biomed Central (BMC) Genomics. 15:781. https://doi.org/10.1186/1471-2164-15-781.
Dietary modulators of statin efficacy in cardiovascular disease and cognition - (Review Article)
Wang, H., Blumberg, J.B., Chen, C., Choi, S., Corcoran, M.P., Harris, S.S., Jacques, P.F., Kristo, A.S., Lai, C., Lamon-Fava, S., Matthan, N.R., Mckay, D.L., Meydani, M., Parnell, L.D., Prokopy, M.P., Scott, T.M., Lichtenstein, A.H. 2014. Dietary modulators of statin efficacy in cardiovascular disease and cognition. Molecular Aspects of Medicine. 38:1-53.
Genome-wide association studies identified novel loci for non-high-density lipoprotein cholesterol and its postprandial lipemic response - (Peer Reviewed Journal)
An, P., Straka, R.J., Pollin, T.I., Feitosa, M.F., Wojczynski, M.K., Daw, E., O'Connell, J.R., Gibson, Q., Ryan, K.A., Hopkins, P.N., Tsai, M.Y., Lai, C., Province, M.A., Ordovas, J.M., Shuldiner, A.R., Arnett, D.K., Borecki, I.B. 2014. Genome-wide association studies identified novel loci for non-high-density lipoprotein cholesterol and its postprandial lipemic response. Human Genetics. DOI: 10.1007/s00439-014-1435-3.
Lipoprotein lipase variants interact with polyunsaturated fatty acids to modulate obesity traits in Puerto Ricans - (Abstract Only)
Ma, Y., Tucker, K.L., Smith, C.E., Lee, Y., Huang, T., Lai, C., Parnell, L.D., Richardson, K., Ordovas, J.M. 2014. Lipoprotein lipase variants interact with polyunsaturated fatty acids to modulate obesity traits in Puerto Ricans. Journal of Federation of American Societies for Experimental Biology. 28:1037.7.
CRY1 circadian gene variant interacts with carbohydrate intake for insulin resistance in two independent populations: Mediterranean and North American - (Peer Reviewed Journal)
Dashti, H.S., Smith, C.E., Lee, Y., Parnell, L.D., Lai, C., Arnett, D.K., Ordovas, J.M., Garaulet, M. 2014. CRY1 circadian gene variant interacts with carbohydrate intake for insulin resistance in two independent populations: Mediterranean and North American. Chronobiology International. 31(5):660-668. DOI: 10.3109/07420528.2014.886587.
Integrating nutrigenomics data to identify cardiometabolic gene-environment interactions - (Proceedings)
Parnell, L.D., Lee, Y., Dashti, H., Ma, Y., Pham, L., Sloan, S., Smith, C.E., Richardson, K., Lai, C., Ordovas, J.M. 2013. Integrating nutrigenomics data to identify cardiometabolic gene-environment interactions. Meeting Abstract. p.1 Abstract #5.
Circulating 25-hydroxyvitamin D, IRS1 variant rs2943641 and insulin resistance: replication of a gene-nutrient interaction in four populations of different ancestries - (Peer Reviewed Journal)
Apolipoprotein A2 polymorphism interacts with intakes of dairy foods to influence body weight in 2 U.S. populations - (Peer Reviewed Journal)
Smith, C.E., Tucker, K.L., Arnett, D.K., Noel, S.E., Corella, D., Borecki, I.B., Feitosa, M.F., Aslibekyan, S., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2013. Apolipoprotein A2 polymorphism interacts with intakes of dairy foods to influence body weight in 2 U.S. populations. Journal of Nutrition. 143(12):1865-1871.
Quantifying diet for nutrigenomic studies - (Review Article)
Tucker, K.L., Smith, C.E., Lai, C., Ordovas, J.M. 2013. Quantifying diet for nutrigenomic studies. Annual Review of Nutrition. 33:349-371.
Genetic variants at PSMD3 interact with dietary fat and carbohydrate to modulate insulin resistance - (Peer Reviewed Journal)
Zheng, J., Arnett, D., Parnell, L.D., Lee, Y., Ma, Y., Smith, C., Richardson, K., Li, D., Ordovas, J., Tucker, K., Lai, C., Borecki, I. 2013. Genetic variants at PSMD3 interact with dietary fat and carbohydrate to modulate insulin resistance. Journal of Nutrition. 143(3):354-361.
Curcumin and aging - (Review Article)
Shen, L., Parnell, L.D., Ordovas, J., Lai, C. 2013. Curcumin and aging. Biofactors. 39(1):133-140.
Genetic variants associated with VLDL, LDL and HDL particle size differ with race/ethnicity - (Peer Reviewed Journal)
Frazier-Wood, A.C., Manichaikul, A., Aslibekyan, S., Borecki, I.B., Goff, D.C., Hopkins, P.N., Lai, C., Ordovas, J.M., Post, W.S., Rich, S.S., Sale, M.M., Siscovick, D., Straka, R.J., Tiwari, H.K., Tsai, M.Y., Rotter, J.I., Arnett, D.K. 2013. Genetic variants associated with VLDL, LDL and HDL particle size differ with race/ethnicity. Human Genetics. 132(4):405-413.
