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ARS Home » Northeast Area » Beltsville, Maryland (BHNRC) » Beltsville Human Nutrition Research Center » Diet, Genomics and Immunology Laboratory » People & Locations » Sukla Lakshman
Sukla Lakshman
Diet, Genomics and Immunology Laboratory
Microbiologist

Phone: (301) 504-8031 ext. 289
Fax: (301) 504-9062

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Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Metabolic pathway and network analysis integration for discovering the biomarkers in pig feces after a controlled fruit-vegetable dietary intervention Reprint Icon - (Peer Reviewed Journal)
Liu, Z., Solano Aguilar, G., Lakshman, S., Urban, J.F., Zhang, M., Chen, P., Yu, L., Sun, J. 2024. Metabolic pathway and network analysis integration for discovering the biomarkers in pig feces after a controlled fruit-vegetable dietary intervention. Food Chemistry. 461:140836. https://doi.org/10.1016/j.foodchem.2024.140836.
Fruit and vegetable supplemented diet modulates the pig transcriptome and microbiome after a two-week feeding intervention Reprint Icon - (Peer Reviewed Journal)
Solano-Aguilar, G.I., Lakshman, S., Shao, J.Y., Chen, C.T., Beshah, E., Dawson, H.D., Vinyard, B.T., Schroeder, S.G., Jang, S., Molokin, A., Urban Jr., J.F. 2021. Fruit and vegetable supplemented diet modulates the pig transcriptome and microbiome after a two-week feeding intervention. Nutrients. 13:4350. https://doi.org/10.3390/nu13124350.
The effects of consuming white button mushroom-Agaricus Bisporus-on the brain and liver metabolome using a targeted metabolomic analysis Reprint Icon - (Peer Reviewed Journal)
Solano-Aguilar, G.I., Lakshman, S., Jang, S., Gupta, R., Molokin, A., Schroeder, S.G., Gillevet, P.M., Urban Jr., J.F. 2021. The effects of consuming white button mushroom Agaricus bisporus on the brain and liver metabolome using a targeted metabolomic analysis. Metabolites. 11(11):779. https://doi.org/10.3390/metabo11110779.
Western and heart healthy dietary patterns differentially affect the expression of genes associated with lipid metabolism, interferon signaling and inflammation in the jejunum of Ossabaw pigs Reprint Icon - (Peer Reviewed Journal)
Ye, S., Matthan, N., Lamon-Fava, S., Solano Aguilar, G., Turner, J., Walker, M.E., Chai, Z., Lakshman, S., Urban Jr, J.F., Lichtenstein, A.H. 2021. Western and heart healthy dietary patterns differentially affect the expression of genes associated with lipid metabolism, interferon signaling and inflammation in the jejunum of Ossabaw pigs. Journal of Nutritional Biochemistry. 90:108577. https://doi.org/doi: 10.1016/j.jnutbio.2020.108577.
Colon transcriptome is modified by dietary pattern/Atorvastatin interaction in the Ossabaw pig Reprint Icon - (Peer Reviewed Journal)
Shumao, Y., Nirupa, M., Lamon-Fava, S., Solano Aguilar, G., Turner, J.R., Walker, M.E., Zhi, C., Lakshman, S., Chen, C.T., Dawson, H.D., Urban Jr, J.F., Lichtenstein, A.H. 2021. Colon transcriptome is modified by dietary pattern/Atorvastatin interaction in the Ossabaw pig. Journal of Nutritional Biochemistry. 90:108577. https://doi.org/10.1016/j.jnutbio.2020.108570.
Method: isolation of epithelial cell RNA from frozen jejunum segments while minimizing smooth muscle cell rNA contamination Reprint Icon - (Abstract Only)
Ye, S., Matthan, N.R., Lamon-Fava, S., Solano Aguilar, G., Turner, J.R., Wang, X., Walker, M.E., Chai, Z., Lakshman, S., Urban Jr, J.F., Lichtenstein, A.H. 2020. Method: isolation of epithelial cell RNA from frozen jejunum segments while minimizing smooth muscle cell rNA contamination. Current Developments in Nutrition. 4(Suppl_2):1182. https://doi.org/10.1093/cdn/nzaa056_029.
Western versus heart healthy dietary pattern alters genes expression associated with lipid metabolism, interferon signaling and inflammation in jejunum of Ossabaw pigs Reprint Icon - (Abstract Only)
Ye, S., Matthan, N.R., Lamon-Fava, S., Solano Aguilar, G., Turner, J.R., Wang, X., Walker, M.E., Chai, Z., Lakshman, S., Urban Jr, J.F., Lichtenstein, A.H. 2020. Western versus heart healthy dietary pattern alters genes expression associated with lipid metabolism, interferon signaling and inflammation in jejunum of Ossabaw pigs. Current Developments in Nutrition. 4(Suppl_2):577. https://doi.org/10.1093/cdn/nzaa046_077.
