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Ediane Silva
Foreign Animal Disease Research
RESEARCH SCIENTIST

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Projects
Intervention Strategies to Control and Eradicate Foreign Animal Diseases of Swine
In-House Appropriated (D)
  Accession Number: 441308
Defining the Upper and Lower Respiratory Tract Transcriptome of Cattle Health and Disease
Non-Assistance Cooperative Agreement (S)
  Accession Number: 443407

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Deletion of the EP402R gene from the genome of African swine fever vaccine strain ASFV-G-deltaI177L provides the potential capability of differentiating between infected and vaccinated animals Reprint Icon - (Peer Reviewed Journal)
Borca, M.V., Ramirez Medina, E., Espinoza, N.N., Rai, A., Spinard III, E.J., Velazquez Salinas, L., Valladares, A., Silva, E.B., Burton, L.J., Meyers, A., Clark, J.A., Wu, P., Gay, C.G., Gladue, D.P. 2024. Deletion of the EP402R gene from the genome of African swine fever vaccine strain ASFV-G-deltaI177L provides the potential capability of differentiating between infected and vaccinated animals. Viruses. 16(3). Article 376. https://doi.org/10.3390/v16030376.
Evaluation of the deletion of the African swine fever virus gene O174L from the genome of the Georgia isolate Reprint Icon - (Peer Reviewed Journal)
Ramirez Medina, E., Velazquez Salinas, L., Rai, A., Espinoza, N.N., Valladares, A., Silva, E.B., Burton, L.J., Spinard Iii, E.J., Meyers, A., Risatti, G., Calvelage, S., Blome, S., Gladue, D.P., Borca, M.V. 2023. Evaluation of the deletion of the African swine fever virus gene O174L from the genome of the Georgia isolate. Viruses. 15(10):2134. https://doi.org/10.3390/v15102134.
African swine fever vaccine candidate ASFV-g-deltaI177l produced in the swine macrophage-derived cell line IPKM remains genetically stable and protective against homologous virulent challenge Reprint Icon - (Peer Reviewed Journal)
Borca, M.V., Rai, A., Espinoza, N.N., Ramirez Medina, E., Spinard III, E.J., Velazquez Salinas, L., Valladares, A., Silva, E.B., Burton, L.J., Meyers, A., Gay, C.G., Gladue, D.P. 2023. African swine fever vaccine candidate ASFV-g-deltaI177l produced in the swine macrophage-derived cell line IPKM remains genetically stable and protective against homologous virulent challenge. Viruses. 5(10). Article 2064. https://doi.org/10.3390/v15102064.
African Swine Fever Vaccine Candidate ASFV-G-deltaI177L Produced in the Swine Macrophage-Derived Cell Line IPKM Remains Genetically Stable and Protective against Homologous Virulent Challenge Reprint Icon - (Peer Reviewed Journal)
Ramirez Medina, E., Rai, A., Espinoza, N.N., Spinard III, E.J., Meyers, A., Valladares, A., Velazquez Salinas, L., Gay, C.G., Gladue, D.P., Borca, M.V., Silva, E.B., Burton, L.J., Clark, J.A. 2023. African Swine Fever Vaccine Candidate ASFV-G-deltaI177L Produced in the Swine Macrophage-Derived Cell Line IPKM Remains Genetically Stable and Protective against Homologous Virulent Challenge. Pathogens. 15(10). Article 2064. https://doi.org/10.3390/v15102064.
ASF vaccine candidate ASFV-G-deltaI177l does not exhibit residual virulence in long-term clinical studies Reprint Icon - (Peer Reviewed Journal)
Borca, M.V., Ramirez Medina, E., Silva, E.B., Ayushi, R., Espinoza, N.N., Velazquez Salinas, L., Gladue, D.P. 2023. ASF vaccine candidate ASFV-G-deltaI177l does not exhibit residual virulence in long-term clinical studies. Pathogens. 12(6). https://doi.org/10.3390/pathogens12060805.
Pathogenesis and transmissibility studies of the ASFV strain currently causing outbreaks in the Dominican Republic Reprint Icon - (Abstract Only)
Ramirez Medina, E., O'Donell, V., Silva, E.B., Espinoza, N.N., Velazquez Salinas, L., Moran, K., Daite, D., Barrette, R., Bonto, F., Holland, R., Gladue, D.P., Borca, M.V. 2023. Pathogenesis and transmissibility studies of the ASFV strain currently causing outbreaks in the Dominican Republic. Meeting Abstract. https://doi.org/10.3390/v14051090.
Classical swine fever virus structural glycoprotein E2 interacts with host protein ACADM during the virus infectious cycle Reprint Icon - (Peer Reviewed Journal)
Vuono, E., Ramirez Medina, E., Silva, E.B., Berggren, K., Rai, A., Espinoza, N.N., Gladue, D.P., Borca, M.V. 2023. Classical swine fever virus structural glycoprotein E2 interacts with host protein ACADM during the virus infectious cycle. Viruses. 15(5). https://doi.org/10.3390/v15051036.
Deletion of an African swine fever ATP-dependent RNA hel-icase QP509L from the highly virulent Georgia 2010 strain does not affect replication or virulence Reprint Icon - (Peer Reviewed Journal)
Ramirez Medina, E., Vuono, E., Pruitt, S., Rai, A., Espinoza, N.N., Spinard III, E.J., Valadares, A., Silva, E.B., Velazquez Salinas, L., Borca, M.V., Gladue, D.P. 2022. Deletion of an African swine fever ATP-dependent RNA hel-icase QP509L from the highly virulent Georgia 2010 strain does not affect replication or virulence. Viruses. 14(11). https://doi.org/10.3390/v14112548.