Association between BDNF-rs6265 and obesity in the Boston Puerto Rican Health Study - (Peer Reviewed Journal)
Ma, X., Qiu, W., Smith, C., Parnell, L.D., Jiang, Z., Ordovas, J., Tucker, K., Lai, C. 2012. Association between BDNF-rs6265 and obesity in the Boston Puerto Rican Health Study. Journal of Obesity. DOI: 10.1155/2012102942.
Gain-of-function Lipoprotein Lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site - (Peer Reviewed Journal)
Richardson, K., Nettleton, J.A., Rotlan, N., Tanaka, T., Smith, C.E., Lai, C., Parnell, L.D., Lee, Y., Lahti, J., Lemaitre, R.N., Manichaikul, A., Keller, M., Mikkila, V., Ngwa, J., Van Rooij, F., Ballentyne, C.M., Borecki, I.B., Cupples, L., Garcia, M., Hofman, A., Ferrucci, L., Mozaffarian, D., Perala, M., Raitakari, O., Tracy, R.P., Arnett, D.K., Bandinelli, S., Boerwinkle, E., Eriksson, J.G., Franco, O.H., Kahonen, M., Nalls, M., Siscovick, D.S., Houston, D.K., Psaty, B.M., Viikari, J., Witteman, J., Goodarzi, M.O., Lehtimaki, T., Liu, Y., Zillikens, M., Chen, Y.I., Uitterlinden, A.G., Rotter, J.I., Fernandez-Hernando, C., Ordovas, J. 2013. Gain-of-function Lipoprotein Lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site. The American Journal of Human Genetics. 92(1):5-14.
Genetic analysis of 16 NMR-lipoprotein fractions in humans, the GOLDN study - (Peer Reviewed Journal)
Kraja, A.T., Borecki, I.B., Tsai, M.Y., Ordovas, J.M., Hopkins, P.N., Lai, C., Frazier-Wood, A.C., Straka, R.J., Hixson, J.E., Province, M.A. 2013. Genetic analysis of 16 NMR-lipoprotein fractions in humans, the GOLDN study. Lipids. 48(2):155-165.
Mechanism of action of recombinant Acc-royalisin from royal jelly of Chinese honeybee against gram-positive bacteria - (Peer Reviewed Journal)
Shen, L., Liu, D., Yang, X., Jin, F., Din, M., Parnell, L.D., Lai, C. 2012. Mechanism of action of recombinant Acc-royalisin from royal jelly of Chinese honeybee against gram-positive bacteria. PLoS One. 7(10):e47194 DOI: 10.1371/journal.pone.0047194.
Genome-wide association study indicates variants associated with insulin signaling and inflammation mediate lipoprotein responses to fenofibrate - (Peer Reviewed Journal)
Frazier-Wood, A.C., Aslibekyan, S., Borecki, I.B., Hopkins, P.N., Lai, C., Ordovas, J.M., Straka, R.J., Tiwari, H.K., Arnett, D.K. 2012. Genome-wide association study indicates variants associated with insulin signaling and inflammation mediate lipoprotein responses to fenofibrate. Pharmacogenetics and Genomics. 22(10):750-757.
Low density lipoprotein receptor related protein 1 variant interacts with saturated fatty acids in Puerto Ricans - (Peer Reviewed Journal)
Smith, C.E., Tucker, K.L., Lee, Y., Lai, C., Parnell, L.D., Ordovas, J.M. 2013. Low density lipoprotein receptor related protein 1 variant interacts with saturated fatty acids in Puerto Ricans. Obesity. 21:602-608.
Status of vitamin B-12 and B-6 but not of folate, homocysteine and the methylenetetrahydrofolate reductase C677T polymorphism are associated with impaired cognition and depression in adults - (Peer Reviewed Journal)
Moorthy, D., Inga, P., Scott, T.M., Parnell, L.D., Lai, C., Crott, J.W., Ordovas, J.M., Selhub, J., Griffith, J., Rosenberg, I.H., Tucker, K.L., Troen, A.M. 2012. Status of vitamin B-12 and B-6 but not of folate, homocysteine and the methylenetetrahydrofolate reductase C677T polymorphism are associated with impaired cognition and depression in adults. Journal of Nutrition. 142(8):1554-1560.
Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila - (Peer Reviewed Journal)
Shen, L., Xiao, F., Peng, Y., Chen, Y., Qi-Kang, G., Parnell, L.D., Meydani, M., Ordovas, J.M., Li, D., Lai, C. 2013. Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila. Journal of the American Aging Association (AGE). 35(4):1133-1142. DOI 10.1007/s11357-012-9438-2.
Aging is a more significant determinant of hepatic DNA methylation patterns than a western style diet - (Abstract Only)
Park, L.K., Saltzman, E., Schnitzler, G., Yoon, B., Parnell, L.D., Lai, C., Choi, S. 2012. Aging is a more significant determinant of hepatic DNA methylation patterns than a western style diet. Journal of Federation of American Societies for Experimental Biology. 2012(26):243.5.
Adaptive genetic variation and population differences - (Book / Chapter)
Lai, C. 2012. Adaptive genetic variation and population differences. In: Bouchard, C., Ordovas, J. M., editors. Recent Advances in Nutrigenetics and Nutrigenomics. Oxford, UK: Elsevier. 108:461-489. PMID.22656388.