5-(Hydroxyphenyl)-y-valerolactone-sulfate, a key microbial metabolite of flavan-3-ols, is able to reach the brain: evidence from different in silico, in vitro and in vivo experimental models Reprint Icon - (Peer Reviewed Journal)
Angelino, D., Carregora, D., Domenech-Coca, C., Savi, M., Figueira, I., Brindani, N., Jang, S., Lakshman, S., Molokin, A., Urban Jr, J.F., Davies, C.D., Britto, M.A., Kim, K.S., Brighenti, F., Curti, C., Blade, C., Del Bas, J.M., Stilli, D., Solano Aguilar, G., Nunes Del Santos, C., Del Rio, D., Mena, P. 2019. 5-(Hydroxyphenyl)-y-valerolactone-sulfate, a key microbial metabolite of flavan-3-ols, is able to reach the brain: evidence from different in silico, in vitro and in vivo experimental models. Nutrients. 11(11). pii: E2678. https://doi.org/10.3390/nu11112678.
A Western-type dietary pattern induces an atherogenic gene expression profile in the coronary arteries of the Ossabaw pig Reprint Icon - (Peer Reviewed Journal)
Walker, M., Matthan, N., Lamon-Fava, S., Solano-Aguilar, G., Jang, S., Lakshman, S., Molokin, A., Urban Jr, J.F., Faits, T., Johnson, W.E., Lichtenstein, A.H. 2019. A Western-type dietary pattern induces an atherogenic gene expression profile in the coronary arteries of the Ossabaw pig. Current Developments in Nutrition. 3(5). https://doi.org/10.1093/cdn/nzz023.
Dietary patterns influence epicardial adipose tissue fatty acid composition and inflammatory gene expression in the Ossabaw pig Reprint Icon - (Peer Reviewed Journal)
Walker, M., Matthan, N., Goldbaum, A., Meng, H., Lamon-Fava, S., Lakshman, S., Jang, S., Molokin, A., Solano Aguilar, G., Urban Jr, J.F., Lichtenstein, A.H. 2019. Dietary patterns influence epicardial adipose tissue fatty acid composition and inflammatory gene expression in the Ossabaw pig. Journal of Nutritional Biochemistry. 70:138-146. https://doi.org/10.1016/j.jnutbio.2019.04.013.
A Western dietary pattern and atorvastatin induce epicardial adipose tissue interferon signaling in the Ossabaw pig Reprint Icon - (Peer Reviewed Journal)
Walker, M., Matthan, N., Solano Aguilar, G., Jang, S., Lakshman, S., Molokin, A., Faits, T., Urban Jr, J.F., Johnson, W.E., Lamon-Fava, S., Lichtenstein, A.H. 2019. A Western dietary pattern and atorvastatin induce epicardial adipose tissue interferon signaling in the Ossabaw pig. Journal of Nutritional Biochemistry. https://doi.org/10.1016/j.jnutbio.2019.02.003.
The effect of dietary Agaricus bisporus mushroom on intestinal microbiota composition and host immunological function Reprint Icon - (Peer Reviewed Journal)
Solano Aguilar, G., Jang, S., Lakshman, S., Gupta, R., Beshah, E., Sikaroodi, M., Vinyard, B.T., Molokin, A., Gillevet, P., Urban Jr, J.F. 2018. The effect of dietary Agaricus bisporus mushroom on intestinal microbiota composition and host immunological function. Nutrients. 10(11):1721. https://doi.org/10.3390/nu10111721.
Bifidobacterium animalis subspecies lactis modulates the local immune response and glucose uptake in the small intestine of juvenile pigs infected with the parasitic nematode Ascaris suum Reprint Icon - (Peer Reviewed Journal)
Solano Aguilar, G., Shea-Donohue, T., Madden, K., Quinones, A., Beshah, E., Lakshman, S., Xie, Y., Dawson, H.D., Urban Jr, J.F. 2018. Bifidobacterium animalis subspecies lactis modulates the local immune response and glucose uptake in the small intestine of juvenile pigs infected with the parasitic nematode Ascaris suum. Gut Microbes. 19:1-15. https://doi.org/10.1080/19490976.2018.1460014.
