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ARS Home » Northeast Area » Boston, Massachusetts » People & Locations » Laurence Parnell
Laurence D Parnell (PhD)
Boston, Massachusetts
Computational Biologist

Phone: (617) 556-3089
Fax: (617) 556-3299

(Employee information on this page comes from the REE Directory. Please contact your front office staff to update the REE Directory.)

Projects
Precision Nutrition for Health and Optimal Aging
In-House Appropriated (D)
  Accession Number: 445473

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Rate-limiting enzymes in cardiometabolic health and aging in humans Reprint Icon - (Peer Reviewed Journal)
Parnell, L.D., McCaffrey, K.S., Brooks, A., Smith, C.E., Lai, C., Christensen, J.J., Wiley, C.D., Ordovas, J.M. 2023. Rate-limiting enzymes in cardiometabolic health and aging in humans. Lifestyle Genomics. 16:124-138. https://doi.org/10.1159/000531350.
The impact of alcoholic drinks and dietary factors on epigenetic markers associated with triglyceride levels Reprint Icon - (Peer Reviewed Journal)
Lai, C., Parnell, L.D., Lee, Y., Zeng, H., Smith, C., Mckeowan, N.M., Ordovas, J.M. 2023. The impact of alcoholic drinks and dietary factors on epigenetic markers associated with triglyceride levels. Frontiers in Genetics. https://doi.org/10.3389/fgene.2023.1117778.
Dietary responses of dementia-related genes encoding metabolic enzymes Reprint Icon - (Peer Reviewed Journal)
Parnell, L.D., Magadmi, R., Zwanger, S., Shukitt Hale, B., Lai, C., Ordovas, J.M. 2023. Dietary responses of dementia-related genes encoding metabolic enzymes. Nutrients. 15(3):644. https://doi.org/10.3390/nu15030644.
Metabolomic profiling in dogs with dilated cardiomyopathy eating non-traditional or traditional diets and in healthy controls Reprint Icon - (Peer Reviewed Journal)
Smith, C.E., Parnell, L.D., Lai, C., Rush, J.E., Adin, D.B., Ordovas, J.M., Freeman, L.M. 2022. Metabolomic profiling in dogs with dilated cardiomyopathy eating non-traditional or traditional diets and in healthy controls. Scientific Reports. https://doi.org/10.1038/s41598-022-26322-8.
Using machine learning to predict obesity based on genome-wide, epigenome-wide gene-gene and gene-diet interactions Reprint Icon - (Peer Reviewed Journal)
Lee, Y., Christensen, J.J., Parnell, L.D., Smith, C.E., Shao, J.Y., McKeown, N.M., Ordovas, J.M., Lai, C. 2022. Using machine learning to predict obesity based on genome-wide, epigenome-wide gene-gene and gene-diet interactions. Frontiers in Genetics. 12:783845. https://doi.org/10.3389/fgene.2021.783845.
A catalog of natural products occurring in watermelon - Citrullus lanatus Reprint Icon - (Peer Reviewed Journal)
Sorokina, M., Mccaffrey, K.S., Ordovas, J.M., Deaton, E.E., Ma, G., Perkins-Veazie, P.M., Steinbeck, C., Levi, A., Parnell, L.D. 2021. A catalog of natural products occurring in watermelon - Citrullus lanatus. Frontiers in Nutrition. 8:602. https://doi.org/10.3389/fnut.2021.729822.
Associations of network-derived metabolite clusters with prevalent type 2 diabetes among adults of Puerto Rican descent Reprint Icon - (Peer Reviewed Journal)
Haslam, D.E., Liang, L., Wang, D.D., Kelly, R.S., Wittenbecher, C., Perez, C.M., Martinez, M., Lee, C., Clish, C., Wong, D., Parnell, L.D., Lai, C., Ordovas, J.M., Manson, J.E., Hu, F.B., Stampfer, M.J., Tucker, K.L., Joshipura, K., Bhupathiraju, S.N. 2021. Associations of network-derived metabolite clusters with prevalent type 2 diabetes among adults of Puerto Rican descent. BMJ Open Diabetes Research & Care. https://doi.org/10.1136/bmjdrc-2021-002298.
Investigation of diets associated with dilated cardiomyopathy in dogs using foodomics analysis Reprint Icon - (Peer Reviewed Journal)
Smith, C., Parnell, L.D., Lai, C., Rush, J.E., Freeman, L.M. 2021. Investigation of diets associated with dilated cardiomyopathy in dogs using foodomics analysis. Scientific Reports. 11:15881. https://doi.org/10.1038/s41598-021-94464-2.
When and how to use a free database tool on fiber and health outcomes - (Abstract Only)
Mckeown, N.M., Staffier, K.L., Parnell, L.D. 2020. When and how to use a free database tool on fiber and health outcomes. [abstract] 12th Vahouny Fiber Symposium. Abstract 3.
Carbohydrate and fat intake associated with risk of metabolic diseases through epigenetics of CPT1A Reprint Icon - (Peer Reviewed Journal)
Lai, C., Parnell, L.D., Smith, C.E., Guo, T., Sayols-Baixeras, S., Aslibekyan, S., Tiwari, H.K., Irvin, M.R., Bender, C., Fei, D., Hidalgo, B., Hopkins, P., Absher, D.M., Province, M., Elosua, R., Arnett, D.K., Ordovas, J.M. 2020. Carbohydrate and fat intake associated with risk of metabolic diseases through epigenetics of CPT1A. American Journal of Clinical Nutrition. 112(5):1200–1211. https://doi.org/10.1093/ajcn/nqaa233.
PhyteByte: Identification of foods containing compounds with specific pharmacological properties Reprint Icon - (Peer Reviewed Journal)
Westerman, K., Harrington, S.M., Ordovas, J.M., Parnell, L.D. 2020. PhyteByte: Identification of foods containing compounds with specific pharmacological properties. BMC Bioinformatics. https://doi.org/10.1186/s12859-020-03582-7.
Metabolomic links between sugar-sweetened beverage intake and obesity Reprint Icon - (Peer Reviewed Journal)
Zhou, B., Ichikawa, R., Parnell, L.D., Noel, S.E., Zhang, X., Bhupathiraju, S., Smith, C., Tucker, K.L., Ordovas, J.M., Lai, C. 2020. Metabolomic links between sugar-sweetened beverage intake and obesity. Journal of Obesity. https://doi.org/10.1155/2020/7154738.
Salivary AMY1 copy number variation modifies age-related type 2 diabetes risk Reprint Icon - (Peer Reviewed Journal)
Liu, Y., Smith, C.E., Parnell, L.D., Lee, Y., An, P., Straka, R.J., Tiwari, H.K., Wood, A.C., Kabagame, E.K., Hopkins, P., Province, M., Arnett, D.K., Tucker, K., Ordovas, J.M., Lai, C. 2020. Salivary AMY1 copy number variation modifies age-related type 2 diabetes risk. Clinical Chemistry. 66(5):718-726. https://doi.org/10.1093/clinchem/hvaa072.
A gene-diet interaction-based score predicts response to dietary fat in the Women's Health Initiative Reprint Icon - (Peer Reviewed Journal)
Westerman, K., Liu, Q., Liu, S., Parnell, L.D., Sebastiani, P., Jacques, P.F., Demeo, D.L., Ordovas, J. 2020. A gene-diet interaction-based score predicts response to dietary fat in the Women's Health Initiative. American Journal of Clinical Nutrition. 111(4):893-902. https://doi.org/10.1093/ajcn/nqaa037.
Development of a genetic score to predict an increase in HDL cholesterol concentration after a dietary intervention in adults with metabolic syndrome Reprint Icon - (Peer Reviewed Journal)
Guevara-Cruz, M., Medina-Vera, I., Flores-Lopez, A., Aguilar-Lopez, M., Smith, C.E., Parnell, L.D., Lee, Y., Lai, C., Tovar, A.R., Ordovas, J.M., Torres, N. 2019. Development of a genetic score to predict an increase in HDL cholesterol concentration after a dietary intervention in adults with metabolic syndrome. Journal of Nutrition. https://doi.org/10.1093/jn/nxz060.