The effect of CYP7A1 polymorphisms on lipid responses to fenofibrate - (Peer Reviewed Journal)
Shen, J., Arnett, D., Parnell, L.D., Lai, C., Straka, R., Hopkins, P., An, P., Feitosa, M., Ordovas, J. 2012. The effect of CYP7A1 polymorphisms on lipid responses to fenofibrate. Journal of Cardiovascular Pharmacology. 59(3):254-259.
A genome-wide survey for SNPs altering microRNA seed sites identifies functional candidates in GWAS - (Peer Reviewed Journal)
Richardson, K., Lai, C., Parnell, L.D., Lee, Y., Ordovas, J. 2011. A genome-wide survey for SNPs altering microRNA seed sites identifies functional candidates in GWAS. Biomed Central (BMC) Genomics. 2:504.
A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI - (Peer Reviewed Journal)
Corella, D., Arnett, D.K., Tucker, K.L., Kabagambe, E.K., Tsai, M.Y., Parnell, L.D., Lai, C., Lee, Y., Warodomwichit, D., Hopkins, P.N., Ordovas, J.M. 2011. A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI. Journal of Nutrition. 141(12):2219-2225.
A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network - (Peer Reviewed Journal)
Aslibekyan, S., Kabagambe, E.K., Irvin, M.R., Straka, R.J., Borecki, I.B., Tiwari, H.K., Tsai, M.Y., Hopkins, P.N., Shen, J., Lai, C., Ordovas, J.M., Arnett, D.K. 2012. A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network. Pharmacogenetics and Genomics. 22(3):191-197.
Apolipoprotein A1/C3/A5 haplotypes and serum lipid levels - (Peer Reviewed Journal)
Yin, R., Li, Y., Lai, C. 2011. Apolipoprotein A1/C3/A5 haplotypes and serum lipid levels. Lipids in Health and Disease. 10:140. DOI: 10.1186/1476-511X-10-140.
The PLIN4 variant rs8887 modulates obesity related phenotypes in humans through creation of a novel miR-522 seed site - (Peer Reviewed Journal)
Richardson, K., Louie-Gao, Q., Arnett, D., Parnell, L.D., Lai, C., Davalos, A., Fox, C., Demissie, S., Cupples, L., Fernandez-Hernando, C., Ordovas, J. 2011. The PLIN4 variant rs8887 modulates obesity related phenotypes in humans through creation of a novel miR-522 seed site. PLoS One. 6(4):e17944.
A database of gene-environment interactions pertaining to blood lipid traits, cardiovascular disease and type 2 diabetes - (Peer Reviewed Journal)
Lee, Y., Lai, C., Ordovas, J.M., Parnell, L.D. 2011. A database of gene-environment interactions pertaining to blood lipid traits, cardiovascular disease and type 2 diabetes. Journal of Data Mining in Genomics & Proteomics. 2:106. DOI:10.4172/2153-0602.1000106.
The folate hydrolase 1561 C>T polymorphism is associated with depressive symptoms in Puerto Rican adults - (Peer Reviewed Journal)
Ye, X., Lai, C., Crott, J., Troen, A., Ordovas, J., Tucker, K. 2011. The folate hydrolase 1561 C>T polymorphism is associated with depressive symptoms in Puerto Rican adults. Psychosomatic Medicine. 73(5):385-392.
Interactions between genetic variants of folate metabolism genes and lifestyle affect plasma homocysteine concentrations in the Boston Puerto Rican Population - (Peer Reviewed Journal)
Huang, T., Tucker, K., Lee, Y., Crott, J., Parnell, L.D., Shen, J., Smith, C., Ordovas, J., Li, D., Lai, C. 2011. Interactions between genetic variants of methionine metabolism genes and lifestyle affect plasma homocysteine concentrations in the Boston Puerto Rican Population. Molecular Nutrition and Food Research. DOI: 10.1017/S1368980011000140.
Modulation of gene expression by alpha-tocopherol and alpha-tocopheryl phosphate in thp-1 monocytes - (Peer Reviewed Journal)
Zingg, J., Libinaki, R., Lai, C., Meydani, M., Gianello, R., Ogru, E., Azzi, A. 2010. Modulation of gene expression by alpha-tocopherol and alpha-tocopheryl phosphate in thp-1 monocytes. Journal of Free Radical Biology and Medicine. 49:1989-2000.
Perilipin polymorphism interacts with saturated fat and carbohydrates to modulate insulin resistance - (Peer Reviewed Journal)
Smith, C.E., Arnett, D.K., Corella, D., Tsai, M.Y., Lai, C., Parnell, L.D., Lee, Y., Ordovas, J.M. 2012. Perilipin polymorphism interacts with saturated fat and carbohydrates to modulate insulin resistance. Nutrition, Metabolism and Cardiovascular Diseases. 22(5):449-455.
Gene variations of nitric oxide synthase regulate the effects of a saturated fat rich meal on endothelial function - (Peer Reviewed Journal)
Delgado-Lista, J., Fuentes, F., Jimenez-Gomez, Y., Perez-Martinez, P., Gomez-Luna, M.J., Parnell, L.D., Marin, C., Lai, C., Perez-Jimenez, F., Ordovas, J.M., Lopez-Miranda, J. 2010. Gene variations of nitric oxide synthase regulate the effects of a saturated fat rich meal on endothelial function. Clinical Nutrition. 30(2):234-238.