The presence of virus neutralizing antibodies is highly associated with protection against virulent challenge in domestic pigs immunized with ASFV live attenuated vaccine candidates Reprint Icon - (Peer Reviewed Journal)
Silva, E.B., Krug, P., Ramirez Medina, E., Pruitt, S., Rai, A., Espinoza, N.N., Valadares, A., Gladue, D.P., Borca, M.V. 2022. The presence of virus neutralizing antibodies is highly associated with protection against virulent challenge in domestic pigs immunized with ASFV live attenuated vaccine candidates. Pathogens. 11(11). Article 1311. https://doi.org/10.3390/pathogens11111311.
ASFV Gene A151R is involved in the process of virulence in domestic swine Reprint Icon - (Peer Reviewed Journal)
Ramirez Medina, E., Vuono, E., Pruitt, S., Rai, A., Espinoza, N.N., Valladres, A., Spinard III, E.J., Silva, E.B., Velazquez Salinas, L., Gladue, D.P., Borca, M.V. 2022. ASFV Gene A151R is involved in the process of virulence in domestic swine. Viruses. 14(8):1834. https://doi.org/10.3390/v14081834.
Deletion of the ASFV dUTPase gene E165R from the genome of highly virulent African swine fever virus Georgia 2010 does not affect virus replication or virulence in domestic pigs Reprint Icon - (Peer Reviewed Journal)
Vuono, E., Ramirez Medina, E., Pruitt, S.E., Rai, A., Espinoza, N.N., Silva, E.B., Velazquez Salinas, L., Gladue, D.P., Borca, M.V. 2022. Deletion of the ASFV dUTPase gene E165R from the genome of highly virulent African swine fever virus Georgia 2010 does not affect virus replication or virulence in domestic pigs. Viruses. 14(7):1409. https://doi.org/10.3390/v14071409.
Deletion of H108R reduces virulence of the Georgia strain of African swine fever virus with surviving animals being protected against virulent challenge Reprint Icon - (Peer Reviewed Journal)
Vuono, E., Ramirez Medina, E., Silva, E.B., Rai, A., Pruitt, S.E., Espinoza, N.N., Valladares, A., Velazquez Salinas, L., Gladue, D.P., Borca, M.V. 2022. Deletion of H108R reduces virulence of the Georgia strain of African swine fever virus with surviving animals being protected against virulent challenge. Journal of Virology. https://doi.org/10.1128/jvi.00545-22.
Experimental infection of domestic pigs with an African swine fever virus field strain isolated in 2021 from the Dominican Republic Reprint Icon - (Peer Reviewed Journal)
Ramirez Medina, E., O'Donnell, V., Silva, E.B., Espinoza, N.N., Velazquez Salinas, L., Gladue, D.P., Borca, M.V. 2022. Experimental infection of domestic pigs with an African swine fever virus field strain isolated in 2021 from the Dominican Republic. Viruses. https://doi.org/10.3390/v14051090.
Identification of genetic deletions in ASFV that could be potentially used as targets for the development of DIVA vaccines Reprint Icon - (Abstract Only)
Vuono, E., Ramirez Medina, E., Silva, E.B., Rai, A., Pruitt, S.E., Espinoza, N.N., Velazquez Salinas, L., Borca, M.V., Gladue, D.P. 2022. Identification of genetic deletions in ASFV that could be potentially used as targets for the development of DIVA vaccines. Meeting Abstract. https://doi.org/10.1128/JVI.01419-21.
Development of a novel African swine fever virus (ASFV) live attenuated vaccine candidate: deletion of A137R gene drastically attenuates Georgia strain and induce protection against the virulent challenge Reprint Icon - (Peer Reviewed Journal)
Gladue, D.P., Ramirez Medina, E., Vuono, E., Silva, E.B., Rai, A., Pruitt, S.E., Espinoza, N.N., Velazquez-Salinas, L., Borca, M.V. 2021. Development of a novel African swine fever virus (ASFV) live attenuated vaccine candidate: deletion of A137R gene drastically attenuates Georgia strain and induce protection against the virulent challenge. Journal of Virology. https://doi.org/10.1128/JVI.01139-21.
A cell culture-adapted vaccine virus against the current pandemic African swine fever virus strain Reprint Icon - (Peer Reviewed Journal)
Borca, M.V., Rai, A., Ramirez-Medina, E., Silva, E.B., Velazquez-Salinas, L., Vuono, E., Espinoza, N.N., Pruitt, S.E., Gladue, D.P. 2021. A cell culture-adapted vaccine virus against the current pandemic African swine fever virus strain. Nature Communications. https://doi.org/10.1128/JVI.00123-21.
Leukocyte gene expression of dairy cattle in response to flooring type and additional substance P - (Abstract Only)
Eicher, S.D., Silva, E.B., Marchant-Forde, J.N., Schutz, M.M. 2018. Leukocyte gene expression of dairy cattle in response to flooring type and additional substance P. IN: Proceedings of the Society for Leukocyte Biology, October 14-16, 2018, Chandler, Arizona. p. 30.
The effects of orally administered cortisol and norepinephrine on weanling piglet gut microbial populations and Salmonella passage - (Peer Reviewed Journal)
Acute brief heat stress in late gestation alters neonatal calf innate immune functions - (Peer Reviewed Journal)
Strong, R.A., Silva, E.B., Cheng, H., Eicher, S.D. 2015. Acute brief heat stress in late gestation alters neonatal calf innate immune functions. Journal of Dairy Science. 98:7771-7783. doi.org/10.3168/jds.2015-9591.