Incremental elevations of TNF-alpha and IL-6 in the human colon and procancerous changes in the mucosal transcriptome accompany adiposity Reprint Icon - (Peer Reviewed Journal)
Pfalzer, A.C., Leung, K., Crott, J.W., Kim, S.J., Tai, A.K., Parnell, L.D., Kamanu, F.K., Liu, Z., Rogers, G., Shea, K., Garcia, P.E., Mason, J.B. 2018. Incremental elevations of TNF-alpha and IL-6 in the human colon and procancerous changes in the mucosal transcriptome accompany adiposity. Cancer Epidemiology Biomarkers and Prevention. https://doi.org/10.1158/1055-9965.EPI-18-0121.
Dietary epicatechin improves survival and skeletal muscle function in aged mice Reprint Icon - (Peer Reviewed Journal)
Si, H., Wang, X., Zhang, L., Parnell, L.D., Admed, B., Leroith, T., Ansah, T., Zhang, L., Ordovas, J.M., Liu, D., Lai, C. 2018. Dietary epicatechin improves survival and skeletal muscle function in aged mice. Journal of Federation of American Societies for Experimental Biology. https://doi.org/10.1096/fj.201800554RR.
Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. - (Peer Reviewed Journal)
Lai, C., Smith, C.E., Parnell, L.D., Lee, Y., Corella, D., Hopkins, P., Hidalgo, B.A., Aslibekyan, S., Province, M.A., Absher, D.M., Arnett, D.K., Tucker, K.L., Ordovas, J.M. 2018. Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. American Journal of Clinical Nutrition. 108:188-200.
Environmental and epigenetic regulation of postprandial lipemia - (Peer Reviewed Journal)
Lai, C., Ordovas, J.M., Parnell, L.D. 2018. Environmental and epigenetic regulation of postprandial lipemia. Current Opinion in Lipidology. 29(1):30-35.
Mediterranean Diet adherence and genetic background roles within a web-based nutritional intervention: The Food4Me Study Reprint Icon - (Peer Reviewed Journal)
San-Cristobal, R., Navas-Carretero, S., Livingstone, K.M., Celis-Morales, C., Macready, A.L., Fallaize, R., O'Donovan, C.B., Lambrinou, C.P., Moschonis, G., Marsaux, C.F., Manios, Y., Miroslaw, J., Hannelore, D., Gibney, E.R., Brennan, L., Drevon, C.A., Gundersen, T.E., Gibney, M., Saris, W.H., Lovegrove, J.A., Grimaldi, K., Parnell, L.D., Bouwman, J., Van Ommen, B., Mathers, J.C., Martinez, J. 2017. Mediterranean Diet adherence and genetic background roles within a web-based nutritional intervention: The Food4Me Study. Nutrients. https://doi.org/10.3390/nu9101107.
Genome-wide interactions with dairy intake for body mass index in adults of European descent Reprint Icon - (Peer Reviewed Journal)
Smith, C.E., Follis, J.L., Dashti, H., Tanaka, T., Graff, M., Fretts, A.M., Kilpelainen, T., Wojczynski, M., Richardson, K., Nalls, M., Schulz, C.N., Liu, Y., Frazier-Wood, A., Van Eekelen, E., Wang, C., De Vries, P.S., Mikkila, V., Rohde, R., Psaty, B.M., Hansen, T., Feitosa, M.F., Lai, C., Houston, D.K., Ferrucci, L., Ericson, U., Wang, Z., De Mutsert, R., Oddy, W.H., De Jonge, E.A., Seppala, I., Justice, A.E., Lemaitre, R.N., Sorensen, T.I., Province, M.A., Parnell, L.D., Garcia, M.E., Bandinelli, S., Orho-Melander, M., Rich, S.S., Rosendaal, F.R., Pennell, C.E., Kiefte-Dejong, J.C., Kahonen, M., Young, K.L., Pederesen, O., Aslibekyan, S., Rotter, J.I., Mook-Kanamori, D.O., Zillikens, M.C., Raitakari, O.T., North, K.E., Overvad, K., Arnett, D.K., Hofman, A., Lehtimaki, T., Tjonneland, A., Uitterlinden, A.G., Rivadeneira, F., Franco, O.H., German, J., Siscovick, D.S., Cupples, L.A., Ordovas, J.M. 2017. Genome-wide interactions with dairy intake for body mass index in adults of European descent. Molecular Nutrition and Food Research. https://doi.org/10.1002/mnfr.201700347.
Epigenome-wide association study of triglyceride postprandial responses to high-fat dietary challenge in the Genetics of Lipid Lowering Drugs and Diet Network study - (Peer Reviewed Journal)
Lai, C., Wojczynski, M.K., Parnell, L.D., Hidalgo, B., Irvin, M.R., Aslibekyan, S., Province, M.A., Devin, A., Arnett, D.K., Ordovas, J. 2016. Epigenome-wide association study of triglyceride postprandial responses to high-fat dietary challenge in the Genetics of Lipid Lowering Drugs and Diet Network study. Journal of Lipid Research. 57:2200-2207.
Supplementation with major royal jelly proteins increases lifespan, feeding and fecundity in Drosophila - (Peer Reviewed Journal)
Xin, X., Chen, Y., Chen, D., Xiao, F., Parnell, L.D., Zhao, J., Liu, L., Ordovas, J.M., Lai, C., Shen, L. 2016. Supplementation with major royal jelly proteins increases lifespan, feeding and fecundity in Drosophila. Journal of Agricultural and Food Chemistry. 64(29):5803–5812. doi: 10.1021/acs.jafc.6b00514.
Interactions between the colonic transcriptome, metabolome and microbiome in mouse models of obesity-induced intestinal cancer - (Peer Reviewed Journal)
Pfalzer, A., Kamanu, F.K., Parnell, L.D., Tai, A., Liu, Z., Mason, J.B., Crott, J.W. 2016. Interactions between the colonic transcriptome, metabolome and microbiome in mouse models of obesity-induced intestinal cancer. Physiological Genomics. 48(8):545-553.
Effect of personalized nutrition on health-related behavior change: evidence from the Food4Me randomized controlled trial - (Peer Reviewed Journal)
Celis-Morales, C., Livingstone, K.M., O'Donovan, C.B., Woolhead, C., Forster, H., Walsh, M.C., Marsaux, C.F., Macready, A.L., Fallaize, R., Tsirigoti, L., Lambrinou, C.P., Efstathopoulou, E., Moschonis, G., Navas-Carretero, S., Can-Cristobal, R., Kolossa, S., Hallmann, J., Godlewska, M., Surwilla, A., Traczyk, I., Drevon, C.A., Bouwman, J., Grimaldi, K., Parnell, L.D., Manios, Y., Daniel, H., Martinez, J., Lovegrove, J.A., Gibney, E.R., Brennan, L., Saris, W.H., Gibney, M., Mathers, J.C. 2016. Effect of personalized nutrition on health-related behavior change: evidence from the Food4Me randomized controlled trial. International Journal of Epidemiology. doi: 10.1093/ije/dyw186.
Interaction of an S100A9 gene variant with saturated fat and carbohydrates to modulate insulin resistance in 3 populations of different ancestries - (Peer Reviewed Journal)
Blanco-Rojo, R., Delgado-Lista, J., Lee, Y., Lai, C., Perez-Martinez, P., Rangel-Zuniga, O., Smith, C.E., Hidalgo, B., Alcala-Diaz, J.F., Gomez-Delgado, F., Parnell, L.D., Arnett, D.K., Tucker, K.L., Lopez-Miranda, J., Ordovas, J.M. 2016. Interaction of an S100A9 gene variant with saturated fat and carbohydrates to modulate insulin resistance in 3 populations of different ancestries. American Journal of Clinical Nutrition. 104:508–517.
Paternal B vitamin intake is a determinant of growth, hepatic lipid metabolism and intestinal tumor volume in female Apc1638N mouse offspring - (Peer Reviewed Journal)
Sabet, J.A., Park, L.K., Iyer, L.K., Tai, A.K., Koh, G., Pfalzer, A., Parnell, L.D., Mason, J.B., Liu, Z., Byun, A.J., Crott, J.W. 2016. Paternal B vitamin intake is a determinant of growth, hepatic lipid metabolism and intestinal tumor volume in female Apc1638N mouse offspring. PLoS One. 11(3):e0151579. https://doi.org/10.1371/journal.pone.0151579.
Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies & methylation analysis of 3 studies in the Cohorts for Heart & Aging Research - (Peer Reviewed Journal)
Ma, Y., Follis, J., Smith, C.E., Tanaka, T., Manichaikl, A., Chu, A.Y., Samieri, C., Zhou, X., Guan, W., Wang, L., Biggs, M., Chen, Y., Hernandez, D., Borecki, I.B., Chasman, D.I., Rich, S.S., Ferrucci, L., Irvin, M.R., Aslibekyan, S., Zhi, D., Tiwari, H.K., Claas, S.A., Sha, J., Kabagambe, E.K., Lai, C., Parnell, L.D., Lee, Y., Amouyel, P., Lambert, J., Psaty, B.M., King Irena, Mozaffarian, D., Mcknight, B., Bandinelli, S., Tsai, M.Y., Ridker, P.M., Ding, J., Mstat, K.L., Liu, Y., Sotoodehnia, N., Barberger-Gateau, P., Steffen, L.M., Siscovick, D.S., Absher, D.M., Arnett, D.K., Ordovas, J.M., Lemaitre, R.N. 2016. Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies & methylation analysis of 3 studies in the Cohorts for Heart & Aging Research. American Journal of Clinical Nutrition. doi: 10.3945/ajcn.115.112987.
Physical activity attenuates the effect of the FTO genotype on obesity-related traits in European adults: Findings from the Food4Me study - (Peer Reviewed Journal)
Celis-Morales, C., Marsaux, C.F., Livingstone, K.M., Navas-Carretero, S., San-Cristobal, R., O'Donovan, C.B., Forster, H., Woolhead, C., Fallaize, R., Macready, A.L., Kolossa, S., Hallmann, J., Tsirigoti, L., Lambrinou, C.P., Moschonis, G., Godlewska, M., Surwillo, A., Grimaldi, K., Bouwman, J., Manios, Y., Traczyk, I., Drevon, C.A., Parnell, L.D., Daniel, H., Gibney, E.R., Brennan, L., Walsh, M., Gibney, M., Lovegrove, J.A., Martinez, J., Saris, W.H., Mathers, J.C. 2016. Physical activity attenuates the effect of the FTO genotype on obesity-related traits in European adults: Findings from the Food4Me study. International Journal of Obesity. 24:962-969. doi: 10.1002/oby.21422.
Genetic variant modifies the effect of N3 PUFAs on DNA methylation of IL6 in the Genetics of Lipid Lowering Drugs and Diet Network study - (Peer Reviewed Journal)
Ma, Y., Smith, C.E., Lai, C., Invin, R.M., Parnell, L.D., Lee, Y., Pham, L., Aslibekyan, S., Claas, S.A., Tsai, M.Y., Borecki, I.B., Kabagambe, E.K., Ordovas, J.M., Absher, D., Donna, A.K. 2016. Genetic variant modifies the effect of N3 PUFAs on DNA methylation of IL6 in the Genetics of Lipid Lowering Drugs and Diet Network study. Epigenetics. doi: 10.1002/mnfr.201500436.
The effects of omega-3 polyunsaturated fatty acids and genetic variants on methylation levels of the interleukin-6 gene promoter - (Peer Reviewed Journal)
Ma, Y., Smith, C.E., Lai, C., Irvin, M.R., Parnell, L.D., Lee, Y., Pham, L.D., Aslibekyan, S., Claas, S.A., Tsai, M.Y., Borecki, I.B., Kagambe, E.K., Ordovas, J.M., Absher, D., Arnett, D.K. 2016. The effects of omega-3 polyunsaturated fatty acids and genetic variants on methylation levels of the interleukin-6 gene promoter. Epigenetics. 60(2):410-419. doi: 10.1002/mnfr.201500436.
Genetics and gene-environment interactions on longevity and lifespan - (Book / Chapter)
Lai, C., Ma, Y., Parnell, L.D. 2016. Genetics and gene-environment interactions on longevity and lifespan. In: Qi, L., Editor. Gene-Environment Interactions and Human Diseases. Hauppauge, NY: Nova Science Publishers, Inc. p. 245-264.
Diet- and genetically-induced obesity differentially affect the fecal microbiome and metabolome in Apc1638N mice - (Peer Reviewed Journal)
Pfalzer, A.C., Nesbeth, P.C., Parnell, L.D., Iyer, L.K., Liu, Z., Kane, A.V., Chen, C., Tai, A.K., Bowman, T.A., Obin, M.S., Mason, J.B., Greenberg, A., Choi, S., Selhub, J., Paul Pottenplackel, L., Crott, J.W. 2015. Diet- and genetically-induced obesity differentially affect the fecal microbiome and metabolome in Apc1638N mice. PLoS One. 10(8):e0135758. doi:10.1371/journal.pone.0135758.
Genome-wide association study of triglyceride response to a high-fat meal among participants of the NHLBI genetics of lipid lowering drugs and diet network (GOLDN) - (Peer Reviewed Journal)
Wojczynski, M.K., Parnell, L.D., Pollin, T.I., Lai, C., Feitosa, M.F., O'Connel, J.R., Frazier-Wood, A.C., Gibson, Q., Aslibkeyan, S., Ryan, K.A., Province, M.A., Tiwari, H.K., Ordovas, J.M., Shuldiner, A.R., Arnett, D.K., Borecki, I.B. 2015. Genome-wide association study of triglyceride response to a high-fat meal among participants of the NHLBI genetics of lipid lowering drugs and diet network (GOLDN). Metabolism. 64:1359-1371.
Validation of internet-based self-reported anthropometric, demographic data and participant identity in the Food4Me study - (Peer Reviewed Journal)
Celis-Morales, C., Livingstone, K.M., Woolhead, C., Forster, H., O'Donovan, C.B., Macready, A.L., Fallaize, R., Marsaux, C.F., Tsirigoti, L., Efstathopoulou, E., Moschonis, G., Navas-Carretero, S., San-Cristobal, R., Kolossa, S., Godlewska, M., Surwillo, A., Drevon, C.A., Gjelstad, I.F., Karlsen, A.S., Bouwman, J., Grimaldi, K., Parnell, L.D., Manios, Y., Traczyk, I., Gibney, E.R., Brrennan, L., Hallmann, J., Walsh, M.C., Lovegrove, J.A., Martinez, J., Daniel, H., Saris, W.H., Gibney, M., Mathers, J.C. 2015. Validation of internet-based self-reported anthropometric, demographic data and participant identity in the Food4Me study. International Journal of Obesity. 10:476.
Network-based characterization of inflammation biomarkers, phytochemicals and disease - (Abstract Only)
Kamanu, F., Zirkler, E., Obin, M.S., Ordovas, J.M., Parnell, L.D., Smith, C.E. 2015. Network-based characterization of inflammation biomarkers, phytochemicals and disease. Journal of Federation of American Societies for Experimental Biology. 29(1):923.18.
Genetic variants modify the effect of age on APOE methylation in the Genetics of Lipid Lowering Drugs and Diet Network study - (Peer Reviewed Journal)
Ma, Y., Smith, C.E., Lai, C., Irvin, M.R., Parnell, L.D., Pham, L., Aslibekyan, S., Claas, S.A., Tsai, M.Y., Borecki, I.B., Kabagambe, E.K., Berciano, S., Ordovas, J.M., Absher, D.M. 2014. Genetic variants modify the effect of age on APOE methylation in the Genetics of Lipid Lowering Drugs and Diet Network study. Aging Cell. 14:49-59.
Genome-wide interaction of genotype by erythrocyte n-3 PUFAs contributes to phenotypic variance of diabetes-related traits Reprint Icon - (Peer Reviewed Journal)
Ordovas, J., Lai, C., Parnell, L.D., Lee, Y., Shen, J., Smith, C.E., Richardson, K., Li, D., Arnett, D.K., Borecki, I.B., Zheng, J. 2014. Genome-wide interaction of genotype by erythrocyte n-3 PUFAs contributes to phenotypic variance of diabetes-related traits. Biomed Central (BMC) Genomics. 15:781. https://doi.org/10.1186/1471-2164-15-781.
Phytochemicals for personalized health - (Abstract Only)
Zirkler, E., Parnell, L.D., Smith, C.E., Obin, M.S., Ordovas, J.M. 2014. Phytochemicals for personalized health. [Abstract]. 11th NuGO Week: Nutrigenomics of Foods p.142.
S-adenosylmethionine lowers the inflammatory response in macrophages associated with changes in DNA methylation - (Peer Reviewed Journal)
Pfalzer, A., Choi, S., Tammen, S.A., Park, L.K., Bottiglieri, T., Parnell, L.D., Lamon-Fava, S. 2014. S adenosylmethionine lowers the inflammatory response in macrophages associated with changes in DNA methylation. Physiological Genomics. DOI: 10.1152/physiolgenomics.00056.2014.