Apolipoprotein B genetic variants modify the response to fenofibrate: a GOLDN study - (Peer Reviewed Journal)
Wojczynski, M.K., Gao, G., Borecki, I., Hopkins, P.N., Parnell, L.D., Lai, C., Ordovas, J.M., Arnett, D.K. 2010. Apolipoprotein B genetic variants modify the response to fenofibrate: a GOLDN study. Journal of Lipid Research. 51(11):3316-3323.
MAT1A variants modulate the effect of dietary fatty acids on plasma homocysteine concentrations and DNA damage - (Peer Reviewed Journal)
Huang, T., Tucker, K., Lee, Y., Crott, J., Parnell, L.D., Shen, J., Smith, C.E., Ordovas, J.M., Li, D., Lai, C. 2010. MAT1A variants modulate the effect of dietary fatty acids on plasma homocysteine concentrations and DNA damage. Nutrition, Metabolism and Cardiovascular Diseases. DOI: 1016/j.numecd.2010.07.015.
Drosophila lacks C20 and C22 polyunsaturated fatty acids - (Peer Reviewed Journal)
Shen, L., Lai, C., Feng, X., Parnell, L.D., Wang, J., Li, D., Ordovas, J.M., Kang, J. 2010. Drosophila lacks C20 and C22 polyunsaturated fatty acids. Journal of Lipid Research. 51(10)2985-2992.
Urinary 8-hydroxy-2-deoxyguanosine and cognitive function in Puerto Rican adults - (Peer Reviewed Journal)
Gao, X., Lai, C., Scott, T., Shen, J., Cai, T., Ordovas, J.M., Tucker, K. 2010. Urinary 8-hydroxy-2-deoxyguanosine and cognitive function in Puerto Rican adults. American Journal of Epidemiology. 172(3):271-278.
Effect variants of the CD36 gene and metabolic syndrome in Boston Puerto Rican adults - (Peer Reviewed Journal)
Noel, S.E., Lai, C., Mattei, J., Parnell, L.D., Ordovas, J., Tucker, K.L. 2010. Effect variants of the CD36 gene and metabolic syndrome in Boston Puerto Rican adults. Atherosclerosis. 211(1):210-215.
MAT1A variants are associated with hypertension, stroke, and DNA damage and are modulated by vlasma vitamin B6 and folate concentration - (Peer Reviewed Journal)
Lai, C., Tucker, K., Parnell, L.D., Shen, J., Caouette, H., Warodomwichit, D., Lee, Y., Crott, J., Ordovas, J.M. 2010. MAT1A variants are associated with hypertension, stroke, and DNA damage and are modulated by plasma vitamin B6 and folate concentration. American Journal of Clinical Nutrition. 91(5):1377-1386.
Expression of recombinant AccMRJP1 protein from royal jelly of Chinese honeybee in Pichia pastoris and its proliferation activity in an insect cell line - (Peer Reviewed Journal)
Shen, L., Zhang, W., Jin, F., Zhang, L., Chen, Z., Liu, L., Parnell, L.D., Lai, C., Li, D. 2010. Expression of recombinant AccMRJP1 protein from royal jelly of Chinese honeybee in Pichia pastoris and its proliferation activity in an insect cell line. Journal of Agricultural and Food Chemistry. 58(4):2266-2273.
Adaptive genetic variation and heart disease risk - (Review Article)
Parnell, L.D., Lee, Y., Lai, C. 2010. Adaptive genetic variation and heart disease risk. Current Opinion in Lipidology. 21(2):116-122.
Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study - (Peer Reviewed Journal)
Shen, J., Lai, C., Mattei, J., Ordovas, J.M., Tucker, K.L. 2010. Association of vitamin B-6 status with inflammation, oxidative stress, and chronic inflammatory conditions: the Boston Puerto Rican Health Study. American Journal of Clinical Nutrition. 91(2):337-342.
CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids - (Peer Reviewed Journal)
Garaulet, M., Lee, Y., Shen, J., Parnell, L.D., Arnett, D.K., Tsai, M.Y., Lai, C., Ordovas, J.M. 2009. CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids. American Journal of Clinical Nutrition. 90(6):1466-1475.
Genetic variants in human CLOCK associate with total energy intake and cytokine sleep factors - (Peer Reviewed Journal)
Garaulet, M., Lee, Y., Shen, J., Parnell, L.D., Arnett, D.K., Tsai, M.Y., Lai, C., Ordovas, J.M. 2009. Genetic variants in human CLOCK associate with total energy intake and cytokine sleep factors. Human Molecular Genetics. 18(3):364-369.
Disparities in allele frequencies and population differentiation for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and non-Hispanic whites - (Peer Reviewed Journal)
Mattei, J., Parnell, L.D., Lai, C., Garcia-Bailo, B., Adiconis, X., Shen, J., Arnett, D., Demissie, S., Tucker, K., Ordovas, J.M. 2009. Disparities in allele frequencies and population differentiation for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and non-Hispanic whites. BioMed Central (BMC) Genetics. 10:45.