Dietary fat influences epicardial adipose tissue fatty acid composition in the Ossabaw miniature pig - (Abstract Only)
Walker, M., Matthan, N., Solano-Aguilar, G., Goldbaum, A., Lakshman, S., Meng, H., Jang, S., Urban Jr, J.F., Lamon-Fava, S., Lichtenstein, A.H. 2018. Dietary fat influences epicardial adipose tissue fatty acid composition in the Ossabaw miniature pig [abstract]. American Society of Nutrition 2018 Meeting. Abstract No. P10-131.
Associations between epicardial adipose tissue fatty acid composition and gene expression in the Ossabaw miniature pig - (Abstract Only)
Walker, M., Matthan, N., Solano-Aguilar, G., Goldbaum, A., Jang, S., Urban Jr, J.F., Molokin, A., Lakshman, S., Lamon-Fava, S., Lichtenstein, A.H. 2018. Associations between epicardial adipose tissue fatty acid composition and gene expression in the Ossabaw miniature pig [abstract]. American Society of Nutrition 2018 Meeting. Abstract No. P10-132.
The effect of feeding cocoa powder and Lactobacillus rhamnosus LGG on the composition and function of the intestinal microbiome Reprint Icon - (Peer Reviewed Journal)
Solano Aguilar, G., Lakshman, S., Jang, S., Beshah, E., Xie, Y., Sikaroodi, M., Gupta, R., Vinyard, B.T., Molokin, A., Urban Jr, J.F., Gillevet, P., Davis, C. 2018. The effect of feeding cocoa powder and Lactobacillus rhamnosus LGG on the composition and function of the intestinal microbiome. Current Developments in Nutrition. (2)5. https://doi.org/10.1093/cdn/nzy011.
The Ossabaw pig is a suitable translational model to evaluate dietary patterns and coronary artery disease risk Reprint Icon - (Peer Reviewed Journal)
Matthan, N.R., Solano Aguilar, G., Meng, H., Lamon-Fava, S., Goldbaum, A., Walker, M.E., Jang, S., Lakshman, S., Molokin, A., Xie, Y., Beshah, E., Stanley, J., Urban Jr, J.F., Lichtenstein, A.H. 2018. The Ossabaw pig is a suitable translational model to evaluate dietary patterns and coronary artery disease risk. Journal of Nutrition. 148(4):542-552. https://doi.org/10.1093/jn/nxy002.
Lactobacillus rhamnosus LGG and flavanol-enriched cocoa powder altered the immune response to infection with the parasitic nematode Ascaris suum Reprint Icon - (Peer Reviewed Journal)
Jang, S., Lakshman, S., Beshah, E., Xie, Yue, Molokin, A., Vinyard, B.T., Urban Jr, J.F., Davis, C., Solano Aguilar, G. 2017. Lactobacillus rhamnosus LGG and flavanol-enriched cocoa powder altered the immune response to infection with the parasitic nematode Ascaris suum. Nutrients. pii: 1113. https://doi.org/10.3390/nu9101113.
The Ossabaw pig as a model for diet induced atherosclerosis and statin responsiveness - (Abstract Only)
Matthan, N.R., Solano Aguilar, G., Lamon-Fava, S., Goldbaum, A., Walker, M., Meng, H., Stanley, J., Jang, S., Lakshman, S., Molokin, A., Xie, Y., Beshah, E., Urban Jr, J.F., Lichtenstein, A.H. 2016. The Ossabaw pig as a model for diet induced atherosclerosis and statin responsiveness. Journal of Federation of American Societies for Experimental Biology. 31(1):140.4.
Characterization of soybean storage and allergen protein affected by environmental and genetic factors - (Peer Reviewed Journal)
Natarajan, S.S., Khan, F., Song, Q., Lakshman, S., Cregan, P., Scott, R.A., Shipe, E., Garrett, W.M. 2016. Characterization of soybean storage and allergen protein affected by environmental and genetic factors. Journal of Agricultural and Food Chemistry. 64(6):1433-1445.
An efficient extraction method to enhance analysis of low abundant proteins from soybean seed - (Peer Reviewed Journal)
Natarajan, S.S., Krishnan, H.B., Lakshman, S., Garrett, W.M. 2009. An efficient extraction method to enhance analysis of low abundant proteins from soybean seed. Analytical Biochemistry. 394(2):259-268.
Optimized protein extraction methods for proteomic analysis of Rhizoctonia solani - (Peer Reviewed Journal)
Lakshman, D.K., Natarajan, S.S., Garrett, W.M., Lakshman, S., Dhar, A.K. 2008. Optimized protein extraction methods for proteomic analysis of Rhizoctonia solani. Mycologia. 100:867-875.