Diminished skeletal muscle microRNA expression with aging is associated with attenuated muscle plasticity and inhibition of IGF-1 signaling - (Peer Reviewed Journal)
Rivas, D.A., Lessard, S.J., Rice, N.P., Lustgarten, M.S., So, K., Goodyear, L.J., Parnell, L.D., Fielding, R.A. 2014. Diminished skeletal muscle microRNA expression with aging is associated with attenuated muscle plasticity and inhibition of IGF-1 signaling. Journal of Federation of American Societies for Experimental Biology. DOI: 10.1096/fj.14-254490.
Dietary modulators of statin efficacy in cardiovascular disease and cognition - (Review Article)
Wang, H., Blumberg, J.B., Chen, C., Choi, S., Corcoran, M.P., Harris, S.S., Jacques, P.F., Kristo, A.S., Lai, C., Lamon-Fava, S., Matthan, N.R., Mckay, D.L., Meydani, M., Parnell, L.D., Prokopy, M.P., Scott, T.M., Lichtenstein, A.H. 2014. Dietary modulators of statin efficacy in cardiovascular disease and cognition. Molecular Aspects of Medicine. 38:1-53.
Lipoprotein metabolism indicators improve cardiovascular risk prediction - (Peer Reviewed Journal)
Van Schalkwijk, D., De Graaf, A., Tsivtsivadze, E., Parnell, L.D., Van Der Werff-Van De, R., Van Ommen, B., Van Der Greef, J., Ordovas, J.M. 2014. Lipoprotein metabolism indicators improve cardiovascular risk prediction. PLoS One. 9:e92840.
Lipoprotein lipase variants interact with polyunsaturated fatty acids to modulate obesity traits in Puerto Ricans - (Abstract Only)
Ma, Y., Tucker, K.L., Smith, C.E., Lee, Y., Huang, T., Lai, C., Parnell, L.D., Richardson, K., Ordovas, J.M. 2014. Lipoprotein lipase variants interact with polyunsaturated fatty acids to modulate obesity traits in Puerto Ricans. Journal of Federation of American Societies for Experimental Biology. 28:1037.7.
CRY1 circadian gene variant interacts with carbohydrate intake for insulin resistance in two independent populations: Mediterranean and North American - (Peer Reviewed Journal)
Dashti, H.S., Smith, C.E., Lee, Y., Parnell, L.D., Lai, C., Arnett, D.K., Ordovas, J.M., Garaulet, M. 2014. CRY1 circadian gene variant interacts with carbohydrate intake for insulin resistance in two independent populations: Mediterranean and North American. Chronobiology International. 31(5):660-668. DOI: 10.3109/07420528.2014.886587.
Integrating nutrigenomics data to identify cardiometabolic gene-environment interactions - (Proceedings)
Parnell, L.D., Lee, Y., Dashti, H., Ma, Y., Pham, L., Sloan, S., Smith, C.E., Richardson, K., Lai, C., Ordovas, J.M. 2013. Integrating nutrigenomics data to identify cardiometabolic gene-environment interactions. Meeting Abstract. p.1 Abstract #5.
Circulating 25-hydroxyvitamin D, IRS1 variant rs2943641 and insulin resistance: replication of a gene-nutrient interaction in four populations of different ancestries - (Peer Reviewed Journal)
Apolipoprotein A2 polymorphism interacts with intakes of dairy foods to influence body weight in 2 U.S. populations - (Peer Reviewed Journal)
Smith, C.E., Tucker, K.L., Arnett, D.K., Noel, S.E., Corella, D., Borecki, I.B., Feitosa, M.F., Aslibekyan, S., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2013. Apolipoprotein A2 polymorphism interacts with intakes of dairy foods to influence body weight in 2 U.S. populations. Journal of Nutrition. 143(12):1865-1871.
The emerging relevance of the gut microbiome in cardiometabolic health - (Review Article)
Obin, M., Parnell, L.D., Ordovas, J.M. 2013. The emerging relevance of the gut microbiome in cardiometabolic health. Current Cardiovascular Risk Reports. DOI 10.1007/s12170-013-0357-2.
REV-ERB-ALPHA circadian gene variant associates with obesity in two independent populations: Mediterranean and North American - (Peer Reviewed Journal)
Garaulet, M., Smith, C.E., Gomez-Abellan, P., Ordova S-Montanes, M., Lee, Y., Parnell, L.D., Arnett, D.K., Ordovas, J.M. 2014. REV-ERB-ALPHA circadian gene variant associates with obesity in two independent populations: Mediterranean and North American. Molecular Nutrition and Food Research. 58(4):821-829.
Genetic variants at PSMD3 interact with dietary fat and carbohydrate to modulate insulin resistance - (Peer Reviewed Journal)
Zheng, J., Arnett, D., Parnell, L.D., Lee, Y., Ma, Y., Smith, C., Richardson, K., Li, D., Ordovas, J., Tucker, K., Lai, C., Borecki, I. 2013. Genetic variants at PSMD3 interact with dietary fat and carbohydrate to modulate insulin resistance. Journal of Nutrition. 143(3):354-361.
Curcumin and aging - (Review Article)
Shen, L., Parnell, L.D., Ordovas, J., Lai, C. 2013. Curcumin and aging. Biofactors. 39(1):133-140.
Association between BDNF-rs6265 and obesity in the Boston Puerto Rican Health Study - (Peer Reviewed Journal)
Ma, X., Qiu, W., Smith, C., Parnell, L.D., Jiang, Z., Ordovas, J., Tucker, K., Lai, C. 2012. Association between BDNF-rs6265 and obesity in the Boston Puerto Rican Health Study. Journal of Obesity. DOI: 10.1155/2012102942.
Gain-of-function Lipoprotein Lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site - (Peer Reviewed Journal)
Richardson, K., Nettleton, J.A., Rotlan, N., Tanaka, T., Smith, C.E., Lai, C., Parnell, L.D., Lee, Y., Lahti, J., Lemaitre, R.N., Manichaikul, A., Keller, M., Mikkila, V., Ngwa, J., Van Rooij, F., Ballentyne, C.M., Borecki, I.B., Cupples, L., Garcia, M., Hofman, A., Ferrucci, L., Mozaffarian, D., Perala, M., Raitakari, O., Tracy, R.P., Arnett, D.K., Bandinelli, S., Boerwinkle, E., Eriksson, J.G., Franco, O.H., Kahonen, M., Nalls, M., Siscovick, D.S., Houston, D.K., Psaty, B.M., Viikari, J., Witteman, J., Goodarzi, M.O., Lehtimaki, T., Liu, Y., Zillikens, M., Chen, Y.I., Uitterlinden, A.G., Rotter, J.I., Fernandez-Hernando, C., Ordovas, J. 2013. Gain-of-function Lipoprotein Lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site. The American Journal of Human Genetics. 92(1):5-14.
Mechanism of action of recombinant Acc-royalisin from royal jelly of Chinese honeybee against gram-positive bacteria - (Peer Reviewed Journal)
Shen, L., Liu, D., Yang, X., Jin, F., Din, M., Parnell, L.D., Lai, C. 2012. Mechanism of action of recombinant Acc-royalisin from royal jelly of Chinese honeybee against gram-positive bacteria. PLoS One. 7(10):e47194 DOI: 10.1371/journal.pone.0047194.
Low density lipoprotein receptor related protein 1 variant interacts with saturated fatty acids in Puerto Ricans - (Peer Reviewed Journal)
Smith, C.E., Tucker, K.L., Lee, Y., Lai, C., Parnell, L.D., Ordovas, J.M. 2013. Low density lipoprotein receptor related protein 1 variant interacts with saturated fatty acids in Puerto Ricans. Obesity. 21:602-608.
Status of vitamin B-12 and B-6 but not of folate, homocysteine and the methylenetetrahydrofolate reductase C677T polymorphism are associated with impaired cognition and depression in adults - (Peer Reviewed Journal)
Moorthy, D., Inga, P., Scott, T.M., Parnell, L.D., Lai, C., Crott, J.W., Ordovas, J.M., Selhub, J., Griffith, J., Rosenberg, I.H., Tucker, K.L., Troen, A.M. 2012. Status of vitamin B-12 and B-6 but not of folate, homocysteine and the methylenetetrahydrofolate reductase C677T polymorphism are associated with impaired cognition and depression in adults. Journal of Nutrition. 142(8):1554-1560.
Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila - (Peer Reviewed Journal)
Shen, L., Xiao, F., Peng, Y., Chen, Y., Qi-Kang, G., Parnell, L.D., Meydani, M., Ordovas, J.M., Li, D., Lai, C. 2013. Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila. Journal of the American Aging Association (AGE). 35(4):1133-1142. DOI 10.1007/s11357-012-9438-2.
Aging is a more significant determinant of hepatic DNA methylation patterns than a western style diet - (Abstract Only)
Park, L.K., Saltzman, E., Schnitzler, G., Yoon, B., Parnell, L.D., Lai, C., Choi, S. 2012. Aging is a more significant determinant of hepatic DNA methylation patterns than a western style diet. Journal of Federation of American Societies for Experimental Biology. 2012(26):243.5.
Genetic predisposition to coronary heart disease and stroke using an additive genetic risk score: a population-based study in Greece - (Peer Reviewed Journal)
Yiannakouris, N., Katsoulis, M., Dilis, V., Parnell, L.D., Trichopoulos, D., Ordovas, J., Trichopoulou, A. 2012. Genetic predisposition to coronary heart disease and stroke using an additive genetic risk score: a population-based study in Greece. Atherosclerosis. 222(1):175-179.
SIRT1 and CLOCK 3111T greater than C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity - (Peer Reviewed Journal)
Garaulet, M., Esteban Tardido, A., Lee, Y., Smith, C., Parnell, L.D., Ordovas, J. 2012. SIRT1 and CLOCK 3111T greater than C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity. International Journal of Obesity. DOI: 10.1038/ijo.2011.270.
The effect of CYP7A1 polymorphisms on lipid responses to fenofibrate - (Peer Reviewed Journal)
Shen, J., Arnett, D., Parnell, L.D., Lai, C., Straka, R., Hopkins, P., An, P., Feitosa, M., Ordovas, J. 2012. The effect of CYP7A1 polymorphisms on lipid responses to fenofibrate. Journal of Cardiovascular Pharmacology. 59(3):254-259.
A genome-wide survey for SNPs altering microRNA seed sites identifies functional candidates in GWAS - (Peer Reviewed Journal)
Richardson, K., Lai, C., Parnell, L.D., Lee, Y., Ordovas, J. 2011. A genome-wide survey for SNPs altering microRNA seed sites identifies functional candidates in GWAS. Biomed Central (BMC) Genomics. 2:504.
A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI - (Peer Reviewed Journal)
Corella, D., Arnett, D.K., Tucker, K.L., Kabagambe, E.K., Tsai, M.Y., Parnell, L.D., Lai, C., Lee, Y., Warodomwichit, D., Hopkins, P.N., Ordovas, J.M. 2011. A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI. Journal of Nutrition. 141(12):2219-2225.
Advances in technologies and study design - (Book / Chapter)
Parnell, L.D. 2012. Advances in technologies and study design. In: Bouchard, C., Ordovas, J.M., editors. Progress in Molecular Biology and Translational Science. New York, NY: Elsevier Inc. 108:17-50.
BioStar: an online question & answer resource for the bioinformatics community - (Peer Reviewed Journal)
Parnell, L.D., Lindenbaum, P., Shameer, K., Dall'Olio, G.M., Swan, D.C., Jensen, L.J., Cockell, S.J., Pedersen, B.P., Mangan, M.E., Miller, C., Albert, I. 2011. BioStar: an online question & answer resource for the bioinformatics community. PLoS Computational Biology. 7:e1002216.
The PLIN4 variant rs8887 modulates obesity related phenotypes in humans through creation of a novel miR-522 seed site - (Peer Reviewed Journal)
Richardson, K., Louie-Gao, Q., Arnett, D., Parnell, L.D., Lai, C., Davalos, A., Fox, C., Demissie, S., Cupples, L., Fernandez-Hernando, C., Ordovas, J. 2011. The PLIN4 variant rs8887 modulates obesity related phenotypes in humans through creation of a novel miR-522 seed site. PLoS One. 6(4):e17944.
A database of gene-environment interactions pertaining to blood lipid traits, cardiovascular disease and type 2 diabetes - (Peer Reviewed Journal)
Lee, Y., Lai, C., Ordovas, J.M., Parnell, L.D. 2011. A database of gene-environment interactions pertaining to blood lipid traits, cardiovascular disease and type 2 diabetes. Journal of Data Mining in Genomics & Proteomics. 2:106. DOI:10.4172/2153-0602.1000106.
Interleukin 1B variant -1473G/C (rs1143623) influences triglyceride and interleukin 6 metabolism - (Peer Reviewed Journal)
Delgado-Lista, J., Garcia-Rios, A., Perez-Martinez, P., Solivera, J., Yubero-Serrano, E.M., Fuentes, F., Parnell, L.D., Shen, J., Gomez, P., Jimenez-Gomez, Y., Gomez-Luna, M.J., Marin, C., Belisle, S.E., Rodriguez-Cantalejo, F., Meydani, S.N., Ordovas, J.M., Perez-Jimenez, F., Lopez-Miranda, J. 2011. Interleukin 1B variant -1473G/C (rs1143623) influences triglyceride and interleukin 6 metabolism. Journal of Clinical Endocrinology and Metabolism. 96(5):E816-820.
Interactions between genetic variants of folate metabolism genes and lifestyle affect plasma homocysteine concentrations in the Boston Puerto Rican Population - (Peer Reviewed Journal)
Huang, T., Tucker, K., Lee, Y., Crott, J., Parnell, L.D., Shen, J., Smith, C., Ordovas, J., Li, D., Lai, C. 2011. Interactions between genetic variants of methionine metabolism genes and lifestyle affect plasma homocysteine concentrations in the Boston Puerto Rican Population. Molecular Nutrition and Food Research. DOI: 10.1017/S1368980011000140.
Perilipin polymorphism interacts with saturated fat and carbohydrates to modulate insulin resistance - (Peer Reviewed Journal)
Smith, C.E., Arnett, D.K., Corella, D., Tsai, M.Y., Lai, C., Parnell, L.D., Lee, Y., Ordovas, J.M. 2012. Perilipin polymorphism interacts with saturated fat and carbohydrates to modulate insulin resistance. Nutrition, Metabolism and Cardiovascular Diseases. 22(5):449-455.
Gene variations of nitric oxide synthase regulate the effects of a saturated fat rich meal on endothelial function - (Peer Reviewed Journal)
Delgado-Lista, J., Fuentes, F., Jimenez-Gomez, Y., Perez-Martinez, P., Gomez-Luna, M.J., Parnell, L.D., Marin, C., Lai, C., Perez-Jimenez, F., Ordovas, J.M., Lopez-Miranda, J. 2010. Gene variations of nitric oxide synthase regulate the effects of a saturated fat rich meal on endothelial function. Clinical Nutrition. 30(2):234-238.
Apolipoprotein B genetic variants modify the response to fenofibrate: a GOLDN study - (Peer Reviewed Journal)
Wojczynski, M.K., Gao, G., Borecki, I., Hopkins, P.N., Parnell, L.D., Lai, C., Ordovas, J.M., Arnett, D.K. 2010. Apolipoprotein B genetic variants modify the response to fenofibrate: a GOLDN study. Journal of Lipid Research. 51(11):3316-3323.
MAT1A variants modulate the effect of dietary fatty acids on plasma homocysteine concentrations and DNA damage - (Peer Reviewed Journal)
Huang, T., Tucker, K., Lee, Y., Crott, J., Parnell, L.D., Shen, J., Smith, C.E., Ordovas, J.M., Li, D., Lai, C. 2010. MAT1A variants modulate the effect of dietary fatty acids on plasma homocysteine concentrations and DNA damage. Nutrition, Metabolism and Cardiovascular Diseases. DOI: 1016/j.numecd.2010.07.015.
Drosophila lacks C20 and C22 polyunsaturated fatty acids - (Peer Reviewed Journal)
Shen, L., Lai, C., Feng, X., Parnell, L.D., Wang, J., Li, D., Ordovas, J.M., Kang, J. 2010. Drosophila lacks C20 and C22 polyunsaturated fatty acids. Journal of Lipid Research. 51(10)2985-2992.