APOA2, dietary fat and body mass index: replication of a gene-diet interaction in three independent populations - (Peer Reviewed Journal)
Corella, D., Peloso, G., Arnett, D.K., Demissie, S., Cupples, L., Tucker, K., Lai, C., Parnell, L.D., Coltell, O., Lee, Y., Ordovas, J.M. 2009. APOA2, dietary fat and body mass index: replication of a gene-diet interaction in three independent populations. Archives of Internal Medicine. 169:1897-1906.
ADAM17_i33780A>G polymorphism interacts with dietary n-6 polyunsaturated fatty acids to modulate obesity risk in the genetics of lipid lowering drugs and diet network study - (Peer Reviewed Journal)
Junyent, M., Arnett, D.A., Tsai, M.Y., Kabagambe, E.K., Straka, R.J., Province, M., An, P., Smith, C., Borecki, I., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2010. ADAM17_i33780A>G polymorphism interacts with dietary n-6 polyunsaturated fatty acids to modulate obesity risk in the genetics of lipid lowering drugs and diet network study. Nutrition Metabolism and Cardiovascular Disease. 20(101):698-705.
Novel variants at KCTD10 and MVK/MMAB genes interact with dietary carbohydrates to modulate HDL-C concentrations in the genetics of lipid lowering drugs and diet network study - (Peer Reviewed Journal)
Junyent, M., Arnett, D.A., Tsai, M.Y., Kabagambe, E.K., Straka, R.J., Province, M., An, P., Smith, C., Borecki, I., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2009. Novel variants at KCTD10 and MVK/MMAB genes interact with dietary carbohydrates to modulate HDL-C concentrations in the genetics of lipid lowering drugs and diet network study. American Journal of Clinical Nutrition. 90(3):686-694.
Apolipoprotein A5 and lipoprotein lipase interact to modulate anthropometric measures in Hispanics of Caribbean origin - (Peer Reviewed Journal)
Smith, C.E., Tucker, K.L., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2010. Apolipoprotein A5 and lipoprotein lipase interact to modulate anthropometric measures in Hispanics of Caribbean origin. Obesity. 18(2):327-332.
The effect of ABCG5/G8 polymorphisms on plasma HDL cholesterol levels depends on the ABCA1 gene variation in the Boston Puerto Rican Health Study - (Peer Reviewed Journal)
Junyent, M., Tucker, K.L., Lane, J.M., Mattei, J., Smith, C., Parnell, L.D., Lai, C., Ordovas, J.M. 2009. The effect of ABCG5/G8 polymorphisms on plasma HDL cholesterol levels depends on the ABCA1 gene variation in the Boston Puerto Rican Health Study. Nutrition Metabolism and Cardiovascular Disease. 18:64-69.
The effects of ABCG5/G8 polymorphisms on HDL-cholesterol concentrations depend on ABCA1 genetic variants in the Boston Puerto Rican health study - (Peer Reviewed Journal)
Junyent, M., Tucker, K., Smith, C., Lane, J., Mattei, J., Lai, C., Parnell, L.D., Ordovas, J. 2010. The effects of ABCG5/G8 polymorphisms on HDL-cholesterol concentrations depend on ABCA1 genetic variants in the Boston Puerto Rican health study. Nutrition Metabolism and Cardiovascular Disease. 20(8):558-566.
Apolipoprotein C3 polymorphism is associated with cognitive function in Caribbean Hispanics - (Peer Reviewed Journal)
Smith, C.E., Tucker, K.L., Scott, T.M., Van Rompay, M., Parnell, L.D., Lai, C., Mattei, J., Junyent, M., Lee, Y., Garcia-Bailo, B., Ordovas, J.M. 2009. Apolipoprotein C3 polymorphism is associated with cognitive function in Caribbean Hispanics. PLoS One. 4(5):e5465.
A composite scoring of genotypes discriminates coronary heart disease risk beyond conventional risk factors in the Boston Puerto Rican Health Study - (Peer Reviewed Journal)
Junyent, M., Parnell, L.D., Lai, C., Ordovas, J.M., Tucker, K.L., Shen, J., Mattei, J., Smith, C., Lee, Y. 2009. A composite scoring of genotypes discriminates coronary heart disease risk beyond conventional risk factors in the Boston Puerto Rican Health Study. Nutrition Metabolism and Cardiovascular Disease.20(3):157-167.
A composite scoring of genotypes discriminates coronary heart disesase risk beyond conventional risk factors in the Boston Puerto Rican Health Study - (Peer Reviewed Journal)
Junyent, M., Tucker, K., Shen, J., Lee, Y., Smith, C., Mattei, J., Lai, C., Parnell, L.D., Ordovas, J. 2010. A composite scoring of genotypes discriminates coronary heart disesase risk beyond conventional risk factors in the Boston Puerto Rican Health Study. Nutrition Metabolism and Cardiovascular Disease. 20(3):157-164.
Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study - (Peer Reviewed Journal)
Smith, C.E., Arnett, D.K., Tsai, M.Y., Lai, C., Parnell, L.D., Shen, J., Laclaustra, M., Junyent, M., Ordovas, J.M. 2009. Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study. Atherosclerosis.206:500-504.
The effect of a novel intergenic polymorphism (rs11774572) on HDL cholesterol concentrations depends on the TaqIB polymorphism in the cholesterol ester transfer protein gene - (Peer Reviewed Journal)
Junyent, M., Arnett, D.A., Tsai, M.Y., Kabagambe, E.K., Straka, R.J., Province, M., An, P., Smith, C., Shen, J., Borecki, I., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2009. The effect of a novel intergenic polymorphism (rs11774572) on HDL cholesterol concentrations depends on the TaqIB polymorphism in the cholesterol ester transfer protein gene. Nutrition Metabolism and Cardiovascular Disease.20:34-40.
Genetic Variants at the PDZ-Interacting Domain of the Scavenger Receptor Class B Type I Interact with Diet to Influence the Risk of Metabolic Syndrome in Obese Men and Women - (Peer Reviewed Journal)
Junyent, M., Arnett, D.A., Tsai, M.Y., Kabagambe, E.K., Straka, R.J., Province, M., An, P., Shen, J., Borecki, I., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2009. Genetic Variants at the PDZ-Interacting Domain of the Scavenger Receptor Class B Type I Interact with Diet to Influence the Risk of Metabolic Syndrome in Obese Men and Women. Journal of Nutrition. 139(6):842-848.
Polyunsaturated fatty acids modulate the effect of TCF7L2 gene variants on postprandial lipemia - (Peer Reviewed Journal)
Warodomwichit, D., Arnett, D.K., Kabagambe, E.K., Tsai, M.Y., Hixson, J.E., Straka, R.J., Province, M., An, P., Lai, C., Borecki, I., Ordovas, J. 2009. Polyunsaturated fatty acids modulate the effect of TCF7L2 gene variants on postprandial lipemia. Journal of Nutrition. 139:439-446.
The effects of ABCG5/G8 polymorphisms on plasma HDL cholesterol concentrations depend on smoking habit in the Boston Puerto Rican Health Study - (Peer Reviewed Journal)
Junyent, M., Tucker, K., Smith, C., Garcia-Rios, A., Mattei, J., Lai, C., Parnell, L.D., Ordovas, J.M. 2008. The effects of ABCG5/G8 polymorphisms on plasma HDL cholesterol concentrations depend on smoking habit in the Boston Puerto Rican Health Study. Journal of Lipid Research. 50:565-573.
WDTC1, an ortholog of Drosphilia adipose gene, associates with human obesity - (Peer Reviewed Journal)
Lai, C., Parnell, L.D., Garcia-Bailo, B., Tucker, K., Ordovas, J.M. 2008. WDTC1, an ortholog of Drosphilia adipose gene, associates with human obesity. Obesity. 17(3):593-600.
Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states - (Peer Reviewed Journal)
Perez-Martinez, P., Corella, D., Shen, J., Arnett, D.K., Yiannakouris, N., Tai, E., Orho-Melander, M., Tucker, K.L., Tsai, M., Straka, R.J., Province, M., Kai, C., Perez-Jimenez, F., Lai, C., Lopez-Miranda, J., Guillen, M., Parnell, L.D., Borecki, I., Kathiresan, S., Ordovas, J.M. 2009. Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states. American Journal of Clinical Nutrition. 89:391-399.
ADIPOQ Polymorphisms, Monounsaturated Fatty Acids, and Obesity Risk: The GOLDN Study - (Peer Reviewed Journal)
Warodomwichit, D., Shen, J., Arnett, D., Tsai, M., Kabagambe, E., Peacock, J., Hixson, J., Straka, R., Province, M., An, P., Lai, C., Parnell, L.D., Borecki, I., Ordovas, J.M. 2009. ADIPOQ Polymorphisms, Monounsaturated Fatty Acids, and Obesity Risk: The GOLDN Study. Obesity. 17:510-517.
Perilipin polymorphism interacts with dietary carbohydrates to modulate anthropometric traits in Hispanics of Caribbean origin - (Peer Reviewed Journal)
Smith, C., Tucker, K., Yiannakouris, N., Garcia-Bailo, B., Mattei, J., Lai, C., Parnell, L.D., Ordovas, J.M. 2008. Perilipin Polymorphism Interacts with Dietary Carbohydrates to Modulate Anthropometric Traits in Hispanics of Caribbean Origin. Journal of Nutrition. 138(10):1852-1858.
A Common Missense Variant in the Glucokinase Regulatory Protein Gene (GCKR) Is Associated with Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations - (Peer Reviewed Journal)
Orho-Melander, M., Melander, O., Guiducci, C., Perez-Martinez, P., Corella, D., Roos, C., Tewhey, R., Rieder, M.J., Hall, J., Abecasis, G., Tai, E., Welch, C., Arnett, D.K., Lyssenko, V., Lindholm, E., Saxena, R., De Bakker, P., Burtt, N., Voight, B.F., Hirschhorn, J.N., Tucker, K., Hedner, T., Tuomi, T., Isomaa, B., Eriksson, K., Taskinen, M., Wahlstrand, B., Hughes, T.E., Parnell, L.D., Lai, C., Berglund, G., Peltonen, L., Vartiainen, E., Jousilahti, P., Havulinna, A.S., Salomaa, V., Nilsson, P., Groop, L., Altshuler, D., Ordovas, J.M., Kathiresan, S. 2008. A Common Missense Variant in the Glucokinase Regulatory Protein Gene (GCKR) Is Associated with Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations. Diabetes. 57:3112-3121.