Apolipoprotein E polymorphisms and postprandial triglyceridemia before and after fenofibrate treatment in the Genetics of Lipid Lowering and Diet Network (GOLDN) Study - (Peer Reviewed Journal)
Irvin, M.R., Kabagambe, E.K., Tiwari, H.K., Parnell, L.D., Straka, R.J., Tsai, M., Ordovas, J.M., Arnett, D.K. 2010. Apolipoprotein E polymorphisms and postprandial triglyceridemia before and after fenofibrate treatment in the Genetics of Lipid Lowering and Diet Network (GOLDN) Study. Circulation: Cardiovascular Genetics. 3(5):462-467.
Gene expression changes in peripheral blood mononuclear cells from patients with metabolic syndrome after acute intake of phenol-rich virgin olive oil - (Peer Reviewed Journal)
Camargo, A., Ruano, J., Fernandez, J.M., Parnell, L.D., Jimenez, A., Santos-Gonzalez, M., Marin, C., Perez-Martinez, P., Uceda, M., Lopez-Miranda, J., Perez-Jimenez, F. 2010. Gene expression changes in peripheral blood mononuclear cells from patients with metabolic syndrome after acute intake of phenol-rich virgin olive oil. Biomed Central (BMC) Genomics. 11:253-267.
Effect variants of the CD36 gene and metabolic syndrome in Boston Puerto Rican adults - (Peer Reviewed Journal)
Noel, S.E., Lai, C., Mattei, J., Parnell, L.D., Ordovas, J., Tucker, K.L. 2010. Effect variants of the CD36 gene and metabolic syndrome in Boston Puerto Rican adults. Atherosclerosis. 211(1):210-215.
ABCA1 gene variants regulate posprandial lipid metabolism in healthy men - (Peer Reviewed Journal)
Delgado-Lista, J., Perez-Martinez, P., Perez-Jiminez, F., Garcia-Rios, A., Fuentes, F., Marin, C., Gomez-Luna, P., Camargo, A., Parnell, L.D., Ordovas, J.M., Lopez-Miranda, J. 2010. ABCA1 gene variants regulate posprandial lipid metabolism in healthy men. Arteriosclerosis Thrombosis and Vascular Biology. 30(5):1051-1057.
MAT1A variants are associated with hypertension, stroke, and DNA damage and are modulated by vlasma vitamin B6 and folate concentration - (Peer Reviewed Journal)
Lai, C., Tucker, K., Parnell, L.D., Shen, J., Caouette, H., Warodomwichit, D., Lee, Y., Crott, J., Ordovas, J.M. 2010. MAT1A variants are associated with hypertension, stroke, and DNA damage and are modulated by plasma vitamin B6 and folate concentration. American Journal of Clinical Nutrition. 91(5):1377-1386.
Expression of recombinant AccMRJP1 protein from royal jelly of Chinese honeybee in Pichia pastoris and its proliferation activity in an insect cell line - (Peer Reviewed Journal)
Shen, L., Zhang, W., Jin, F., Zhang, L., Chen, Z., Liu, L., Parnell, L.D., Lai, C., Li, D. 2010. Expression of recombinant AccMRJP1 protein from royal jelly of Chinese honeybee in Pichia pastoris and its proliferation activity in an insect cell line. Journal of Agricultural and Food Chemistry. 58(4):2266-2273.
Adaptive genetic variation and heart disease risk - (Review Article)
Parnell, L.D., Lee, Y., Lai, C. 2010. Adaptive genetic variation and heart disease risk. Current Opinion in Lipidology. 21(2):116-122.
PER2 variants are associated with abdominal obesity, psycho-behavioral factors and attrition in the dietary treatment of obesity - (Peer Reviewed Journal)
Garaulet, M., Corbalan-Tutau, D., Madrid, J.A., Baraza, J.C., Parnell, L.D., Lee, Y., Ordovas, J.M. 2010. PER2 variants are associated with abdominal obesity, psycho-behavioral factors and attrition in the dietary treatment of obesity. Journal of American Dietetic Association. 110(6):917-921.
Gene-environment interactions and the impact on obesity and lipid profile phenotypes - (Review Article)
Parnell, L.D. 2009. Gene-environment interactions and the impact on obesity and lipid profile phenotypes. Clinical Lipidology. 4:104-107.
CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids - (Peer Reviewed Journal)
Garaulet, M., Lee, Y., Shen, J., Parnell, L.D., Arnett, D.K., Tsai, M.Y., Lai, C., Ordovas, J.M. 2009. CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids. American Journal of Clinical Nutrition. 90(6):1466-1475.
Genetic variants in human CLOCK associate with total energy intake and cytokine sleep factors - (Peer Reviewed Journal)
Garaulet, M., Lee, Y., Shen, J., Parnell, L.D., Arnett, D.K., Tsai, M.Y., Lai, C., Ordovas, J.M. 2009. Genetic variants in human CLOCK associate with total energy intake and cytokine sleep factors. Human Molecular Genetics. 18(3):364-369.
Disparities in allele frequencies and population differentiation for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and non-Hispanic whites - (Peer Reviewed Journal)
Mattei, J., Parnell, L.D., Lai, C., Garcia-Bailo, B., Adiconis, X., Shen, J., Arnett, D., Demissie, S., Tucker, K., Ordovas, J.M. 2009. Disparities in allele frequencies and population differentiation for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and non-Hispanic whites. BioMed Central (BMC) Genetics. 10:45.
APOA2, dietary fat and body mass index: replication of a gene-diet interaction in three independent populations - (Peer Reviewed Journal)
Corella, D., Peloso, G., Arnett, D.K., Demissie, S., Cupples, L., Tucker, K., Lai, C., Parnell, L.D., Coltell, O., Lee, Y., Ordovas, J.M. 2009. APOA2, dietary fat and body mass index: replication of a gene-diet interaction in three independent populations. Archives of Internal Medicine. 169:1897-1906.
Effects of variations in the APOA1/C3/A4/A5 gene cluster on different parameters of postprandial lipid metabolism in healthy young men - (Peer Reviewed Journal)
Delgado-Lista, J., Perez-Jimenez, F., Ruano, J., Perez-Martinez, P., Fuentes, F., Criado-Garcia, J., Parnell, L.D., Ordovas, J.M., Lopez-Miranda, J. 2009. Effects of variations in the APOA1/C3/A4/A5 gene cluster on different parameters of postprandial lipid metabolism in healthy young men. Journal of Lipid Research. 51:63-73.
ADAM17_i33780A>G polymorphism interacts with dietary n-6 polyunsaturated fatty acids to modulate obesity risk in the genetics of lipid lowering drugs and diet network study - (Peer Reviewed Journal)
Junyent, M., Arnett, D.A., Tsai, M.Y., Kabagambe, E.K., Straka, R.J., Province, M., An, P., Smith, C., Borecki, I., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2010. ADAM17_i33780A>G polymorphism interacts with dietary n-6 polyunsaturated fatty acids to modulate obesity risk in the genetics of lipid lowering drugs and diet network study. Nutrition Metabolism and Cardiovascular Disease. 20(101):698-705.
Novel variants at KCTD10 and MVK/MMAB genes interact with dietary carbohydrates to modulate HDL-C concentrations in the genetics of lipid lowering drugs and diet network study - (Peer Reviewed Journal)
Junyent, M., Arnett, D.A., Tsai, M.Y., Kabagambe, E.K., Straka, R.J., Province, M., An, P., Smith, C., Borecki, I., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2009. Novel variants at KCTD10 and MVK/MMAB genes interact with dietary carbohydrates to modulate HDL-C concentrations in the genetics of lipid lowering drugs and diet network study. American Journal of Clinical Nutrition. 90(3):686-694.
Apolipoprotein A5 and lipoprotein lipase interact to modulate anthropometric measures in Hispanics of Caribbean origin - (Peer Reviewed Journal)
Smith, C.E., Tucker, K.L., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2010. Apolipoprotein A5 and lipoprotein lipase interact to modulate anthropometric measures in Hispanics of Caribbean origin. Obesity. 18(2):327-332.