The effect of IL6-174C/G polymorphisms on postprandial triglycerides metabolism in the GOLDN study - (Peer Reviewed Journal)
Shen, J., Arnett, D.K., Perez-Martinez, P., Parnell, L.D., Peacock, J.M., Hixson, J.E., Tsai, M.Y., Lai, C., Straka, R.J., Hopkins, P.N., Ordovas, J.M. 2008. The effect of IL6-174C/G polymorphisms on postprandial triglycerides metabolism in the GOLDN study. Journal of Lipid Research. 49:1839-1845.
Association of common C-protein (CRP) gene polymorphism with baseline plasma CRP levels and fenofibrate response: The GOLDN Study - (Peer Reviewed Journal)
Shen, J., Arnett, D.K., Parnell, L.D., Peacock, J.M., Lai, C., Hixson, J.E., Tsai, M.Y., Province, M., Straka, R.J., Ordovas, J.M. 2008. Association of common C-protein (CRP) gene polymorphism with baseline plasma CRP levels and fenofibrate response: The GOLDN Study. Diabetes Care. 31(5):910-915.
PPARGC1A Variations Associated with DNA Damage, Diabetes, and Cardiovascular Diseases: The Boston Puerto Rican Study - (Review Article)
Lai, C., Tucker, K., Parnell, L.D., Adiconis, X., Garcia-Bailo, B., Griffith, J., Meydani, M., Ordovas, J.M. 2008. PPARGC1A Variations Associated with DNA Damage, Diabetes, and Cardiovascular Diseases: The Boston Puerto Rican Study. Diabetes. 57:809-816.
THE MODULATION OF ENDOTHELIAL CELL GENE EXPRESSION BY GREEN TEA POLYPHENOL-EGCG - (Peer Reviewed Journal)
Liu, L., Lai, C., Nie, L., Ordovas, J.M., Band, M., Moser, L., Meydani, M. 2008. THE MODULATION OF ENDOTHELIAL CELL GENE EXPRESSION BY GREEN TEA POLYPHENOL-EGCG. Molecular Nutrition and Food Research. 52:1182-1192.
Speed-Mapping Quantitative Trait Loci Using Microarrays - (Peer Reviewed Journal)
Lai, C., Leips, J., Zou, W., Roberts, J.F., Wollenberg, K.R., Parnell, L.D., Zeng, Z., Ordovas, J.M., Mckay, T.F. 2007. Speed-Mapping Quantitative Trait Loci Using Microarrays. Nature Methods. 4(10):839-841.
Gene expression analysis in pregnant women and their infants identifies unique fetal biomarkers that circulate in maternal blood - (Peer Reviewed Journal)
Maron, J.L., Johnson, K.L., Sionim, D., Lai, C., Ramoni, M., Alterovitz, G., Jerrah, Z., Yang, Z., Bianchi, D.W. 2007. Gene expression analysis in pregnant women and their infants identifies unique fetal biomarkers that circulate in maternal blood. Journal of Clinical Investigation. 117:3007-3019.
Interleukin 1B genetic polymorphisms interact with polyunsaturated fatty acids to affect risk of the metabolic syndrome in the GOLDN Study - (Peer Reviewed Journal)
Shen, J., Arnett, D.K., Peacock, J.M., Parnell, L.D., Aldi, K., Hixson, J.E., Tsai, M.Y., Kabagambe, E.K., Lai, C., Stratka, R.J., Ordovas, J.M. 2007. Interleukin 1B genetic polymorphisms interact with polyunsaturated fatty acids to affect risk of the metabolic syndrome in the GOLDN Study. Journal of Nutrition. 137(8):1846-1851.
The -256T>C Polymorphism in the Apolipoprotein A-II Gene Promoter Is Associated with Body Mass Index and Food Intake in the Genetics of Lipid Lowering Drugs and Diet Network Study - (Peer Reviewed Journal)
Corella, D., Arnett, D.K., Tsai, M.Y., Kabagambe, E.K., Peacock, J.M., Hixson, J.E., Straka, R.J., Province, M., Lai, C., Parnell, L.D., Borecki, I., Ordovas, J.M. 2007. The -256T>C Polymorphism in the Apolipoprotein A-II Gene Promoter Is Associated with Body Mass Index and Food Intake in the Genetics of Lipid Lowering Drugs and Diet Network Study. Clinical Chemistry.53:1144-1152.
Fenofibrate Effect on Triglyceride and Postprandial Response of Apolipoprotein A5 Variants: The GOLDN Study - (Peer Reviewed Journal)
Lai, C., Arnett, D.K., Straka, R.J., Tsai, M.Y., Peacock, J.M., Adiconis, X., Parnell, L.D., Hixson, J.E., Province, M.A., Ordovas, J.M. 2007. Fenofibrate Effect on Triglyceride and Postprandial Response of Apolipoprotein A5 Variants: The GOLDN Study. Arteriosclerosis Thrombo Vasc Biol. 27:1417-1425.
Candidate genes affecting Drosophila life span identified by integrating microarray gene expression analysis and QTL mapping - (Abstract Only)
Lai, C., Parnell, L.D., Lyman, R.F., Ordovas, J.M., Mackay, T.F. 2006. Candidate genes affecting Drosophila life span identified by integrating microarray gene expression analysis and QTL mapping. Mechanisms of Aging and Development 128:237-249.
APOA5 gene variation modulates the effects of dietary fat intake on body mass index and obesity risk in the Framingham Heart Study - (Peer Reviewed Journal)
Corella, D., Lai, C., Demissie, S., Cupples, A., Manning, A.K., Tucker, K., Ordovas, J.M. 2007. APOA5 gene variation modulates the effects of dietary fat intake on body mass index and obesity risk in the Framingham Heart Study. Journal of Molecular Medicine.85:119-128.
Lifespan modification by glucose and methionine in Drosophila melanogaster fed a chemically defined diet - (Peer Reviewed Journal)
Troen, A.M., French, E.E., Roberts, J.F., Selhub, J., Ordovas, J.M., Parnell, L.D., Lai, C. 2006. Lifespan modification by glucose and methionine in Drosophila melanogaster fed a chemically defined diet. Age.29:29-39.
DIETARY INTAKE OF N-6 FATTY ACIDS MODULATES EFFECT OF APOLIPOPROTEIN A5 GENE ON PLASMA FASTING TRIGLYCERIDES, REMNANT LIPOPROTEIN CONCENTRATIONS, AND LIPOPROTEIN PARTICLE SIZE: THE FRAMINGHAM HEART STUDY - (Peer Reviewed Journal)
Lai, C., Corella, D., Demissie, S., Cupples, A., Adiconis, X., Zhu, Y., Ordovas, J.M. 2006. Dietary intake of n-6 fatty acids modulates effect of apolipoprotein a5 gene on plasma fasting triglycerides, remnant lipoprotein concentrations, and lipoprotein particle size: the framingham heart study. Circulation. 113(17):2062-70.
VARIANTS AT THE APOA5 LOCUS, ASSOCIATION WITH CAROTID ATHEROSCLEROSIS, AND MODIFICATION BY OBESITY: THE FRAMINGHAM STUDY - (Peer Reviewed Journal)
Elosua, R., Ordovas, J.M., Cupples, L., Lai, C., Demissie, S., Fox, C., Polak, J.F., Wolf, P.A., D'Agostino, R.A., O'Donnell, C. 2006. Variants at the apoa5 locus, association with carotid atherosclerosis, and modification by obesity: the framingham study. Journal of Lipid Research. 47(5):990-6.
GENOME-WIDE LINKAGE ANALYSES AND CANDIDATE GENE FINE MAPPING FOR HDL3 CHOLESTEROL: THE FRAMINGHAM STUDY - (Peer Reviewed Journal)
Yang, Q., Lai, C., Parnell, L.D., Cupples, L., Adiconis, X., Zhu, Y., Wilson, P.W., Housman, D.E., Sherman, A.M., D'Agostino, R.B., Ordovas, J.M. 2005. Genome-wide linkage analyses and candidate gene fine mapping for HDL3 cholesterol: the Framingham Study. Journal of Lipid Research. 46(7):1416-1425.
THE APOA1/C3/A4/A5 GENE CLUSTER, LIPID METABOLISM AND CARDIOVASCULAR DISEASE RISK - (Review Article)
Lai, C., Parnell, L.D., Ordovas, J.M. 2005. The apoa1/c3/a4/a5 gene cluster, lipid metabolism and cardiovascular disease risk. Current Opinion in Lipidology 2005, 16:153-166.
GLOBAL GENE EXPRESSION ANALYSIS OF THE LIVING HUMAN FETUS USING CELL-FREE MESSENGER RNA IN AMNIOTIC FLUID - (Peer Reviewed Journal)
Larrabee, P.B., Johnson, K.L., Lai, C., Ordovas, J.M., Cowan, J.W., Tantravahi, U., Bianchi, D.W. 2005. Global gene expression analysis of the living human fetus using cell-free messenger RNA in amniotic fluid. Journal of the American Medical Association. 16;293(7):836-42.
INFLUENCE OF THE APOLIPOPROTEIN A5 LOCUS ON PLASMA TRIGLYCERIDE, REMNANT-LIKE PARTICLES, AND LIPOPROTEIN SUBFRACTION CONCENTRATIONS -IMPLICATION FOR CARDIOVASCULAR RISK IN THE FRAMINGHAM HEART STUDY - (Peer Reviewed Journal)
Lai, C., Demissie, S., Cupples, A., Zhu, Y., Adiconis, X., Parnell, L.D., Corella, D., Ordovas, J.M. 2004. Influence of the apolipoprotein a5 locus on plasma triglyceride, remnant-like particles, and lipoprotein subfraction concentrations -implication for cardiovascular risk in the framingham heart study. Arteriosclerosis Thrombosis and Vascular Biology. 2004; 45: 2096-2105
THE APOLIPOPROTEIN A5 LOCUS IS A STRONG DETERMINANT OF PLASMA TRIGLYCERIDE CONCENTRATIONS ACROSS ETHNIC GROUPS IN SINGAPORE - (Peer Reviewed Journal)
Lai, C., Tai, E., Tan, C., Cutter, J., Chew, S., Zhu, Y., Adiconis, X., Ordvas, J. 2003. The apolipoprotein a5 locus is a strong determinant of plasma triglyceride concentrations across ethnic groups in singapore. Journal Of Lipid Research 2003;44:2365-73.
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