The effect of ABCG5/G8 polymorphisms on plasma HDL cholesterol levels depends on the ABCA1 gene variation in the Boston Puerto Rican Health Study - (Peer Reviewed Journal)
Junyent, M., Tucker, K.L., Lane, J.M., Mattei, J., Smith, C., Parnell, L.D., Lai, C., Ordovas, J.M. 2009. The effect of ABCG5/G8 polymorphisms on plasma HDL cholesterol levels depends on the ABCA1 gene variation in the Boston Puerto Rican Health Study. Nutrition Metabolism and Cardiovascular Disease. 18:64-69.
The effects of ABCG5/G8 polymorphisms on HDL-cholesterol concentrations depend on ABCA1 genetic variants in the Boston Puerto Rican health study - (Peer Reviewed Journal)
Junyent, M., Tucker, K., Smith, C., Lane, J., Mattei, J., Lai, C., Parnell, L.D., Ordovas, J. 2010. The effects of ABCG5/G8 polymorphisms on HDL-cholesterol concentrations depend on ABCA1 genetic variants in the Boston Puerto Rican health study. Nutrition Metabolism and Cardiovascular Disease. 20(8):558-566.
Apolipoprotein C3 polymorphism is associated with cognitive function in Caribbean Hispanics - (Peer Reviewed Journal)
Smith, C.E., Tucker, K.L., Scott, T.M., Van Rompay, M., Parnell, L.D., Lai, C., Mattei, J., Junyent, M., Lee, Y., Garcia-Bailo, B., Ordovas, J.M. 2009. Apolipoprotein C3 polymorphism is associated with cognitive function in Caribbean Hispanics. PLoS One. 4(5):e5465.
Polymorphisms in uracil-processing genes, but not one-carbon nutrients, are associated with altered DNA uracil concentrations in an urban Puerto Rican population - (Peer Reviewed Journal)
Chanson, A., Parnell, L.D., Ciappio, E.D., Liu, Z., Crott, J.W., Tucker, K., Mason, J.B. 2009. Polymorphisms in uracil-processing genes, but not one-carbon nutrients, are associated with altered DNA uracil concentrations in an urban Puerto Rican population. American Journal of Clinical Nutrition. 89:1927-1936.
A composite scoring of genotypes discriminates coronary heart disease risk beyond conventional risk factors in the Boston Puerto Rican Health Study - (Peer Reviewed Journal)
Junyent, M., Parnell, L.D., Lai, C., Ordovas, J.M., Tucker, K.L., Shen, J., Mattei, J., Smith, C., Lee, Y. 2009. A composite scoring of genotypes discriminates coronary heart disease risk beyond conventional risk factors in the Boston Puerto Rican Health Study. Nutrition Metabolism and Cardiovascular Disease.20(3):157-167.
A composite scoring of genotypes discriminates coronary heart disesase risk beyond conventional risk factors in the Boston Puerto Rican Health Study - (Peer Reviewed Journal)
Junyent, M., Tucker, K., Shen, J., Lee, Y., Smith, C., Mattei, J., Lai, C., Parnell, L.D., Ordovas, J. 2010. A composite scoring of genotypes discriminates coronary heart disesase risk beyond conventional risk factors in the Boston Puerto Rican Health Study. Nutrition Metabolism and Cardiovascular Disease. 20(3):157-164.
Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study - (Peer Reviewed Journal)
Smith, C.E., Arnett, D.K., Tsai, M.Y., Lai, C., Parnell, L.D., Shen, J., Laclaustra, M., Junyent, M., Ordovas, J.M. 2009. Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study. Atherosclerosis.206:500-504.
The effect of a novel intergenic polymorphism (rs11774572) on HDL cholesterol concentrations depends on the TaqIB polymorphism in the cholesterol ester transfer protein gene - (Peer Reviewed Journal)
Junyent, M., Arnett, D.A., Tsai, M.Y., Kabagambe, E.K., Straka, R.J., Province, M., An, P., Smith, C., Shen, J., Borecki, I., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2009. The effect of a novel intergenic polymorphism (rs11774572) on HDL cholesterol concentrations depends on the TaqIB polymorphism in the cholesterol ester transfer protein gene. Nutrition Metabolism and Cardiovascular Disease.20:34-40.
Genetic Variants at the PDZ-Interacting Domain of the Scavenger Receptor Class B Type I Interact with Diet to Influence the Risk of Metabolic Syndrome in Obese Men and Women - (Peer Reviewed Journal)
Junyent, M., Arnett, D.A., Tsai, M.Y., Kabagambe, E.K., Straka, R.J., Province, M., An, P., Shen, J., Borecki, I., Parnell, L.D., Lai, C., Lee, Y., Ordovas, J.M. 2009. Genetic Variants at the PDZ-Interacting Domain of the Scavenger Receptor Class B Type I Interact with Diet to Influence the Risk of Metabolic Syndrome in Obese Men and Women. Journal of Nutrition. 139(6):842-848.
The effects of ABCG5/G8 polymorphisms on plasma HDL cholesterol concentrations depend on smoking habit in the Boston Puerto Rican Health Study - (Peer Reviewed Journal)
Junyent, M., Tucker, K., Smith, C., Garcia-Rios, A., Mattei, J., Lai, C., Parnell, L.D., Ordovas, J.M. 2008. The effects of ABCG5/G8 polymorphisms on plasma HDL cholesterol concentrations depend on smoking habit in the Boston Puerto Rican Health Study. Journal of Lipid Research. 50:565-573.
WDTC1, an ortholog of Drosphilia adipose gene, associates with human obesity - (Peer Reviewed Journal)
Lai, C., Parnell, L.D., Garcia-Bailo, B., Tucker, K., Ordovas, J.M. 2008. WDTC1, an ortholog of Drosphilia adipose gene, associates with human obesity. Obesity. 17(3):593-600.
Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states - (Peer Reviewed Journal)
Perez-Martinez, P., Corella, D., Shen, J., Arnett, D.K., Yiannakouris, N., Tai, E., Orho-Melander, M., Tucker, K.L., Tsai, M., Straka, R.J., Province, M., Kai, C., Perez-Jimenez, F., Lai, C., Lopez-Miranda, J., Guillen, M., Parnell, L.D., Borecki, I., Kathiresan, S., Ordovas, J.M. 2009. Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states. American Journal of Clinical Nutrition. 89:391-399.
ADIPOQ Polymorphisms, Monounsaturated Fatty Acids, and Obesity Risk: The GOLDN Study - (Peer Reviewed Journal)
Warodomwichit, D., Shen, J., Arnett, D., Tsai, M., Kabagambe, E., Peacock, J., Hixson, J., Straka, R., Province, M., An, P., Lai, C., Parnell, L.D., Borecki, I., Ordovas, J.M. 2009. ADIPOQ Polymorphisms, Monounsaturated Fatty Acids, and Obesity Risk: The GOLDN Study. Obesity. 17:510-517.
Perilipin polymorphism interacts with dietary carbohydrates to modulate anthropometric traits in Hispanics of Caribbean origin - (Peer Reviewed Journal)
Smith, C., Tucker, K., Yiannakouris, N., Garcia-Bailo, B., Mattei, J., Lai, C., Parnell, L.D., Ordovas, J.M. 2008. Perilipin Polymorphism Interacts with Dietary Carbohydrates to Modulate Anthropometric Traits in Hispanics of Caribbean Origin. Journal of Nutrition. 138(10):1852-1858.
A Common Missense Variant in the Glucokinase Regulatory Protein Gene (GCKR) Is Associated with Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations - (Peer Reviewed Journal)
Orho-Melander, M., Melander, O., Guiducci, C., Perez-Martinez, P., Corella, D., Roos, C., Tewhey, R., Rieder, M.J., Hall, J., Abecasis, G., Tai, E., Welch, C., Arnett, D.K., Lyssenko, V., Lindholm, E., Saxena, R., De Bakker, P., Burtt, N., Voight, B.F., Hirschhorn, J.N., Tucker, K., Hedner, T., Tuomi, T., Isomaa, B., Eriksson, K., Taskinen, M., Wahlstrand, B., Hughes, T.E., Parnell, L.D., Lai, C., Berglund, G., Peltonen, L., Vartiainen, E., Jousilahti, P., Havulinna, A.S., Salomaa, V., Nilsson, P., Groop, L., Altshuler, D., Ordovas, J.M., Kathiresan, S. 2008. A Common Missense Variant in the Glucokinase Regulatory Protein Gene (GCKR) Is Associated with Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations. Diabetes. 57:3112-3121.
Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine and DNA uracil concentrations - (Peer Reviewed Journal)
Devos, L., Chanson, A., Liu, Z., Ciappo, E., Parnell, L.D., Mason, J.B., Tucker, K., Crott, J.W. 2008. Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine and DNA uracil concentrations. American Journal of Clinical Nutrition. 88(4):1149-1158.
The effect of IL6-174C/G polymorphisms on postprandial triglycerides metabolism in the GOLDN study - (Peer Reviewed Journal)
Shen, J., Arnett, D.K., Perez-Martinez, P., Parnell, L.D., Peacock, J.M., Hixson, J.E., Tsai, M.Y., Lai, C., Straka, R.J., Hopkins, P.N., Ordovas, J.M. 2008. The effect of IL6-174C/G polymorphisms on postprandial triglycerides metabolism in the GOLDN study. Journal of Lipid Research. 49:1839-1845.
Association of common C-protein (CRP) gene polymorphism with baseline plasma CRP levels and fenofibrate response: The GOLDN Study - (Peer Reviewed Journal)
Shen, J., Arnett, D.K., Parnell, L.D., Peacock, J.M., Lai, C., Hixson, J.E., Tsai, M.Y., Province, M., Straka, R.J., Ordovas, J.M. 2008. Association of common C-protein (CRP) gene polymorphism with baseline plasma CRP levels and fenofibrate response: The GOLDN Study. Diabetes Care. 31(5):910-915.
Genetic variants in uracil processing enzymes are associated with abnormal DNA uracil content - (Abstract Only)
Chanson, A., Parnell, L.D., Crott, J., Choi, S., Han, H., Mason, J.B. 2008. Genetic variants in uracil processing enzymes are associated with abnormal DNA uracil content. American Association for Cancer Research (AACR) 2008 Annual Meeting, April 12-16, 2008. Paper No. 1891.
PPARGC1A Variations Associated with DNA Damage, Diabetes, and Cardiovascular Diseases: The Boston Puerto Rican Study - (Review Article)
Lai, C., Tucker, K., Parnell, L.D., Adiconis, X., Garcia-Bailo, B., Griffith, J., Meydani, M., Ordovas, J.M. 2008. PPARGC1A Variations Associated with DNA Damage, Diabetes, and Cardiovascular Diseases: The Boston Puerto Rican Study. Diabetes. 57:809-816.
Speed-Mapping Quantitative Trait Loci Using Microarrays - (Peer Reviewed Journal)
Lai, C., Leips, J., Zou, W., Roberts, J.F., Wollenberg, K.R., Parnell, L.D., Zeng, Z., Ordovas, J.M., Mckay, T.F. 2007. Speed-Mapping Quantitative Trait Loci Using Microarrays. Nature Methods. 4(10):839-841.
An apolipoprotein A-II polymorphism (-265T/C, rs5082), regulates postprandial response to a saturated fat overload in healthy men - (Peer Reviewed Journal)
Delgado-Lista, J., Perez-Jimenez, F., Tanaka, T., Perez-Martinez, P., Jiminez-Gomez, Y., Marin, C., Ruano, J., Parnell, L.D., Ordovas, J.M., Lopez-Miranda, J. 2007. An apolipoprotein A-II polymorphism (-265T/C, rs5082), regulates postprandial response to a saturated fat overload in healthy men. Journal of Nutrition. 137:2024-2028.
Interleukin 1B genetic polymorphisms interact with polyunsaturated fatty acids to affect risk of the metabolic syndrome in the GOLDN Study - (Peer Reviewed Journal)
Shen, J., Arnett, D.K., Peacock, J.M., Parnell, L.D., Aldi, K., Hixson, J.E., Tsai, M.Y., Kabagambe, E.K., Lai, C., Stratka, R.J., Ordovas, J.M. 2007. Interleukin 1B genetic polymorphisms interact with polyunsaturated fatty acids to affect risk of the metabolic syndrome in the GOLDN Study. Journal of Nutrition. 137(8):1846-1851.
The -256T>C Polymorphism in the Apolipoprotein A-II Gene Promoter Is Associated with Body Mass Index and Food Intake in the Genetics of Lipid Lowering Drugs and Diet Network Study - (Peer Reviewed Journal)
Corella, D., Arnett, D.K., Tsai, M.Y., Kabagambe, E.K., Peacock, J.M., Hixson, J.E., Straka, R.J., Province, M., Lai, C., Parnell, L.D., Borecki, I., Ordovas, J.M. 2007. The -256T>C Polymorphism in the Apolipoprotein A-II Gene Promoter Is Associated with Body Mass Index and Food Intake in the Genetics of Lipid Lowering Drugs and Diet Network Study. Clinical Chemistry.53:1144-1152.
Fenofibrate Effect on Triglyceride and Postprandial Response of Apolipoprotein A5 Variants: The GOLDN Study - (Peer Reviewed Journal)
Lai, C., Arnett, D.K., Straka, R.J., Tsai, M.Y., Peacock, J.M., Adiconis, X., Parnell, L.D., Hixson, J.E., Province, M.A., Ordovas, J.M. 2007. Fenofibrate Effect on Triglyceride and Postprandial Response of Apolipoprotein A5 Variants: The GOLDN Study. Arteriosclerosis Thrombo Vasc Biol. 27:1417-1425.
Candidate genes affecting Drosophila life span identified by integrating microarray gene expression analysis and QTL mapping - (Abstract Only)
Lai, C., Parnell, L.D., Lyman, R.F., Ordovas, J.M., Mackay, T.F. 2006. Candidate genes affecting Drosophila life span identified by integrating microarray gene expression analysis and QTL mapping. Mechanisms of Aging and Development 128:237-249.
Lifespan modification by glucose and methionine in Drosophila melanogaster fed a chemically defined diet - (Peer Reviewed Journal)
Troen, A.M., French, E.E., Roberts, J.F., Selhub, J., Ordovas, J.M., Parnell, L.D., Lai, C. 2006. Lifespan modification by glucose and methionine in Drosophila melanogaster fed a chemically defined diet. Age.29:29-39.
INTERLEUKIN 6-174C>G POLYMORPHISM IS ASSOCIATED WITH LOW BONE MINERAL DENSITY IN OLDER SUBJECTS CONSUMING LOW CALCIUM - (Abstract Only)
Shen, J., Crosier, M.D., Parnell, L.D., Shea, K., Dawson-Hughes, B., Ordovas, J.M., Booth, S.L. 2006. Interleukin 6-174c>g polymorphism is associated with low bone mineral density in older subjects consuming low calcium. Experimental Biology 2006 Annual Meeting. April 1- 5, 2006. San Francisco, CA. Abstract no. 398.1.
GENOME-WIDE LINKAGE ANALYSES AND CANDIDATE GENE FINE MAPPING FOR HDL3 CHOLESTEROL: THE FRAMINGHAM STUDY - (Peer Reviewed Journal)
Yang, Q., Lai, C., Parnell, L.D., Cupples, L., Adiconis, X., Zhu, Y., Wilson, P.W., Housman, D.E., Sherman, A.M., D'Agostino, R.B., Ordovas, J.M. 2005. Genome-wide linkage analyses and candidate gene fine mapping for HDL3 cholesterol: the Framingham Study. Journal of Lipid Research. 46(7):1416-1425.
THE APOA1/C3/A4/A5 GENE CLUSTER, LIPID METABOLISM AND CARDIOVASCULAR DISEASE RISK - (Review Article)
Lai, C., Parnell, L.D., Ordovas, J.M. 2005. The apoa1/c3/a4/a5 gene cluster, lipid metabolism and cardiovascular disease risk. Current Opinion in Lipidology 2005, 16:153-166.
INFLUENCE OF THE APOLIPOPROTEIN A5 LOCUS ON PLASMA TRIGLYCERIDE, REMNANT-LIKE PARTICLES, AND LIPOPROTEIN SUBFRACTION CONCENTRATIONS -IMPLICATION FOR CARDIOVASCULAR RISK IN THE FRAMINGHAM HEART STUDY - (Peer Reviewed Journal)
Lai, C., Demissie, S., Cupples, A., Zhu, Y., Adiconis, X., Parnell, L.D., Corella, D., Ordovas, J.M. 2004. Influence of the apolipoprotein a5 locus on plasma triglyceride, remnant-like particles, and lipoprotein subfraction concentrations -implication for cardiovascular risk in the framingham heart study. Arteriosclerosis Thrombosis and Vascular Biology. 2004; 45: 2096-2105
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